CN203465233U

CN203465233U - Handheld expiration analyzer

Info

Publication number: CN203465233U
Application number: CN201320601971.2U
Authority: CN
Inventors: 韩益苹; 谢雷; 韩杰; 曹青; 邓中全
Original assignee: Wuxi Sunvou Medical Treatment Electronic Co Ltd
Current assignee: Wuxi Sunvou Medical Treatment Electronic Co Ltd
Priority date: 2013-09-27
Filing date: 2013-09-27
Publication date: 2014-03-05
Anticipated expiration: 2023-09-27

Abstract

The utility model discloses a handheld expiration analyzer. An air path consists of a sampling air path and an analyzing air path; the sampling air path is formed by connecting a pressure or flow sensor, an air chamber and a one-way valve in series; the air chamber is composed of a slender pipeline; the diameter of the pipeline is 2-40mm; in expiration and measurement, the air path resistance of the air chamber is lower than 1cm H2O, the forward opening resistance of the one-way valve is lower than 10cm H2O, and the reverse air leakage resistance is higher than 20cm H2O; the analyzing air path is formed by connecting a sensor and a pump in series, and the sensor and the pump are connected with the tail end of the air chamber and the front end of the one-way valve through capillary tubes.

Description

Hand-held breath analyzing instrument

Technical field

The present invention relates to the equipment of characteristics of contaminated respiratory droplets gas analysis.

Background technology

By the composition of characteristics of contaminated respiratory droplets gas and the auxiliary diagnosis disease that patient takes a disease of the measurement of concentration thereof, monitoring disease states and observation result for the treatment of etc.

As exhaled ¹³c/ ¹⁴c for helicobacter pylori patient's diagnosis, expiration nitric oxide for the diagnosis of airway inflammation and monitoring, breath hydrogen for the control that is used for giving up smoking of diagnosis, the expiration carbon monoxide of enterogastritis, expiration ammonia is used for the diagnosis of liver-kidney diseases etc.The measuring method that different application is taked is different, and the mode of the sampling of exhaling is also different.

The available electrochemical methods such as expiration nitric oxide, the oxidation of exhaling, breath hydrogen, expiration ammonia are measured, but 90% response time of electrochemical gas sensor is generally all greater than 10 seconds, the particularly measurement of hydrogen, ammonia, the response time of sensor is all greater than 40 seconds, while adopting described slow-response sensor to carry out on-line measurement, need under the condition of coutroi velocity, continue for a long time to exhale so that sensor reaches stable state to the response of expiration sample, this is difficult to most people, has limited the widespread use of the method.

In addition, according to different clinical practices, need to control the mode of the sampling of exhaling, as expiration nitric oxide is analyzed and has been obtained medical profession abundant affirmation for the detection of the respiratory diseases such as asthma as the mark of airway inflammation, U.S. thoracic cavity association combined in 2005 and has formulated and announced standardized method " the ATS/ERS Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Low Respiratory Nitric Oxide and Nasal Nitric Oxide that carries out this measurement with Europe breathing association, 2005 ", requirement is at 5cmH at least ₂under the breath pressure of O, under the fixedly exhalation flow rate of 50ml/s, carry out single continue to exhale 10 seconds (or children 6 seconds), this for children and part by the adult of respiratory disease, there is certain difficulty, but compared with slow galvanochemistry nitric oxide gas sensor (90% response time is greater than 10 seconds), the duration of ventilation of 10 seconds can not make the response of sensor reach steady-state value for response.Thereby carry out expiration nitric oxide while measuring with electrochemical gas sensor, it is inconvenient expiration nitric oxide concentration being carried out measuring in real time in the process of exhaling.

To breath hydrogen and expiration Carbon Monoxide Detection, the method of clinical recommendation is that air-breathing rear first feeling suffocated continues to exhale to detect to sensor for 15 seconds afterwards, General Requirements expiratory duration is greater than 10 seconds, even 70 seconds (as the breath hydrogen detecting device of center Hai Dewei need to continue to exhale 70 seconds), this is because the object gas that breath hydrogen and expiration Carbon Monoxide Detection need to be measured derives from alveolar air, need to guarantee can when sensor reaches steady-state response, continue by (continuing to exhale) from the gas of alveolar air when measuring.The more difficult assurance of this patient in actual application.

