CN102671262A - Disposable sterile particulate-retaining syringe - Google Patents
Disposable sterile particulate-retaining syringe Download PDFInfo
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- CN102671262A CN102671262A CN2012101859507A CN201210185950A CN102671262A CN 102671262 A CN102671262 A CN 102671262A CN 2012101859507 A CN2012101859507 A CN 2012101859507A CN 201210185950 A CN201210185950 A CN 201210185950A CN 102671262 A CN102671262 A CN 102671262A
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- syringe
- urceolus
- filter membrane
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- use sterile
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3145—Filters incorporated in syringes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
- A61M2005/342—Off-center needles, i.e. needle connections not being coaxial with the longitudinal symmetry axis of syringe barrel
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention discloses a disposable sterile particulate-retaining syringe, which comprises a barrel, a plunger, a needle holder and a filter, the plunger is arranged in the barrel, the needle holder is arranged on one side of the front end of the barrel and is used for holding a needle, the barrel is communicated with the needle holder through a liquid outlet, and the filter is provided with a filter membrane, which is attached on the liquid outlet and can be closed toward the front end and opened toward the rear end. According to the structure design, the thickened interlayer-wrapped round unilaterally hung filter is only arranged in the tip of a conventional and ordinary syringe, the syringe can be automatically opened and closed and suck dissolved medicine during the microflow of the liquid, and can retain particulates in the injection in one step, so that particulates which are 0.45Mu m or bigger cannot be produced in the discharged liquid any more, and thereby the safety of injection is guaranteed.
Description
Technical field
The invention belongs to medical instruments field, relate to a kind of syringe, relate in particular to a kind of disposable use sterile particles and hold back syringe.
Background technology
Infusion treatment is that a kind of important treatment means, especially venous transfusion and intravenous injection directly get into blood circulation owing to medicinal liquid, and drug effect is brought into play fast and extensively employing of quilt.Yet in recent years, the harm that foreign body and particle contamination caused during injection was particularly infused has caused people's common concern, and it is very urgent to solve particle contamination.
Intravenous drip and intravenous injection; That microgranule is meant is that the involuntary adding that is present in the liquid can be moved about, insoluble allogenic material and solvable and medicine that dissolve; Particulate matter comprises rubber particle, polyester flake, thin bits, color dot, insoluble inorganic salt, micro activated carbon particle, fiber and the improper chemical particle that produces of drug combination compatibility etc.; If these microgranules are sneaked in the transfusion, just possibly cause infusion reaction during clinical practice, possibly cause acute reaction or long-term potential danger.As, a large amount of injection human bodies of microgranule possibly produce serious body damage, and the microgranule phase of holing up in the body is many decades can't metabolism; Big microgranule is detained formation with blood circulation at little blood vessel and stops up, and causes in various degree tissue necrosis and damage, like phlebitis; Pulmonary's granuloma; Thrombosis and blood vessel embolism, induced tumor formation etc., even jeopardize patient's life.In view of the serious consequence that particle contamination in the medicinal liquid possibly cause, China's " pharmacopeia " regulation, the particulate matter of particle diameter＞10 μ m (micron) must not be above 10 in every milliliter of transfusion.
The microgranule source has following several kinds in the medicinal liquid:
1, brings in article and the transfusion device production technology.
2, the maloperation in the medicine process for preparation produces, and during like multiple compatibility of drugs, possibly in medicinal liquid, have the drug microparticles more than 1～50 μ m.
3, the glass chip that sucks during the glass ampule breakdown.
4, syringe needle puncture bottle stopper dissolves the plug bits under the medicine cutting.
5, the plastics pin of transfusion device is when inserting the liquid bottles plug, also can make that microgranule increases by 1.6～27.6 times in the liquid.
