CN103271036B - Sterilization composition containing SYP-1620 - Google Patents
Sterilization composition containing SYP-1620 Download PDFInfo
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- CN103271036B CN103271036B CN201310233208.3A CN201310233208A CN103271036B CN 103271036 B CN103271036 B CN 103271036B CN 201310233208 A CN201310233208 A CN 201310233208A CN 103271036 B CN103271036 B CN 103271036B
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Abstract
The invention discloses a sterilization composition containing SYP-1620. Effective ingredients of the composition are SYP-1620 and Tebufloquin, and the weight ratio of the SYP-1620 to the Tebufloquin is 1:20-20:1. The composition can be prepared into a water dispersible granule, wettable powder, a suspending agent, a suspended seed coating or a granule which is allowed in agriculture. The composition is reasonable in component, good in sterilizing effect and low in drug use cost; the activity and the sterilizing effect of the composition are not simple addition of the activity of all the components; compared with a conventional single preparation, besides the remarkable sterilizing effect, the composition has a remarkable synergistic effect, has no pollution to crops, is good in safety, and meets the safety requirements of pesticide preparations; and the sterilization composition has a remarkable control effect upon rice blasts.
Description
Technical field
Patent application of the present invention is that invention and created name is a kind of bactericidal composition containing alkene oxime amine, and application number is 201210173315.7, and the applying date is dividing an application of 20120531 patent applications.
The present invention relates to a kind of bactericidal composition containing alkene oxime amine, particularly contain alkene oxime amine as the first active component a kind of comprising, be selected from the isotianil, ring propionyl bacterium amine, Rabcide, Tebufloquin of control rice blast bactericide as the bactericidal composition of the second active component, belong to technical field of compounded pesticide.
Background technology
Alkene oxime amine, chemical name: (E, E, E)-N-methyl-2-[((((1-methyl-3-(2,6-dichlorophenyl)-2-acrylic) imino group) oxygen base) methyl) phenyl]-2-methoxyimino acetic amide.The methoxy acrylic bactericide of alkene oxime amine Shi You Shenyang Chemical Engineering Inst exploitation, has unique mechanism of action, and it suppresses its mitochondrial respiratory by the electronics transmission between pinning cytochrome b and c1 and brings into play bacteriostasis.Its fungicidal spectrum is wide, active high, can be used for preventing and treating the plurality of plant diseases such as wheat rust, wheat powdery mildew, rice sheath blight disease, false smut, powdery mildew of cucumber, cucumber downy mildew, downy mildew of garpe, alternaria leaf spot of apple, apple mildew, sigatoka, early blight of tomato, pear scab, powdery mildew of strawberry, rust of sunflower.Although this bactericide mechanism of action is unique, the speed that pathogen produces resistance to it is also very fast, and use cost is high, so limited the spread of alkene oxime amine, uses.
Rice blast is one of important disease of paddy rice, can cause the significantly underproduction, the underproduction 40%～50% when serious, and even No kernels or seeds are gathered, as in a year of scarcity.All there is generation in Ge Dao district, the world.Introduce several pesticide species that can be used for preventing and treating rice blast below:
Isotianil, English common name isotianil, the chloro-N-of chemical name: 3,4-bis-(2-cyano-phenyl)-5-isothiazole formamide, is the isothiazole carboxamides that the common research and development of Bayer and Sumitomo Chemical are used for preventing and treating rice blast.Feature is that it does not produce direct antibacterial action to pathogen, but by exciting the natural immunology defense of paddy rice self to rice blast, reaches the object of opposing rice blast.
Ring propionyl bacterium amine, English common name fenhexamid, is a kind of acid amide fungicides, belongs to interior suction, protective fungicide.Different from existing bactericide, without bactericidal activity, do not suppress the growth of pathogen mycelia.Be mainly used in rice field control rice blast.
Rabcide, has another name called rabcide, English common name fthalide, chemical name: 4,5,6,7-Rabcide.For organochlorine bactericide, be foliage spray protectant, there is impermeabilisation and disturb melanin biosynthesis effect, be mainly used in preventing and treating rice blast.
Tebufloquin(test code number OK-02, SN4524), chemical name: 6-tert-butyl-8-fluoro-2,3-dimethyl-4-quinolyl acetate, the quinoline bactericide of Shi You Meiji Pharmaceutial Ltd. exploitation, mainly rice blast and banded sclerotial blight are had to extraordinary preventive effect, also can be for the control of soybean and vegetable disease.