In order to solve the contradiction between expiration sampling request and sensor response speed, it is natural selection that expiration sampling and two processes of analysis to measure are separated to control, the simplest method is that breath is collected in airbag, then analyze, a kind of improved method is that breath is collected in elongated sample chamber, then by valve, switch, with pump, will in sample chamber, in gas suction sensor, carry out analysis to measure, Aerocirne(US20040082872) and still irrigate the disclosed breath analysis device of medical electronics (CN2012 1,020 7872.6) and all adopted the method.

The method has solved exhale sampling and the unmatched problem of expiration sample measurement speed, the sampling process that makes to exhale is more light, by the adjustment of solenoid valve state, automatically realize the switching of exhale sampling and sample analysis process, but because exhalation process exhalation flow rate is larger, in order to control expiratory resistance, need to select the solenoid valve of larger latus rectum, the power consumption of solenoid valve and transient current are larger like this, during work, heating is larger, in power supply coupling and circuit design, need this to carry out special consideration, when frequency of operation is higher, instrument heat radiation is also the problem that must consider, the general volume of solenoid valve of simultaneously large latus rectum is larger, be not easy to the miniaturization of instrument.

Summary of the invention

The present invention is directed to gas circuit design proposal that the deficiency of said method proposed a kind of simplification so that a kind of hand-held expiration gas analyser to be provided, this analyser is simple in structure, volume is little, low in energy consumption, cost is low, is applicable to very much family or uses at beside sickbed.

The hand-held breath analyzing instrument that the present invention discloses, its gas circuit is comprised of sample gas circuit and analysis gas circuit two parts, it is characterized by: described sampling gas routing pressure or flow sensor, air chamber and retaining valve are composed in series, wherein said air chamber consists of elongate conduit, pipeline diameter scope is 2 ~ 40mm, and when exhaling and measure, air chamber gas circuit resistance is less than 1cmH ₂o, described retaining valve forward is opened resistance and is less than 10cmH ₂o, the resistance that oppositely leaks gas is greater than 20cmH ₂o; Described analysis gas routing sensor and series connection of pumps form, and they are connected to air chamber end and retaining valve front end by kapillary.

Retaining valve in above-mentioned air chamber is replaceable is air resistance part, as the tubule of the pipeline of filling porous material, reduced inner diameter, permeable porous film, now described analysis gas circuit accesses the middle part of main gas circuit air chamber, and its position can regulate according to the size of front and back Drag distribution in main gas circuit.

Accompanying drawing explanation

Fig. 1 hand-held breath analyzing instrument gas circuit structure schematic diagram.

The sound of Fig. 2 hand-held expiration of the present invention carbonyl analyzer to carbon monoxide Standard Gases.

Fig. 3 utilize hand-held expiration carbonyl analyzer of the present invention exhale CO measurement result with utilize Carefusion Micro CO expiration carbonyl analyzer to carry out the comparison of expiratory measurements result.

The response of Fig. 4 hand-held breath hydrogen of the present invention analyser to hydrogen Standard Gases.

Fig. 5 utilizes hand-held breath hydrogen analyser of the present invention carry out breath hydrogen measurement result and utilize center Hai get Wei breath hydrogen analyser to carry out the comparison of expiratory measurements result.

Embodiment

Fig. 1 is the utility model hand-held breath analyzing instrument gas circuit structure schematic diagram, described gas circuit is comprised of sample gas circuit and analysis gas circuit, wherein sample gas routing pressure or flow sensor 1, air chamber 2 and retaining valve 6 is composed in series, wherein said air chamber consists of elongate conduit, the gas mobile piston flow that is therein when its principle of design is exhaled and measures for assurance, air chamber resistance is less than 1cmH ₂o, measures expiration carbon monoxide and breath hydrogen, and the optional scope of its pipeline diameter is 2 ~ 40mm, is preferably 4 ~ 10mm, described retaining valve tool following characteristics: its forward is opened resistance and is less than 10cmH ₂o, the resistance that oppositely leaks gas is greater than 20cmH ₂o; Described analysis gas routing sensor 3 and pump 4 are composed in series, and they are connected to air chamber 2 ends and retaining valve 6 front ends, described capillary diameter 0.1 ~ 2mm, preferably 0.2 ~ 0.5mm by kapillary.

Under above-mentioned gas circuit condition, during expiration, breath flows in main gas circuit, the gas remaining in air chamber 2 and pipeline is replaced in time, during analysis, pump 4 is bled and is carried out Measurement and analysis by sensor 3 from air chamber 2, measured gaseous sample is mainly derived from air chamber 2, and air oppositely leaks gas and can ignore the impact of measurement result from retaining valve 6.

