CN102657675A - Radiation-resisting medicament and preparation method thereof - Google Patents
Radiation-resisting medicament and preparation method thereof Download PDFInfo
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- CN102657675A CN102657675A CN2012101220828A CN201210122082A CN102657675A CN 102657675 A CN102657675 A CN 102657675A CN 2012101220828 A CN2012101220828 A CN 2012101220828A CN 201210122082 A CN201210122082 A CN 201210122082A CN 102657675 A CN102657675 A CN 102657675A
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Abstract
A radiation-resisting medicament and a preparation method thereof relate to a health care product with a radiation-resisting function and a preparation method thereof. In order to solve the problem that the existing radiation-resisting product contains various plant extracts, is unsatisfactory in radiation-resisting effect and complicated in production process due to the fact that various components are contained The radiation-resisting medicament is prepared by main raw materials of blueberry anthocyanin, indigo fruit anthocyanin and auricularian extractives. The preparation method includes: choosing materials, weighing, extracting effective active components and mixing the extractives. The radiation-resisting medicament and the preparation method of...are simple in production process, have the advantages of strengthening immunity, resisting radiation and being convenient to take and fast and complete in absorbing due to the electuary and capsule type proved by cell experiments, and are suitable for all crowd and wide in market prospect.
Description
Technical field
The present invention relates to a kind of health product and preparation method thereof with radiation-resisting functional.
Background technology
In the modern society; People are bearing the injury of the ionizing radiation of being sent from high radioactivity background material in industry, medical treatment and the environment constantly; Radiation can damage immunologic function and the body resistivity is descended, but and mutagenesis and canceration, a large amount of free radical mediated that the damaging action of ray leans on hydrolysis to produce to a great extent; Free radical can damage various biomacromolecules and various biomembrane, causes the unstability of cell function forfeiture, cycle disorder and heredity.Malignant tumor patient is the special population of one type of contact ray.Actinotherapy remains the important means of treatment tumor at present, it is reported that China has 70% malignant tumor patient to need radiation cure approximately.How fundamentally to reduce the damage that radiation brings, actively seeking effective radiation protection health product has become a hot issue.
Summary of the invention
The purpose of this invention is to provide a kind of blue berry, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit and the compound radioprotective medicament of Auricularia and preparation method thereof; Solved and contained the various plants extract in the existing anti-radiation product; The radioprotective effect is undesirable, and owing to contains multiple composition, the problem of complex production process.
Radioprotective medicament of the present invention is that primary raw material processes with vaccinium oxycoccus pigment, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin and Auricularia polycose extract, and percent by volume is: 20～48% vaccinium oxycoccus pigments, 10～40% Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait)s fruit anthocyanidin, 40～60% dried black fungus polysaccharide compounded extracts.
The present invention prepares the radioprotective medicament according to following method:
1) preparation of blue berry, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit concentrated juice: take by weighing blue berry and Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit jelly is deposited berry, water is squeezed the juice after cleaning, filter, filtered off with suction liquid, vacuum concentration, concentrated condition is 45～50 ℃, vacuum is 0.1～0.15mbar, blue berry, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit concentrated solution;
2) preparation of Auricularia polycose concentrated juice: after Auricularia cleaned, oven dry was pulverized; Sieve, then black fungus powder is soaked in water, lixiviate in the boiled water; Filtered off with suction liquid is filtered in lixiviate three times; Vacuum concentration gets the Auricularia polycose concentrated juice, and concentrated condition is 55～60 ℃, and vacuum is 0.1～0.15mbar;
3) above-mentioned concentrated juice is mixed, controlling each composition percent by volume is 20～48% vaccinium oxycoccus pigments, 10～40% Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait)s fruit anthocyanidin and 40～60% dried black fungus polysaccharide compounded extracts, is processed into the radioprotective medicament of various dosage forms.
Effective ingredient anthocyanidin and the polysaccharide of blue berry, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit all have antioxidation, remove biological activitys such as free radical, antitumor, immunomodulating, radioprotective.Blue berry, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin and Auricularia polycose is composite; Compound antioxidant is except having high efficiency and security features; All right Synergistic, the performance different physiological roles, antioxidant combination is significant for the oxidative damage that human radioprotective produces.