The main mode of eliminating particle contamination in the transfusion is to install miniature displacer additional to make medicinal liquid get into human body before earlier through filtering.Existing researcher is installed a kind of filter that accompanies filter membrane additional to transfusion device, and this filter is installed in transfusion device terminal (lower end of dropping funnel), and work principle of filter is to rely on the negative pressure that liquid sinks to being produced in the transfusion bottle to realize filtering.Add defecator in this link and solved part particle contamination problem really, but should be with the defecator transfusion device, price significantly increases, and has increased the patient burden; And on the other hand, the transfusion device of this band defecator filters behind 500～1500ml liquid along with the gathering of microgranule, and also exists the defecator fenestra to stop up, influence phenomenon such as initial flow, filtering velocity decay and causes the transfusion device can't normal infusion.
The intravenous injection administration is common Therapeutic Method.At present; Disposable asepsis injector structure is very classical; It only can accomplish simple suction function of injection, is focusing more in the disposal safety that how to guarantee disposable use and syringe itself and improve research, and how these achievements in research eliminates particle contamination if all not relating to.Along with the raising that requires for the treatment means degree of purity with patient of improving of quality of medical care management system, reinforcement is to particulate matter control in the intravenous fluid and reduce the harm of particulate matter to the intravenous injection patient, is more and more paid attention to by hospital and patient.Yet up to the present still have no the defecator of form in syringe, to use safely; Its difference of holding back principle is used for the defecator of transfusion device owing to also can't be diverted in the syringe; Except that the circumscribed filtration syringe, miniature defecator is held back syringe in the disposable use sterile particles of one also not appearance of product is installed.
Summary of the invention
The object of the invention be to provide a kind of miniature displacer is installed can hold back syringe to the disposable use sterile particles that injection carries out particulate trap.
The disposable use sterile particles of the present invention is held back syringe; The needle stand that comprises urceolus, places interior fluid push rod of urceolus and outer cylinder front end one side to be used to adorn pin, urceolus and needle stand are communicated with liquid outlet, also comprise a defecator; This defecator is established a filter membrane; This filter membrane invests liquid outlet, and the forward end sealing, opens to the back-end.
Said defecator is embedded in urceolus top antetheca.
Said defecator comprises a plug-in unit, and filter membrane is fixed in this plug-in unit, and said urceolus top antetheca leans on a side of needle stand to offer the assembling slotted hole that matees with this plug-in unit along the urceolus arc direction, and this plug-in unit is assemblied in this slotted hole.
Said plug-in unit comprises the film circle of pin head, brace and hollow that order is connected as a single entity, and said filter membrane is fixed on the film circle, and brace and film circle are within urceolus, and the pin head is outside urceolus.
Said filter membrane is fixed between loam cake and the lower cover of one group of make-up and forms diaphragm, and filter membrane is assembled with this diaphragm-operated form.
Said loam cake and lower cover are circle body, and the hollow space of circle body is provided with the grid in order to holder lining filter membrane, and the circle body entity part of loam cake and lower cover is established fixed indenture of para-position and convexity respectively.
Detent is offered in the inboard corresponding diaphragm of said urceolus top antetheca position, and this detent size is greater than diaphragm edge size 0.05mm.
Said urceolus top antetheca is thickeied to 4mm.
Said outer cylinder front end is to thicken to the stressed sidewall of the half cone-shaped of 2mm in that a diaphragm-operated side is housed.
The thick 0.15mm of said diaphragm-operated loam cake, the thick 0.05mm of lower cover filters thickness 0.11-0.12mm; The pin of a said plug-in unit thick 12mm, brace thickness 0.32mm, the thick 0.35mm of film circle; The arc length of said pin head is greater than the arc length of urceolus assembling slotted hole.
Adopt above design; The aseptic syringe of holding back of the disposable use of the present invention can once be held back the microgranule in the injection; Absolute control is released and is no longer produced the above microgranule of >=0.45 μ m in the liquid, and the syringe that this band is held back extracts medicinal liquid can directly quietly push away intramuscular injection, has guaranteed injection safety.On the other hand; When the syringe that uses this band to hold back cooperates transfusion; Extract medicinal liquid and inject the microgranule that transfusion bottle has been removed other link generation; Therefore, transfusion device terminal institute band defecator only need hinder the microgranule that self passage of filter infusion apparatus is produced, and can alleviate like this that transfusion device end-filtration device stops up, the filtering velocity decay, influence the phenomenon generation of initial flow.
