CN102671262B - Disposable sterile particulate-retaining syringe - Google Patents
Disposable sterile particulate-retaining syringe Download PDFInfo
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- CN102671262B CN102671262B CN201210185950.7A CN201210185950A CN102671262B CN 102671262 B CN102671262 B CN 102671262B CN 201210185950 A CN201210185950 A CN 201210185950A CN 102671262 B CN102671262 B CN 102671262B
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- disposable use
- urceolus
- syringe
- use sterile
- filter membrane
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3145—Filters incorporated in syringes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
- A61M2005/342—Off-center needles, i.e. needle connections not being coaxial with the longitudinal symmetry axis of syringe barrel
Abstract
The invention discloses a disposable sterile particulate-retaining syringe, which comprises a barrel, a plunger, a needle holder and a filter, the plunger is arranged in the barrel, the needle holder is arranged on one side of the front end of the barrel and is used for holding a needle, the barrel is communicated with the needle holder through a liquid outlet, and the filter is provided with a filter membrane, which is attached on the liquid outlet and can be closed toward the front end and opened toward the rear end. According to the structure design, the thickened interlayer-wrapped round unilaterally hung filter is only arranged in the tip of a conventional and ordinary syringe, the syringe can be automatically opened and closed and suck dissolved medicine during the microflow of the liquid, and can retain particulates in the injection in one step, so that particulates which are 0.45Mu m or bigger cannot be produced in the discharged liquid any more, and thereby the safety of injection is guaranteed.
Description
Technical field
The invention belongs to medical instruments field, relate to a kind of syringe, relate in particular to a kind of disposable use sterile particles and hold back syringe.
Background technology
Infusion treatment be a kind of important treatment means, especially venous transfusion and intravenous injection because medicinal liquid directly enters blood circulation, drug effect performance is fast and be widely adopted.But, in recent years, injection particularly infuse in the harm that causes of foreign body and particle contamination, caused people's common concern, solve particle contamination very urgent.
Intravenous drip and intravenous injection; microgranule refers to involuntary allogenic material that can move about, insoluble and the solvable and not molten medicine of adding being present in liquid; particulate matter comprises the chemical particle that rubber particle, polyester flake, thin bits, color dot, insoluble inorganic salt, micro activated carbon particle, fiber and drug combination compatibility are improper produced etc.; if these microgranules are sneaked in transfusion; during clinical practice, just may cause infusion reaction, may cause acute reaction or long-term potential danger.As, a large amount of injection human bodies of microgranule may produce serious body damage, the microgranule phase of holing up in the body is many decades cannot metabolism, larger microgranule is detained and forms obstruction at little blood vessel with blood circulation, causes tissue necrosis and damage in various degree, as phlebitis, pulmonary's granuloma, thrombosis and blood vessel embolism, induced tumor formation etc., even jeopardize patients ' lives.The serious consequence that may cause in view of particle contamination in medicinal liquid, China < < pharmacopeia > > regulation, particle diameter > 10 μ m(microns in every milliliter of transfusion) particulate matter must not exceed 10.
In medicinal liquid, microgranule source may have following several:
1, in article and transfusion device production technology, bring.
2, the maloperation in medicine process for preparation produces, and during as multi-medicament compatibility, may in medicinal liquid, have drug microparticles more than 1～50 μ m.
3, the glass chip sucking during glass ampule breakdown.
4, the plug bits under the molten medicine cutting of syringe needle puncture bottle stopper.
5, the plastics pin of transfusion device, when inserting liquid bottles plug, also can make microgranule in liquid increase by 1.6～27.6 times.
The major way of eliminating particle contamination in transfusion is to install miniature displacer additional to make medicinal liquid enter human body before first through filtering.Existing research worker installs a kind of defecator that accompanies filter membrane additional for transfusion device, and this defecator is arranged on transfusion device terminal (lower end of dropping funnel), and work principle of filter is that the negative pressure that relies on transfusion bottle Inner liquid to sink to producing realizes filtration.In this link, add defecator and really solved part particle contamination problem, but this band defecator transfusion device, price significantly increases, and has increased patient burden; And on the other hand, this transfusion device with defecator, filters after 500～1500ml liquid along with the gathering of microgranule, also there is defecator Pore Blocking, affect initial flow, the phenomenon such as filtering velocity decay and cause the transfusion device cannot normal infusion.