Production technology of the present invention is simple, and cell experiment proves to have enhancing immunity, radiation-resisting functional, electuary, capsule form taking convenience, absorbs rapidly characteristics completely, and suitable all groups take, and market prospect is wide.
Description of drawings
Fig. 1 be blue berry, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin and dried black fungus polysaccharide compounded extract to irradiation after the impact effect figure of cell viability;
Fig. 2 be blue berry, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin and dried black fungus polysaccharide compounded extract to irradiation after the impact effect figure of cell mda content.
The specific embodiment
The specific embodiment one: the blue berry of this embodiment, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit and the compound radioprotective electuary of Auricularia proportioning raw materials are seen table 1, and the nutritional labeling of blue berry, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit and Auricularia is seen table 2～4, and the nutritional labeling of 100g electuary is seen table 5.In this embodiment, the volume proportion of blue berry, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin and Auricularia polycose extract is: 25～40% vaccinium oxycoccus pigments, 10～25% Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait)s fruit anthocyanidin and 40～60% Auricularia polycoses.
Table 1 electuary proportioning raw materials
| The electuary raw material | Vaccinium oxycoccus pigment | Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin | Auricularia polycose |
| Content (wt.%) | 5～8% | 2～5% | 8～12% |
Table 2 blue berry (100g) nutritional labeling
| Protein (g) | 0.5 | Tannin (g) | 0.2 | Ferrum (mg) | 0.2 |
| Fat (g) | 0.1 | V C（mg） | 53 | Phosphorus (mg) | 9 |
| Carbohydrate (g) | 12.9 | V A（U） | 81 | Potassium (mg) | 70 |
| Anthocyanidin (mg) | 163 | V E（mg） | 2.7 | Sodium (mg) | 1.0 |
| Ellagic acid (mg) | 0.5 | SOD（U） | 5.39 | Zinc (mg) | 0.26 |
| Pectin (g) | 0.4 | Dietary fiber (g) | 2 | Selenium (mg) | 0.1 |
| Chlorogenic acid (mg) | 154 | Calcium (mg) | 8 | ? | ? |
Table 3 Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit (100g) nutritional labeling
| Protein (g) | 1 | VB 2（mg） | 0.51 | Calcium (mg) | 45.8 |
| Aminoacid (g) | 1 | VB 6（mg） | 0.64 | Ferrum (mg) | 8.5 |
| Fat (g) | 0.6 | V PP（mg） | 34 | Phosphorus (mg) | 38.62 |
| Anthocyanidin (mg) | 240 | V C（mg） | 10.19 | Potassium (mg) | 9.84 |
| Tannin (g) | 0.69 | Cobalt (mg) | 0.83 | Magnesium (mg) | 35.5 |
| Pectin (g) | 0.06 | Manganese (mg) | 3.2 | Zinc (mg) | 1.85 |
| VB 1（mg） | 0.14 | Copper (mg) | 0.83 | Selenium (mg) | 0.33 |
Table 4 Auricularia (100g) nutritional labeling
| Protein (g) | 11 | VB 1（mg） | 0.33 |
| Fat (g) | 0.27 | VB 2（mg） | 0.11 |
| Aminoacid (g) | 11.5 | Ferrum (mg) | 122 |
| Polysaccharide (g) | 6.434 | Calcium (mg) | 345.363 |
| Cellulose (g) | 1.68 | Zinc (mg) | 1.804 |
| Carotene (mg) | 0.22 | Selenium (μ g) | 0.4 |
| V C（mg） | 32 | ? | ? |
The nutrient composition content of table 5 100g electuary
| Protein (g) | 1.75 | Ellagic acid (mg) | 0.5 | V PP（mg） | 10.2 |
| Fat (g) | 0.28 | Chlorogenic acid (mg) | 154 | Calcium (mg) | 53.87 |
| Aminoacid (g) | 1.45 | SOD（U） | 3.78 | Ferrum (mg) | 14.89 |
| Polysaccharide (g) | 6.43 | V A（U） | 81 | Phosphorus (mg) | 17.89 |
| Anthocyanidin (mg) | 186.1 | VB 1（mg） | 0.08 | Potassium (mg) | 51.95 |
| Cellulose (g) | 0.17 | VB 2（mg） | 0.16 | Sodium (mg) | 0.7 |
| Carotene (μ g) | 22 | VB 6（mg） | 0.19 | Magnesium (mg) | 10.65 |
| Tannin (g) | 0.35 | V C（mg） | 43.36 | Zinc (mg) | 0.92 |
| Pectin (g) | 0.30 | V E（mg） | 1.89 | Selenium (mg) | 0.17 |
The specific embodiment two: the blue berry of this embodiment, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit and the compound radioprotective capsule of Auricularia proportioning raw materials are seen table 6, and the capsular nutrient composition content of 100g is seen table 7.In this embodiment, the volume proportion of blue berry, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin and Auricularia polycose extract is: 25～40% vaccinium oxycoccus pigments, 10～25% Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait)s fruit anthocyanidin and 40～60% Auricularia polycoses.
