CN102655938B - 装置及设备 - Google Patents

装置及设备 Download PDF

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Publication number
CN102655938B
CN102655938B CN201080049483.4A CN201080049483A CN102655938B CN 102655938 B CN102655938 B CN 102655938B CN 201080049483 A CN201080049483 A CN 201080049483A CN 102655938 B CN102655938 B CN 102655938B
Authority
CN
China
Prior art keywords
wellhole
well
diluent
nucleic acid
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201080049483.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN102655938A (zh
Inventor
菲利普·韦克利
格雷厄姆·古特赛尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UK Secretary of State for Environment Food and Rural Affairs
Original Assignee
UK Secretary of State for Environment Food and Rural Affairs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UK Secretary of State for Environment Food and Rural Affairs filed Critical UK Secretary of State for Environment Food and Rural Affairs
Publication of CN102655938A publication Critical patent/CN102655938A/zh
Application granted granted Critical
Publication of CN102655938B publication Critical patent/CN102655938B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201080049483.4A 2009-11-02 2010-11-02 装置及设备 Expired - Fee Related CN102655938B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0919159.4 2009-11-02
GBGB0919159.4A GB0919159D0 (en) 2009-11-02 2009-11-02 Device and apparatus
PCT/GB2010/051832 WO2011051735A2 (en) 2009-11-02 2010-11-02 Device and apparatus

Publications (2)

Publication Number Publication Date
CN102655938A CN102655938A (zh) 2012-09-05
CN102655938B true CN102655938B (zh) 2014-09-17

Family

ID=41435004

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080049483.4A Expired - Fee Related CN102655938B (zh) 2009-11-02 2010-11-02 装置及设备

Country Status (10)

Country Link
US (1) US9163279B2 (enExample)
EP (1) EP2496351B1 (enExample)
JP (1) JP5934100B2 (enExample)
CN (1) CN102655938B (enExample)
AU (1) AU2010311138B2 (enExample)
CA (1) CA2778329C (enExample)
ES (1) ES2712666T3 (enExample)
GB (1) GB0919159D0 (enExample)
TR (1) TR201900390T4 (enExample)
WO (1) WO2011051735A2 (enExample)

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US10775370B2 (en) 2015-07-17 2020-09-15 Stat-Diagnostica & Innovation, S.L. Fluidic system for performing assays

