CN102665702A - 羟基酪醇化合物 - Google Patents

羟基酪醇化合物 Download PDF

Info

Publication number
CN102665702A
CN102665702A CN2010800527081A CN201080052708A CN102665702A CN 102665702 A CN102665702 A CN 102665702A CN 2010800527081 A CN2010800527081 A CN 2010800527081A CN 201080052708 A CN201080052708 A CN 201080052708A CN 102665702 A CN102665702 A CN 102665702A
Authority
CN
China
Prior art keywords
hydroxytyrosol
polymer
coupling
antioxidant
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010800527081A
Other languages
English (en)
Chinese (zh)
Inventor
S.G.伯顿
L.M.戴维兹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Cape Town
Original Assignee
University of Cape Town
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Cape Town filed Critical University of Cape Town
Publication of CN102665702A publication Critical patent/CN102665702A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G61/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G61/02—Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes
    • C08G61/10—Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aromatic carbon atoms, e.g. polyphenylenes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C08G65/38—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives derived from phenols
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/10—Definition of the polymer structure
    • C08G2261/14—Side-groups
    • C08G2261/142—Side-chains containing oxygen
    • C08G2261/1422—Side-chains containing oxygen containing OH groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/30—Monomer units or repeat units incorporating structural elements in the main chain
    • C08G2261/31—Monomer units or repeat units incorporating structural elements in the main chain incorporating aromatic structural elements in the main chain
    • C08G2261/312—Non-condensed aromatic systems, e.g. benzene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/50—Physical properties
    • C08G2261/59—Stability
    • C08G2261/594—Stability against light, i.e. electromagnetic radiation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/50—Physical properties
    • C08G2261/59—Stability
    • C08G2261/596—Stability against oxidation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN2010800527081A 2009-09-22 2010-09-22 羟基酪醇化合物 Pending CN102665702A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ZA2009/06592 2009-09-22
ZA200906592 2009-09-22
PCT/IB2010/002373 WO2011036537A1 (en) 2009-09-22 2010-09-22 Hydroxytyrosol compounds

Publications (1)

Publication Number Publication Date
CN102665702A true CN102665702A (zh) 2012-09-12

Family

ID=43795454

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800527081A Pending CN102665702A (zh) 2009-09-22 2010-09-22 羟基酪醇化合物

Country Status (6)

Country Link
US (1) US8663608B2 (enExample)
EP (1) EP2480223A4 (enExample)
JP (1) JP2013527126A (enExample)
CN (1) CN102665702A (enExample)
WO (1) WO2011036537A1 (enExample)
ZA (1) ZA201202288B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106987098A (zh) * 2017-05-04 2017-07-28 中国林业科学研究院林产化学工业研究所 一类高抗氧化和热稳定性的羟基酪醇聚合物及其制备方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9334229B2 (en) 2013-11-04 2016-05-10 Eastman Chemical Company Hydroxytyrosol derivatives, their method of preparation and use in personal care
KR101945987B1 (ko) 2018-03-19 2019-02-08 주식회사 엑티브온 티로솔을 포함하는 피부 외용제용 보존제, 이를 포함하는 화장료 조성물 및 약학 조성물
CN109929227B (zh) * 2019-04-03 2021-09-24 哈工大机器人（山东）智能装备研究院 一种可降解的芹菜纤维复合材料及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4013A (en) * 1845-04-26 Machine fqe making match-splihts and arranging them in dipping
US6437004B1 (en) * 2000-04-06 2002-08-20 Nicholas V. Perricone Treatment of skin damage using olive oil polyphenols
US6602527B1 (en) 2000-11-22 2003-08-05 Thomas J. Slaga Processing method for manufacturing black tea and an improved black tea

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DE LUCIA MET AL: "Oxidative chemistry of the natural antioxidant hydroxytyrosol:hydrogen peroxide-dependent hydroxylation and hydroxyquinonefo-quinone coupling pathways", 《TETRAHEDRON》 *
FERNANDEZ-BOLANOS J.G ET AL: "Hydroxytyrosol and Derivatives: Isolation, Synthesis,and Biological Properties", 《CURRENT ORGANIC CHEMISTRY》 *
ROCHE M ET AL: "Antioxidant activity of olive phenols: mechanistic investigation and characterization of oxidation products by mass spectrometry", 《J OF RCS》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106987098A (zh) * 2017-05-04 2017-07-28 中国林业科学研究院林产化学工业研究所 一类高抗氧化和热稳定性的羟基酪醇聚合物及其制备方法
CN106987098B (zh) * 2017-05-04 2019-06-11 中国林业科学研究院林产化学工业研究所 一类高抗氧化和热稳定性的羟基酪醇聚合物及其制备方法