Table 6 capsule proportioning raw materials
| The capsule raw material | Vaccinium oxycoccus pigment | Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin | Auricularia polycose |
| Content (wt.%) | 20～32% | 8～20% | 32～48% |
The capsular nutrient composition content of table 7 100g
| Protein (g) | 7 | Ellagic acid (mg) | 2 | V PP（mg） | 40.8 |
| Fat (g) | 1.12 | Chlorogenic acid (mg) | 616 | Calcium (mg) | 215.48 |
| Aminoacid (g) | 5.8 | SOD（U） | 15.12 | Ferrum (mg) | 59.56 |
| Polysaccharide (g) | 25.73 | V A（U） | 324 | Phosphorus (mg) | 71.56 |
| Anthocyanidin (mg) | 744.4 | VB 1（mg） | 0.32 | Potassium (mg) | 207.8 |
| Cellulose (g) | 0.68 | VB 2（mg） | 0.64 | Sodium (mg) | 2.8 |
| Carotene (μ g) | 88 | VB 6（mg） | 0.76 | Magnesium (mg) | 42.6 |
| Tannin (g) | 1.4 | V C（mg） | 173.44 | Zinc (mg) | 3.68 |
| Pectin (g) | 1.2 | V E（mg） | 7.56 | Selenium (mg) | 0.68 |
The specific embodiment three: this embodiment prepares blue berry, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit and the compound radioprotective electuary of Auricularia, capsule according to following step:
1) preparation of blue berry, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit concentrated juice: take by weighing frozen berry, water is squeezed the juice with juice extractor after cleaning; 200 orders filter, filtered off with suction liquid, vacuum concentration; Concentrated condition is 45～50 ℃, and vacuum is 0.1～0.15mbar, makes blue berry, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit 10 g (FW)/ml concentrated juice respectively;
2) preparation of Auricularia polycose concentrated juice: after Auricularia cleaned, oven dry was pulverized, and crosses 40 order mesh screens; Then black fungus powder is soaked 2 h, lixiviate 1 h in the boiled water, lixiviate three times in water (1:40w/v); 200 orders filter, filtered off with suction liquid, vacuum concentration juice to 1 (DW) g/ml;
3) preparation of electuary: 65 ℃ of oven dry of white sugar, to pulverize, the 100g Icing Sugar mixes with the compound concentrated juice of 10ml (35% vaccinium oxycoccus pigment, 15% Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin and 50% dried black fungus polysaccharide compounded extract); 65 ℃ of oven dry are pulverized, and mix with compound concentrated juice again; Use 20 eye mesh screens, pelletize.
4) capsular preparation: 100g starch mixes with the compound concentrated juice of 200ml, and 65 ℃ of oven dry are pulverized, and incapsulate.
The specific embodiment four: what this embodiment and the specific embodiment three were different is: step 1) marc reuse 60 % (v/v) ethanol, press solid-liquid ratio 1:4 (w/v), supersound extraction 30 min; Centrifugal 5 min of 4000 rpm/min; Get supernatant,, concentrate then with the filtrate sucking filtration.Other steps are identical with the specific embodiment three.