Intravenous injection administration is common Therapeutic Method.At present, disposable asepsis injector structure is very classical, it only can complete simple suction function of injection, and improve research, is focusing more in the disposal safety that how to guarantee disposable use and syringe itself, and how these achievements in research eliminates particle contamination if all not relating to.Along with the raising requiring for treatment means degree of purity with patient of improving of Medical Service Quality Management System, strengthen particulate matter control in intravenous fluid and reduce the harm of particulate matter to intravenous injection patient, more and more by hospital and patient, paid attention to.But up to the present still without any the defecator of form, can in syringe, use safely, be used for the defecator of transfusion device because its difference of holding back principle also cannot be diverted in syringe, except circumscribed filtration syringe, the product that miniature defecator holds back syringe in the disposable use sterile particles of one is installed and is not also occurred.
Summary of the invention
The object of the invention is to provide a kind of disposable use sterile particles that can carry out particulate trap to injection that miniature displacer is installed to hold back syringe.
The disposable use sterile particles of the present invention is held back syringe, comprise urceolus, be placed in fluid push rod in urceolus and outer cylinder front end one side for filling the needle stand of pin, urceolus and needle stand are communicated with liquid outlet, also comprise a defecator, this defecator is established a filter membrane, this filter membrane invests liquid outlet, and forward end sealing, opens to the back-end.
Described defecator is embedded in urceolus top antetheca.
Described defecator comprises a plug-in unit, and filter membrane is fixed in this plug-in unit, and described urceolus top antetheca offers by a side of needle stand the assembling slotted hole mating with this plug-in unit along urceolus arc direction, and this plug-in unit is assemblied in this slotted hole.
Described plug-in unit comprises the film circle of the plunger, brace and the hollow that are sequentially connected as a single entity, and described filter membrane is fixed on film circle, and brace and film circle are within urceolus, and plunger is outside urceolus.
Described filter membrane is fixed between the upper cover of one group of make-up and lower cover and forms diaphragm, and filter membrane is assembled with the form of this diaphragm.
Described upper cover and lower cover are circle body, and the hollow space of circle body is provided with the grid in order to holder lining filter membrane, and the circle body entity part of upper cover and lower cover is established respectively the fixing indenture of para-position and projection.
Inside described urceolus top antetheca, detent is offered in corresponding diaphragm position, and this detent size is greater than diaphragm edge size 0.05mm.
Described urceolus top antetheca is thickeied to 4mm.
Described outer cylinder front end is the stressed sidewall of half cone-shaped thickening to 2mm filling a chaffy side.
The thick 0.15mm of upper cover of described diaphragm, the thick 0.05mm of lower cover, filters thickness 0.11-0.12mm; The thick 12mm of plunger of described plug-in unit, brace thickness 0.32mm, the thick 0.35mm of film circle; The arc length of described plunger is greater than the arc length of urceolus assembling slotted hole.
Adopt above design, the aseptic syringe of holding back of the disposable use of the present invention can once be held back the microgranule in injection, definitely control to release and in liquid, no longer produce the above microgranule of >=0.45 μ m, the syringe extraction medicinal liquid that this band is held back is can be directly quiet pushes away intramuscular injection, has guaranteed injection safety.On the other hand, use the syringe that this band is held back to coordinate while infusing, extract medicinal liquid injection transfusion bottle and removed the microgranule that other link produces, therefore, transfusion device terminal with defecator, only need hinder the microgranule that filter infusion apparatus self passage produces, can alleviate like this that transfusion device end-filtration device stops up, filtering velocity decay, affect the phenomenon generation of initial flow.
The invention has the advantages that:
1, to hold back syringe be disposable use to disposable use sterile particles.
2, to hold back syringe outward appearance very simple for disposable use sterile particles, but particulate trap rate reaches absolutely while using.
