CN102663947A - Apparatus for actively simulating autonomous respiration of human body in vitro and gas analyzing method employing the same - Google Patents
Apparatus for actively simulating autonomous respiration of human body in vitro and gas analyzing method employing the same Download PDFInfo
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- CN102663947A CN102663947A CN201210087612XA CN201210087612A CN102663947A CN 102663947 A CN102663947 A CN 102663947A CN 201210087612X A CN201210087612X A CN 201210087612XA CN 201210087612 A CN201210087612 A CN 201210087612A CN 102663947 A CN102663947 A CN 102663947A
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Abstract
The invention, which belongs to the psychological research filed of respiratory medicine, relates to an apparatus for actively simulating autonomous respiration of a human body in vitro and a gas analyzing method employing the same. The apparatus includes a circulating gas circuit formed by a driving respirator, a dual-cavity simulation lung device and a head dead space model; and the output end of the dual-cavity simulation lung device is connected with the head dead space model by a gas analyzing device. The gas analyzing method comprises the following steps that: data are collected; integration is carried out on results by multiplication of obtained real-time oxygen concentration inside the apparatus and inspiration /expiration flow rates so as to obtain oxygen fluxes and tidal volumes of expiration/ inspiration in each respiratory cycle; and division operation is carried out on the oxygen fluxes and tidal volumes to obtain mean effective inspired oxygen concentration in inspiratory/expiratory phases. According to the invention, the apparatus having a compact structure can be applied to scientific research and training of various ventilation modes; and the applied gas analyzing method enables a detection result to be accurate and to approach a real one.
Description
Technical field
The invention belongs to and breathe medical science physiology research field, be specifically related to a kind of novel external active simulated lung model and design, realization and the application of gas analyzing apparatus.
Background technology
The using artificial simulated lung does not possess simulation human body autonomous breathing in the clinical position at present; Can't satisfy the research demand of auxiliary type ventilating mode; And lack measurement and analytic function, a kind of objective data analysing method that can be quantitative is provided for clinical practice and medical scientific flowing through simulated lung gas flow and gas ingredients.
Summary of the invention
The objective of the invention is to set up a kind of novel external active simulated lung model, provide a kind of can be accurately to the gas flow of the simulated lung of flowing through, the method that composition carries out Measurement and analysis.
The objective of the invention is to realize: a kind of external device of initiatively simulating the human body autonomous respiration through following technical scheme; It is characterized in that: comprise the circulation gas circuit that constitutes by driving lung ventilator, two-chamber simulated lung, head dead space model; Driving lung ventilator is connected with the input end of two-chamber simulated lung; Two-chamber simulated lung output terminal is connected with head dead space model through gas analyzing apparatus, and described gas analyzing apparatus comprises oxygen concentration sensor, pressure transducer, flow sensor, signal conditioning circuit, data acquisition unit and communication interface; Described flow sensor is provided with an air intake opening, a gas outlet; Flow sensor air intake opening end is connected with head dead space model; Flow sensor gas outlet end is connected with the two-chamber simulated lung; Described pressure transducer links to each other with the air intake opening of flow sensor through the interface flexible pipe; The output terminal of oxygen concentration sensor is connected with data acquisition unit through signal conditioning circuit, and flow sensor, pressure transducer output terminal are connected with data acquisition unit, and data acquisition unit is connected with computing machine through communication interface.