Although alkene oxime amine is a kind of disinfectant use in agriculture of high-efficiency broad spectrum, it is as methoxy acrylic ester compounds, and the mechanism of action is single, and germ is reused in field for a long time can produce resistance, cause preventive effect to reduce, and use cost is high.After the bactericide isotianil of above-mentioned several control rice blast, ring propionyl bacterium amine, Rabcide, Tebufloquin listing, exist resistance risk.Inventor finds by test; bactericide compounded by the different alkene oxime amine of the mechanism of action and control rice blast, has obvious synergistic effect, can significantly improve control efficiency, the minimizing dosage for the treatment of, protection; reduce cost accounting, high to crop safety.
Summary of the invention
The object of the present invention is to provide a kind of component reasonable, synergistic effect is remarkable, and bactericidal effect is good, and drug cost is low, the agricultural bactericidal composition to crop safety.
Another object of the present invention is to provide the application of above-mentioned composition on control rice blast.
In order to overcome the defect of existing unitary agent, technical scheme of the present invention is to solve like this:
A) the first active component alkene oxime amine;
B) the second active component is selected from isotianil, ring propionyl bacterium amine, Rabcide, the Tebufloquin of control rice blast bactericide;
The weight ratio of the first active component and the second active component is 1:20～20:1, is preferably 1:10-10:1, and more preferably 1:5～5:1, most preferably is 1:2～2:1.
The cumulant of the first active component and the second active component is 5%～90% of described composition total weight, is preferably 8%～75%.
The preparation formulation that bactericidal composition of the present invention can be prepared according to method known in those skilled in the art is water dispersible granules, wetting powder, suspending agent, suspension seed-coating agent, granule.
For water dispersible granules, those skilled in the art are familiar with the corresponding auxiliary agent of use and complete the present invention very much.Dispersant as in polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate one or more; Wetting agent as in alkyl sulfate, alkylsulfonate, naphthalene sulfonate one or more; Disintegrant as in ammonium sulfate, urea, sucrose, glucose one or more; Binding agent is as one or more in diatomite, corn starch, PVA, carboxymethyl (ethyl) cellulose family; Filler as diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite, potter's clay one or more.
To wetting powder, spendable auxiliary agent has: dispersant as in polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate one or more; Wetting agent as in alkyl sulfate, alkylsulfonate, naphthalene sulfonate one or more; Filler as ammonium sulfate, urea, sucrose, glucose, diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite, potter's clay one or more.
To suspending agent, spendable auxiliary agent has: dispersant is produced as polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate (dispersing agent NNO), TERSPERSE 2020(U.S. Huntsman Corporation, alkyl naphthalene sulfonic acid salt) in one or more; Polyoxyethylene sorbitan stearate), agriculture breast 1601#(common name Span60), Tween-60 #(common name alkyl phenol formaldehyde resin polyoxyethylene ether), agriculture breast 2201, this dish-60#(common name emulsifier is as Nongru-700 #(common name:::: triphen ethyl-phenol polyoxyethylene polyoxypropylene block polymer), TERSPERSE 4894(U.S. Huntsman Corporation produces) in one or more; Wetting agent is produced as alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate, alkylphenol-polyethenoxy base ether phosphate, phenethyl phenol polyethenoxy base ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate, TERSPERSE 2500(U.S. Huntsman Corporation) in one or more; Thickener as in xanthans, polyvinyl alcohol, bentonite, aluminium-magnesium silicate one or more; Preservative as in formaldehyde, benzoic acid, Sodium Benzoate one or more; Defoamer is as organic silicon defoamer; Antifreezing agent as ethylene glycol, propane diols, glycerine, urea, inorganic salts as in sodium chloride one or more; Water is deionized water.