3, disposable use sterile particles is held back syringe and is not changed nursing injection field medical worker tradition injection operation custom, has retained traditional appearance, makes injection operation in full accord with traditional operation from vision, intuition, sense organ right-angle plane etc.
4, disposable use sterile particles is held back the defecator that syringe presents interlayer embedding, and its diaphragm static state is closed voluntarily, aspirated voluntarily and open, push away liquid closure voluntarily, forces liquid through filter membrane passage, effectively to stop microgranule simultaneously.
5, the design of this structure, only a tradition and common syringe top is established and thickened the round one-sided hanging defecator of interlayer embedding one, this device can be opened voluntarily closure and realize the suction of molten medicine with liquid miniflow, follows one's bent.
6, guarantee no matter nursing procedure injection field adopts the molten medicine of what method, microgranule to come from what channel; molten medicine is complete can be released with wish with wish suction; realize holding back completely of microgranule and be not introduced into gravity infusion and transfusion bag; while having avoided as rescue, intravenous drip, intravenous injection, microgranule enters the harm that blood circulation of human body system is brought, and particulate trap rate safety coefficient reaches 100%.
Accompanying drawing explanation
Fig. 1 is that the disposable use sterile particles of the present invention is held back syringe construction schematic diagram;
Fig. 2 is that the disposable use sterile particles of the present invention is held back diaphragm pie graph in syringe;
Fig. 3 is the structure chart that the disposable use sterile particles of the present invention is held back defecator in syringe;
Fig. 4 is the front-end architecture profile that disposable use sterile particles is held back urceolus 3 in syringe;
Fig. 5 is the left view (urceolus part) of Fig. 4;
Fig. 6 is the installation diagram that the disposable use sterile particles of the present invention is held back defecator 6 in syringe;
Fig. 7 is the structure chart that Fig. 6 has assembled rear syringe outer cylinder front end;
Fig. 8 is the disposable use sterile particles of the present invention variable condition figure of diaphragm 1 in defecator 6 when holding back syringe and using, and A width is for preparing aspiration phases, and B width is imbibition state, and C width is for pushing away liquid status, and D width is for completing inject state.
The specific embodiment
The invention provides a kind of disposable use sterile particles and hold back syringe, for existing structure syringe, make transformation, on its top, add a defecator, to reach when injection, can hold back the object that guarantees injection safety to microgranule in medicinal liquid.
As shown in Figure 1, disposable use sterile particles provided by the invention is held back syringe, comprise existing ordinary syringe urceolus 3, be placed in fluid push rod 4 in urceolus and outer cylinder front end one side for filling the needle stand 5 of pin, feature of the present invention is, also comprise a defecator 6, it is embedded in urceolus 3 inwall foremost, and just to needle stand 5 liquid outlet positions.
This defecator 6 is comprised of a diaphragm 1 and a plug-in unit 2, shown in Figure 3.Wherein:
As shown in Figure 2, diaphragm 1 order is by upper cover 11, filter membrane 12 and lower cover 13 hot pressing form an oval lamellar body, upper cover 11 and lower cover 13 are filter membrane support, be circle body shape, the hollow space of circle body is provided with grid 14 in order to holder lining filter membrane 12, the circle body entity part of upper cover 11 and lower cover 13 is established respectively the fixing indenture of para-position and projection, filter membrane 12 is lamellar body, be placed between upper cover 11 and lower cover 13 and to being positioned at grid 14 positions, upper cover 11 and lower cover 13 with indenture and protruding para-position after through hot pressing, filter membrane 12 is compressed between upper and lower covers, form diaphragm 1(" interlayer " concept).
Preferably, the upper cover 11 of diaphragm 1 is made by polypropylene material, thick 0.15mm; Lower cover 13 is made by PP material, thick 0.05mm; Filter membrane 12 can adopt poly (ether sulfone) film (aperture 0.45 μ m), thickness 00.11-0.12mm.