A kind of analysis method for gases of using said apparatus, its step is following:
1) data of the real-time acquisition stream quantity sensor of data acquisition unit, oxygen concentration sensor obtain gas flow rate, oxygen concentration;
2) oxygen concentration and air-breathing/exhalation flow rate multiplied result are carried out integration in real time in the device that monitoring is obtained; Obtain the oxygen flow and the tidal volume of exhalation/inhalation in each respiratory cycle; Again both are carried out division arithmetic, obtain average effective fraction of inspired oxygen in inspiratory phase/expiratory phase; Concrete formula is following:
The oxygen flow of inspiratory phase:
The tidal volume of inspiratory phase:
The oxygen flow of expiratory phase:
The tidal volume of expiratory phase:
Effective inhaled oxygen concentration:
=
Beneficial effect of the present invention: the present invention has made up a kind of novel external device of initiatively simulating the human body autonomous respiration, and this apparatus structure is compact, is easy to routine maintenance and changes element, and easy accessibility is simple.Can be used for the scientific research of various ventilating modes: through the driving ventilator parameter being set, the breathing state of simulation different crowd; Also can be used for the comparison and detection of lung ventilator performance: lung ventilator to be tested is connected with head dead space model; Gas analyzing apparatus can be accurately to flowing through the pressure of gas; Flow velocity and oxygen content gas are measured and are analyzed, and draw corresponding trend map and oscillogram.Oxygen concentration sensor adopts novel oxygen concentration cell; Concentration-response speed is exceedingly fast; Can monitor fast-changing oxygen concentration in the high-speed gas in real time, and utilize self-editing software that oxygen concentration and air-breathing/exhalation flow rate multiplied result are carried out integration, can obtain the oxygen flow and the tidal volume of exhalation/inhalation in each respiratory cycle; Again both are carried out division arithmetic, obtain the average oxygen concentration that sucks gas in inspiratory phase/expiratory phase.Such computing method make testing result more accurate, and testing result is near true.
Description of drawings
Fig. 1 structural representation of the present invention.
Gas analyzing apparatus structural representation among Fig. 2 the present invention.
Fig. 3 oxygen concentration sensor signal conditioning circuit figure.
Fig. 4 is the analysis method for gases software flow pattern.
Fig. 5 is tidal volume and effective fraction of inspired oxygen output waveform figure.
Specific embodiments
As shown in Figure 1: apparatus of the present invention air path part comprises driving lung ventilator 9, two-chamber simulated lung 8 and head dead space model 7; Be connected with a chamber (as actuator chamber) of two-chamber simulated lung 8 driving lung ventilator 9, another one chamber (as test chamber) is connected with head dead space model 7.Drive lung ventilator 9 according to setup parameter work; The rule that drives the actuator chamber volume of two-chamber simulated lung 8 changes; Be connected through a metal connecting rod between actuator chamber and the test chamber, make that the air-flow between test chamber and the actuator chamber conducts synchronously, simulate the autonomous respiration of human body.
Wherein drive lung ventilator and produce model: the HT50 of button nation for NEWPORT company.Two-chamber simulated lung 8 is commercial product (U.S. FLUKE 1600).Head dead space model 7 apery body head cavity size design, the vent line that the built-in pipe volume equates with the person's windpipe volume.
The gas analyzing apparatus I structure that is connected between two-chamber simulated lung 8, the head dead space model 7 is as shown in Figure 2, comprises oxygen concentration sensor 1, pressure transducer 2, flow sensor 3, signal conditioning circuit 4, data acquisition unit 5 and communication interface 6; The MPXV5004G type product produced of the Free scale company that adopts of pressure transducer 2 wherein; What flow sensor 3 adopted is the AWM700 series of products of Honeywell company; Gather real-time inspiratory flow rate (SF is 30 milliseconds), oxygen concentration sensor 1 adopts oxygen cell (response time (t
10% ~ 90%) be 300 milliseconds) be the OOM109 type product that ENVITEC company produces, be used for gathering real-time oxygen concentration, what data acquisition unit 5 adopted is the USB2832 product of Beijing Art Technology Development Co., Ltd..Flow sensor 3 is provided with an air intake opening, a gas outlet; Flow sensor 3 air intake opening ends are connected with head dead space model 7; Flow sensor 3 gas outlet ends are connected with two-chamber simulated lung 8; Pressure transducer 2 links to each other with the air intake opening of flow sensor 3 through the interface flexible pipe, and flow and pressure transducer just can prepare to detect pressure and the flow that flows through gas.Oxygen concentration sensor 1 is used for detecting the oxygen concentration of two-chamber simulated lung 8 of flowing through.The output area of flow, pressure transducer all in the allowed band of data acquisition unit 5, need not be carried out signal condition.The signal of oxygen concentration sensor 1 output is fainter, not in the acquisition range of data acquisition unit 5, so will carry out being input in the data acquisition unit 5 after the necessary amplification conditioning to signal again.Signal conditioning circuit is as shown in Figure 3: the output signal of oxygen concentration sensor 1 is connected to the forward input signal end of OP07, and through regulating R1, the resistance of Rf is amplified 100 times with signal, and the signal of output is removed through RC filtering and disturbed, and obtains stable voltage signal.