To suspension seed-coating agent, spendable auxiliary agent has: binding agent is as polysaccharose macromolecular compound (soluble starch, polypropylene graft copolymer, xanthan gum, microorganism mucilage), cellulose derivatives (hydroxypropyl methylcellulose, sodium carboxymethylcellulose, ethyl cellulose), seaweeds is as sodium alginate, agar, rosin, paraffin, gelatin, pectin, polyvinyl alcohol, polyethylene glycol, polyvinyl acetate, polyacrylamide, the water-soluble composite of polyvinylpyrrolidone and polyhydric alcohol polymer, inorganic binder (aluminium-magnesium silicate, clay, waterglass, gypsum) in one or more, dispersant as in polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate, TERSPERSE 2020 one or more, emulsifier is as Nongru-700 #, agriculture breast 2201, this dish-60#, emulsifier T-60(common name: one or more sorbitan monostearate APEO), in agriculture breast 1601#, TERSPERSE 4894, wetting agent as in alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate, alkylphenol-polyethenoxy base ether phosphate, phenethyl phenol polyethenoxy base ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate, TERSPERSE 2500 one or more, thickener as in xanthans, polyvinyl alcohol, bentonite one or more, preservative as in formaldehyde, benzoic acid, Sodium Benzoate one or more, defoamer is as organic silicon defoamer, antifreezing agent as ethylene glycol, propane diols, glycerine, urea, inorganic salts as in sodium chloride one or more, water is deionized water.
To granule, spendable auxiliary agent has: carrier is as clay, kaolin, talcum, calcium carbonate, diatomite, corn starch, alumina silicate etc.; Dispersant as in polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate one or more; Wetting agent as in alkyl sulfate, alkylsulfonate, naphthalene sulfonate one or more; Adhesive as in polyvinyl alcohol, dextrin, polyvinylpyrrolidone one or more.
Component of the present invention is reasonable, and treatment adds protective effect, and bactericidal effect is good, and drug cost is low, and its active and bactericidal effect is not the simple superposition of each composition activity, but has significant synergistic effect, good to crop safety, meets the security requirement of pesticidal preparations.The present invention has good control efficiency to rice blast.
Embodiment
In order to prevent and treat the rice blast in agricultural production, inventor has carried out mutual composite synergy research with alkene oxime amine and isotianil, ring propionyl bacterium amine, Rabcide, Tebufloquin, different according to pharmacy effect mechanism, adopt respectively pot-culture method and mycelial growth rate method to carry out toxicity test.
Pot-culture method:
Alkene oxime amine and isotianil or the ring propionyl bacterium amine employing the method that is mixed.For examination germ, being wild sensitive rice Pyricularia oryzae Pyricularia oryzae Cav. bacterial strain, is paddy rice sense rice blast kind for studying thing, and after vernalization, every basin sowing is 20, selects the 10 strain 3 leaf 1 heart stage rice seedlings that wherein growing way is consistent standby.Test is cultivated on suitable medium with pathogen, after spore to be generated, with spore under aseptic washing, and by 2 layers～4 layers filtered through gauze, make the suspension that concentration is 1 * 105 spore/milliliter, standby.The medicament preparing is diluted with water to 1mg/L, 2mg/L, 4mg/L, 8mg/L, 5 concentration of 16mg/L.Liquid is evenly sprayed in blade face to all wetting, standby after liquid natural air drying.Every processing 1 basin, repeats for 4 times, and only establishes the processing that does not contain active ingredient containing solvent and surfactant and do not make blank.Use spore suspension spray inoculation, in chemicals treatment, after 3 days, inoculate.After inoculation, move in humidistat moisturizing under (relative moisture more than 95%, keeps blade face to have dewfall, 25 ℃～26 ℃ of temperature) dark condition and cultivate 24 h.Then under 25 ℃～26 ℃, the condition of 12h alternation of light and darkness (intensity of illumination 20000 Lux), relative moisture 85%～90%, cultivate 7 days.Until the sick leaf rate of blank, reach 50% when above, the incidence of whole strain blade is investigated in classification, and classification and statistical method are:
0 grade: whole strain is anosis;
1 grade: occur brown some scab;
3 grades: occur typical spindle scab, lesion area accounts for below 5% of whole leaf area;
5 grades: typical scab, lesion area accounts for 6%～25% of whole leaf area;
7 grades: typical scab, lesion area accounts for 26%～50% of whole leaf area;
9 grades: typical scab, lesion area accounts for the more than 50% of whole leaf area.
Disease index=[Σ (the sick number of sheets * relative level numerical value at different levels)/investigate the total number of sheets * 9] * 100%
Control efficiency (%)=[(contrast disease index-processing disease index)/contrast disease index] * 100
By the linear regression analysis between the probit value of preventive effect and the logarithm value of series concentration, obtain the EC of each medicament
50value, with the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun mixture, evaluates the activity of reagent agent to germ with this.
The co-toxicity coefficient of complex preparation (CTC) >=120 shows as synergistic effect; CTC≤80 show as antagonism; 80 < CTC < 120 show as summation action.
