CN102670839B - External traditional Chinese medicine composition for treating hyperosteogeny - Google Patents
External traditional Chinese medicine composition for treating hyperosteogeny Download PDFInfo
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Abstract
The invention discloses an external traditional Chinese medicine composition for treating hyperosteogeny, which belongs to the technical field of traditional Chinese medicine preparations. The external traditional Chinese medicine composition for treating the disease of the hyperosteogeny is characterized by being prepared through processing the following Chinese herbal medicines according to parts by weight: 10 to 18 parts of babylon weeping willow root-bark, 5 to 8 parts of ramulus mori, 6 to 12 parts of peach leaf, 5 to 8 parts of hot pepper stem, 4 to 8 parts of ligusticum wallichii, 4 to 8 parts of radix gentianae macrophyllae, 4 to 8 parts of twotooth achyranthes root, 4 to 8 parts of spatholobus stem and 30 to 50 parts of vinegar. The external traditional Chinese medicine composition for treating the disease of the hyperosteogeny is an ionic penetration agent and is suitable for the auxiliary treatment of the osteoarthritis of knee joints. The external traditional Chinese medicine composition for treating the disease of the hyperosteogeny can be used for enhancing the local medicine concentration of a focus, is quick in acting and is safe in treatment. Moreover, the external traditional Chinese medicine composition for treating the disease of the hyperosteogeny can be used for softening or eliminating bony spurs. Therefore, the external traditional Chinese medicine composition for treating the disease of the hyperosteogeny has good curative effect and has extensive popularization and application prospect.
Description
Technical field
The present invention relates to medicine, particularly relate to a kind of Chinese medicine preparation.
Background technology
Bone matrix hyperplasia claims osteoarthritis again, is commonly encountered diseases, the frequently-occurring disease of middle-aged and elderly people.Think at present
[1], pathological change generally can not reverse, its therapeutic purposes are relief of symptoms, the quality of making the life better, Drug therapy with NSAID (non-steroidal anti-inflammatory drug) as common drug, the analgesic drug product of adapted relieve muscle spasms, acute inflammation stage gives antibiotic therapy
[2]Chinese traditional treatment is mainly alleviated clinical symptoms by methods such as blood circulation promoting and blood stasis dispelling, dispelling cold and dehumidification and liver and kidney tonifying, but exists the performance curative effect slow, and the pathological changes local drug concentration is low, the deficiency that curative effect is not remarkable.Local Dressed plaster treatment also has certain therapeutical effect
[3,4], but curative effect is also unsatisfactory.In recent years, operative treatment can be eliminated bony spur, repair pathological tissues, but the strictness of operative treatment indication exists wound to have a big risk, and sequela is many, the defective that treatment cost is high.Chinese patent " beneficial bone electric conductance liquid dispels the wind "
[5]Solved above deficiency, but the bony spur of hypertrophy has not been had the improvement effect.
Summary of the invention
At above deficiency, the object of the present invention is to provide a kind of energy by the pulse current of electronic therapeutic instrument medicine to be imported lesions position performance curative effect, not only can make the local drug concentration height, instant effect, treat safety, and can soften or eliminate the external medicine composition of the treatment bone matrix hyperplasia of bony spur.
For reaching above purpose, the technical solution adopted in the present invention is: this a kind of external medicine composition for the treatment of bone matrix hyperplasia is characterized in that being processed into by the Chinese herbal medicine of following weight portion:
10～18 parts of Cortex Salicis Babylonicae Radiciss, 5～8 parts of Ramulus Moris, 6～12 parts of Folium Persicaes, 5～8 parts of Caulis Capsicis, 4～8 parts of Rhizoma Chuanxiongs, 4～8 parts of Radix Gentianae Macrophyllae, 4～8 parts of Radix Achyranthis Bidentataes, 4～8 parts of Caulis Spatholobis, 30～50 parts of vinegar.