1) initialization data;
2) whether judgment data is effective;
3) if data are effective, data are stored;
4) according to data computation flow and the oxygen concentration gathered;
5) display waveform.
Data analysis process:
1) data of the real-time acquisition stream quantity sensor of data acquisition unit, oxygen concentration sensor obtain gas flow rate, oxygen concentration;
2) oxygen concentration and air-breathing/exhalation flow rate multiplied result are carried out integration in real time in the device that monitoring is obtained; Obtain the oxygen flow and the tidal volume of exhalation/inhalation in each respiratory cycle; Again both are carried out division arithmetic, obtain average effective fraction of inspired oxygen in inspiratory phase/expiratory phase;
Concrete formula is following:
The oxygen flow of inspiratory phase:
The tidal volume of inspiratory phase:
The oxygen flow of expiratory phase:
The tidal volume of expiratory phase:
Effective inhaled oxygen concentration:
=
: the oxygen flow of inspiratory phase
Claims (2)
1. external device of initiatively simulating the human body autonomous respiration; It is characterized in that: comprise the circulation gas circuit that constitutes by driving lung ventilator, two-chamber simulated lung, head dead space model; Driving lung ventilator is connected with the input end of two-chamber simulated lung; Two-chamber simulated lung output terminal is connected with head dead space model through gas analyzing apparatus, and described gas analyzing apparatus comprises oxygen concentration sensor, pressure transducer, flow sensor, signal conditioning circuit, data acquisition unit and communication interface; Described flow sensor is provided with an air intake opening, a gas outlet; Flow sensor air intake opening end is connected with head dead space model; Flow sensor gas outlet end is connected with the two-chamber simulated lung; Described pressure transducer links to each other with the air intake opening of flow sensor through the interface flexible pipe; The output terminal of oxygen concentration sensor is connected with data acquisition unit through signal conditioning circuit, and flow sensor, pressure transducer output terminal are connected with data acquisition unit, and data acquisition unit is connected with computing machine through communication interface.
2. an application rights requires the analysis method for gases of 1 said device, and its step is following:
1) data of the real-time acquisition stream quantity sensor of data acquisition unit, oxygen concentration sensor obtain gas flow rate, oxygen concentration;
2) oxygen concentration and air-breathing/exhalation flow rate multiplied result are carried out integration in real time in the device that monitoring is obtained; Obtain the oxygen flow and the tidal volume of exhalation/inhalation in each respiratory cycle; Again both are carried out division arithmetic, obtain average effective fraction of inspired oxygen in inspiratory phase/expiratory phase; Concrete formula is following:
The oxygen flow of inspiratory phase:
The tidal volume of inspiratory phase:
The oxygen flow of expiratory phase:
The tidal volume of expiratory phase:
Effective inhaled oxygen concentration:?