Mycelial growth rate method:
Alkene oxime amine and Rabcide or the Tebufloquin employing the method that is mixed.Subjects is Pyricularia oryzae (Pyriculariagrisea).Former medicine is mixed with to the test medicine needing, test method is with reference to < < People's Republic of China's agricultural industry criteria NY/T1156.2-2006 > >.First single dose and each Mixed Pharmacy are arranged to 5 variable concentrations gradients (0.25 mg/L, 0.5 mg/L, 1 mg/L, 2 mg/L, 4 mg/L).If clear water contrast, repeats 3 times.Adopt mycelial growth rate method, by cultured pathogen, be 5mm card punch with diameter under aseptic condition, from colony edge, cuts bacterium cake, with transfer needle, bacterium cake is connected on the culture medium flat plate of different drug concentrations, puts in 26 ℃ of incubators and cultivate 72h; Check colony diameter, calculate the percentage that each chemicals treatment suppresses mycelial growth, by the linear regression analysis between the probit value of inhibiting rate and the logarithm value of series concentration, obtain the EC of each medicament
50value, with the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun mixture, evaluates the activity of reagent agent to germ with this.
The co-toxicity coefficient of complex preparation (CTC) >=120 shows as synergistic effect; CTC≤80 show as antagonism; 80 < CTC < 120 show as summation action.
Toxicity Determination result shows: a kind of in alkene oxime amine and isotianil, ring propionyl bacterium amine, Rabcide, Tebufloquin, the weight ratio of take has good virulence as 1:20～20:1 is mixed to rice blast fungus, all has significant synergistic effect.
Below in conjunction with FORMULATION EXAMPLE and biological Examples, content of the present invention is described further.
FORMULATION EXAMPLE 1
Take 6% alkene oxime amine, 60% isotianil, 4% Morwet D-425(alkyl naphthalene sulfonic acid condensation polymer sodium salt, Akzo Nobel N.V. produces), 3% dispersing agent NNO, 2% Nekal BX, 2% K-12(lauryl sodium sulfate), 2% corn starch, 2% sucrose, kaolin add to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule mixes, ultra micro air-flow crushing, mixing, granulation step are produced 66% alkene oxime amine isotianil water dispersible granules.
FORMULATION EXAMPLE 2
Take 25% alkene oxime amine, 25% ring propionyl bacterium amine, 4% TERSPERSE 2700,2% dispersing agent NNO, 2% Nekal BX (nekal), 2%K-12,3% corn starch, 5% ammonium sulfate, attapulgite and add to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule mixes, ultra micro air-flow crushing, mixing, granulation step are produced 50% alkene oxime amine ring propionyl bacterium amine water dispersible granules.
FORMULATION EXAMPLE 3
Take 15% alkene oxime amine, 75% Rabcide, 1% TERSPERSE 2700,1% dispersing agent NNO (alkylnaphthalene sulfonate formaldehyde condensation products), 1% Nekal BX, 1%K-12,1% carboxymethyl cellulose, diatomite and add to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule mixes, ultra micro air-flow crushing, mixing, granulation step are produced 90% alkene oxime amine Rabcide water dispersible granules.
FORMULATION EXAMPLE 4
Take 50% alkene oxime amine, 2.5%Tebufloquin, 3% TERSPERSE 2700,3% dispersing agent NNO, 2% Nekal BX, 2%K-12,1% carboxymethyl cellulose, 5% urea, diatomite and add to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule mixes, ultra micro air-flow crushing, mixing, granulation step are produced 52.5% alkene oxime amine Tebufloquin water dispersible granules.
FORMULATION EXAMPLE 5
Take 3% alkene oxime amine, 60% isotianil, 5% calcium lignosulfonate, 2% Nekal BX, 2%K-12,5% White Carbon black, kaolin and add to 100% weight portion.Above-mentioned raw materials, through mixing, makes 63% alkene oxime amine isotianil wetting powder after air-flow crushing.
FORMULATION EXAMPLE 6
Take 5% alkene oxime amine, 70% ring propionyl bacterium amine, 4% calcium lignosulfonate, 3% TERSPERSE 2700(polycarboxylate, U.S. Huntsman Corporation produces), 2% Nekal BX, 2%K-12,3% White Carbon black, fine particle calcium carbonate add to 100% weight portion.Above-mentioned raw materials, through mixing, makes 75% alkene oxime amine ring propionyl bacterium amine wetting powder after air-flow crushing.