Preferred version of the present invention is: this a kind of external medicine composition for the treatment of bone matrix hyperplasia is characterized in that being processed into by the Chinese herbal medicine of following weight portion: 15 parts of Cortex Salicis Babylonicae Radiciss, 6 parts of Ramulus Moris, 9 parts of Folium Persicaes, 6 parts of Caulis Capsicis, 6 parts of Rhizoma Chuanxiongs, 6 parts of Radix Gentianae Macrophyllae, 6 parts of Radix Achyranthis Bidentataes, 6 parts of Caulis Spatholobis, 40 parts of vinegar.
Production method of the present invention
Take by weighing Chinese crude drug by the top, with wherein Cortex Salicis Babylonicae Radicis, Ramulus Mori, Folium Persicae, Caulis Capsici, Rhizoma Chuanxiong, Radix Gentianae Macrophyllae, Radix Achyranthis Bidentatae, Caulis Spatholobi cutting, put compacting in the container, add above-mentioned vinegar, add water again, make water cover Chinese herbal medicine, soak after 6～12 hours, decoct 2 times, boiled 1 hour for the first time, leach medicinal liquid, add water again for the second time and boil 30 minutes, leach medicinal liquid; Merge medicinal liquid, post precipitation filters, and filtrate decompression is concentrated into relative density 1.05～1.09 (60 ℃).Regulate pH value to 2.0～4.0, add antiseptic, shake up, in the medicine bottle of packing into, seal, namely.
Beneficial effect of the present invention
1. compare with interior application treatment, the performance curative effect is fast, focus local drug concentration height, and it is long to keep curative effect time.Oral medicine is brought into play curative effect to drug conveying to lesions position by blood circulation, because articular surface, intervertebral disc and the soft tissue thereof of bone do not have blood vessel, be difficult to medicine is delivered to lesions position, and the time that medicine stops in vivo is short, excretes in general 24 hours.The present invention is that the pulse current by electronic therapeutic instrument forces medicine to penetrate the through focus of Intradermal and brings into play curative effect rapidly, this local targeting administrated method is concentrated medicine ion and is penetrated focus, make the focus local drug concentration higher tens times to tens times than oral medicine, and because lesions position does not have blood vessel, so medicine is long in the time that lesions position stops, gave full play to curative effect to tens days in general several days.
2. compare instant effect, good effect with local Dressed plaster.Dressed plaster treatment is that percutaneous pore infiltrates Intradermal naturally, and when summer sky heat perspiration and during the cold pore closure in sky in winter, the effective ingredient of plaster can not infiltrate Intradermal; And the penetration of plaster a little less than, the medicine that infiltrates Intradermal naturally can arrive the deep lesions position seldom, therefore, it is slow to take effect, weak curative effect; And the present invention is by the pulse current of electronic therapeutic instrument, enforceablely follows electric current to penetrate the through focus of Intradermal rapidly in the medicine ion, to focus performance curative effect.Therefore, instant effect, good effect.
3. with the beneficial bone electric conductance liquid phase ratio that dispels the wind, can soften or eliminate bony spur.The medicinal liquid of beneficial bone electric conductance liquid of dispeling the wind is alkalescence, because the main component of bony spur is calcium, calcium is more stable in weakly alkaline solution, so bony spur is not had therapeutical effect.Calcium easily is dissolved in the acid solution, therefore, the present invention adopts old rice vinegar adjusting medicinal liquid to be faintly acid, through the pulse electric current acetate ion and effective ingredient is imported lesions position, the therapeutic effect of bony spur is eliminated in the performance dissolving, has broken through the understanding of " pathological change generally can not reverse ".
Treatment Analysis on Mechanism of the present invention
Cortex Salicis Babylonicae Radicis: be the branch of Salicaceae plant Salix babylonica L. or the bast of root.Function cures mainly: expelling wind and removing dampness, reducing swelling and alleviating pain.The dispelling the wind and dampness pathogens osteodynia, swelling due to wind pruritus, jaundice, stranguria with turbid discharge.