=
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103106827A (en) * | 2013-01-29 | 2013-05-15 | 营口巨成教学科技开发有限公司 | Respirator |
| CN103148899A (en) * | 2013-02-01 | 2013-06-12 | 中山大学附属第一医院 | Liquid micro-flow detection method |
| CN103330982A (en) * | 2013-07-08 | 2013-10-02 | 北京航空航天大学 | Test lung with self learning function |
| CN103340631A (en) * | 2013-07-02 | 2013-10-09 | 上海理工大学 | Maximum positive-negative pressure detecting device and detecting method |
| CN103632597A (en) * | 2013-10-29 | 2014-03-12 | 中国人民解放军空军航空医学研究所 | Multipath simulation gas suction device |
| CN103983612A (en) * | 2014-04-11 | 2014-08-13 | 中国人民解放军第四军医大学 | Heavy metal breathing simulation detection system |
| CN104464475A (en) * | 2014-12-25 | 2015-03-25 | 苏州大学 | Medical simulated respiratory system |
| CN104700697A (en) * | 2015-03-17 | 2015-06-10 | 中山大学 | Simulation system of human respiratory tract |
| CN106683515A (en) * | 2016-12-28 | 2017-05-17 | 中国航空工业集团公司西安飞机设计研究所 | Airplane oxygen system simulation training device |
| CN107044946A (en) * | 2016-10-10 | 2017-08-15 | 中国计量大学 | A kind of dynamic respiratory resistance automatic testing equipment of mouth mask |
| CN107328597A (en) * | 2017-08-25 | 2017-11-07 | 四川海特亚美航空技术有限公司 | A kind of automatic test control system |
| CN109259766A (en) * | 2018-11-16 | 2019-01-25 | 培婴（湖北）医学技术有限公司 | The monitoring device and ventilator of tidal volume |
| CN113056777A (en) * | 2018-09-05 | 2021-06-29 | 天津天堰科技股份有限公司 | Breathing simulator, medical human body simulator and method for simulating breathing scene |
| CN113920838A (en) * | 2021-10-26 | 2022-01-11 | 北京航空航天大学 | Electronic active lung simulation system |
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Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103106827A (en) * | 2013-01-29 | 2013-05-15 | 营口巨成教学科技开发有限公司 | Respirator |
| CN103148899A (en) * | 2013-02-01 | 2013-06-12 | 中山大学附属第一医院 | Liquid micro-flow detection method |
| CN103340631A (en) * | 2013-07-02 | 2013-10-09 | 上海理工大学 | Maximum positive-negative pressure detecting device and detecting method |
| CN103330982B (en) * | 2013-07-08 | 2016-02-10 | 北京航空航天大学 | A kind of test lung with self-learning function |
| CN103330982A (en) * | 2013-07-08 | 2013-10-02 | 北京航空航天大学 | Test lung with self learning function |
| CN103632597A (en) * | 2013-10-29 | 2014-03-12 | 中国人民解放军空军航空医学研究所 | Multipath simulation gas suction device |
| CN103983612A (en) * | 2014-04-11 | 2014-08-13 | 中国人民解放军第四军医大学 | Heavy metal breathing simulation detection system |
| CN103983612B (en) * | 2014-04-11 | 2016-05-18 | 中国人民解放军第四军医大学 | A kind of detection system of simulated respiration heavy metal |
| CN104464475A (en) * | 2014-12-25 | 2015-03-25 | 苏州大学 | Medical simulated respiratory system |
| CN104700697A (en) * | 2015-03-17 | 2015-06-10 | 中山大学 | Simulation system of human respiratory tract |
| CN104700697B (en) * | 2015-03-17 | 2017-04-12 | 中山大学 | Simulation system of human respiratory tract |
| CN107044946A (en) * | 2016-10-10 | 2017-08-15 | 中国计量大学 | A kind of dynamic respiratory resistance automatic testing equipment of mouth mask |
| CN106683515A (en) * | 2016-12-28 | 2017-05-17 | 中国航空工业集团公司西安飞机设计研究所 | Airplane oxygen system simulation training device |
| CN107328597A (en) * | 2017-08-25 | 2017-11-07 | 四川海特亚美航空技术有限公司 | A kind of automatic test control system |
| CN113056777A (en) * | 2018-09-05 | 2021-06-29 | 天津天堰科技股份有限公司 | Breathing simulator, medical human body simulator and method for simulating breathing scene |
| CN109259766A (en) * | 2018-11-16 | 2019-01-25 | 培婴（湖北）医学技术有限公司 | The monitoring device and ventilator of tidal volume |
| CN113920838A (en) * | 2021-10-26 | 2022-01-11 | 北京航空航天大学 | Electronic active lung simulation system |
| CN113920838B (en) * | 2021-10-26 | 2023-10-03 | 北京航空航天大学 | Electronic active simulation lung |
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