CN102680280B - Liquid sampling device - Google Patents
Liquid sampling device Download PDFInfo
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- CN102680280B CN102680280B CN201210160309.8A CN201210160309A CN102680280B CN 102680280 B CN102680280 B CN 102680280B CN 201210160309 A CN201210160309 A CN 201210160309A CN 102680280 B CN102680280 B CN 102680280B
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- peristaltic pump
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Abstract
The invention discloses a liquid sampling device which comprises a liquid infusion container, two or more containers with liquid to be tested, a sampling pipeline, a sampling container, a sampling needle arranged at one end of the sampling pipeline correspondingly, and a peristaltic pump corresponding to the corresponding sampling pipeline, wherein one end of the peristaltic pump is communicated with the container with liquid to be tested, the other end of the peristaltic pump is provided with a liquid infusion pipe connected with the liquid infusion container, and a liquid outlet to be connected with the other end of the sampling pipeline. Compared with the prior art, the liquid sampling device has the beneficial effects that the sampling pipeline is controlled by the peristaltic pump, so that the structure is simple and the control cost is lowered; in addition, a metering gage additionally arranged is used for testing the sampling pipeline and feeding back control on the peristaltic pump, thus objectively realizing automatic alignment on the sampling pipeline and ensuring the sampling accuracy.
Description
Technical field
The present invention relates to a kind of fluid sampling device, the especially a kind of and matching used fluid sampling device of dissolution determination instrument.
Background technology
The sample analysis instrument of on-line monitoring pipeline and liquid in containers is widely used, realize the on-line monitoring to liquid, matter of utmost importance will collect in the analytical instrument of on-line monitoring by fluid to be measured, as the analysis mensuration etc. to drug dissolution in the quality analysis of industrial circle ultrapure water, urban sewage discharge detection and pharmaceutical field.Existing sampling system mainly takes the mode of the supporting solenoid valve of peristaltic pump or the supporting solenoid valve of syringe pump to sample testing sample, but when adopting peristaltic pump system to sample, because be usually provided with different liquid incoming line in detection system, and different pipelines often self with resistance be no, and the power that peristaltic pump provides is constant, peristaltic pump under same equal time will be caused thus to provide identical power but the sampling result of different pipeline but there will be corresponding deviation, affect sampling result precision; Adopt the mode of syringe pump to sample, the peristaltic pump sampling that precision is more single can be higher, but supporting solenoid valve controls different pipelines, and whole system complex structure, volume are large, cost is high and it is also comparatively difficult to safeguard.
Summary of the invention
The present invention provides a kind of simple and effective fluid sampling device for solving the shortcomings and deficiencies described in above-mentioned background technology.
For achieving the above object, the technical solution used in the present invention is: a kind of device of liquid sampling, comprise fluid infusion container, two or more liquid container to be measured, sampling line, sampling container, the sampling probe being arranged at corresponding sampling line one end, the peristaltic pump corresponding with corresponding sampling line, described peristaltic pump one end is communicated with liquid container to be measured, and the other end is provided with the liquid outlet of replenishing line and the sampling line other end to be connected be connected with fluid infusion container.
As a further improvement on the present invention, described sampling line is also provided with two-dimensional motion mechanism and feedback pipe pressure to the weigher of peristaltic pump control system.Above-mentioned two-dimensional motion mechanism adopts motor, ball-screw respectively, by controlling to realize moving forward and backward of liquid outlet and moving up and down of tie point to the rotating of motor.Above-mentioned weigher comprises pressure transducer and is located at the liquid container above pressure transducer, weigher records the pressure produced during each pipeline work and feeds back to peristaltic pump control system, by control system, close-loop feedback control is carried out to peristaltic pump sampling value, ensure that the precision of sampling.
As a further improvement on the present invention, a described three-way connection is connected between peristaltic pump, liquid outlet, replenishing line.
As a further improvement on the present invention, described replenishing line is provided with the first retaining valve of the unidirectional inflow peristaltic pump of conducting liquid stream, described liquid outlet front end and sampling line are respectively equipped with second, third retaining valve, the second described retaining valve conducting liquid stream flows to liquid outlet from peristaltic pump, and the 3rd described retaining valve conducting liquid stream flows into sampling line; First, second described retaining valve is arranged on rear side of three-way connection.
As a further improvement on the present invention, a three-way solenoid valve connects liquid outlet and sampling line
Compared with prior art, the invention has the beneficial effects as follows: with peristaltic pump, sampling line is controlled, structure is simple, and reduce and control cost, in addition, by setting up weigher, detection being carried out and FEEDBACK CONTROL peristaltic pump to sampling line, objectively achieving the automatic calibration to sampling line, ensure that sampling precision.