Ramulus Mori: be the twig of moraceae plants Mulberry.Function cures mainly: wind-damp dispelling, sharp joint, row aqueous vapor.Control anemofrigid-damp arthralgia, spasm of the limbs, beriberi edema, human body pruritus due to wind pathogen.
Folium Persicae: be the leaf of rosaceous plant peach or Prunus davidiana.Function cures mainly: wind-damp dispelling, heat clearing away, parasite killing.Control wind syndrome of head, headache, migratory arthralgia, malaria, eczema, skin infection, tinea skin ulcer.
Caulis Capsici: be the stem of solanaceae plant pepper.Function cures mainly: except rheumatism, by arthralgia due to cold, the dissipating blood stasis blood clotting stagnates.The dispelling the wind and dampness pathogens cold type of pain, chilblain.
Rhizoma Chuanxiong: activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, promoting blood circulation and stopping pain.It is dizzy to cure mainly air-cooled headache, and the costalgia abdomen is painful, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour ， mass in the abdomen stomachache.
Radix Gentianae Macrophyllae: expelling wind and removing dampness and blood Shujin, clearing away heat and promoting diuresis.Cure mainly rheumatic arthralgia, muscles and bones osteopyrexia and fever, children's's infantile malnutrition with fever, dysuria.
Radix Achyranthis Bidentatae: ripely use invigorating the liver and kidney, bone and muscle strengthening.Cure mainly waist knee joint arthralgia pain, spasm of the limbs, fistula numbness.
Caulis Spatholobi: invigorate blood circulation Shujin.Cure mainly soreness of waist and knee joint, paralysis and numbness, menoxenia.
Vinegar: dissipating blood stasis, hemostasis, detoxifcation, parasite killing.The transdermal characteristic of vinegar is strong, the man TAO Hong-Jing cloud of the famous medicine of China: " vinegar wine is usefulness, does not have institute and does not go into, and is better ".The supplement to the Herbal record: use it in the medicine, two, three years rice vinegars are good when getting.The present invention adopts old rice vinegar, as the transdermal medicine.
Motherland's medical science is summarized as bone matrix hyperplasia " rheumatism involving the bone " category, thinks that primary disease is many by worn with age, congenital or the day after tomorrow is not enough and intemperate sexual intercourse and causing is suffered from a deficiency of the kidney, and it is foster that bone is become homeless, or wound blood stasis, joint stay the stasis of blood, or excessively painstaking, wind, cold, wet three heresies are invaded the skeleton joint in an opponent's defence, form rheumatism involving the bone.Therefore, treatment should be the rule for the treatment of with expelling wind and removing dampness, dispersing cold for relieving pain, promoting blood circulation to remove obstruction in the collateral.Cortex Salicis Babylonicae Radicis expelling wind and removing dampness among the side of the present invention, reducing swelling and alleviating pain; Ramulus Mori wind-damp dispelling, sharp joint, the meridian dredging; The Folium Persicae wind-damp dispelling, heat clearing away; Caulis Capsici is except rheumatism, and by arthralgia due to cold, the dissipating blood stasis blood clotting stagnates; Above four Chinese medicine share, and is common to the wind-damp numbness meridians, and muscles and bones is ached, the time of numb limbs and tense tendons; Be monarch drug.Radix Gentianae Macrophyllae expelling wind and removing dampness and blood Shujin, clearing away heat and promoting diuresis; The Rhizoma Chuanxiong activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, promoting blood circulation and stopping pain; The effect that strengthens monarch drug expelling wind and removing dampness, eliminating stasis to stop pain is ministerial drug.Radix Achyranthis Bidentatae promoting blood circulation to restore menstrual flow, easing joint movement; Caulis Spatholobi enrich blood promoting the circulation of blood, relaxing muscles and tendons and activating QI and blood in the collateral; Be adjuvant drug.The dissolving emollescence plays to the bony spur of hypertrophy, for making medicine in can the priming through sick institute of vinegar.All medicines share have expelling wind and removing dampness, the merit of dispersing cold for relieving pain, promoting blood circulation to remove obstruction in the collateral, reach wind-cold damp pathogen and all remove, bony spur is softening or disappear the effect of arthralgia pain releasing.
