CN102686261B - 增强型的喷射器设计 - Google Patents

增强型的喷射器设计 Download PDF

Info

Publication number
CN102686261B
CN102686261B CN201080058137.2A CN201080058137A CN102686261B CN 102686261 B CN102686261 B CN 102686261B CN 201080058137 A CN201080058137 A CN 201080058137A CN 102686261 B CN102686261 B CN 102686261B
Authority
CN
China
Prior art keywords
injector
constriction
length
physical dimension
siphon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201080058137.2A
Other languages
English (en)
Chinese (zh)
Other versions
CN102686261A (zh
Inventor
B·斯特德曼
P·卡卡德
D·韦勒
J·伦纳德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MAP Pharmaceuticals Inc
Original Assignee
MAP Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MAP Pharmaceuticals Inc filed Critical MAP Pharmaceuticals Inc
Publication of CN102686261A publication Critical patent/CN102686261A/zh
Application granted granted Critical
Publication of CN102686261B publication Critical patent/CN102686261B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A61M15/0026—Hinged caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B01F25/312—Injector mixers in conduits or tubes through which the main component flows with Venturi elements; Details thereof
    • B01F25/3124—Injector mixers in conduits or tubes through which the main component flows with Venturi elements; Details thereof characterised by the place of introduction of the main flow
    • B01F25/31242—Injector mixers in conduits or tubes through which the main component flows with Venturi elements; Details thereof characterised by the place of introduction of the main flow the main flow being injected in the central area of the venturi, creating an aspiration in the circumferential part of the conduit
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04F—PUMPING OF FLUID BY DIRECT CONTACT OF ANOTHER FLUID OR BY USING INERTIA OF FLUID TO BE PUMPED; SIPHONS
    • F04F5/00—Jet pumps, i.e. devices in which flow is induced by pressure drop caused by velocity of another fluid flow
    • F04F5/44—Component parts, details, or accessories not provided for in, or of interest apart from, groups F04F5/02 - F04F5/42
    • F04F5/46—Arrangements of nozzles
    • F04F5/463—Arrangements of nozzles with provisions for mixing
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
    • F15D—FLUID DYNAMICS, i.e. METHODS OR MEANS FOR INFLUENCING THE FLOW OF GASES OR LIQUIDS
    • F15D1/00—Influencing flow of fluids
    • F15D1/02—Influencing flow of fluids in pipes or conduits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0096—Hindering inhalation before activation of the dispenser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/20—Flow characteristics having means for promoting or enhancing the flow, actively or passively

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Jet Pumps And Other Pumps (AREA)
CN201080058137.2A 2009-12-23 2010-12-23 增强型的喷射器设计 Expired - Fee Related CN102686261B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28478409P 2009-12-23 2009-12-23
US61/284,784 2009-12-23
PCT/US2010/062084 WO2011079310A1 (en) 2009-12-23 2010-12-23 Enhanced eductor design

Publications (2)

Publication Number Publication Date
CN102686261A CN102686261A (zh) 2012-09-19
CN102686261B true CN102686261B (zh) 2014-09-10

Family

ID=44185936

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080058137.2A Expired - Fee Related CN102686261B (zh) 2009-12-23 2010-12-23 增强型的喷射器设计

Country Status (9)

