CN102671231A - Method for preparing marine-derived compound collagen dressing - Google Patents
Method for preparing marine-derived compound collagen dressing Download PDFInfo
- Publication number
- CN102671231A CN102671231A CN201110427726XA CN201110427726A CN102671231A CN 102671231 A CN102671231 A CN 102671231A CN 201110427726X A CN201110427726X A CN 201110427726XA CN 201110427726 A CN201110427726 A CN 201110427726A CN 102671231 A CN102671231 A CN 102671231A
- Authority
- CN
- China
- Prior art keywords
- marine fishes
- collagen
- fishbone
- solution
- dressing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000008186 Collagen Human genes 0.000 title claims abstract description 120
- 108010035532 Collagen Proteins 0.000 title claims abstract description 120
- 229920001436 collagen Polymers 0.000 title claims abstract description 66
- 238000000034 method Methods 0.000 title claims abstract description 29
- 150000001875 compounds Chemical class 0.000 title abstract 7
- 241000251468 Actinopterygii Species 0.000 claims abstract description 72
- 230000003110 anti-inflammatory effect Effects 0.000 claims abstract description 13
- 239000000645 desinfectant Substances 0.000 claims abstract description 11
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 9
- 230000001954 sterilising effect Effects 0.000 claims abstract description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 81
- 239000000243 solution Substances 0.000 claims description 76
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims description 43
- 229920001287 Chondroitin sulfate Polymers 0.000 claims description 43
- 229940059329 chondroitin sulfate Drugs 0.000 claims description 43
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 41
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 41
- 239000002131 composite material Substances 0.000 claims description 35
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 32
- 238000003756 stirring Methods 0.000 claims description 30
- 238000000502 dialysis Methods 0.000 claims description 29
- 210000002615 epidermis Anatomy 0.000 claims description 29
- 239000012153 distilled water Substances 0.000 claims description 24
- 210000003722 extracellular fluid Anatomy 0.000 claims description 24
- 238000004108 freeze drying Methods 0.000 claims description 21
- 102000004190 Enzymes Human genes 0.000 claims description 20
- 108090000790 Enzymes Proteins 0.000 claims description 20
- 238000001816 cooling Methods 0.000 claims description 20
- 229940088598 enzyme Drugs 0.000 claims description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
- 239000004365 Protease Substances 0.000 claims description 18
- 108090000526 Papain Proteins 0.000 claims description 17
- 229940055729 papain Drugs 0.000 claims description 17
- 235000019834 papain Nutrition 0.000 claims description 17
- 239000007788 liquid Substances 0.000 claims description 16
- 239000011780 sodium chloride Substances 0.000 claims description 16
- 239000002244 precipitate Substances 0.000 claims description 15
- 239000000284 extract Substances 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 13
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical group O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 12
- 238000000605 extraction Methods 0.000 claims description 12
- 238000012856 packing Methods 0.000 claims description 12
- 229920002971 Heparan sulfate Polymers 0.000 claims description 11
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 11
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims description 10
- 102000013275 Somatomedins Human genes 0.000 claims description 10
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims description 9
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims description 9
- 108090000631 Trypsin Proteins 0.000 claims description 9
- 102000004142 Trypsin Human genes 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 9
- 229960002233 benzalkonium bromide Drugs 0.000 claims description 9
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical group [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 claims description 9
- 229940126864 fibroblast growth factor Drugs 0.000 claims description 9
- 239000012588 trypsin Substances 0.000 claims description 9
- 102000036693 Thrombopoietin Human genes 0.000 claims description 8
- 108010041111 Thrombopoietin Proteins 0.000 claims description 8
- 239000000047 product Substances 0.000 claims description 8
- 238000004659 sterilization and disinfection Methods 0.000 claims description 8