Also Published As

Publication number Publication date
WO2011036537A1 (en) 2011-03-31
US8663608B2 (en) 2014-03-04
EP2480223A4 (en) 2013-02-27
JP2013527126A (ja) 2013-06-27
ZA201202288B (en) 2012-11-28
US20120269745A1 (en) 2012-10-25
EP2480223A1 (en) 2012-08-01

Similar Documents

Publication Publication Date Title
Jiang et al. Ceria nanozyme coordination with curcumin for treatment of sepsis-induced cardiac injury by inhibiting ferroptosis and inflammation
Lohézic-Le Dévéhat et al. Lichenic extracts and metabolites as UV filters
Torres et al. Comparative analysis of in vitro antioxidant capacities of mycosporine-like amino acids (MAAs)
Gao et al. Effects of N-trans-feruloyltyramine isolated from laba garlic on antioxidant, cytotoxic activities and H2O2-induced oxidative damage in HepG2 and L02 cells
Wei et al. Certain (−)-epigallocatechin-3-gallate (EGCG) auto-oxidation products (EAOPs) retain the cytotoxic activities of EGCG
Song et al. Characterization of graphislactone A as the antioxidant and free radical-scavenging substance from the culture of Cephalosporium sp. IFB-E001, an endophytic fungus in Trachelospermum jasminoides
Oliveira et al. Development, characterization, antioxidant and hepatoprotective properties of poly (Ɛ-caprolactone) nanoparticles loaded with a neuroprotective fraction of Hypericum perforatum
Spasojević et al. Mn porphyrin-based superoxide dismutase (SOD) mimic, MnIIITE-2-PyP5+, targets mouse heart mitochondria
Allegra et al. Mechanism of interaction of betanin and indicaxanthin with human myeloperoxidase and hypochlorous acid
Sechi et al. Nanoencapsulation of dietary flavonoid fisetin: Formulation and in vitro antioxidant and α-glucosidase inhibition activities
Jafari et al. Stability and loading properties of curcumin encapsulated in Chlorella vulgaris
Dietz et al. Xanthohumol isolated from Humulus lupulus inhibits menadione-induced DNA damage through induction of quinone reductase
Nestora et al. Solid-phase extraction of betanin and isobetanin from beetroot extracts using a dipicolinic acid molecularly imprinted polymer
Song et al. Inhibitory effects and molecular mechanism on mushroom tyrosinase by condensed tannins isolation from the fruit of Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex HF Chow
Ittadwar et al. Novel umbelliferone phytosomes: development and optimization using experimental design approach and evaluation of photo-protective and antioxidant activity
US20260062555A1 (en) Selenium-containing analogues of pheomelanin and related materials and methods of making
Manjunatha et al. Synthesis of amino acid conjugates of tetrahydrocurcumin and evaluation of their antibacterial and anti-mutagenic properties
Zhou et al. Lysosome-oriented, dual-stage pH-responsive polymeric micelles for β-lapachone delivery
KR20100039104A (ko) 패 유래 화합물 함유 항산화 활성 조성물
US8663608B2 (en) Hydroxytyrosol compounds
Dang et al. Activatable NIR-II fluorescent nanoprobe for rapid detection and imaging of methylglyoxal facilitated by the local nonpolar microenvironment
Thapa et al. Suntamide A, a neuroprotective cyclic peptide from Cicadidae Periostracum
Orallo et al. Sensitized photo-oxidation of gadusol species mediated by singlet oxygen
Azuma et al. Improved isolation procedure for shikonin from the root of the Chinese medicinal plant Lithospermum erythrorhizon and its solubilization with cyclodextrins
Cateni et al. Synthesis and controlled drug delivery studies of a novel Ubiquinol-Polyethylene glycol-Vitamin E adduct

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20120912