The invention has the advantages that:
1, to hold back syringe be disposable use to disposable use sterile particles.
2, to hold back the syringe outward appearance very simple for disposable use sterile particles, but the particulate trap rate reaches absolutely when using.
3, disposable use sterile particles is held back syringe and is not changed nursing injection field medical worker's conventional injection operating habit, has kept traditional appearance, makes injection operation in full accord with traditional operation from vision, intuition, sense organ right-angle plane etc.
4, disposable use sterile particles is held back the defecator that syringe presents the interlayer embedding, and its diaphragm static state is closed voluntarily, aspirated voluntarily and open, push away liquid closure voluntarily, forces liquid effectively to stop microgranule through the filter membrane passage simultaneously.
5, this structure Design, only a tradition and the common syringe top is established and thickened interlayer embedding one round one-sided hanging defecator, this device can be opened suction closed and that realize dissolving medicine voluntarily with the liquid miniflow, follows one's bent.
6, guarantee what method no matter NP injection field adopt dissolve medicine, what channel microgranule comes from; Molten medicine finishes and can release with desire with the desire suction; Realize holding back fully of microgranule and be not introduced into gravity transfusion and packed transfusion; Microgranule gets into the harm that the blood of human body blood circulation is brought when having avoided like rescue, intravenous drip, intravenous injection, and particulate trap rate safety coefficient reaches 100%.
Description of drawings
Fig. 1 holds back the syringe construction sketch map for the disposable use sterile particles of the present invention;
Fig. 2 holds back diaphragm pie graph in the syringe for the disposable use sterile particles of the present invention;
Fig. 3 holds back the structure chart of defecator in the syringe for the disposable use sterile particles of the present invention;
Fig. 4 holds back the front-end architecture profile of urceolus 3 in the syringe for disposable use sterile particles;
Fig. 5 is the left view (urceolus part) of Fig. 4;
Fig. 6 holds back the installation diagram of defecator 6 in the syringe for the disposable use sterile particles of the present invention;
The structure chart of syringe outer cylinder front end after Fig. 7 accomplishes for Fig. 6 assembles;
The variable condition figure of diaphragm 1 in the defecator 6 when Fig. 8 holds back the syringe use for the disposable use sterile particles of the present invention, the A width of cloth is for preparing aspiration phases, and the B width of cloth is the imbibition state, and the C width of cloth is for pushing away liquid status, and the D width of cloth is for accomplishing inject state.
The specific embodiment
The present invention provides a kind of disposable use sterile particles to hold back syringe, makes transformation to the existing structure syringe, adds a defecator on its top, can hold back the purpose that guarantees injection safety to microgranule in the medicinal liquid to reach when injecting.
As shown in Figure 1; Disposable use sterile particles provided by the invention is held back syringe; Comprise the urceolus 3 of existing ordinary syringe, the needle stand 5 that places interior fluid push rod 4 of urceolus and outer cylinder front end one side to be used to adorn pin, characteristics of the present invention are also to comprise a defecator 6; It is embedded in urceolus 3 inwall foremost, and over against needle stand 5 liquid outlet positions.
This defecator 6 is made up of a diaphragm 1 and a plug-in unit 2, referring to shown in Figure 3.Wherein:
As shown in Figure 2, diaphragm 1 order forms an oval lamellar body by loam cake 11, filter membrane 12 and lower cover 13 hot pressing, and loam cake 11 is the filter membrane support with lower cover 13; Be the circle body shape; The hollow space of circle body is provided with grid 14 in order to holder lining filter membrane 12, and the circle body entity part of loam cake 11 and lower cover 13 is established fixed indenture of para-position and convexity respectively, and filter membrane 12 is a lamellar body; Place between loam cake 11 and the lower cover 13 and to being positioned at grid 14 positions; Loam cake 11 with lower cover 13 with indenture with protruding para-position after hot pressing is compressed on filter membrane 12 between the covers formation diaphragm 1 (" interlayer " notion).