Country Link
US (4) US9227030B2 (enExample)
EP (1) EP2515978B1 (enExample)
JP (3) JP5781540B2 (enExample)
CN (1) CN102686261B (enExample)
AU (1) AU2010336338B2 (enExample)
CA (1) CA2781313C (enExample)
IL (3) IL219744A (enExample)
IN (1) IN2012DN04857A (enExample)
WO (1) WO2011079310A1 (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1494732T1 (sl) 2002-03-20 2008-08-31 Mannking Corp Inhalacijski aparat
JP5078014B2 (ja) 2004-08-20 2012-11-21 マンカインド コーポレイション ジケトピペラジン合成の触媒反応
JP4990142B2 (ja) 2004-08-23 2012-08-01 マンカインド コーポレイション 薬物送達のためのジケトピペラジン塩、ジケトモルホリン塩、又はジケトジオキサン塩
EP1937219B1 (en) 2005-09-14 2015-11-11 MannKind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
CN104383546B (zh) 2006-02-22 2021-03-02 曼金德公司 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法
CA2661266A1 (en) * 2006-08-22 2008-02-28 Glaxo Group Limited Actuator for an inhaler
RU2009105642A (ru) * 2006-08-22 2010-09-27 Глаксо Груп Лимитед (GB) Средство приведения в действие для ингалятора
US8875697B2 (en) * 2007-07-24 2014-11-04 Ric Investments, Llc Drug delivery apparatus and method
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
US9358352B2 (en) * 2008-06-13 2016-06-07 Mannkind Corporation Dry powder drug delivery system and methods
CN109568740B (zh) 2008-06-13 2022-05-27 曼金德公司 干粉吸入器和用于药物输送的系统
MX336361B (es) 2008-06-20 2015-12-03 Mannkind Corp Un metodo y un aparato interactivo para perfilar en tiempo real esfuerzos de inhalacion.
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
GB2476611B (en) * 2009-08-07 2011-08-31 Kind Consumer Ltd An inhaler
IN2012DN04857A (enExample) * 2009-12-23 2015-09-25 Map Pharmaceuticals Inc
SG10201606220QA (en) 2011-04-01 2016-09-29 Mannkind Corp Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
MX2014004983A (es) 2011-10-24 2014-09-22 Mannkid Corp Metodos y composiciones para tratar dolor.
SG10201605800UA (en) 2012-07-12 2016-09-29 Mannkind Corp Dry powder drug delivery system and methods
WO2014033057A1 (en) * 2012-08-29 2014-03-06 Chiesi Farmaceutici S.P.A. Aerosol inhalation device
CA3056509C (en) * 2013-03-14 2021-11-16 Trudell Medical International Metered dose inhaler applicator
US20160081394A1 (en) * 2013-05-10 2016-03-24 Loec, Inc. Flavor vortex device
GB201308679D0 (en) * 2013-05-14 2013-06-26 3M Innovative Properties Co Actuator for an inhaler
US9925144B2 (en) 2013-07-18 2018-03-27 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
CN103877655B (zh) * 2014-04-08 2015-12-30 隋宁昕 自吸固定式吸氧鼻塞
US11291780B2 (en) * 2014-12-04 2022-04-05 Vyaire Medical Consumables Llc Breath-actuated nebulizer for medicine inhalation
JP7152954B2 (ja) * 2015-12-21 2022-10-13 キンデーバ ドラッグ デリバリー リミティド パートナーシップ 医療用吸入器
GB201702407D0 (en) 2017-02-14 2017-03-29 Norton (Waterford) Ltd Inhalers and related methods
GB201707095D0 (en) 2017-05-04 2017-06-21 3M Innovative Properties Co Inhaler flow control mechanism
CN109210374B (zh) * 2017-06-30 2021-06-08 北京北方华创微电子装备有限公司 进气管路及半导体加工设备
CN112203704A (zh) * 2018-04-06 2021-01-08 弗兰克·利维 用于产生浓缩医疗悬浮液的设备和方法
CN110433366B (zh) * 2019-08-12 2022-03-04 杭州市红十字会医院 一种便携式呼吸科给药器
CN113898570B (zh) * 2021-12-08 2022-02-08 常州萨柏美格医用气体设备有限公司 气体流动过程检测装置及方法、空气压缩机组及检测方法
CN114798201B (zh) * 2022-06-29 2022-10-04 山东沃德净水科技有限公司 一种喷射器优化方法及喷射器
WO2025030129A2 (en) * 2023-08-03 2025-02-06 United Industries Corporation Aerosol spray device, insecticide composition, and method of use
US12268807B1 (en) 2023-12-20 2025-04-08 Yale University Devices, systems, and methods for providing individualized delivery of suspended medication

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5740794A (en) * 1994-09-21 1998-04-21 Inhale Therapeutic Systems Apparatus and methods for dispersing dry powder medicaments
US5826570A (en) * 1991-03-05 1998-10-27 Aradigm Corporation Delivery of aerosol medications for inspiration
CN1255869A (zh) * 1998-02-06 2000-06-07 日商优尼希雅·杰克斯股份有限公司 药物吸入器
US20040011357A1 (en) * 2000-07-05 2004-01-22 Philip Braithwaite Actuator comprising moveable membrane
CN101410189A (zh) * 2006-03-27 2009-04-15 贝林格尔英格海姆法玛两合公司 用以施用药物制剂的剂量喷雾器