FORMULATION EXAMPLE 7
Take 15% alkene oxime amine, 30% Rabcide, 2% calcium lignosulfonate, 2% dispersing agent NNO, 1% Nekal BX, 1%K-12, attapulgite and add to 100% weight portion.Above-mentioned raw materials, through mixing, makes 45% alkene oxime amine Rabcide wetting powder after air-flow crushing.
FORMULATION EXAMPLE 8
Take 50% alkene oxime amine, 5%Tebufloquin, 4% calcium lignosulfonate, 4% dispersing agent NNO, 2% Nekal BX, 2%K-12,3% White Carbon black, attapulgite and add to 100% weight portion.Above-mentioned raw materials, through mixing, makes 55% alkene oxime amine Tebufloquin wetting powder after air-flow crushing.
FORMULATION EXAMPLE 9
Taking 6% alkene oxime amine, 30% isotianil, 4%TERSPERSE 4894(U.S. Huntsman Corporation produces), 1.5%TERSPERSE 2500(U.S. Huntsman Corporation produces), 2%TERSPERSE 2020(U.S. Huntsman Corporation produces), 1% aluminium-magnesium silicate, 0.2% xanthans, 5% ethylene glycol, 0.5% formaldehyde, 0.5% silicone defoaming agent (trade name: s-29 Nanjing "four news" (new ideas applied chemistry product company produces), deionized water add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 36% alkene oxime amine isotianil suspending agent after sand mill sand milling.
FORMULATION EXAMPLE 10
Take 7% alkene oxime amine, 28% ring propionyl bacterium amine, 5%TERSPERSE 4894,2%TERSPERSE 2500,3%TERSPERSE 2020,0.2% xanthans, 5% propane diols, 0.5% benzoic acid, 0.5% silicone defoaming agent, deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 35% alkene oxime amine ring propionyl bacterium amine suspending agent after sand mill sand milling.
FORMULATION EXAMPLE 11
Take 30% alkene oxime amine, 10% Rabcide, 2%TERSPERSE 2020,2% this dish-60#, 2% Tween-60 #, 1%TERSPERSE 2500,0.5% white carbon, 0.3% xanthans, 5% ethylene glycol, 0.5% benzoic acid, 0.5% silicone defoaming agent, deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 40% alkene oxime amine Rabcide suspending agent after sand mill sand milling.
FORMULATION EXAMPLE 12
Take 20% alkene oxime amine, 10%Tebufloquin, 1%TERSPERSE 2020,3% agriculture breast 1601#, 2% agriculture breast 2201#, 1%TERSPERSE 2500,0.3% xanthans, 5% ethylene glycol, 0.5% formaldehyde, 0.5% silicone defoaming agent, deionized water and add to 100% weight portion.High speed shear is disperseed 30min, with making 30% alkene oxime amine Tebufloquin suspending agent after sand mill sand milling.
FORMULATION EXAMPLE 13
Take 20% alkene oxime amine, 5% isotianil, 1%TERSPERSE 2700,1%TERSPERSE 2500,3% TERSPERSE 4894,5.0% polyvinylpyrrolidone, 0.2% xanthans, 5% ethylene glycol, 0.3% benzoic acid, 0.5% silicone defoaming agent deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 25% alkene oxime amine isotianil suspension seed-coating agent after sand mill sand milling.
FORMULATION EXAMPLE 14
Take 8% alkene oxime amine, 24% ring propionyl bacterium amine, 3%TERSPERSE 4894,2%TERSPERSE 2500,1%TERSPERSE 2020,4.0% hydroxypropyl methylcellulose, 0.5% bentonite, 5% ethylene glycol, 0.3% Sodium Benzoate, 0.5% silicone defoaming agent deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 32% alkene oxime amine ring propionyl bacterium amine suspension seed-coating agent after sand mill sand milling.
FORMULATION EXAMPLE 15
Take 6% alkene oxime amine, 2% Rabcide, 1%TERSPERSE 2700,1%TERSPERSE 2500,3% TERSPERSE 4894,5.0% polyvinylpyrrolidone, 0.2% xanthans, 5% ethylene glycol, 0.3% benzoic acid, 0.5% silicone defoaming agent deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 8% alkene oxime amine Rabcide suspension seed-coating agent after sand mill sand milling.