Referring to Fig. 3, plug-in unit 2 entirety are lamellar, comprise plunger 21, brace 22 and film circle 23 that order is connected as a single entity, likeness in form rivet, and plunger 21 outers are camber line, and interior edge is contact pin 22 in succession, and in brace 22, hollow out has been outputed cast film forming circle 23 for installing diaphragm 1.Plug-in unit 2 entirety are made into integration by PP material, the thick 12mm of plunger 21, the thick 0.2mm of brace 22, the thick 0.35mm of film circle, the long 15mm of plug-in unit 2 entirety.
For assembling this defecator 6, syringe urceolus 3 front ends of the present invention need adjust.Adjustment comprises:
One) syringe top liquid outlet is with middle line computation, and 3 ㎜ are shifted to syringe axis;
Two) referring to shown in Fig. 4-Fig. 5, the antetheca 31 on the top of syringe urceolus 3 need thicken (seeing Fig. 4 and Fig. 5), conventionally can thicken to 4 ㎜, object is that the top wall of syringe urceolus 3 is thickeied to (" thickening " concept) by original thinner (1.5mm), is beneficial to following three) open design;
Three) at this antetheca 31, by a side (" one-sided " concept) of needle stand 5, along urceolus arc direction, for example offer assembling slotted hole 32(, the thick 0.35mm in hole, the long 20mm of camber line) for defecator 6 is inserted, the arc length (20mm) of assembling slotted hole 32 be less than plunger 21 arc length (plunger is thick >=0.36mm, length >=21mm), so that defecator 6 is located; And to assembling the position of slotted hole 32, offer detent 33 (the thick 0.35mm of groove in urceolus 3 antetheca 31 inner sides, wide 12.mm, long 15mm) for holding defecator 6, the diaphragm 1(that the size of this detent 33 is greater than defecator 6 enters trough rim edge) 0.05mm (referring to Fig. 4), the closed slot milling of the unlatching of diaphragm 1 while using for syringe, not draw-in groove and close (" embedding " concept) freely;
Four) for increasing injector cartridge intensity, urceolus 3 needs thickening at the sidewall of a side that has assembling slotted hole 32, the mode of thickening forms the stressed sidewall 34(of a half cone-shaped referring to Fig. 5 for these urceolus 3 sidewalls, thick 2mm × wide 15mm × long 20mm), when the stressed sidewall 34 that thickening strengthens can guarantee that defecator 6 inserts the assembling slotted hole 32 of urceolus 3 antethecas 31, urceolus 3 has enough intensity and bearing capacity (" reinforcement " concept).
Above through one) to four) thickening after adjusting strengthen the syringe urceolus 3 of one-sided fluting and be integrated injection mo(u)lding.
In assembling, by the diaphragm of defecator 1 towards syringe urceolus 3, from assembling slotted hole 32, insert antetheca 31 and enter (referring to Fig. 6) detent 33, the plunger 21 of plug-in unit 2 is stuck in outside assembling slotted hole 32 fixing (" hanging " concept), referring to Fig. 7, shown the structure of having assembled rear syringe outer cylinder front end, with this, assemble to obtain having and thicken the disposable use sterile particles of strengthening interlayer embedding one round one-sided hanging defecator and hold back syringe (referring to Fig. 1, having loaded onto syringe needle on needle stand 5).
During use, the variation that the disposable use sterile particles of the present invention is held back diaphragm 1 in syringe filter device is shown in Figure 8, wherein:
A width show disposable use sterile particles hold back syringe sky draw air-flow, syringe fluid push rod 4 in syringe foremost, enters preparation aspiration phases, now diaphragm 1 is arranged in groove, in closed condition;
B width show disposable use sterile particles hold back syringe implement suction action, syringe fluid push rod 4 post-tensionings, medicinal liquid enters from imbibing hole, pushes backward diaphragm 1 open and enters in injector syringe, now diaphragm 1 is in opening;
C width show disposable use sterile particles hold back syringe implement push away the work that surges, before syringe fluid push rod 4, push away, hydraulic drive diaphragm 1 is forward closed condition from opening, medicinal liquid is pushed out by the hole of diaphragm 1;
D width shows that disposable use sterile particles holds back syringe and push away liquid and complete, and now syringe fluid push rod 4 is pushed to syringe foremost, and diaphragm 1 is arranged in groove, in closed condition, medicinal liquid is pushed out by the hole of diaphragm 1, and the microgranule existing in medicinal liquid is tackled by diaphragm 1, remains in syringe.