Preferably, the loam cake 11 of diaphragm 1 is processed by the polypropylene material, thick 0.15mm; Lower cover 13 is processed by the PP material, thick 0.05mm; Filter membrane 12 can adopt poly (ether sulfone) film (aperture 0.45 μ m), thickness 00.11-0.12mm.
Referring to Fig. 3, plug-in unit 2 integral body are lamellar, comprise the pin that is connected as a single entity of order 21, brace 22 and film circle 23, the likeness in form rivet, and pin 21 outer are camber line, and interior edge is contact pin 22 in succession, and hollow out has been left cast film forming circle 23 and has been used to install diaphragm 1 in the brace 22.Plug-in unit 2 integral body are made into integration by the PP material, pin 21 a thick 12mm, brace 22 thick 0.2mm, the thick 0.35mm of film circle, plug-in unit 2 whole long 15mm.
For assembling this defecator 6, syringe urceolus 3 front ends of the present invention need adjust.Adjustment comprises:
One) syringe top liquid outlet is with middle line computation, to syringe axis 3 ㎜ that are shifted;
Two) referring to Fig. 4-shown in Figure 5; The vertical antetheca 31 of syringe urceolus 3 need thicken (seeing Fig. 4 and Fig. 5); Usually can thicken to 4 ㎜, purpose be with the top wall of syringe urceolus 3 by original thin (1.5mm) thickening (" thickening " notion), be beneficial to following three) open design;
Three) lean on a side (" one-sided " notion) of needle stand 5 (for example to offer assembling slotted hole 32 at this antetheca 31 along the urceolus arc direction; The thick 0.35mm in hole; The long 20mm of camber line) is used for defecator 6 is inserted; The arc length (20mm) of assembling slotted hole 32 less than the arc length of pin head 21 (pin thick >=0.36mm, long >=21mm), with defecator 6 location; And detent 33 (the thick 0.35mm of groove is offered in the position that should assemble slotted hole 32 in urceolus 3 antethecas 31 inboards; Wide 12.mm; Long 15mm) is used to hold defecator 6; The size of this detent 33 is greater than the diaphragm 1 of defecator 6 (advance trough rim along) 0.05mm (referring to Fig. 4), the unlatching of diaphragm 1 closure slot milling when using for syringe, not draw-in groove and close (" embedding " notion) freely;
Four) for increasing injector cartridge intensity; Urceolus 3 need be thickeied at the sidewall of a side that has assembling slotted hole 32; The mode of thickening forms the stressed sidewall 34 of a half cone-shaped (referring to Fig. 5 for these urceolus 3 sidewalls; Urceolus 3 has enough intensity and bearing capacity (" reinforcement " notion) when thick 2mm * wide 15mm * long 20mm), thickening enhanced stressed sidewall 34 and can guarantee that defecator 6 inserts the assembling slotted hole 32 of urceolus 3 antethecas 31.
Above warp one) to four) the adjusted syringe urceolus 3 of strengthening one-sided fluting that thickens is integrated injection molding.
In the assembling; With the diaphragm 1 of defecator towards syringe urceolus 3; Inserting antetheca 31 from assembling slotted hole 32 gets into the detent 33 (referring to Fig. 6); The pin of plug-in unit 2 21 is stuck in outside the assembling slotted hole 32 fixing (" hanging " notion), referring to Fig. 7, shown assembling accomplish after the structure of syringe outer cylinder front end; Assemble to obtain having with this and thicken the disposable use sterile particles of strengthening interlayer embedding one round one-sided hanging defecator and hold back syringe (, having loaded onto syringe needle on the needle stand 5) referring to Fig. 1.