The specific embodiment five: what this embodiment and the specific embodiment three, four were different is: in step 2) in, after Auricularia cleans, oven dry; Pulverize, cross 40 order mesh screens, then with Auricularia polycose with 60% (v/v) ethanol; Solid-liquid ratio 1:40 (w/v), supersound extraction, ultrasonic power 400 W; Ultrasonic time 30 min extract three times.Other steps are identical with the specific embodiment three, four.
The blue berry that this embodiment obtains, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin and dried black fungus polysaccharide compounded thing extract (35% vaccinium oxycoccus pigment, 15% Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin and 50% dried black fungus polysaccharide compounded extract) are done its radiation-resistant function of cell test explanation.With the method for mechanical lapping, preparation Rats Spleen cell is divided into normal group, irradiation group and irradiation dosing group with cell, and irradiation dosing group is in predose 12 h dosings, and 24 h behind the irradiation detect cell viability and mda content.Irradiation carries out radiated by gamma-ray at Heilongjiang Institute of Agricultural Sciences's corn institute, radiation dose 10 Gy, close rate 1.59 Gy/min, disposable radiated time 8 ˊ 22 〞, irradiation distance 130 cm.Mtt assay detects cell viability, representes with survival rate.Malonaldehyde (MDA) Determination on content is used sulfo-barbital method.
Blue berry, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin and dried black fungus polysaccharide compounded extract to irradiation after the influence of cell viability; The result shows; The normal group cell survival rate is 100 ± 0.92%, and irradiation group cell survival rate is 49.26 ± 1.21%, and irradiation dosing group cell survival rate is higher than according to group; Be concentration dependent; When concentration reached 10 mg/ml, cell survival rate was up to 77.90 ± 4.12%, showed that blue berry, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin and dried black fungus polysaccharide compounded extract have played certain protective action (Fig. 1) to irradiation.
Blue berry, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin and dried black fungus polysaccharide compounded extract to irradiation after the influence of mda content, MDA is the representative index of cell injury.Normal group cell mda content is 16.20 ± 0.62 nmol/mg; Significantly increase after receiving gamma-irradiation; Content reaches 23.12 ± 0.71 nmol/mg, and blue berry, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin and dried black fungus polysaccharide compounded extract have obvious reduction MDA level, are concentration dependent; When concentration reaches 30 mg/ml; The cell mda content is minimum to be 17.50 ± 1.25 nmol/mg, shows the damage that blue berry, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin and dried black fungus polysaccharide compounded extract pair cell irradiation cause, play certain protective action (Fig. 2).
The specific embodiment six: in this embodiment, the volume proportion of blue berry, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin and Auricularia polycose extract is: 30% vaccinium oxycoccus pigment, 25% Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin and 45% Auricularia polycose.
The specific embodiment seven: in this embodiment, the volume proportion of blue berry, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin and Auricularia polycose extract is: 40% vaccinium oxycoccus pigment, 20% Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin and 40% Auricularia polycose.
The specific embodiment eight: in this embodiment, the volume proportion of blue berry, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin and Auricularia polycose extract is: 25% vaccinium oxycoccus pigment, 15% Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin and 60% Auricularia polycose.
Claims (8)
1. radioprotective medicament; It is characterized in that said medicament is that primary raw material processes with vaccinium oxycoccus pigment, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin and Auricularia polycose extract, percent by volume is: 20～48% vaccinium oxycoccus pigments, 10～40% Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait)s fruit anthocyanidin, 40～60% dried black fungus polysaccharide compounded extracts.
2. radioprotective medicament according to claim 1 is characterized in that said percent by volume is: 35% vaccinium oxycoccus pigment, 15% Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin and 50% dried black fungus polysaccharide compounded extract.
3. radioprotective medicament according to claim 1 is characterized in that said percent by volume is: 30% vaccinium oxycoccus pigment, 25% Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin and 45% Auricularia polycose.
4. radioprotective medicament according to claim 1 is characterized in that said percent by volume is: 40% vaccinium oxycoccus pigment, 20% Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin and 40% Auricularia polycose.