By above shot operating process, can see, the syringe of defecator is housed, while there is unpredictable or microgranule that be difficult to avoid in medicinal liquid, diaphragm can be effectively by particulate trap, guaranteed not have microgranule in the medicinal liquid of input human body, eliminated the particle contamination of serious puzzlement infusion safety.
From the security consideration of product of the present invention own, filter membrane support (upper cover and lower cover) adopts the manufacture of PP material, not containing bisphenol-A material, its safety meets European Union's standard completely, and possess the advantages such as not easily broken and good stability, even the in the situation that of high-temperature heating, can not discharge harmful material yet; Filter membrane is embedding hot pressing one-shot forming.
By related experiment, further illustrate disposable use sterile particles of the present invention and hold back below function and the effect of syringe.
Experiment one: disposable use sterile particles is held back the check of filter membrane material in syringe
This experiment is held back filter membrane material used in syringe for disposable use sterile particles and is tested, and confirms rejection effect, hydrophobic, air-permeability performance and the security performance of membrane material used.Wherein for the assay of micropore polyether sulfone filter membrane referring to table 1, show that selected filter membrane material can use.Before selecting other filter membrane, also need to carry out similar detection, in literary composition, enumerate no longer one by one testing result.
The disposable use medical micro porouse of table 1 polyether sulfone filter membrane is by batch test report
Conclusion:
Advantage: have good thermostability and chemical resistance, without powder or fibre shedding phenomenon, toughness is good
Experiment two: syringe particulate trap rate experiment
Particle contamination amount when this experiment exam vial is opened.Method: each 100 of the injection of taking respectively ampoule and antibiotic glass bottle packing, with the present invention's " disposable use sterile particles is held back syringe " opening and medicine-sucking routinely, specification of syringe 10ml, wherein filter membrane adopts the definite PES of experiment one, aperture 0.45 μ m, bubble is pressed 0.31Mpa, and filter membrane allows by flow 31-44ml/cm
2/ min, 20 ℃ of operating temperatures, film thickness 0.11-0.12mm.After extracting medicinal liquid, through syringe, be pushed out to the straight microscopical glass slide of biology, micro-Microscopic observation counts to get the particle number in medicinal liquid, and average result is recorded in table 2 test group.Take out in addition corresponding filter membrane, Microscopic observation filter membrane is received dirty face and is stopped >=0.45 μ m microgranule and reach absolutely.
Control experiment: to 100 of the above same injection, with common same specification syringe opening and medicine-sucking according to a conventional method, the medicinal liquid extracting moves to the straight microscopical glass slide of biology, the particle number in micro-Microscopic observation counting medicinal liquid, and average result is recorded in table 2 matched group.
The different syringes of table 2 are released fraction of particle (individual/ml) in medicinal liquid
Experimental result shows, uses ordinary syringe, has a large amount of microgranules in injection, does not meet the relevant criterion index request (referring to table 3) in industry, analyzes wherein microgranule source, can be summarized as table 4 listed.And the disposable use sterile particles of the present invention is held back after syringe, the microgranule of release in injection >=0.45 μ m is all trapped, and has guaranteed the safety of injection.
Table 3: each method detects index
Table 4: microgranule source in injection
Filter membrane support intensity experiment in experiment three, defecator
Disposable use sterile particles is held back in syringe, the film circle (the filter membrane support of upper cover and lower cover composition) of its defecator adheres to diaphragm, with syringe action, open and close, this experiment is checked this support and filter film strength with push-and-pull air-flow, observes its tension warpage holding capacity repeatedly.
Method: adopt the empty section disposable use sterile particles of 1～50ml to hold back syringe.Empty cutting to retreat the most fast to end returned to top again as one-off, finishes for totally 10 times.Whether after each action, observe the one-sided mounted bracket in top in syringe is shifted in inner core, taking out defecator is placed under biological microscope again, whether looseningly observe filter membrane embedding support, whether filter membrane is out of shape, support whether with syringe in top keep horizontal plane, whether as before support inserts syringe, and whether annular filter membrane embedding edge departs from, and between film circle and diaphragm, whether filter membrane bores a hole.