During use, the disposable use sterile particles of the present invention is held back the variation of diaphragm 1 in the syringe filtering device referring to shown in Figure 8, wherein:
The A width of cloth show disposable use sterile particles hold back syringe sky draw air-flow, syringe fluid push rod 4 is in syringe foremost, get into to prepare aspiration phases, this moment, diaphragm 1 was arranged in groove, was in closed condition;
The B width of cloth shows that disposable use sterile particles holds back syringe and implement suction action, syringe fluid push rod 4 post-tensionings, and medicinal liquid gets into from imbibing hole, pushes diaphragm 1 backward open and gets in the injector syringe, and this moment, diaphragm 1 was in opening;
The C width of cloth shows that disposable use sterile particles holds back syringe and implement to push away the work that surges, and pushes away before the syringe fluid push rod 4, and hydraulic drive diaphragm 1 is closed condition forward from opening, and medicinal liquid is pushed out through the hole of diaphragm 1;
The D width of cloth shows that disposable use sterile particles holds back syringe and push away liquid and accomplish, and this moment, the syringe fluid push rod 4 was pushed to syringe foremost, and diaphragm 1 is arranged in groove; Be in closed condition; Medicinal liquid is pushed out through the hole of diaphragm 1, and the microgranule that exists in the medicinal liquid is remained in the syringe by diaphragm 1 interception.
Can see through above shot operating process; The syringe of defecator is housed; In medicinal liquid, exist unpredictable or during the microgranule that is difficult to avoid; Diaphragm can be effectively with particulate trap, has guaranteed not have microgranule in the medicinal liquid of input human body, has eliminated the particle contamination of serious puzzlement transfusion safety.
From the security consideration of product of the present invention own; Filter membrane support (loam cake and lower cover) adopts the manufacturing of PP material; Do not contain the bisphenol-A material, its safety meets European Union's standard fully, and possesses advantages such as not easily broken and good stability; Even under the situation of heat, can not discharge deleterious material yet; Filter membrane is embedding hot pressing one-shot forming.
Below further specify function and the effect that disposable use sterile particles of the present invention is held back syringe through related experiment.
Experiment one: disposable use sterile particles is held back the check of filter membrane material in the syringe
This experiment holds back to disposable use sterile particles that used filter membrane material experimentizes in the syringe, and that proves conclusively used membrane material holds back effect, hydrophobic, air-permeability performance and security performance.Wherein to the assay of micropore polyether sulfone filter membrane referring to table 1, show that the filter membrane material of being selected for use can use.Also need carry out similar detection before selecting other filter membrane for use, enumerate testing result in the literary composition no longer one by one.
The disposable use medical micro porouse of table 1 polyether sulfone filter membrane is by batch test report
Conclusion:
Advantage: have good thermostability and chemical resistance, no powder or fibre shedding phenomenon, toughness is good
Experiment two: syringe particulate trap rate experiment
Particle contamination amount when this experiment exam vial is opened.Method: take respectively ampoule and antibiotic glass bottle the packing injection each 100; With the present invention's " disposable use sterile particles is held back syringe " by conventional opening and medicine-sucking; Syringe specification 10ml, wherein filter membrane adopts the PES that experiment one is confirmed, aperture 0.45 μ m; Bubble is pressed 0.31Mpa, and filter membrane allows through flow 31-44ml/cm
2/ min, 20 ℃ of operating temperatures, film thickness 0.11-0.12mm.Extract medicinal liquid after syringe is pushed out to the straight microscopical glass slide of biology, microscopically is observed and is counted to get the particle number in the medicinal liquid, and average result is recorded in table 2 test group.Take out corresponding filter membrane in addition, mirror is observed down filter membrane and is received dirty face and stop >=0.45 μ m microgranule and reach absolutely.
Control experiment: to 100 of the above same injection; Press the conventional method opening and medicine-sucking with common same specification syringe; The medicinal liquid that extracts moves to the straight microscopical glass slide of biology, and microscopically is observed the particle number in the counting medicinal liquid, and average result is recorded in table 2 matched group.
Fraction of particle in the different syringes release of table 2 medicinal liquid (individual/ml)
Experimental result shows, uses ordinary syringe, has a large amount of microgranules in the injection, does not meet the relevant criterion index request (referring to table 3) in the industry, analyzes wherein microgranule source, and it is listed to reduce table 4.And after the disposable use sterile particles of the present invention holds back syringe, release in the injection >=microgranule of 0.45 μ m all is trapped, and guaranteed the safety of injection.