Retaining valve 6 described in above-mentioned gas circuit can replace with an air resistance part, as the pipeline of filling porous material, the tubule of reduced inner diameter, permeable porous film etc., now analyze the middle part that gas circuit accesses main gas circuit air chamber, particular location can regulate according to the size of front and back Drag distribution in main gas circuit, a special case is: main gas circuit is an elongate conduit, to analyze gas circuit and access main gas circuit middle part, when analyzing, opening pump 4 measures, due to gas flowing for piston flow in elongated tubular, air air chamber 2 two ends promote gases enter analyze gas circuit and not can with original sample gas blend in air chamber, thereby guaranteed the accuracy of the gasmetry that 3 pairs of air chambers 2 of sensor are collected.

For exhalation carbon monoxide and breath hydrogen, measure, need to collect alveolar air measures, moment sensor measuring method is subject to the restriction of sensor response time, the accuracy that the general guarantee of all will exhaling is long-term and stably measured (as utilized Zhong He the breath hydrogen analyser of Hai get Wei carry out need to stablizing and continuing to exhale 70 seconds when breath hydrogen is measured), this is difficult to most people.

The instrument of the present invention of sampling can separate sampling with analytic process, patient only needs normal expiration to expiration end just passable, this greatly reduces expiration difficulty (to measuring with breath hydrogen and expiration carbon monoxide, owing to not needing to measure expiratory gas flow, pressure in instrument and flow sensor also can omit), then open pump 4, according to the response time of sensor, with suitable flow velocity, expiration sample suction sensor 3 collected in air chamber 2 is measured and got final product (according to air chamber volume, the flow velocity of bleeding generally can be controlled in 5 ~ 10ml/s).

Fig. 2 selects expiration carbon monoxide transducer to utilize the measurement result of described instrument to carbon monoxide Standard Gases within the scope of 0 ~ 250ppm, and result shows that this analysis instrument is linear to the response of carbon monoxide within the scope of 0 ~ 250ppm, and linear dependence is 0.998.

Fig. 3 is described instrument to the exhale measurement result contrast of Micro CO carbon monoxide breath analyzing instrument of carbon monoxide measurement result and medicine prison Registering product Carefusion company of volunteer, show that two product measurement results are basically identical, Person related coefficient 0.991(P<0.001), linearly dependent coefficient 0.982.

Fig. 4 selects breath hydrogen sensor to utilize the measurement result of described instrument to hydrogen Standard Gases within the scope of 0 ~ 200ppm, and result shows that this analysis instrument is linear to the response of hydrogen within the scope of 0 ~ 200ppm, and linear dependence is 0.999.

Fig. 5 is that described instrument carries out respectively the result contrast of breath tester at one time on described expiration detector and center Hai get Wei HHBT-1 type breath hydrogen analyser to 55 volunteers (taking lactulose), the Pearson correlativity of two groups of data is 0.992(P<0.001), linearly dependent coefficient is 0.983.

More than implement to disclose be breath hydrogen and expiration carbon monoxide measurement, in fact the application of this new device is not limited only to this, to the measurement of expiration nitric oxide, expiration ammonia and expiration aldehyde etc., also can utilize this instrument to realize.

Claims

1. a hand-held breath analyzing instrument, its gas circuit is comprised of sample gas circuit and analysis gas circuit two parts, it is characterized by: described sampling gas routing pressure or flow sensor, air chamber and retaining valve are composed in series, wherein said air chamber consists of elongate conduit, pipeline diameter scope is 2 ~ 40mm, and when exhaling and measure, air chamber gas circuit resistance is less than 1cmH ₂o, described retaining valve forward is opened resistance and is less than 10cmH ₂o, the resistance that oppositely leaks gas is greater than 20cmH ₂o; Described analysis gas routing sensor and series connection of pumps form, and they are connected to air chamber end and retaining valve front end by kapillary.

2. hand-held breath analyzing instrument as claimed in claim 1, it is characterized by: wherein said retaining valve replaces with air resistance part, as the tubule of the pipeline of filling porous material, reduced inner diameter, permeable porous film, described analysis gas circuit accesses the middle part of main gas circuit air chamber, and particular location regulates according to the size of front and back Drag distribution in main gas circuit.