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 7
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 7
- 239000008394 flocculating agent Substances 0.000 claims description 7
- 235000013372 meat Nutrition 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 7
- 102100022987 Angiogenin Human genes 0.000 claims description 6
- 230000001476 alcoholic effect Effects 0.000 claims description 6
- 108010072788 angiogenin Proteins 0.000 claims description 6
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 6
- 239000000385 dialysis solution Substances 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000002386 leaching Methods 0.000 claims description 6
- 238000005406 washing Methods 0.000 claims description 6
- 238000001556 precipitation Methods 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- 230000008859 change Effects 0.000 claims description 4
- -1 hEGF Proteins 0.000 claims description 4
- 238000002791 soaking Methods 0.000 claims description 2
- 208000027418 Wounds and injury Diseases 0.000 abstract description 21
- 206010052428 Wound Diseases 0.000 abstract description 20
- 230000035876 healing Effects 0.000 abstract description 9
- 238000004132 cross linking Methods 0.000 abstract description 3
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 abstract 3
- 239000011259 mixed solution Substances 0.000 abstract 2
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 40
- 241001417045 Lophius litulon Species 0.000 description 15
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 12
- 210000004027 cell Anatomy 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- 244000184734 Pyrus japonica Species 0.000 description 8
- 230000001105 regulatory effect Effects 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 6
- 210000000845 cartilage Anatomy 0.000 description 6
- 239000004744 fabric Substances 0.000 description 6
- 235000018102 proteins Nutrition 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 5
- 230000007062 hydrolysis Effects 0.000 description 5
- 238000006460 hydrolysis reaction Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000003513 alkali Substances 0.000 description 4
- 229910021529 ammonia Inorganic materials 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 230000012010 growth Effects 0.000 description 4
- 208000014674 injury Diseases 0.000 description 4
- 230000035699 permeability Effects 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 230000008439 repair process Effects 0.000 description 4
- 230000029663 wound healing Effects 0.000 description 4
- 230000007850 degeneration Effects 0.000 description 3
- 238000004821 distillation Methods 0.000 description 3
- 229960004756 ethanol Drugs 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 230000023597 hemostasis Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 230000008733 trauma Effects 0.000 description 3
- 208000035143 Bacterial infection Diseases 0.000 description 2
- 206010063560 Excessive granulation tissue Diseases 0.000 description 2
- 241000628997 Flos Species 0.000 description 2
- 229920002683 Glycosaminoglycan Polymers 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 108090000190 Thrombin Proteins 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 208000022362 bacterial infectious disease Diseases 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
- 230000008602 contraction Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 230000003328 fibroblastic effect Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 210000001126 granulation tissue Anatomy 0.000 description 2
- 230000000025 haemostatic effect Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 229960004072 thrombin Drugs 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000017423 tissue regeneration Effects 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 230000037314 wound repair Effects 0.000 description 2
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
- 241000238366 Cephalopoda Species 0.000 description 1
- 241000251730 Chondrichthyes Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000007212 Foot-and-Mouth Disease Diseases 0.000 description 1
- 241000710198 Foot-and-mouth disease virus Species 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 208000018756 Variant Creutzfeldt-Jakob disease Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 230000008952 bacterial invasion Effects 0.000 description 1