Accompanying drawing explanation
Below in conjunction with drawings and Examples, the present invention is further described
Fig. 1 is one-piece construction schematic diagram of the present invention.
Embodiment
The present invention includes fluid infusion container 8, two or more liquid container 9 to be measured, sampling line, sampling container 7, the sampling probe 1 being arranged at corresponding sampling line one end, the peristaltic pump 2 corresponding with corresponding sampling line, peristaltic pump 2 one end is communicated with liquid container 9 to be measured, liquid outlet 10, one three-way connection that the other end is provided with replenishing line and the sampling line other end to be connected be connected with fluid infusion container 8 is connected between peristaltic pump 2, liquid outlet 10, replenishing line.
Sampling line is also provided with two-dimensional motion mechanism and feedback pipe pressure to the weigher 11 of peristaltic pump 2 control system, and weigher 11 comprises pressure transducer and is located at the liquid container 12 above pressure transducer.
Replenishing line is provided with the first retaining valve 3 of the unidirectional inflow peristaltic pump 2 of conducting liquid stream, liquid outlet 10 front end and sampling line are respectively equipped with second, third retaining valve 4,6, second retaining valve 4 conducting liquid stream flows to liquid outlet 10 from peristaltic pump 2, and the 3rd described retaining valve 6 conducting liquid stream flows into sampling line; First, second retaining valve 3,4 is arranged on rear side of three-way connection.
Fluid sampling device is divided into following several stage work:
First stage: preparatory stage
Sampling probe 1 is in a position, and peristaltic pump 2 operates counterclockwise, draws fluid infusion solvent, makes fluid infusion solvent be full of the pipeline between fluid infusion container and peristaltic pump by the first retaining valve 3, peristaltic pump 2; System starts, the tie point 5 of mobile sampling line or liquid outlet 10, make liquid outlet 10 be connected with tie point 5.Now peristaltic pump 2 operates clockwise, draw the testing liquid of liquid container to be measured 9 li, testing liquid is made to be full of whole pipeline by peristaltic pump 2, second retaining valve 4, tie point 5, the 3rd retaining valve 6, and form loop and finally get back in liquid container to be measured, now sampling system is full of solvent, and in sampling line, air is thoroughly discharged.
Subordinate phase: calibration phase
Before sampling, during as needs automatic calibration, by being located at the liquid container 12 above pressure transducer.Solution to be measured is introduced in sampling line, now weigher is recorded by pressure transducer the pressure produced during each pipeline work and feeds back to peristaltic pump control system, controlled with to peristaltic pump sampling value by control system, ensure that the precision of sampling.
Phase III: sample phase
Before formal sampling, operated counterclockwise by peristaltic pump 2, the pressure produced in discharge conduit flow duct, then mobile link point 5 or liquid outlet 10, makes liquid outlet 10 and tie point 5 disconnect.Consider that liquid outlet 10 is with the separated of tie point 5 and be connected the operational complicacy caused, now, also by setting up a three-way solenoid valve, connecting liquid outlet 10, sampling line and tie point 5, so can carry out direct sample under the condition not disconnecting tie point and liquid outlet.During sampling, the control system of the peristaltic pump 2 configured respectively by every bar sampling line carries out signal control to the running accuracy of peristaltic pump, now peristaltic pump 2 operates clockwise, a bit quantitative liquid to be measured is extracted from liquid container 9 to be measured, by retaining valve 4, testing liquid is incorporated in sampling container 7.
Fourth stage: fluid infusion stage
For ensureing that the total amount of liquid in liquid container 9 to be measured does not reduce, need supplement and the solution of sample flow equivalent in testing container 9, now, peristaltic pump 2 antiport, by retaining valve 3, peristaltic pump 2, takes out the solvent of equivalent in liquid container 9 to be measured from fluid infusion container 8.
Five-stage: return the liquid stage
The position of sampling probe 1 rises to a from b, mobile link point 5 or liquid outlet 10, liquid outlet 10 is connected with tie point 5, solution is introduced in liquid container 9 to be measured by the peristaltic pump 2 of clockwise running, retaining valve 4, tie point 5, retaining valve 6, now, peristaltic pump 2 running makes to be full of air in pipeline, for lower sub-sampling is prepared.
Claims (4)
1. a fluid sampling device, it is characterized in that: comprise fluid infusion container (8), two or more liquid container to be measured (9), sampling line, sampling container (7), be arranged at the sampling probe (1) of corresponding sampling line one end, the peristaltic pump corresponding with corresponding sampling line (2), described peristaltic pump (2) one end is communicated with liquid container to be measured (9), and the other end is provided with the liquid outlet (10) of replenishing line and the sampling line other end to be connected be connected with fluid infusion container (8); Described sampling line is also provided with two-dimensional motion mechanism and feedback pipe pressure to the weigher (11) of peristaltic pump (2) control system; Described weigher (11) comprises pressure transducer and is located at the liquid container (12) above pressure transducer.