FORMULATION EXAMPLE 16
Take 2% alkene oxime amine, 3%Tebufloquin, 3%TERSPERSE 4894,2%TERSPERSE 2500,1%TERSPERSE 2020,6.0% hydroxypropyl methylcellulose, 0.5% bentonite, 5% ethylene glycol, 0.3% Sodium Benzoate, 0.5% silicone defoaming agent deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 5% alkene oxime amine Tebufloquin suspension seed-coating agent after sand mill sand milling.
FORMULATION EXAMPLE 17
Take 5% alkene oxime amine, 10% isotianil, 3% sodium lignin sulfonate, 2% neopelex, 3% polyvinyl alcohol, kaolin and add to 100% weight portion.Mentioned component is added to water and mediate, use pinch-out granulator pinch out and be shaped, afterwards by particle fluid-bed drying, adjust particle size, make 15% alkene oxime amine isotianil granule.
FORMULATION EXAMPLE 18
Take 7.5% alkene oxime amine, 7.5% ring propionyl bacterium amine, 2% sodium lignin sulfonate, 3% TERSPERSE 2700,3% polyvinylpyrrolidone, clay and add to 100% weight portion.Above-mentioned raw materials is mediated through mixing and water adding, uses pinch-out granulator pinch out and be shaped, and afterwards by particle fluid-bed drying, adjusts particle size, makes 15% alkene oxime amine ring propionyl bacterium amine granule.
FORMULATION EXAMPLE 19
Take 7% alkene oxime amine, 14% Rabcide, 2% neopelex, 3% dispersing agent NNO, 3% polyvinylpyrrolidone, kaolin and add to 100% weight portion.Above-mentioned raw materials is mediated through mixing and water adding, uses pinch-out granulator pinch out and be shaped, and afterwards by particle fluid-bed drying, adjusts particle size, makes 21% alkene oxime amine ring propionyl bacterium amine granule.
FORMULATION EXAMPLE 20
Take 15% alkene oxime amine, 5% Tebufloquin, 3% lauryl sodium sulfate, 3% dispersing agent NNO, 4% dextrin, diatomite and add to 100% weight portion.Above-mentioned raw materials is mediated through mixing and water adding, uses pinch-out granulator pinch out and be shaped, and afterwards by particle fluid-bed drying, adjusts particle size, makes 20% alkene oxime amine Tebufloquin granule.
Biological Examples 1: control rice blast field trial (spraying)
2011 Nian Shaanxi Province Hanzhong Cities have carried out FORMULATION EXAMPLE 9(36% alkene oxime amine isotianil suspending agent), FORMULATION EXAMPLE 2(50% alkene oxime amine ring propionyl bacterium amine water dispersible granules), FORMULATION EXAMPLE 7(45% alkene oxime amine Rabcide wetting powder), FORMULATION EXAMPLE 12(30% alkene oxime amine Tebufloquin suspending agent) control rice blast field trial, verify that this medicament is to the control efficiency of rice blast, effective dose and the safety to paddy rice.Trial crops is paddy rice, and controlling object is rice blast (Pyricularia oryzae Cav.).Test is located at Hanzhong City Hantai District, and test medicine and dosage refer to table 5.Separately establish blank, every processing repeats for 4 times, every community area 30 ㎡, and Gong72Ge community, random district group is arranged.Adopt conventional spray-on process, mu dispenser liquid 50kg, evenly sprays paddy rice complete stool.Altogether dispenser is 2 times, paddy rice booting latter stage and each dispenser of full heading time 1 time.
Investigation and statistical method:
Investigation in 14 days after the 2nd dispenser, the sampling of 5 of investigation method Wei Mei communities, every some investigation 50 fringes, grade scale is as follows:
0 grade: anosis;
1 grade: every fringe loss is (morbidity of indivedual branch stalk) below 5%;
3 grades: every fringe loss 6%-20% (1/3 left and right branch stalk morbidity);
5 grades: every fringe loss 21%-50% (fringe neck or main shaft morbidity, grain half is flat);
7 grades: every fringe loss 51%-70% (morbidity of fringe neck, most of shrivelled kernel);
9 grades: every fringe loss 71%-100% (morbidity of fringe neck, causes dead ears).
According to disease, refer to calculate preventive effect.After each spray medicine after the 1st day and medicine some days, each processed the impact on paddy rice to observe medicament.
Disease index=[Σ (sick spike number * relative level numerical value at different levels)/investigate total spike number * 9] * 100%
Control efficiency (%)=[(contrast disease index-processing disease index)/contrast disease index] * 100.
