CN102686261B - 增强型的喷射器设计 - Google Patents

增强型的喷射器设计 Download PDF

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Publication number
CN102686261B
CN102686261B CN201080058137.2A CN201080058137A CN102686261B CN 102686261 B CN102686261 B CN 102686261B CN 201080058137 A CN201080058137 A CN 201080058137A CN 102686261 B CN102686261 B CN 102686261B
Authority
CN
China
Prior art keywords
injector
constriction
length
physical dimension
siphon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201080058137.2A
Other languages
English (en)
Chinese (zh)
Other versions
CN102686261A (zh
Inventor
B·斯特德曼
P·卡卡德
D·韦勒
J·伦纳德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MAP Pharmaceuticals Inc
Original Assignee
MAP Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MAP Pharmaceuticals Inc filed Critical MAP Pharmaceuticals Inc
Publication of CN102686261A publication Critical patent/CN102686261A/zh
Application granted granted Critical
Publication of CN102686261B publication Critical patent/CN102686261B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A61M15/0026—Hinged caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B01F25/312—Injector mixers in conduits or tubes through which the main component flows with Venturi elements; Details thereof
    • B01F25/3124—Injector mixers in conduits or tubes through which the main component flows with Venturi elements; Details thereof characterised by the place of introduction of the main flow
    • B01F25/31242—Injector mixers in conduits or tubes through which the main component flows with Venturi elements; Details thereof characterised by the place of introduction of the main flow the main flow being injected in the central area of the venturi, creating an aspiration in the circumferential part of the conduit
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04F—PUMPING OF FLUID BY DIRECT CONTACT OF ANOTHER FLUID OR BY USING INERTIA OF FLUID TO BE PUMPED; SIPHONS
    • F04F5/00—Jet pumps, i.e. devices in which flow is induced by pressure drop caused by velocity of another fluid flow
    • F04F5/44—Component parts, details, or accessories not provided for in, or of interest apart from, groups F04F5/02 - F04F5/42
    • F04F5/46—Arrangements of nozzles
    • F04F5/463—Arrangements of nozzles with provisions for mixing
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
    • F15D—FLUID DYNAMICS, i.e. METHODS OR MEANS FOR INFLUENCING THE FLOW OF GASES OR LIQUIDS
    • F15D1/00—Influencing flow of fluids
    • F15D1/02—Influencing flow of fluids in pipes or conduits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0096—Hindering inhalation before activation of the dispenser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/20—Flow characteristics having means for promoting or enhancing the flow, actively or passively

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Jet Pumps And Other Pumps (AREA)
CN201080058137.2A 2009-12-23 2010-12-23 增强型的喷射器设计 Expired - Fee Related CN102686261B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28478409P 2009-12-23 2009-12-23
US61/284,784 2009-12-23
PCT/US2010/062084 WO2011079310A1 (en) 2009-12-23 2010-12-23 Enhanced eductor design

Publications (2)

Publication Number Publication Date
CN102686261A CN102686261A (zh) 2012-09-19
CN102686261B true CN102686261B (zh) 2014-09-10

Family

ID=44185936

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080058137.2A Expired - Fee Related CN102686261B (zh) 2009-12-23 2010-12-23 增强型的喷射器设计

Country Status (9)