2. fluid sampling device as claimed in claim 1, is characterized in that: be connected with a three-way connection between described peristaltic pump (2), liquid outlet (10), replenishing line.
3. fluid sampling device as claimed in claim 2, it is characterized in that: described replenishing line is provided with first retaining valve (3) of the unidirectional inflow peristaltic pump (2) of conducting liquid stream, described liquid outlet (10) front end and sampling line are respectively equipped with second, third retaining valve (4,6), described the second retaining valve (4) conducting liquid stream flows to liquid outlet (10) from peristaltic pump (2), and the 3rd described retaining valve (6) conducting liquid stream flows into sampling line; Described the first retaining valve (3) is arranged between three-way connection and fluid infusion container (8), and the second retaining valve (4) is arranged between three-way connection and liquid outlet (10).
4. fluid sampling device as claimed in claim 1, is characterized in that: be connected with a three-way solenoid valve between described liquid outlet (10) and sampling line.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210160309.8A CN102680280B (en) | 2012-05-16 | 2012-05-16 | Liquid sampling device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210160309.8A CN102680280B (en) | 2012-05-16 | 2012-05-16 | Liquid sampling device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102680280A CN102680280A (en) | 2012-09-19 |
| CN102680280B true CN102680280B (en) | 2015-02-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210160309.8A Active CN102680280B (en) | 2012-05-16 | 2012-05-16 | Liquid sampling device |
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| Country | Link |
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| CN (1) | CN102680280B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103197620B (en) * | 2013-02-28 | 2014-12-24 | 重庆大学 | Precise sampling control system |
| CN104964852A (en) * | 2015-07-10 | 2015-10-07 | 河海大学 | Annular sealed tank sampling device with automatic compensation function and sampling method |
| CN108827715A (en) * | 2018-08-28 | 2018-11-16 | 福建龙岩龙瑆医药科技有限公司 | A kind of fluid sampling device |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2044954A (en) * | 1979-03-21 | 1980-10-22 | Lilly Industries Ltd | Control of fluid sampling apparatus |
| CN2373787Y (en) * | 1999-05-15 | 2000-04-12 | 刘文涛 | Automatic sampler for polarograph |
| CN102313795A (en) * | 2011-07-28 | 2012-01-11 | 广东医学院 | Intelligent numerical control bionic drug dissolubility tester |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7024955B2 (en) * | 2003-03-01 | 2006-04-11 | Symyx Technologies, Inc. | Methods and systems for dissolution testing |
-
2012
- 2012-05-16 CN CN201210160309.8A patent/CN102680280B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2044954A (en) * | 1979-03-21 | 1980-10-22 | Lilly Industries Ltd | Control of fluid sampling apparatus |
| CN2373787Y (en) * | 1999-05-15 | 2000-04-12 | 刘文涛 | Automatic sampler for polarograph |
| CN102313795A (en) * | 2011-07-28 | 2012-01-11 | 广东医学院 | Intelligent numerical control bionic drug dissolubility tester |
Non-Patent Citations (2)
| Title |
|---|
| A widely applicable automated sampling apparatus for dissolution testing;R.A. Hill and B.G. Snider;《International Journal of Pharmaceutics》;19871231;第36卷;第175-183页 * |
| 用于药品溶出度/释放度检定的新型自动取样系统;齐婉玉 等;《现代仪器》;20031231(第3期);第42-44页 * |
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| Publication number | Publication date |
|---|---|
| CN102680280A (en) | 2012-09-19 |
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Owner name: ZHEJIANG TAILIN BIOTECHNOLOGY CO., LTD. Free format text: FORMER NAME: HANGZHOU TAILIN BIOTECHNOLOGY EQUIPMENT CO., LTD. |
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Address after: 310052 Binjiang District, Zhejiang, South Ring Road, No. 2930, No. Patentee after: ZHEJIANG TAILIN BIOENGINEERING Co.,Ltd. Address before: The South Ring Road of Binjiang District Hangzhou city Zhejiang province 310052 No. 2930 Hangzhou Tailin Bioengineering Equipment Co. Ltd. Patentee before: Hangzhou Tailin Bioengineering Equipments Co.,Ltd. |
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Effective date of registration: 20230515 Address after: Building 2, 2nd Floor, No. 2930 South Ring Road, Puyan Street, Binjiang District, Hangzhou City, Zhejiang Province, 310000 Patentee after: Zhejiang Tailin Analytical Instrument Co.,Ltd. Address before: 310052 No. 2930 South Ring Road, Hangzhou, Zhejiang, Binjiang District Patentee before: ZHEJIANG TAILIN BIOENGINEERING Co.,Ltd. |