Table 3: each method detects index
Table 4: microgranule source in the injection
Filter membrane support intensity experiment in experiment three, the defecator
Disposable use sterile particles is held back in the syringe; The film circle of its defecator (the filter membrane support that loam cake and lower cover are formed) adheres to diaphragm; Open and close with the syringe action, this experiment is observed its tension warpage holding capacity repeatedly with the intensity of push-and-pull air-flow this support of check and filter membrane.
Method: adopt the empty section disposable use sterile particles of 1～50ml to hold back syringe.Empty cutting to retreat the most fast returned the top again to end and is once action, totally 10 end.Each action back observes whether the one-sided mounted bracket in top is shifted in the syringe in inner core; Whether take out defecator again and place under the biological microscope, it is loosening to observe filter membrane embedding support, and whether filter membrane is out of shape; Support whether with syringe in the top keep horizontal plane; Whether as before support inserts syringe, and whether annular filter membrane embedding edge breaks away from, and whether filter membrane bores a hole between film circle and the diaphragm.
Result: 1) non-loosening.2) indeformable.3) as before.4) do not break away from.5) puncherless.
Above-mentioned 1～10 experimental result shows: filtration membrane does not come off, annular filter membrane embedding edge does not break away from, holder device is not loosening, filter membrane is puncherless, and promptly all are excellent as before.The defecator that the empty section disposable use sterile particles of the present invention is held back syringe does not have once damaged, and its intensity is qualified.
The damaged experiment of the anti-hydraulic shock of filter membrane in experiment four, the defecator
This experiment is checked the damaged ability of the anti-hydraulic shock power of filter membrane with normal saline.
Method: adopt the disposable use sterile particles of 20ml to hold back syringe; Disposable extraction reason saline 20ml is divided into and once releases 2ml; Finish for totally 10 times; Each observation whether have medicinal liquid to ooze out and feed liquor whether smooth, each back of releasing is taken out and is placed a complete set of side hanging defecator in top in the syringe, places and observes whether intact nothing breakage biological microscope under.
Result: release 10 filter membrane experimental results through an above-mentioned 2ml and show that medicinal liquid seepage, gas leakage all do not occur, it is rapid that medicinal liquid is crossed film, and filter membrane does not have the perforation breakage.
Experiment five, the disposable use sterile particles of different size are held back the particulate trap of syringe
The inventor is based on above-mentioned research, and the disposable use sterile particles that obtains series specification is held back syringe.Its configuration is referring to table 5.
The disposable use sterile particles of table 5 is held back syringe 1ml～100ml specification filter membrane allocation list
Adopt specification:
1, disposable use sterile particles is held back syringe, and specification 1ml～100ml is totally 11 specifications.
2, disposable property use aseptic injection pin, specification 0.4mm～1.6mm.
3, press injection operation, insert and take out the medicine operation after the molten medicine of bottle stopper simulation finishes, press the metering of syringe nominal for every and extract deionized water (deionized water), push the 200ml measuring cup after getting, each specification 10 times, totally 110 simulations.
4, measuring cup liquid pipettes the straight micro-eyeglass of 10 microlitres to biology for 1 time, divides secondary mirror to observe filtrating down, and the result does not all have the granule microgranule and shows.
5, take out syringe inner support and the whole device of filter membrane, place and observe filter membrane biological microscope under and receive dirty face, it is thus clear that mirror is down particle diameter 1 μ m ~ 300 μ m (micron) or bigger granules, and the particulate matter naked eyes can both recognize.Visible granular is retained in entirely holds back syringe filter membrane upper surface; Explain that adopting disposable use sterile particles to hold back syringe can hold back above-mentioned particle diameter >=1 μ m, 5 μ m, 10 μ m, 15 μ m, 20 μ m, 50 μ m, 300 μ m or larger particles, and can disposable thorough trapped particles.