Clinical report
1. diagnosis basis: according to Ministry of Public Health " new Chinese medicine clinical research guideline " knee joint osseous arthritis diagnostic criteria
[6]: (1) has a dull ache from the beginning of knee joint, joint stuffiness, and light activity is alleviated slightly, and climate change increases the weight of, and does not touchingly repeatedly heal; (2) insidious onset, morbidity is slow, how common middle-aged and elderly people; (3) but the knee mild swelling, often there is clickly sound and grating in the joint when movable; (4) the visible osteoporosis of X ray examination, the joint space narrows down, the sclerosis of subchondral bone matter, edge lip sample changes, and hyperosteogeny forms.
2. Therapeutic Method: in the absorbent cotton dish at electronic therapeutic instrument electrode two ends, add external medicine composition of the present invention, the absorbent cotton dish is covered on the acupuncture point of the diseased region both sides that X line or MRI show, fixing, heat 38～58 ℃, make the pore diastole, be beneficial to medicine and penetrate Intradermal by pore.Adjustment for the treatment of intensity can be born with the patient and to be as the criterion from low to high, treats 25 fens at every turn, and every day 1 time, treating for 3 weeks is a course for the treatment of.
3. curative effect determinate standard: " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " of promulgating according to State Administration of Traditional Chinese Medicine in 1994
[7]: clinical cure: knee joint clinical symptom disappearance, function of joint activity recover normal; Produce effects: arthralgia obviously alleviates, and swelling disappears substantially, and knee joint function obviously improves; Effectively: pain alleviates to some extent, and knee joint function makes moderate progress; Invalid: pain and swelling does not have and alleviates, and knee joint function does not have improvement.
4. therapeutic outcome: from May, 2008～2010 year April, treat knee joint hyperosteogeny disease patient 680 examples with the present invention, treat 3 all post-evaluation curative effects, the result: clinical cure 510 examples, account for 75.0%, produce effects 140 examples account for 20.6%, and effective 30 examples account for 4.4%; Invalid: 0 example.Tracing study 1 year is not seen recurrence in the 510 routine cases of clinical cure.
Specific embodiment
Embodiment 1: take by weighing 10 parts of Cortex Salicis Babylonicae Radiciss, 5 parts of Ramulus Moris, 6 parts of Folium Persicaes, 5 parts of Caulis Capsicis, 4 parts of Rhizoma Chuanxiongs, 4 parts of Radix Gentianae Macrophyllae, 8 parts of Radix Achyranthis Bidentataes, 8 parts of Caulis Spatholobis, 50 parts of vinegar.Production method is the same.
With external medicine composition treatment knee joint hyperosteogeny disease patient 200 examples of the treatment bone matrix hyperplasia of this invention, the back check of 3 week for the treatment of, clinical cure 145 examples account for 72.5%, and produce effects 45 examples account for 22.5%, and effective 10 examples account for 5.0%, invalid 0 example.
Model case
Patient Lee xx, man, 64 years old, Laiwu City people from Laicheng district, rural migrant worker.
This patient is the pipeliner, works in the pipe alley of being everlasting, and two gonalgia after cause was suffered from cold in 3 years are afraid of cold, aversion to wind, fearness humidity, increase the weight of day by day, and waist soreness, the difficulty of having squatted, morning, deadlock was come my institute's treatment on May 12nd, 2008.Check: two knee joint swelling, local skin temperature increases, and the capsule sexuality is arranged, and X-ray film checks finding: a plurality of moderate bony spur and sure joint space are narrow, are diagnosed as knee joint hyperosteogeny disease.Give Drug therapy of the present invention, each 25 minutes, every day 1 time, symptom disappeared entirely after 2 weeks for the treatment of, 1 week of after treatment, and the check of X sheet, not recurrence in 1 year is followed up a case by regular visits in the bony spur passivation.