Field test results shows: 36% 1800 times of alkene oxime amine isotianil suspending agents, 2000 times, 2200 times, 50% 4000 times of alkene oxime amine ring propionyl bacterium amine water dispersible granules, 4200 times, 4400 times, 45% 2200 times of alkene oxime amine Rabcide wetting powders, 2400 times, 2600 times, 30% 3200 times of alkene oxime amine Tebufloquin suspending agents, 3400 times, 3600 times, rice blast is had to more significant control efficiency, obviously be better than 1000 times of 10% alkene oxime amine missible oil, 30% 1000 times of isotianil suspending agents, 20% 1000 times of ring propionyl bacterium amine amine suspending agents, 50% 1000 times of Rabcide wetting powders, 1000 times of the 10%Tebufloquin suspending agents control efficiency to rice blast.
Security survey to paddy rice, observes for after spray medicine after the 1st day and medicine some days, and each test is processed paddy rice is occurred without poisoning phenomenon.
After result of the test shows that alkene oxime amine and isotianil, ring propionyl bacterium amine, Rabcide, Tebufloquin are mixed, obviously improved the control efficiency to rice blast, having reduced dosage and drug cost, to paddy growth safety, is the desirable medicament of control rice blast.
Biological Examples 2: control rice blast field trial (seed dressing)
2011 Hanbin district, Nian Shaanxi Province have carried out FORMULATION EXAMPLE 13(25% alkene oxime amine isotianil suspension seed-coating agent), FORMULATION EXAMPLE 14(32% alkene oxime amine ring propionyl bacterium amine suspension seed-coating agent), FORMULATION EXAMPLE 15(8% alkene oxime amine Rabcide suspension seed-coating agent), FORMULATION EXAMPLE 16(5% alkene oxime amine Tebufloquin suspension seed-coating agent) control rice blast field trial.Test medicine and dosage refer to table 6.Separately establish clear water blank, every processing repeats for 4 times, area community, community area 20 ㎡, and random district group is arranged.Each chemicals treatment is processed the ratio of double centner seed in 1.6 hydrargyrum oxydatum crudum liquid, calculate dosing and the amount of being watered.Sowing after rice paddy seed is processed.
Investigation and statistical method, investigate 2 times altogether, and respectively at rice seedling and the investigation of fringe phase, 5 points are investigated in every community, every 20 strains (fringe), and diseased plant (fringe) rate of community rice blast is respectively processed in investigation, calculates preventive effect.Each processes the impact on paddy rice at each crucial growing stage of paddy rice, to observe medicament.
Diseased plant rate (%)=(morbidity strain number/investigate total strain number) * 100
Control efficiency (%)=[(check plot diseased plant rate-treatment region diseased plant rate)/check plot diseased plant rate] * 100.
Field test results shows, 25% alkene oxime amine isotianil suspension seed-coating agent, 32% alkene oxime amine ring propionyl bacterium amine suspension seed-coating agent, 8% alkene oxime amine Rabcide suspension seed-coating agent, 5% alkene oxime amine Tebufloquin suspension seed-coating agent are pressed respectively dosage Rice seeds treated in table 6 to rice blast, rice seedling and the rice blast of fringe phase are all had to good preventive effect, especially control seedling stage rice blast effect remarkable, later stage rice blast is also needed to spraying control.The preventive effect of these several mixture preparations is obviously better than the preventive effect of 5 kinds of single doses such as 10% alkene oxime amine suspension seed-coating agent, 10% isotianil suspension seed-coating agent to rice blast.
Security survey to paddy rice, processes rice seedling rate higher than blank 2% left and right, grows and is also better than blank, shows that medicament is to paddy growth safety, without poisoning.
After result of the test shows that alkene oxime amine and isotianil, ring propionyl bacterium amine, Rabcide, Tebufloquin are mixed, by chemicals treatment rice paddy seed, obviously improved the control efficiency to rice blast, dosage and drug cost have been reduced, to paddy growth safety, it is the desirable medicament of control rice blast.