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2037940A (en) 1932-09-10 1936-04-21 Edward A Stalker Means for preventing the separation of the flow from curved surfaces
US3665949A (en) 1969-06-27 1972-05-30 Bendix Corp Gaseous controlled fluidic throttling valve
YU41046B (en) * 1974-08-22 1986-10-31 Schering Ag Medicine inholating device
US4044763A (en) * 1975-07-07 1977-08-30 Bird F M Ventilator and method
US4592348A (en) * 1984-12-17 1986-06-03 Waters Iv William C Aerosol inhaler
FR2645026B1 (fr) * 1989-03-31 1997-11-21 Boussignac Georges Dispositif d'assistance respiratoire
US5161524A (en) * 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
PL173275B1 (pl) * 1992-09-11 1998-02-27 Glaxo Group Ltd Urządzenie inhalacyjne
US5727546A (en) * 1993-08-18 1998-03-17 Fisons Plc Powder inhaler with breath flow regulation valve
US5415162A (en) 1994-01-18 1995-05-16 Glaxo Inc. Multi-dose dry powder inhalation device
JP3706136B2 (ja) * 1994-09-21 2005-10-12 ネクター セラピューティクス 乾燥粉末薬剤の分散装置及び方法
US6006747A (en) * 1997-03-20 1999-12-28 Dura Pharmaceuticals, Inc. Dry powder inhaler
US5954047A (en) * 1997-10-17 1999-09-21 Systemic Pulmonary Development, Ltd. Methods and apparatus for delivering aerosolized medication
ES2306002T3 (es) * 1999-07-23 2008-11-01 Mannkind Corporation Capsula de dosis unitaria para un inhalador de polvo seco.
US6367471B1 (en) 1999-11-01 2002-04-09 Sheffield Pharmaceuticals, Inc. Internal vortex mechanism for inhaler device
US6443151B1 (en) 2000-03-08 2002-09-03 Aradigm Corporation Fluid velocity-sensitive trigger mechanism
DE10024738A1 (de) * 2000-05-19 2001-11-29 Qvf Engineering Gmbh Glasbauteile mit einer ableitfähigen Beschichtung, ihre Verwendung und daraus hergestellte Apparate, Anlagen und Rohrleitungen
GB2364919A (en) * 2000-07-21 2002-02-13 Cambridge Consultants Inhalers
FI20002363A0 (fi) * 2000-10-27 2000-10-27 Orion Yhtymae Oyj Jauheinhalaattori
GB0222295D0 (en) * 2002-09-25 2002-10-30 3M Innovative Properties Co Breath actuated medicament dispensing devices
DE102005010965B3 (de) * 2005-03-10 2006-08-03 Medspray Xmems Bv Inhalator mit einem Mischkanal zum Erzeugen eines zu inhalierenden Aerosols
WO2007123665A2 (en) * 2006-03-30 2007-11-01 Allegiance Corporation Nebulizer with pressure-based fluidic-control and related methods
WO2007123664A1 (en) * 2006-03-30 2007-11-01 Allegiance Corporation Nebulizer with flow-based fluidic control and related methods
CA2678018A1 (en) * 2007-02-28 2008-09-04 Abbott Respiratory Llc Nozzle-based atomization system
WO2009128491A1 (ja) * 2008-04-17 2009-10-22 帝人ファーマ株式会社 定量噴霧式吸入器用吸入補助器具
CN109568740B (zh) * 2008-06-13 2022-05-27 曼金德公司 干粉吸入器和用于药物输送的系统
IN2012DN04857A (enExample) * 2009-12-23 2015-09-25 Map Pharmaceuticals Inc

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5826570A (en) * 1991-03-05 1998-10-27 Aradigm Corporation Delivery of aerosol medications for inspiration
US5740794A (en) * 1994-09-21 1998-04-21 Inhale Therapeutic Systems Apparatus and methods for dispersing dry powder medicaments
CN1255869A (zh) * 1998-02-06 2000-06-07 日商优尼希雅·杰克斯股份有限公司 药物吸入器
US20040011357A1 (en) * 2000-07-05 2004-01-22 Philip Braithwaite Actuator comprising moveable membrane
CN101410189A (zh) * 2006-03-27 2009-04-15 贝林格尔英格海姆法玛两合公司 用以施用药物制剂的剂量喷雾器

Also Published As

Publication number Publication date
AU2010336338B2 (en) 2015-02-19
CA2781313A1 (en) 2011-06-30
US20160129208A1 (en) 2016-05-12
IN2012DN04857A (enExample) 2015-09-25
IL242205A0 (en) 2015-11-30
IL219744A0 (en) 2012-07-31
CN102686261A (zh) 2012-09-19
WO2011079310A1 (en) 2011-06-30
EP2515978B1 (en) 2018-02-14
AU2010336338A1 (en) 2012-06-21
JP2015221225A (ja) 2015-12-10
IL242205A (en) 2017-07-31
EP2515978A1 (en) 2012-10-31
CA2781313C (en) 2019-09-17
JP5781540B2 (ja) 2015-09-24
US9610415B2 (en) 2017-04-04
US9227030B2 (en) 2016-01-05
US20170056609A1 (en) 2017-03-02
JP2013515577A (ja) 2013-05-09
EP2515978A4 (en) 2015-03-04
US20200030555A1 (en) 2020-01-30
IL252847B (en) 2021-02-28
JP2017164554A (ja) 2017-09-21
JP6157542B2 (ja) 2017-07-05
IL219744A (en) 2015-11-30
IL252847A0 (en) 2017-08-31
US20110155129A1 (en) 2011-06-30

Similar Documents

Publication Publication Date Title
CN102686261B (zh) 增强型的喷射器设计
CA2883143C (en) A breath operated inhaler with plume impiging air jets
US5954047A (en) Methods and apparatus for delivering aerosolized medication
AU777488B2 (en) Method and apparatus for delivering aerosolized medication
HK1172857B (en) Enhanced eductor design
HK1172857A (en) Enhanced eductor design
HK1211186B (en) A breath operated inhaler with plume impiging air jets

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20140910