Embodiment 2: 18 parts of Cortex Salicis Babylonicae Radiciss, 8 parts of Ramulus Moris, 12 parts of Folium Persicaes, 8 parts of Caulis Capsicis, 8 parts of Rhizoma Chuanxiongs, 8 parts of Radix Gentianae Macrophyllae, 4 parts of Radix Achyranthis Bidentataes, 4 parts of Caulis Spatholobis, 30 parts of vinegar.
Production method is the same.
With external medicine composition treatment knee joint hyperosteogeny disease patient 180 examples of the treatment bone matrix hyperplasia of this invention, the back check of 3 week for the treatment of, clinical cure 132 examples account for 73.3%, and produce effects 39 examples account for 21.7%, and effective 9 examples account for 5.0%, invalid 0 example.
Model case
Patient Liu xx, man, 68 years old, Laiwu City people from Laicheng district.
Patient's pain and swelling behind the right sprain of knee joint before 3 years, pain increases the weight of after 1 year, the warm fear of cold of happiness, joint stuffiness, upward difficult downstairs, stiff about 5 minutes of morning, on inspection: right knee joint mild swelling, local skin temperature rise, audible and bony crepitus when song is stretched, X-ray film checks finding: a plurality of moderate bony spur are diagnosed as knee joint hyperosteogeny disease.Therapeutic Method is with embodiment 1 model case, and symptom obviously alleviates after 1 week for the treatment of, treatment 2 all backs clinical symptom disappearance, and 1 week of after treatment, the check of X sheet, the bony spur passivation is followed up a case by regular visits to and was not recurred in 1 year.
Embodiment 3: 15 parts of Cortex Salicis Babylonicae Radiciss, 6 parts of Ramulus Moris, 9 parts of Folium Persicaes, 6 parts of Caulis Capsicis, 6 parts of Rhizoma Chuanxiongs, 6 parts of Radix Gentianae Macrophyllae, 6 parts of Radix Achyranthis Bidentataes, 6 parts of Caulis Spatholobis, 40 parts of vinegar.
Production method is the same.
With external medicine composition treatment knee joint hyperosteogeny disease patient 300 examples of the treatment bone matrix hyperplasia of this invention, the back check of 3 week for the treatment of, clinical cure 233 examples account for 76.7%, and produce effects 56 examples account for 18.7%, and effective 11 examples account for 3.7%, invalid 0 example.
Model case
Patient Liu xx, man, 57 years old, Laiwu City colliery retired worker.
The patient did down-hole worker for many years, working environment humidity.Left knee joint has a dull ache before 5 years, joint stuffiness, there is clickly sound in the joint when movable, movable back pain relief, pain increases the weight of, goes up difficulty downstairs closely over the past half year, morning is obviously stiff, comes my institute's treatment on March 15th, 2009, and check: left knee joint swelling is obvious, local skin temperature rise, audible and bony crepitus when song is stretched, X-ray film checks finding: 2 moderate bony spur are diagnosed as knee joint hyperosteogeny disease.Give Drug therapy of the present invention, Therapeutic Method is with embodiment 1 model case, and symptom obviously alleviates after 1 week for the treatment of, and treatment 3 all backs symptoms disappear entirely, the check of X sheet, and bony spur disappears substantially, follows up a case by regular visits to not recur in 2 years.