Conclusion: show in each specification syringe release liquid provided by the present invention all do not have the granule microgranule through above-mentioned experimental result.
Experiment six: syringe filtering device of the present invention and the principle analysis of transfusion device defecator
Adopt the microporous filter membrane particulate trap under the pressure state, can realize that the disposable of size particles microgranule hold back.But transfusion device terminal filter membrane is provided with and belongs to microgravity (only relying on medicinal liquid gravity); Be prone to stop up fenestra; Only if gap is bigger between membrane aperture and the diameter of particle, the flow rate of can realizing filtrating is unattenuated, but the increase in aperture has obviously weakened the effect of holding back of microgranule again.
Under pressure state; As adopt micropore polyether sulfone filter membrane 0.45 μ m, diameter 25mm filter membrane through the first extract of vacuum decompression filter flask sucking filtration Chinese medicine muddiness; The filter membrane upper surface presents microgranule to be held back entirely, can hold back greater than 1 μ m, 5 μ m, 10 μ m, 20 μ m, 50 μ m, 300 μ m or bigger granule, and the particulate matter naked eyes can both recognize; And no granule microgranule in the filter liquor, this is enough to explain that it is crucial that pressure is held back (or be called " gravity is held back ").
It is to adopt pressure to release to realize filtering that the disposable use sterile particles of the present invention is held back its principle of syringe, is different from the work principle of filter of existing transfusion device.So the filter membrane pore size change not to have significantly that decay hinders among the present invention, along with the increase of fluence, microgranule also increases in film table accumulated amount thereupon, blocking portion filter membrane but attenuation trend does not still appear in flow of filtrate.Disposable use sterile particles is held back syringe and is adopted poly (ether sulfone) film (aperture 0.45 μ m).
Below introduce the best disposable use sterile particles of the present invention in detail and held back the formation and the function of syringe; Yet protection scope of the present invention should not only limit to the form of accompanying drawing and embodiment, for example; Adopt design concept of the present invention; Can outside establish on the disposable sterilized injector top, implant defecator, or paste the miniature defecator of level etc. in the inboard and produce similar products, the particulate trap syringe of these forms still belongs to the open and protection domain of the present invention.Avoid set-up mode shown in the accompanying drawing if any the people, should be appreciated that, this selection of deliberately making for the escape infringement remains infringement of the present invention.
Claims (10)
1. disposable use sterile particles is held back syringe, the needle stand that comprises urceolus, places interior fluid push rod of urceolus and outer cylinder front end one side to be used to adorn pin, and urceolus and needle stand are communicated with liquid outlet; It is characterized in that; Also comprise a defecator, this defecator is established a filter membrane, and this filter membrane invests liquid outlet; And the forward end sealing is opened to the back-end.
2. hold back syringe according to the said disposable use sterile particles of claim 1, it is characterized in that said defecator is embedded in urceolus top antetheca.
3. hold back syringe according to the said disposable use sterile particles of claim 2; It is characterized in that; Said defecator comprises a plug-in unit; Filter membrane is fixed in this plug-in unit, and said urceolus top antetheca leans on a side of needle stand to offer the assembling slotted hole that matees with this plug-in unit along the urceolus arc direction, and this plug-in unit is assemblied in this slotted hole.
4. hold back syringe according to the said disposable use sterile particles of claim 3; It is characterized in that said plug-in unit comprises the film circle of pin head, brace and hollow that order is connected as a single entity, said filter membrane is fixed on the film circle; Brace and film circle are within urceolus, and the pin head is outside urceolus.
5. hold back syringe according to claim 1 or 2 or 3 or 4 said disposable use sterile particles, it is characterized in that, said filter membrane is fixed between loam cake and the lower cover of one group of make-up and forms diaphragm, and filter membrane is assembled with this diaphragm-operated form.
6. hold back syringe according to the said disposable use sterile particles of claim 5; It is characterized in that; Said loam cake and lower cover are circle body, and the hollow space of circle body is provided with the grid in order to holder lining filter membrane, and the circle body entity part of loam cake and lower cover is established fixed indenture of para-position and convexity respectively.