- 208000005881 bovine spongiform encephalopathy Diseases 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000000515 collagen sponge Substances 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000009881 electrostatic interaction Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 230000005251 gamma ray Effects 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012792 lyophilization process Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 235000019419 proteases Nutrition 0.000 description 1
- 238000000751 protein extraction Methods 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (9)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201110427726 CN102671231B (en) | 2011-12-20 | 2011-12-20 | Method for preparing marine-derived compound collagen dressing |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201110427726 CN102671231B (en) | 2011-12-20 | 2011-12-20 | Method for preparing marine-derived compound collagen dressing |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102671231A true CN102671231A (en) | 2012-09-19 |
CN102671231B CN102671231B (en) | 2013-12-25 |
Family
ID=46804211
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 201110427726 Active CN102671231B (en) | 2011-12-20 | 2011-12-20 | Method for preparing marine-derived compound collagen dressing |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102671231B (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103386144A (en) * | 2013-07-23 | 2013-11-13 | 海南光宇生物科技有限公司 | Preparation method of fish collagen combined chitosan biological dressing |
CN106943620A (en) * | 2017-03-17 | 2017-07-14 | 广州赛莱拉干细胞科技股份有限公司 | A kind of gel dressing of medical use liquid containing extracellular matrix components and application |
CN107899080A (en) * | 2017-11-30 | 2018-04-13 | 振德医疗用品股份有限公司 | A kind of dermis restoration stent preparation method |
CN108939153A (en) * | 2018-08-17 | 2018-12-07 | 振德医疗用品股份有限公司 | A kind of collagen-based packing material and preparation method thereof and its application method |
CN109503733A (en) * | 2018-12-29 | 2019-03-22 | 福州宏东食品有限公司 | A kind of extracting method of shark chondroitine |
CN112358018A (en) * | 2020-10-30 | 2021-02-12 | 浙江工商大学 | Protein flocculant and preparation method thereof |
CN115154643A (en) * | 2022-06-27 | 2022-10-11 | 福建医科大学附属协和医院 | Preparation method and application of aloe polysaccharide-collagen composite dressing |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1337270A (en) * | 2000-08-07 | 2002-02-27 | 黄玲惠 | Wound dressing and its prepn. |
CN1406632A (en) * | 2001-09-10 | 2003-04-02 | 中国人民解放军军事医学科学院卫生装备研究所 | Collagen based composite sponge and production thereof |
EP1430911A2 (en) * | 2002-12-20 | 2004-06-23 | Ethicon | Hemostatic wound dressing and fabric containing aldehyde-modified polysaccharide |
CN1788802A (en) * | 2005-12-14 | 2006-06-21 | 温州医学院 | Biological sponge material for promoting injury-restoring and its preparation method |
CN101418328A (en) * | 2008-10-28 | 2009-04-29 | 山东好当家海洋发展股份有限公司 | Method for producing fish scale collagen protein |
CN101701043A (en) * | 2009-11-10 | 2010-05-05 | 浙江澳兴生物科技有限公司 | Extraction method of shark chondroitine |
US20110034410A1 (en) * | 2002-06-14 | 2011-02-10 | Mccarthy Simon J | Wound dressing and method for controlling severe, life-threatening bleeding |
-
2011
- 2011-12-20 CN CN 201110427726 patent/CN102671231B/en active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1337270A (en) * | 2000-08-07 | 2002-02-27 | 黄玲惠 | Wound dressing and its prepn. |
CN1406632A (en) * | 2001-09-10 | 2003-04-02 | 中国人民解放军军事医学科学院卫生装备研究所 | Collagen based composite sponge and production thereof |
US20110034410A1 (en) * | 2002-06-14 | 2011-02-10 | Mccarthy Simon J | Wound dressing and method for controlling severe, life-threatening bleeding |
EP1430911A2 (en) * | 2002-12-20 | 2004-06-23 | Ethicon | Hemostatic wound dressing and fabric containing aldehyde-modified polysaccharide |
CN1788802A (en) * | 2005-12-14 | 2006-06-21 | 温州医学院 | Biological sponge material for promoting injury-restoring and its preparation method |
CN101418328A (en) * | 2008-10-28 | 2009-04-29 | 山东好当家海洋发展股份有限公司 | Method for producing fish scale collagen protein |
CN101701043A (en) * | 2009-11-10 | 2010-05-05 | 浙江澳兴生物科技有限公司 | Extraction method of shark chondroitine |
Non-Patent Citations (1)
Title |
---|
王燕等: "酶法提取鱿鱼皮胶原蛋白", 《食品科技》 * |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103386144A (en) * | 2013-07-23 | 2013-11-13 | 海南光宇生物科技有限公司 | Preparation method of fish collagen combined chitosan biological dressing |
CN103386144B (en) * | 2013-07-23 | 2014-10-01 | 海南光宇生物科技有限公司 | Preparation method of fish collagen combined chitosan biological dressing |
CN106943620A (en) * | 2017-03-17 | 2017-07-14 | 广州赛莱拉干细胞科技股份有限公司 | A kind of gel dressing of medical use liquid containing extracellular matrix components and application |