Country Link
US (4) US9227030B2 (enExample)
EP (1) EP2515978B1 (enExample)
JP (3) JP5781540B2 (enExample)
CN (1) CN102686261B (enExample)
AU (1) AU2010336338B2 (enExample)
CA (1) CA2781313C (enExample)
IL (3) IL219744A (enExample)
IN (1) IN2012DN04857A (enExample)
WO (1) WO2011079310A1 (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6923175B2 (en) 2002-03-20 2005-08-02 Mannkind Corporation Inhalation apparatus
CN101010305B (zh) 2004-08-20 2010-08-11 曼金德公司 二酮哌嗪合成的催化反应
BR122019022692B1 (pt) 2004-08-23 2023-01-10 Mannkind Corporation Composição terapêutica em pó seco contendo dicetopiperazina, pelo menos um tipo de cátion e um agente biologicamente ativo
KR101384456B1 (ko) 2005-09-14 2014-04-10 맨카인드 코포레이션 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법
ES2647080T3 (es) 2006-02-22 2017-12-19 Mannkind Corporation Un método para mejorar las propiedades farmacéuticas de micropartículas que comprenden dicetopiperazina y un agente activo
ES2507504T3 (es) * 2006-08-22 2014-10-15 Glaxo Group Limited Accionador para un inhalador
CA2661266A1 (en) * 2006-08-22 2008-02-28 Glaxo Group Limited Actuator for an inhaler
US8875697B2 (en) * 2007-07-24 2014-11-04 Ric Investments, Llc Drug delivery apparatus and method
WO2011163272A1 (en) * 2010-06-21 2011-12-29 Mannkind Corporation Dry powder drug delivery system and methods
DK2293833T3 (en) 2008-06-13 2016-05-23 Mannkind Corp DRY POWDER INHALER AND MEDICINAL ADMINISTRATION SYSTEM
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
CA2728523C (en) 2008-06-20 2020-03-10 Mannkind Corporation An interactive apparatus and method for real-time profiling of inhalation efforts
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US10456539B2 (en) * 2009-08-07 2019-10-29 Kind Consumer Limited Inhaler
IN2012DN04857A (enExample) * 2009-12-23 2015-09-25 Map Pharmaceuticals Inc
ES2625858T3 (es) 2011-04-01 2017-07-20 Mannkind Corporation Paquete de tipo blíster para cartuchos farmacéuticos
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
HK1201475A1 (en) 2011-10-24 2015-09-04 Mannkind Corporation Methods and compositions for treating pain
CA3098386C (en) 2012-07-12 2022-11-29 Mannkind Corporation Dry powder drug delivery systems and methods
AU2013307389A1 (en) * 2012-08-29 2015-03-19 Chiesi Farmaceutici S.P.A. Aerosol inhalation device
ES2666135T3 (es) * 2013-03-14 2018-05-03 Trudell Medical International Aplicador para inhalador dosificador
CN105722410B (zh) * 2013-05-10 2021-08-03 富特姆4有限公司 香味涡旋装置
GB201308679D0 (en) * 2013-05-14 2013-06-26 3M Innovative Properties Co Actuator for an inhaler
BR122019026637B1 (pt) 2013-07-18 2023-09-26 Mannkind Corporation Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
CN103877655B (zh) * 2014-04-08 2015-12-30 隋宁昕 自吸固定式吸氧鼻塞
WO2016089981A1 (en) * 2014-12-04 2016-06-09 Carefusion 2200, Inc. Breath-actuated nebulizer for medicine inhalation
WO2017112400A1 (en) 2015-12-21 2017-06-29 3M Innovative Properties Company Medicinal inhalers
GB201702407D0 (en) * 2017-02-14 2017-03-29 Norton (Waterford) Ltd Inhalers and related methods
GB201707095D0 (en) * 2017-05-04 2017-06-21 3M Innovative Properties Co Inhaler flow control mechanism
CN109210374B (zh) * 2017-06-30 2021-06-08 北京北方华创微电子装备有限公司 进气管路及半导体加工设备
CA3095939C (en) * 2018-04-06 2023-09-26 Frank Levy Apparatus and method for producing an enriched medical suspension
CN110433366B (zh) * 2019-08-12 2022-03-04 杭州市红十字会医院 一种便携式呼吸科给药器
CN113898570B (zh) * 2021-12-08 2022-02-08 常州萨柏美格医用气体设备有限公司 气体流动过程检测装置及方法、空气压缩机组及检测方法
CN114798201B (zh) * 2022-06-29 2022-10-04 山东沃德净水科技有限公司 一种喷射器优化方法及喷射器
WO2025030129A2 (en) * 2023-08-03 2025-02-06 United Industries Corporation Aerosol spray device, insecticide composition, and method of use
US12268807B1 (en) 2023-12-20 2025-04-08 Yale University Devices, systems, and methods for providing individualized delivery of suspended medication

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5740794A (en) * 1994-09-21 1998-04-21 Inhale Therapeutic Systems Apparatus and methods for dispersing dry powder medicaments
US5826570A (en) * 1991-03-05 1998-10-27 Aradigm Corporation Delivery of aerosol medications for inspiration
CN1255869A (zh) * 1998-02-06 2000-06-07 日商优尼希雅·杰克斯股份有限公司 药物吸入器
US20040011357A1 (en) * 2000-07-05 2004-01-22 Philip Braithwaite Actuator comprising moveable membrane
CN101410189A (zh) * 2006-03-27 2009-04-15 贝林格尔英格海姆法玛两合公司 用以施用药物制剂的剂量喷雾器