Biological Examples 3: control rice blast field trial (spreading fertilizer over the fields granule)
2011 Ankang City Hanyin County, Nian Shaanxi Province have carried out FORMULATION EXAMPLE 17(15% alkene oxime amine isotianil granule), FORMULATION EXAMPLE 18(15% alkene oxime amine ring propionyl bacterium amine particle), FORMULATION EXAMPLE 19(21% alkene oxime amine Rabcide granule), FORMULATION EXAMPLE 20(20% alkene oxime amine Tebuf loquin granule) control rice blast field trial.Test medicine and dosage refer to table 7.Separately establish blank, every processing repeats for 4 times, area community, community area 20 ㎡, and the ridge is built in minizone, single single filling, random district group is arranged.Each medicament is mixed fine sand 10Kg by a design mu consumption and is spread fertilizer over the fields, in rice transplanting phase and each dispenser in booting stage once.
Investigation and statistical method, investigate 2 times altogether, and respectively at investigation in 21 days after each dispenser, 5 points are investigated in every community, every 20 strains (fringe), and diseased plant (fringe) rate of community rice blast is respectively processed in investigation, calculates preventive effect.Each processes the impact on paddy rice at each crucial growing stage of paddy rice, to observe medicament.
Diseased plant rate (%)=(morbidity strain number/investigate total strain number) * 100
Control efficiency (%)=[(check plot diseased plant rate-treatment region diseased plant rate)/check plot diseased plant rate] * 100.
Field test results shows, 15% alkene oxime amine isotianil granule 500g/ mu, 15% alkene oxime amine ring propionyl bacterium amine granule 600g/ mu, 21% alkene oxime amine Rabcide granule 500g/ mu, 20% alkene oxime amine Tebufloquin granule 400g/ mu, in rice transplanting phase and booting stage, respectively spread fertilizer over the fields once, rice seedling and the rice blast of fringe phase are all had to good preventive effect, be obviously better than the preventive effect (table 7) of 5 kinds of single doses such as 10% alkene oxime amine granule, 10% isotianil granule to rice blast.
Security survey to paddy rice, each test is processed to paddy growth safety, without poisoning.
After result of the test shows that alkene oxime amine and isotianil, ring propionyl bacterium amine, Rabcide, Tebufloquin are mixed, control rice blast is spread fertilizer over the fields in granulation agent, and drug effect is obvious, dispenser is easy, saving manpower, to paddy growth safety, is the desirable medicament of control rice blast.
In sum, composition of the present invention is to adopt two kinds of active component compound schemes, its activity and bactericidal effect are not the simple superposition of each composition activity, compare with existing unitary agent, except having significant bactericidal effect, and have significant synergistic effect, and good to crop safety, meet the security requirement of pesticidal preparations.
Claims (8)
1. containing a bactericidal composition for alkene oxime amine, it is characterized in that composition active component is alkene oxime amine and Tebufloquin, the weight ratio of alkene oxime amine and Tebufloquin is 1:20～20:1.
2. according to claim 1 containing the bactericidal composition of alkene oxime amine, it is characterized in that: the weight ratio of alkene oxime amine and Tebufloquin is 1:10～10:1.
3. according to claim 2 containing the bactericidal composition of alkene oxime amine, it is characterized in that: the weight ratio of alkene oxime amine and Tebufloquin is 1:5～5:1.
4. according to claim 3 containing the bactericidal composition of alkene oxime amine, it is characterized in that: the weight ratio of alkene oxime amine and Tebufloquin is 1:2～2:1.
5. according to claim 1 containing the bactericidal composition of alkene oxime amine, it is characterized in that: the cumulant of alkene oxime amine and Tebufloquin is described composition total weight 5%～90%.
6. according to claim 5 containing the bactericidal composition of alkene oxime amine, it is characterized in that: the cumulant of alkene oxime amine and Tebufloquin is described composition total weight 8%～75%.
7. according to claim 1 containing the bactericidal composition of alkene oxime amine, it is characterized in that: described combination dosage form is water dispersible granules, wetting powder, suspending agent, suspension seed-coating agent, granule.
8. described in claim 1, contain the bactericidal composition of alkene oxime amine in the application preventing and treating on rice blast.
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| CN1309897A (en) * | 2000-02-24 | 2001-08-29 | 沈阳化工研究院 | Unsaturated oximino ether bactericide |
| CN1708225A (en) * | 2002-10-30 | 2005-12-14 | 明治制果株式会社 | Fungicidal compositions for the control of paddy rice diseases |
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| CN1309897A (en) * | 2000-02-24 | 2001-08-29 | 沈阳化工研究院 | Unsaturated oximino ether bactericide |
| CN1708225A (en) * | 2002-10-30 | 2005-12-14 | 明治制果株式会社 | Fungicidal compositions for the control of paddy rice diseases |
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