7. hold back syringe according to claim 5 or 6 said disposable use sterile particles, it is characterized in that, detent is offered in the inboard corresponding diaphragm of said urceolus top antetheca position, and this detent size is greater than diaphragm edge size 0.05mm.
8. hold back syringe according to the said disposable use sterile particles of claim 7, it is characterized in that, said urceolus top antetheca is thickeied to 4mm.
9. said according to Claim 8 disposable use sterile particles is held back syringe, it is characterized in that, said outer cylinder front end is to thicken to the stressed sidewall of the half cone-shaped of 2mm in that a diaphragm-operated side is housed.
10. hold back syringe according to the said disposable use sterile particles of claim 9, it is characterized in that, the thick 0.15mm of said diaphragm-operated loam cake, the thick 0.05mm of lower cover filters thickness 0.11-0.12mm; The pin of a said plug-in unit thick 12mm, brace thickness 0.32mm, the thick 0.35mm of film circle; The arc length of said pin head is greater than the arc length of urceolus assembling slotted hole.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210185950.7A CN102671262B (en) | 2012-06-07 | 2012-06-07 | Disposable sterile particulate-retaining syringe |
| PCT/CN2013/076271 WO2013182000A1 (en) | 2012-06-07 | 2013-05-27 | Disposable sterile injector for retaining microparticles |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210185950.7A CN102671262B (en) | 2012-06-07 | 2012-06-07 | Disposable sterile particulate-retaining syringe |
Publications (2)
| Publication Number | Publication Date |
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| CN102671262A true CN102671262A (en) | 2012-09-19 |
| CN102671262B CN102671262B (en) | 2014-04-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210185950.7A Active CN102671262B (en) | 2012-06-07 | 2012-06-07 | Disposable sterile particulate-retaining syringe |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN102671262B (en) |
| WO (1) | WO2013182000A1 (en) |
Cited By (4)
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| WO2013182000A1 (en) * | 2012-06-07 | 2013-12-12 | 广州均和纳米新材料科技有限公司 | Disposable sterile injector for retaining microparticles |
| CN108434551A (en) * | 2018-04-13 | 2018-08-24 | 山东中医药大学 | A kind of dropper with injection filtering function |
| CN112277333A (en) * | 2019-07-25 | 2021-01-29 | 江苏正迈过滤技术有限公司 | Medical filter and production method thereof |
| CN113350619A (en) * | 2021-07-08 | 2021-09-07 | 上海振浦医疗设备有限公司 | Built-in membrane filtering injector |
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| CN102671262B (en) * | 2012-06-07 | 2014-04-16 | 中山未标生物新技术有限公司 | Disposable sterile particulate-retaining syringe |
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| CN200998481Y (en) * | 2006-07-31 | 2008-01-02 | 王哲兴 | Disposable asepsis filtering type injector |
| CN201612904U (en) * | 2010-02-27 | 2010-10-27 | 孙风林 | Syringe with filter function |
| CN201959347U (en) * | 2011-01-25 | 2011-09-07 | 上海振浦医疗设备有限公司 | Disposable precise filter injector |
| CN102406971A (en) * | 2011-12-29 | 2012-04-11 | 雷红力 | Filter type syringe |
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| WO2013182000A1 (en) * | 2012-06-07 | 2013-12-12 | 广州均和纳米新材料科技有限公司 | Disposable sterile injector for retaining microparticles |
| CN108434551A (en) * | 2018-04-13 | 2018-08-24 | 山东中医药大学 | A kind of dropper with injection filtering function |
| CN112277333A (en) * | 2019-07-25 | 2021-01-29 | 江苏正迈过滤技术有限公司 | Medical filter and production method thereof |
| CN113350619A (en) * | 2021-07-08 | 2021-09-07 | 上海振浦医疗设备有限公司 | Built-in membrane filtering injector |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102671262B (en) | 2014-04-16 |
| WO2013182000A1 (en) | 2013-12-12 |
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