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2037940A (en) * 1932-09-10 1936-04-21 Edward A Stalker Means for preventing the separation of the flow from curved surfaces
US3665949A (en) 1969-06-27 1972-05-30 Bendix Corp Gaseous controlled fluidic throttling valve
YU41046B (en) 1974-08-22 1986-10-31 Schering Ag Medicine inholating device
US4044763A (en) * 1975-07-07 1977-08-30 Bird F M Ventilator and method
US4592348A (en) * 1984-12-17 1986-06-03 Waters Iv William C Aerosol inhaler
FR2645026B1 (fr) * 1989-03-31 1997-11-21 Boussignac Georges Dispositif d'assistance respiratoire
US5161524A (en) * 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
SK280014B6 (sk) 1992-09-11 1999-07-12 Glaxo Group Limited Inhalátor
DE69413989T2 (de) 1993-08-18 1999-04-08 Fisons Plc, Ipswich, Suffolk Inhalator mit atemstromregelung
US5415162A (en) 1994-01-18 1995-05-16 Glaxo Inc. Multi-dose dry powder inhalation device
BR9508964A (pt) * 1994-09-21 1998-06-02 Inhale Therapeutic Syst Processo e aparelho de aerossolização conjunto de tubo de alimentação e receptáculo para contenção de um medicamento pulverizado
US6006747A (en) * 1997-03-20 1999-12-28 Dura Pharmaceuticals, Inc. Dry powder inhaler
US5954047A (en) 1997-10-17 1999-09-21 Systemic Pulmonary Development, Ltd. Methods and apparatus for delivering aerosolized medication
NZ516811A (en) * 1999-07-23 2002-10-25 Pharmaceutical Discovery Corp Unit dose capsules and dry powder inhaler
US6367471B1 (en) 1999-11-01 2002-04-09 Sheffield Pharmaceuticals, Inc. Internal vortex mechanism for inhaler device
US6443151B1 (en) * 2000-03-08 2002-09-03 Aradigm Corporation Fluid velocity-sensitive trigger mechanism
DE10024738A1 (de) 2000-05-19 2001-11-29 Qvf Engineering Gmbh Glasbauteile mit einer ableitfähigen Beschichtung, ihre Verwendung und daraus hergestellte Apparate, Anlagen und Rohrleitungen
GB2364919A (en) 2000-07-21 2002-02-13 Cambridge Consultants Inhalers
FI20002363A0 (fi) * 2000-10-27 2000-10-27 Orion Yhtymae Oyj Jauheinhalaattori
GB0222295D0 (en) 2002-09-25 2002-10-30 3M Innovative Properties Co Breath actuated medicament dispensing devices
DE102005010965B3 (de) * 2005-03-10 2006-08-03 Medspray Xmems Bv Inhalator mit einem Mischkanal zum Erzeugen eines zu inhalierenden Aerosols
WO2007123664A1 (en) * 2006-03-30 2007-11-01 Allegiance Corporation Nebulizer with flow-based fluidic control and related methods
EP3034119B1 (en) * 2006-03-30 2018-03-21 Vyaire Medical Consumables LLC Nebulizer with pressure-based fluidic-control
WO2008106411A2 (en) * 2007-02-28 2008-09-04 Abbott Respiratory Llc Nozzle-based atomization system
JP5462152B2 (ja) * 2008-04-17 2014-04-02 帝人ファーマ株式会社 定量噴霧式吸入器用吸入補助器具
DK2293833T3 (en) * 2008-06-13 2016-05-23 Mannkind Corp DRY POWDER INHALER AND MEDICINAL ADMINISTRATION SYSTEM
IN2012DN04857A (enExample) * 2009-12-23 2015-09-25 Map Pharmaceuticals Inc

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5826570A (en) * 1991-03-05 1998-10-27 Aradigm Corporation Delivery of aerosol medications for inspiration
US5740794A (en) * 1994-09-21 1998-04-21 Inhale Therapeutic Systems Apparatus and methods for dispersing dry powder medicaments
CN1255869A (zh) * 1998-02-06 2000-06-07 日商优尼希雅·杰克斯股份有限公司 药物吸入器
US20040011357A1 (en) * 2000-07-05 2004-01-22 Philip Braithwaite Actuator comprising moveable membrane
CN101410189A (zh) * 2006-03-27 2009-04-15 贝林格尔英格海姆法玛两合公司 用以施用药物制剂的剂量喷雾器

Also Published As

Publication number Publication date
EP2515978A4 (en) 2015-03-04
AU2010336338A1 (en) 2012-06-21
EP2515978B1 (en) 2018-02-14
US9610415B2 (en) 2017-04-04
CA2781313C (en) 2019-09-17
AU2010336338B2 (en) 2015-02-19
JP6157542B2 (ja) 2017-07-05
JP2017164554A (ja) 2017-09-21
JP2015221225A (ja) 2015-12-10
IN2012DN04857A (enExample) 2015-09-25
US9227030B2 (en) 2016-01-05
US20160129208A1 (en) 2016-05-12
US20110155129A1 (en) 2011-06-30
CN102686261A (zh) 2012-09-19
JP5781540B2 (ja) 2015-09-24
CA2781313A1 (en) 2011-06-30
IL242205A0 (en) 2015-11-30
IL252847B (en) 2021-02-28
EP2515978A1 (en) 2012-10-31
WO2011079310A1 (en) 2011-06-30
US20200030555A1 (en) 2020-01-30
IL219744A0 (en) 2012-07-31
JP2013515577A (ja) 2013-05-09
IL219744A (en) 2015-11-30
IL252847A0 (en) 2017-08-31
US20170056609A1 (en) 2017-03-02
IL242205A (en) 2017-07-31

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Granted publication date: 20140910