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EP2925448B1 (en) 2012-12-03 2019-05-22 The Secretary of State for Environment, Food and Rural Affairs Device and method for carrying out an assay to detect a nucleic acid in a sample
EP2932266A4 (en) 2012-12-17 2016-11-30 Leukodx Ltd SYSTEMS AND METHOD FOR DETERMINING A CHEMICAL CONDITION
US20140170678A1 (en) * 2012-12-17 2014-06-19 Leukodx Ltd. Kits, compositions and methods for detecting a biological condition
EP2948249A1 (en) 2013-01-22 2015-12-02 University of Washington through its Center for Commercialization Sequential delivery of fluid volumes and associated devices, systems and methods
DK2821138T4 (da) 2013-07-05 2022-05-16 Thinxxs Microtechnology Gmbh Flydecelle med integreret tørstof
US10946376B2 (en) 2013-07-05 2021-03-16 Thinxxs Microtechnology Ag Carrier element for introducing a dry substance into a flow cell
KR101398764B1 (ko) * 2013-08-29 2014-05-27 강릉원주대학교산학협력단 입자의 이동에 의해 분석물질을 검출하는 장치 및 방법
HK1222597A1 (zh) * 2013-10-22 2017-07-07 艾博生物医药(杭州)有限公司 用於检测液体样本中的分析物的检测装置
EP3089823A4 (en) * 2013-12-31 2017-12-20 Canon U.S. Life Sciences, Inc. Field deployable small format fast first result microfluidic system
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FR3032719B1 (fr) * 2015-02-13 2020-05-15 Centre National De La Recherche Scientifique Dispositif de diagnostic par amplification isotherme d'adn
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CN109477835B (zh) * 2016-07-25 2022-08-16 生物辐射实验室股份有限公司 侧流装置及使用方法
GB201616718D0 (en) * 2016-09-30 2016-11-16 Microbiosensor Limited Microbial sensing devices
GB201700340D0 (en) 2017-01-09 2017-02-22 Gsg Tech Ltd fluid manipulation cartridge and controller mechanism
GB201715704D0 (en) * 2017-09-28 2017-11-15 Microbiosensor Ltd Methods and devices
FR3075823A1 (fr) * 2017-12-21 2019-06-28 Nanobiose Procede d’analyse d’un echantillon cellulaire au moyen d’un laboratoire sur puce-micro-fluidique
FR3075817B1 (fr) * 2017-12-21 2020-12-25 Nanobiose Puce micro-fluidique et laboratoire sur puce-micro-fluidique
EP3728556A1 (fr) * 2017-12-21 2020-10-28 Nanobiose Puce micro-fluidique, laboratoire sur puce micro-fluidique, procédé de fabrication d'une telle puce et procédé d'analyse
US10046322B1 (en) * 2018-03-22 2018-08-14 Talis Biomedical Corporation Reaction well for assay device
AU2019397371B2 (en) * 2018-12-10 2025-09-18 Combinati Incorporated Microfluidic array for sample digitization
CN110358665A (zh) * 2019-06-28 2019-10-22 马鞍山众慧惠生生物科技有限公司 箱式集成化核酸定量检测装置
US11008627B2 (en) 2019-08-15 2021-05-18 Talis Biomedical Corporation Diagnostic system
JP7164505B2 (ja) * 2019-10-02 2022-11-01 積水化学工業株式会社 マイクロ流路チップ
WO2021231607A1 (en) * 2020-05-12 2021-11-18 Godx, Inc. Point of need diagnostic device and methods of use thereof
WO2021236850A1 (en) * 2020-05-19 2021-11-25 Mammoth Biosciences, Inc. Devices, assays and methods for detection of nucleic acids
JPWO2022030605A1 (enExample) * 2020-08-07 2022-02-10
US11567071B2 (en) 2020-10-16 2023-01-31 Fresenius Medical Care Holdings, Inc. Devices and methods for lateral flow tests of bodily fluids
EP4173708A1 (de) * 2021-10-28 2023-05-03 thinXXS Microtechnology GmbH Mikrofluidelement, insbesondere flusszelle, mit integriertem trockenreagenz
CA3247043A1 (en) * 2022-04-15 2023-10-19 Siemens Healthcare Diagnostics Inc CREATININE SIDE-FLOW TESTING DEVICES AND METHODS OF MANUFACTURE AND USE
WO2024127334A2 (en) * 2022-12-16 2024-06-20 3M Innovative Properties Company Sample collection and analysis system

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Cited By (2)

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Publication number Priority date Publication date Assignee Title
US10775370B2 (en) 2015-07-17 2020-09-15 Stat-Diagnostica & Innovation, S.L. Fluidic system for performing assays
US12123870B2 (en) 2015-07-17 2024-10-22 Qiagen Gmbh Fluidic system for performing assays

Also Published As

Publication number Publication date
ES2712666T3 (es) 2019-05-14
EP2496351A2 (en) 2012-09-12
TR201900390T4 (tr) 2019-02-21
JP2013509173A (ja) 2013-03-14
US9163279B2 (en) 2015-10-20
WO2011051735A2 (en) 2011-05-05
CA2778329A1 (en) 2011-05-05
EP2496351B1 (en) 2019-01-02
AU2010311138A1 (en) 2012-05-03
AU2010311138B2 (en) 2014-08-28
US20120270225A1 (en) 2012-10-25
CA2778329C (en) 2018-09-04
JP5934100B2 (ja) 2016-06-15
GB0919159D0 (en) 2009-12-16
CN102655938A (zh) 2012-09-05
WO2011051735A3 (en) 2011-08-18

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SE01 Entry into force of request for substantive examination
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Granted publication date: 20140917