Claims (2)
1. external medicine composition for the treatment of bone matrix hyperplasia, it is characterized in that being processed into by the raw material of following weight portion: 10～18 parts of Cortex Salicis Babylonicae Radiciss, 5～8 parts of Ramulus Moris, 6～12 parts of Folium Persicaes, 5～8 parts of Caulis Capsicis, 4～8 parts of Rhizoma Chuanxiongs, 4～8 parts of Radix Gentianae Macrophyllae, 4～8 parts of Radix Achyranthis Bidentataes, 4～8 parts of Caulis Spatholobis, 30～50 parts of vinegar; And adopt following preparation method to make: to take by weighing above raw material, with wherein Cortex Salicis Babylonicae Radicis, Ramulus Mori, Folium Persicae, Caulis Capsici, Rhizoma Chuanxiong, Radix Gentianae Macrophyllae, Radix Achyranthis Bidentatae, Caulis Spatholobi cutting, put compacting in the container, add above-mentioned vinegar, add water again, make water cover Chinese herbal medicine, soak after 6～12 hours, decoct 2 times, boiled 1 hour for the first time, leach medicinal liquid, add water again for the second time and boil 30 minutes, leach medicinal liquid; Merge medicinal liquid, post precipitation filters, and filtrate decompression is concentrated into 60 ℃ of following relative densities 1.05～1.09; Regulate pH value to 2.0～4.0, add antiseptic, shake up, in the medicine bottle of packing into, seal.
2. a kind of external medicine composition for the treatment of bone matrix hyperplasia according to claim 1 is characterized in that being processed into by the raw material of following weight portion: 15 parts of Cortex Salicis Babylonicae Radiciss, 6 parts of Ramulus Moris, 9 parts of Folium Persicaes, 6 parts of Caulis Capsicis, 6 parts of Rhizoma Chuanxiongs, 6 parts of Radix Gentianae Macrophyllae, 6 parts of Radix Achyranthis Bidentataes, 6 parts of Caulis Spatholobis, 40 parts of vinegar.
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| CN1356133A (en) * | 2001-12-04 | 2002-07-03 | 李东斌 | Plaster for treating cervical vertebra hyperplasia |
| CN101095785A (en) * | 2007-07-16 | 2008-01-02 | 韩世昌 | Chinese traditional medicine composition for treating arthritis hyperosteogeny intervertebral disc hernia ion |
| CN101095844A (en) * | 2007-06-26 | 2008-01-02 | 孙爱岚 | Chinese traditional medicine preparations for treating hyperosteogeny and method for preparing the same |
| CN101095929A (en) * | 2007-07-09 | 2008-01-02 | 杨月汉 | Chinese traditional medicine ointment for treating hyperosteogeny and its method for making the same |
| CN101167864A (en) * | 2007-10-28 | 2008-04-30 | 朱瑜琪 | Traditional Chinese medicinal formula for treating hyperosteogeny |
| CN101337061A (en) * | 2008-08-15 | 2009-01-07 | 王蔚 | Blood circulation promoting pain preventing plaster |
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2012
- 2012-04-25 CN CN 201210137747 patent/CN102670839B/en active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1356133A (en) * | 2001-12-04 | 2002-07-03 | 李东斌 | Plaster for treating cervical vertebra hyperplasia |
| CN101095844A (en) * | 2007-06-26 | 2008-01-02 | 孙爱岚 | Chinese traditional medicine preparations for treating hyperosteogeny and method for preparing the same |
| CN101095929A (en) * | 2007-07-09 | 2008-01-02 | 杨月汉 | Chinese traditional medicine ointment for treating hyperosteogeny and its method for making the same |
| CN101095785A (en) * | 2007-07-16 | 2008-01-02 | 韩世昌 | Chinese traditional medicine composition for treating arthritis hyperosteogeny intervertebral disc hernia ion |
| CN101167864A (en) * | 2007-10-28 | 2008-04-30 | 朱瑜琪 | Traditional Chinese medicinal formula for treating hyperosteogeny |
| CN101337061A (en) * | 2008-08-15 | 2009-01-07 | 王蔚 | Blood circulation promoting pain preventing plaster |
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