Result: 1) non-loosening.2) indeformable.3) as before.4) do not depart from.5) puncherless.
Above-mentioned 1～10 experimental result shows: filtration membrane does not come off, annular filter membrane embedding edge does not depart from, holder device is not loosening, filter membrane is puncherless, and all are excellent as before.The empty section disposable use sterile particles of the present invention is held back the defecator of syringe without once damaged, and its intensity is qualified.
The damaged experiment of the anti-hydraulic shock of filter membrane in experiment four, defecator
This experiment is checked the damaged ability of the anti-hydraulic shock power of filter membrane with normal saline.
Method: adopt the disposable use sterile particles of 20ml to hold back syringe, disposable extraction reason saline 20ml is divided into and once releases 2ml, finish for totally 10 times, each observation whether have medicinal liquid to ooze out and feed liquor whether smooth, after each release, take out and be placed in a complete set of side hanging defecator in top in syringe, be placed in biology microscope Microscopic observation whether intact without damaged.
Result: release 10 filter membrane experimental results through an above-mentioned 2ml and show, all do not occur medicinal liquid seepage, gas leakage, it is rapid that medicinal liquid is crossed film, and filter membrane there is no perforation breakage.
Experiment five, the disposable use sterile particles of different size are held back the particulate trap of syringe
Inventor is based on above-mentioned research, and the disposable use sterile particles that obtains series specification is held back syringe.It configures referring to table 5.
The disposable use sterile particles of table 5 is held back syringe 1ml～100ml specification filter membrane allocation list
Adopt specification:
1, disposable use sterile particles is held back syringe, and specification 1ml～100ml is totally 11 specifications.
2, disposable property used aseptic injection pin, specification 0.4mm～1.6mm.
3, press injection operation, insert after bottle stopper is simulated molten medicine and take out medicine operation, press the metering of syringe nominal for every and extract deionized water (deionized water), after getting, push 200ml measuring cup, each specification 10 times, totally 110 simulations.
4, measuring cup liquid pipettes 10 microlitres for 1 time to the straight micro-eyeglass of biology, gradation Microscopic observation filtrate, and result all shows without granule microgranule.
5, take out syringe inner support and the whole device of filter membrane, be placed in biology microscope Microscopic observation filter membrane and receive dirty face, visible particle diameter 1 μ m ~ 300 μ m(micron under mirror) or larger granule, particulate matter naked eyes can recognize.Visible granular is retained in entirely holds back syringe filter membrane upper surface, illustrate that adopting disposable use sterile particles to hold back syringe can hold back above-mentioned particle diameter >=1 μ m, 5 μ m, 10 μ m, 15 μ m, 20 μ m, 50 μ m, 300 μ m or larger particles, and can disposable thorough trapped particles.
Conclusion: show in each specification syringe release liquid provided by the present invention all without granule microgranule through above-mentioned experimental result.
Experiment six: syringe filter device of the present invention and the principle analysis of transfusion device defecator
Adopt the microporous filter membrane particulate trap under pressure state, can realize the disposable of size particles microgranule and hold back.But transfusion device terminal filter membrane arranges and belongs to microgravity (only relying on medicinal liquid gravity), easily stop up fenestra, unless gap is larger between membrane aperture and diameter of particle, can realize filtrate flow rate unattenuated, but the increase in aperture has obviously weakened again the rejection effect of microgranule.
Under pressure state, as adopt micropore polyether sulfone filter membrane 0.45 μ m, diameter 25mm filter membrane through just extract of vacuum decompression filter flask sucking filtration Chinese medicine muddiness, filter membrane upper surface presents microgranule and entirely holds back, can hold back and be greater than 1 μ m, 5 μ m, 10 μ m, 20 μ m, 50 μ m, 300 μ m or larger granule, and particulate matter naked eyes can recognize, and in filter liquor without granule microgranule, this is enough to illustrate that it is crucial that pressure is held back (or be called " gravity is held back ").