CN107899080A (en) * | 2017-11-30 | 2018-04-13 | 振德医疗用品股份有限公司 | A kind of dermis restoration stent preparation method |
CN108939153A (en) * | 2018-08-17 | 2018-12-07 | 振德医疗用品股份有限公司 | A kind of collagen-based packing material and preparation method thereof and its application method |
CN109503733A (en) * | 2018-12-29 | 2019-03-22 | 福州宏东食品有限公司 | A kind of extracting method of shark chondroitine |
CN112358018A (en) * | 2020-10-30 | 2021-02-12 | 浙江工商大学 | Protein flocculant and preparation method thereof |
CN112358018B (en) * | 2020-10-30 | 2022-05-27 | 浙江工商大学 | Protein flocculant and preparation method thereof |
CN115154643A (en) * | 2022-06-27 | 2022-10-11 | 福建医科大学附属协和医院 | Preparation method and application of aloe polysaccharide-collagen composite dressing |
CN115154643B (en) * | 2022-06-27 | 2024-03-12 | 福建医科大学附属协和医院 | Preparation method and application of aloe polysaccharide-collagen composite dressing |
Also Published As
Publication number | Publication date |
---|---|
CN102671231B (en) | 2013-12-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102671231B (en) | Method for preparing marine-derived compound collagen dressing | |
CN109045349A (en) | A kind of hydrogel skin wound dressing and preparation method thereof that antibacterial heal-promoting closes | |
CN107802878A (en) | A kind of modified gelatin/potassium-sodium niobate compound electroactive antibacterial biological dressing and its preparation and application | |
CN103386144B (en) | Preparation method of fish collagen combined chitosan biological dressing | |
CN103756005B (en) | A kind of Composite collagen sponge and preparation method thereof | |
CN105331662A (en) | Non-denatured II type collagen of animal cartilage source and preparation method for non-denatured II type collagen | |
CN101138648A (en) | Method of preparing antimicrobial hemostasis Chinese medicine-containing biological dressings | |
CN101092449A (en) | Technique for preparing collagen of freshwater fish skin | |
CN101434642A (en) | Method for preparing non-denaturation hogskin insoluble collagen powder | |
CN102229971A (en) | Method for preparing collagen peptides by using fresh yak bones | |
CN102550900A (en) | Method for preparing edible gelatin by means of freshwater fish skin | |
CN101507831B (en) | Material for promoting operation wound heal and preparation method thereof | |
CN103882082A (en) | Method for preparing I type collagen and V type collagen | |
CN101792382A (en) | Method for preparing disinfected-decolorized fish-squamosum organic acid calcium and non-denatured collagen | |
CN106432541A (en) | Method for extracting sturgeon cartilage extract | |
CN104474573B (en) | Biological mask and preparation method thereof | |
CN106110367A (en) | Based on natural polymer MULTILAYER COMPOSITE medical dressing and preparation method thereof | |
CN104926935A (en) | Efficient extraction method for extracting collagen from pigskin | |
CN109700998B (en) | Compound skin injury regeneration repairing agent and preparation method thereof | |
CN104805165A (en) | Method for extracting water-insoluble collagen from thoracic aorta of pig | |
CN1544097A (en) | Biologic material for medical use and its preparing process and usage | |
CN1112831A (en) | Long lasting multi-function nutritive skin care liquid containing extract of snail and the mfg. method | |
CN105132510A (en) | Method for preparing biological active peptide by conducting hydrolysis on snail slime through enzymatic method | |
CN102357102B (en) | Preparation method of transfer factor soluble powder for animals | |
CN104497345A (en) | Preparation method of hyaluronic acid-chitosan degradable dressing |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20120919 Assignee: ZHEJIANG YUPOPO FOOD CO.,LTD. Assignor: ZHEJIANG MARINE DEVELOPMENT Research Institute Contract record no.: X2023980043800 Denomination of invention: A Preparation Method of Marine Source Composite Collagen Dressing Granted publication date: 20131225 License type: Common License Record date: 20231019 |
|
EE01 | Entry into force of recordation of patent licensing contract | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20120919 Assignee: Kunyuan Pinjian (Zhejiang) Technology Co.,Ltd. Assignor: ZHEJIANG MARINE DEVELOPMENT Research Institute Contract record no.: X2023980044624 Denomination of invention: A Preparation Method of Marine Source Composite Collagen Dressing Granted publication date: 20131225 License type: Common License Record date: 20231027 |