CN102665762A - 膜状药物剂型 - Google Patents

膜状药物剂型 Download PDF

Info

Publication number
CN102665762A
CN102665762A CN2010800531265A CN201080053126A CN102665762A CN 102665762 A CN102665762 A CN 102665762A CN 2010800531265 A CN2010800531265 A CN 2010800531265A CN 201080053126 A CN201080053126 A CN 201080053126A CN 102665762 A CN102665762 A CN 102665762A
Authority
CN
China
Prior art keywords
film
dosage form
weight
copolymer
film former
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010800531265A
Other languages
English (en)
Chinese (zh)
Inventor
D·久里奇
K·科尔特
M·G·赫廷
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Publication of CN102665762A publication Critical patent/CN102665762A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physiology (AREA)
  • Pulmonology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Otolaryngology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2010800531265A 2009-11-24 2010-11-12 膜状药物剂型 Pending CN102665762A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP09176929 2009-11-24
EP09176929.9 2009-11-24
US26425909P 2009-11-25 2009-11-25
US61/264,259 2009-11-25
PCT/EP2010/067384 WO2011064111A1 (fr) 2009-11-24 2010-11-12 Formes posologiques pharmaceutiques de type film

Publications (1)

Publication Number Publication Date
CN102665762A true CN102665762A (zh) 2012-09-12

Family

ID=43334373

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800531265A Pending CN102665762A (zh) 2009-11-24 2010-11-12 膜状药物剂型

Country Status (5)

Country Link
US (1) US20120244197A1 (fr)
EP (1) EP2504033A1 (fr)
JP (1) JP2013511565A (fr)
CN (1) CN102665762A (fr)
WO (1) WO2011064111A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104971045A (zh) * 2014-04-11 2015-10-14 上海宣泰医药科技有限公司 泊沙康唑药物组合物及其制备方法和药物制剂
CN116617193A (zh) * 2023-07-10 2023-08-22 北京丰科睿泰医药科技有限公司 一种吡仑帕奈口溶膜剂

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8790703B2 (en) * 2009-03-31 2014-07-29 Basf Se Method for producing preparations of substances poorly soluble in water
US8715729B2 (en) 2010-12-22 2014-05-06 Basf Se Rapidly disintegrating, solid coated dosage form
CA2844008A1 (fr) 2011-08-01 2013-02-07 Ranbaxy Laboratories Limited Systeme d'administration de medicaments a liberation controlee et dissolution amelioree pour medicaments peu solubles dans l'eau
EP2572731A1 (fr) * 2011-09-26 2013-03-27 Abbott GmbH & Co. KG Formulations à base de dispersions solides
CA2919442A1 (fr) * 2013-07-31 2015-02-05 Intelgenx Corp. Forme posologique orale en film instantanement mouillable sans tensioactif ni polyol
US20160193151A1 (en) * 2015-01-06 2016-07-07 Maria Del Pilar Noriega Escobar Dosage form incorporating an amorphous drug solid solution
CZ307444B6 (cs) * 2015-04-22 2018-08-29 Jakub Rak Mukoadhezivní polymerní film pro fotosenzitivní terapii v ústní dutině s obsahem fotosenzitizérů
ES2881435T3 (es) * 2015-10-23 2021-11-29 Basf Se Soluciones sólidas de sustancias odorantes y aromatizantes con polímeros de vinilactama
US20210128439A1 (en) * 2017-08-03 2021-05-06 Morinaga Milk Industry Co., Ltd. Edible Film
EP3668505A4 (fr) 2017-08-15 2021-05-12 Nephron Pharmaceuticals Corporation Composition de nébulisation aqueuse
DE102017127452A1 (de) * 2017-11-21 2019-05-23 Lts Lohmann Therapie-Systeme Ag Wasserlösliche Polymerklebschichten
JP7459458B2 (ja) * 2018-06-28 2024-04-02 ライオン株式会社 内服組成物及びその製造方法
DE102019202570A1 (de) * 2019-02-26 2020-08-27 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zum Erhalt von Fucoxanthin und Fettsäuren aus Algenbiomasse

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5512293A (en) * 1992-07-23 1996-04-30 Alza Corporation Oral sustained release drug delivery device
WO2007051743A2 (fr) * 2005-11-04 2007-05-10 Basf Se Utilisation de copolymeres en tant que solubilisants de composes peu solubles dans l'eau