It is to adopt pressure to release to realize filtration that the disposable use sterile particles of the present invention is held back its principle of syringe, is different from the work principle of filter of existing transfusion device.So filter membrane pore size changes without obvious decay and hinders in the present invention, along with the increase of fluence, microgranule also increases in film table accumulated amount thereupon, blocking portion filter membrane but attenuation trend does not still appear in flow of filtrate.Disposable use sterile particles is held back syringe employing poly (ether sulfone) film, and (aperture 0.45 μ m).
More than describe the best disposable use sterile particles of the present invention in detail and hold back formation and the function of syringe; but; protection scope of the present invention should not only limit to the form of drawings and Examples; for example; adopt design concept of the present invention; can establish on disposable sterilized injector top outer implantation defecator, or in inner side, paste leveling miniature defecator etc. and produce similar products, the particulate trap syringe of these forms still belongs to the open and protection domain of the present invention.If any people, avoid set-up mode shown in accompanying drawing, should be appreciated that, this selection of deliberately making for escape infringement remains infringement of the present invention.
Claims (12)
1. disposable use sterile particles is held back syringe, comprise urceolus, be placed in fluid push rod in urceolus and outer cylinder front end one side for filling the needle stand of pin, urceolus and needle stand are communicated with liquid outlet, it is characterized in that, also comprise a defecator, this defecator is established a filter membrane, and this filter membrane invests liquid outlet, and forward end sealing, opens to the back-end; Described defecator is embedded in urceolus top antetheca; Described defecator comprises a plug-in unit, and filter membrane is fixed in this plug-in unit, and described urceolus top antetheca offers by a side of needle stand the assembling slotted hole mating with this plug-in unit along urceolus arc direction, and this plug-in unit is assemblied in this slotted hole.
2. disposable use sterile particles is held back syringe according to claim 1, it is characterized in that, described plug-in unit comprises the film circle of the plunger, brace and the hollow that are sequentially connected as a single entity, and described filter membrane is fixed on film circle, brace and film circle are within urceolus, and plunger is outside urceolus.
3. according to disposable use sterile particles described in claim 1 or 2, hold back syringe, it is characterized in that, described filter membrane is fixed between the upper cover of one group of make-up and lower cover and forms diaphragm, and filter membrane is assembled with the form of this diaphragm.
4. disposable use sterile particles is held back syringe according to claim 3, it is characterized in that, described upper cover and lower cover are circle body, and the hollow space of circle body is provided with the grid in order to holder lining filter membrane, and the circle body entity part of upper cover and lower cover is established respectively the fixing indenture of para-position and projection.
5. disposable use sterile particles is held back syringe according to claim 3, it is characterized in that, detent is offered in corresponding diaphragm position inside described urceolus top antetheca, and this detent size is greater than diaphragm edge size 0.05mm.
6. disposable use sterile particles is held back syringe according to claim 5, it is characterized in that, described urceolus top antetheca is thickeied to 4mm.
7. disposable use sterile particles is held back syringe according to claim 6, it is characterized in that, described outer cylinder front end is the stressed sidewall of half cone-shaped thickening to 2mm filling a chaffy side.
8. disposable use sterile particles is held back syringe according to claim 7, it is characterized in that, and the thick 0.15mm of upper cover of described diaphragm, the thick 0.05mm of lower cover, filters thickness 0.11-0.12mm; The thick 12mm of plunger of described plug-in unit, brace thickness 0.32mm, the thick 0.35mm of film circle; The arc length of described plunger is greater than the arc length of urceolus assembling slotted hole.
9. disposable use sterile particles is held back syringe according to claim 4, it is characterized in that, detent is offered in corresponding diaphragm position inside described urceolus top antetheca, and this detent size is greater than diaphragm edge size 0.05mm.
10. disposable use sterile particles is held back syringe according to claim 9, it is characterized in that, described urceolus top antetheca is thickeied to 4mm.
11. according to claim 10 disposable use sterile particles hold back syringe, it is characterized in that, described outer cylinder front end is the stressed sidewall of half cone-shaped thickening to 2mm filling a chaffy side.