5. radioprotective medicament according to claim 1 is characterized in that said percent by volume is: 25% vaccinium oxycoccus pigment, 15% Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit anthocyanidin and 60% Auricularia polycose.
6. the method for preparing of the said radioprotective medicament of claim 1 is characterized in that said method prepares according to following steps:
1) preparation of blue berry, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit concentrated juice: take by weighing blue berry and Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit jelly is deposited berry, water is squeezed the juice after cleaning, filter, filtered off with suction liquid, vacuum concentration, concentrated condition is 45～50 ℃, vacuum is 0.1～0.15mbar, blue berry, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) fruit concentrated solution;
2) preparation of Auricularia polycose concentrated juice: after Auricularia cleaned, oven dry was pulverized; Sieve, then black fungus powder is soaked in water, lixiviate in the boiled water; Filtered off with suction liquid is filtered in lixiviate three times; Vacuum concentration gets the Auricularia polycose concentrated juice, and concentrated condition is 55～60 ℃, and vacuum is 0.1～0.15mbar;
3) above-mentioned concentrated juice is pressed claim 1 said mixed, be processed into the radioprotective medicament of various dosage forms.
7. the method for preparing of radioprotective medicament according to claim 6 is characterized in that in the step 1), marc reuse ethanol ultrasonic extraction, and supernatant is got in centrifugalize, then with the filtrate sucking filtration, concentrates.
8. the method for preparing of radioprotective medicament according to claim 6 is characterized in that step 2) in, after sieving, Auricularia uses ethanol ultrasonic extraction.
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Cited By (7)
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| CN103564491A (en) * | 2013-10-18 | 2014-02-12 | 伊春林业科学院 | Blueberry and mushroom composite antioxidation capsules |
| CN107198170A (en) * | 2017-06-20 | 2017-09-26 | 哈尔滨工业大学 | A kind of preparation formula of natural raspberry composite oral liquid |
| CN107252113A (en) * | 2017-06-20 | 2017-10-17 | 哈尔滨工业大学 | A kind of special radioresistance lozenge of spacefarer |
| CN107467668A (en) * | 2017-07-21 | 2017-12-15 | 哈尔滨工业大学 | A kind of compound Blackfungus polyhexose energy glue with radiation proof function prepares formula |
| CN107712511A (en) * | 2017-10-14 | 2018-02-23 | 哈尔滨工业大学 | A kind of special anthocyanidin edible natural soda water preparation method of spacefarer |
| CN112826087A (en) * | 2021-01-08 | 2021-05-25 | 哈尔滨工业大学 | Solid preparation with antioxidant factor and preparation method thereof |
| CN112841656A (en) * | 2021-02-19 | 2021-05-28 | 哈尔滨工业大学 | Antioxidant blueberry anthocyanin tablet and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103564491A (en) * | 2013-10-18 | 2014-02-12 | 伊春林业科学院 | Blueberry and mushroom composite antioxidation capsules |
| CN103564491B (en) * | 2013-10-18 | 2015-11-25 | 伊春林业科学院 | Blueberry mushroom composite antioxidation capsule |
| CN107198170A (en) * | 2017-06-20 | 2017-09-26 | 哈尔滨工业大学 | A kind of preparation formula of natural raspberry composite oral liquid |
| CN107252113A (en) * | 2017-06-20 | 2017-10-17 | 哈尔滨工业大学 | A kind of special radioresistance lozenge of spacefarer |
| CN107467668A (en) * | 2017-07-21 | 2017-12-15 | 哈尔滨工业大学 | A kind of compound Blackfungus polyhexose energy glue with radiation proof function prepares formula |
| CN107712511A (en) * | 2017-10-14 | 2018-02-23 | 哈尔滨工业大学 | A kind of special anthocyanidin edible natural soda water preparation method of spacefarer |
| CN112826087A (en) * | 2021-01-08 | 2021-05-25 | 哈尔滨工业大学 | Solid preparation with antioxidant factor and preparation method thereof |
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Application publication date: 20120912 |