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19814730A1 (de) * 1998-04-02 1999-10-07 Basf Ag Verwendung von N-Vinyllacram oder N-Vinylamin haltigen Copolymeren als Matrix zur Herstellung von festen pharmazeutischen und kosmetischen Darreichungsformen
US8658201B2 (en) * 2004-01-30 2014-02-25 Corium International, Inc. Rapidly dissolving film for delivery of an active agent
DE102004049740B4 (de) * 2004-10-13 2009-08-27 Lts Lohmann Therapie-Systeme Ag Selbstklebende Zahnfolie und Verfahren zur Herstellung der Zahnfolie
US20100204425A1 (en) 2007-07-26 2010-08-12 Basf Se Process for preparing copolymers obtained by graft polymerization in solution and based on polyethers in solid form

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5512293A (en) * 1992-07-23 1996-04-30 Alza Corporation Oral sustained release drug delivery device
WO2007051743A2 (fr) * 2005-11-04 2007-05-10 Basf Se Utilisation de copolymeres en tant que solubilisants de composes peu solubles dans l'eau

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104971045A (zh) * 2014-04-11 2015-10-14 上海宣泰医药科技有限公司 泊沙康唑药物组合物及其制备方法和药物制剂
US10022373B2 (en) 2014-04-11 2018-07-17 Sinotherapeutics Inc. Posaconazole pharmaceutical compositions and preparation methods, uses and pharmaceutical formulations thereof
CN116617193A (zh) * 2023-07-10 2023-08-22 北京丰科睿泰医药科技有限公司 一种吡仑帕奈口溶膜剂
CN116617193B (zh) * 2023-07-10 2024-01-30 北京丰科睿泰医药科技有限公司 一种吡仑帕奈口溶膜剂

Also Published As

Publication number Publication date
EP2504033A1 (fr) 2012-10-03
JP2013511565A (ja) 2013-04-04
WO2011064111A1 (fr) 2011-06-03
US20120244197A1 (en) 2012-09-27

Similar Documents

Publication Publication Date Title
CN102665762A (zh) 膜状药物剂型
JP4850346B2 (ja) 粘膜貼付剤
US8840935B2 (en) Orally administrable films and preparation thereof
JP4838723B2 (ja) 医薬又は化粧用薬剤を送達するための迅速分解性フイルム
JP4619894B2 (ja) 粘膜表面への、薬剤化合物の送達に適する薬剤キャリアデバイス
JP4213383B2 (ja) 活性成分を急速放出するための親水性ポリマーの薄膜状多層薬剤
US8840919B2 (en) Method and apparatus for minimizing heat, moisture, and shear damage to medicants and other compositions during incorporation of same with edible films
US9248146B2 (en) Dissolvable adhesive films for delivery of pharmaceutical or cosmetic agents
US6552024B1 (en) Compositions and methods for mucosal delivery
CN103596551B (zh) 含有用于掩味的离子交换树脂的食用口服条或糯米纸囊剂型
US10092651B2 (en) High-content fast dissolving film with masking of bitter taste comprising sildenafil as active ingredient
KR101148470B1 (ko) 구강점막용 펜타닐 함유 패치
WO2008112124A2 (fr) Films administrables par voie orale
JP2001508037A (ja) 粘膜表面への、薬学的化合物の送達に適する薬学的キャリアデバイス
JPH07553B2 (ja) フイルム状製剤
US20100041703A1 (en) Rapid disintegration monolayer film for the oral administration of active substances
JP2024522779A (ja) マクロライドの非ナノ粒子適用形態
US20140271787A1 (en) Continuous single layer film structure including discrete domains
EP2889030A1 (fr) Contrôler les taux d'érosion de dispositifs muco-adhésifs qui fournissent des actifs et d'autres composés et fournir des niveaux sanguins thérapeutiques variables et accrus
TWI612978B (zh) 口溶膜
KR101489752B1 (ko) 도세탁셀 약물을 함유하는 구강 용해 필름형 항암제
Alsaide et al. Insights into medicated films as attractive dosage forms
Joshi et al. REPURPOSING MUCOADHESIVE DRUG DELEVERY SYSTEM: ADVANCEMENTS AND FUTURE PROSPECTS
rights are reserved by Moataz et al. Creation and Assessment of Buccal Mucoadhesive Sustained Release Oral Films

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20120912