12. hold back syringe according to disposable use sterile particles described in claim 11, it is characterized in that, and the thick 0.15mm of upper cover of described diaphragm, the thick 0.05mm of lower cover, filters thickness 0.11-0.12mm; The thick 12mm of plunger of described plug-in unit, brace thickness 0.32mm, the thick 0.35mm of film circle; The arc length of described plunger is greater than the arc length of urceolus assembling slotted hole.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210185950.7A CN102671262B (en) | 2012-06-07 | 2012-06-07 | Disposable sterile particulate-retaining syringe |
| PCT/CN2013/076271 WO2013182000A1 (en) | 2012-06-07 | 2013-05-27 | Disposable sterile injector for retaining microparticles |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210185950.7A CN102671262B (en) | 2012-06-07 | 2012-06-07 | Disposable sterile particulate-retaining syringe |
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| Publication Number | Publication Date |
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| CN102671262A CN102671262A (en) | 2012-09-19 |
| CN102671262B true CN102671262B (en) | 2014-04-16 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210185950.7A Active CN102671262B (en) | 2012-06-07 | 2012-06-07 | Disposable sterile particulate-retaining syringe |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN102671262B (en) |
| WO (1) | WO2013182000A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102671262B (en) * | 2012-06-07 | 2014-04-16 | 中山未标生物新技术有限公司 | Disposable sterile particulate-retaining syringe |
| CN108434551B (en) * | 2018-04-13 | 2021-05-14 | 山东中医药大学 | Dropper with injection filtering function |
| CN112277333A (en) * | 2019-07-25 | 2021-01-29 | 江苏正迈过滤技术有限公司 | Medical filter and production method thereof |
| CN113350619A (en) * | 2021-07-08 | 2021-09-07 | 上海振浦医疗设备有限公司 | Built-in membrane filtering injector |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN200998481Y (en) * | 2006-07-31 | 2008-01-02 | 王哲兴 | Disposable asepsis filtering type injector |
| CN201612904U (en) * | 2010-02-27 | 2010-10-27 | 孙风林 | Syringe with filter function |
| CN201959347U (en) * | 2011-01-25 | 2011-09-07 | 上海振浦医疗设备有限公司 | Disposable precise filter injector |
| CN102406971A (en) * | 2011-12-29 | 2012-04-11 | 雷红力 | Filter type syringe |
| CN202666105U (en) * | 2012-06-07 | 2013-01-16 | 杨昌燕 | Disposable aseptic particle entrapment injector |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1363128A (en) * | 1920-02-11 | 1920-12-21 | Shigezo Nishitani | Injection-syringe |
| US4137917A (en) * | 1977-05-12 | 1979-02-06 | Cohen Milton J | Syringe filter unit |
| CN101648040A (en) * | 2009-09-04 | 2010-02-17 | 上海一童医疗用品有限公司 | Disposable precise filtering injector |
| CN102671262B (en) * | 2012-06-07 | 2014-04-16 | 中山未标生物新技术有限公司 | Disposable sterile particulate-retaining syringe |
-
2012
- 2012-06-07 CN CN201210185950.7A patent/CN102671262B/en active Active
-
2013
- 2013-05-27 WO PCT/CN2013/076271 patent/WO2013182000A1/en active Application Filing
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN200998481Y (en) * | 2006-07-31 | 2008-01-02 | 王哲兴 | Disposable asepsis filtering type injector |
| CN201612904U (en) * | 2010-02-27 | 2010-10-27 | 孙风林 | Syringe with filter function |
| CN201959347U (en) * | 2011-01-25 | 2011-09-07 | 上海振浦医疗设备有限公司 | Disposable precise filter injector |
| CN102406971A (en) * | 2011-12-29 | 2012-04-11 | 雷红力 | Filter type syringe |
| CN202666105U (en) * | 2012-06-07 | 2013-01-16 | 杨昌燕 | Disposable aseptic particle entrapment injector |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102671262A (en) | 2012-09-19 |
| WO2013182000A1 (en) | 2013-12-12 |
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