CN102652682A - Micro brain-tissue sampler - Google Patents
Micro brain-tissue sampler Download PDFInfo
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- CN102652682A CN102652682A CN2012101108298A CN201210110829A CN102652682A CN 102652682 A CN102652682 A CN 102652682A CN 2012101108298 A CN2012101108298 A CN 2012101108298A CN 201210110829 A CN201210110829 A CN 201210110829A CN 102652682 A CN102652682 A CN 102652682A
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- sampling tube
- conduit
- catheter
- spacing head
- brain
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Abstract
The invention discloses a micro brain-tissue sampler which belongs to the technical field of devices for bioscientific experimental researches. The micro brain-tissue sampler comprises a catheter, a needle core, a sampling tube and a rotary cutter, wherein one end of the sampling tube is provided with a serrated blade, and the inner wall of the sampling tube is provided with a thread; after the needle core is inserted into the catheter, the needle core and the catheter are both inserted into the head of an animal, then the catheter is fixed, the needle core is pulled out, and the sampling tube is inserted into the catheter; the sampling tube is lightly pressed and rapidly rotated for a plurality of circles so as to cut apart an envelope; the sampling tube continues to be lightly pressed and rotated, so that the sampling tube moves downwards, and after the sampling tube reaches a target position of the head according to the positioning depth of a limit head, the sampling tube is rotated again, so that a target brain-tissue is pushed into the sampling tube by the thread in the sampling tube; the rotary cutter is inserted into the sampling tube from an opening of the limit head of the sampling tube, and through rotating the rotary cutter, the connection between the tissue in the internal thread and downward tissues is cut off; and the catheter, the sampling tube and the rotary cutter are taken out together, and then the rotary cutter is taken out. The micro brain-tissue sampler disclosed by the invention is easy to operate, small in tissue damage, high in precision, simple in structure and low in manufacturing cost, and can be applied to the establishment of intravital nucleic acid sampling analysis, pathologic examination and special damage models.
Description
Technical field
The invention belongs to the life sciences experimental study and use the device technique field.
Background technology
In the life sciences experimental study, needing to use can be to the device of cerebral tissue living body sampling (to organ and accurately location and the sampling of nuclear group) and special focus modeling.Application number is that 01212276.9 Chinese patent file has been announced a kind of " vacuum ring cutting cell taking gun "; This device leans on negative pressure-pumping; Be a kind of instrument of drawing materials of tumor examination, not only require and the supporting use of suction device for medical use, and be not suitable for the sampling of cerebral tissue; Because: the sampling quantity of negative pressure-pumping is difficult to control to be grasped, and damages surrouding brain tissue easily; The structure of its circular cutter can not be cut the cerebral dura mater that some brain district covers; Its needle point is sharp edge shape, in the process of inserting cerebral tissue, punctures blood vessel easily, causes intracerebral hemorrhage.
Summary of the invention
The object of the present invention is to provide a kind of microcomponent's sampler that can be used for brain.
Apparatus of the present invention include:
One conduit;
One inserts the nook closing member that can move behind the conduit, and nook closing member one end is spherical crown or ellipsoid is crown, and the other end is established the spacing head that can limit the degree of depth of inserting conduit;
One inserts the sampling tube that can move behind the conduit, and sampling tube one end band saw dentation blade and inside pipe wall are threaded, the other end establish the degree of depth that can limit the insertion conduit, hollow and open spacing head, this cavity of spacing docks perforation with the sampling tube cavity;
The one rotary-cut cutter that behind spacing insertion sampling tube of sampling tube, can rotate, rotary-cut cutter one end is a blade, the other end is established the spacing head that can limit the degree of depth of inserting sampling tube, establishes the hands handle on this spacing head;
Nook closing member and sampling tube do not contain the length of spacing head part all greater than catheter length, and the length that the rotary-cut cutter can insert sampling tube is identical with the total length of the spacing head of sampling pipe racks.
As alternative parts; Apparatus of the present invention can be pasted the stifled core of conduit that pipe inner wall moves after can also comprising an insertion conduit; Stifled core one end of conduit is cylindric; The other end is established the spacing head that can limit the degree of depth of inserting conduit, and the length that the stifled core of conduit does not contain spacing head part is identical with the length that sampling tube does not contain spacing head part.
The use of apparatus of the present invention: earlier nook closing member is inserted conduit, inserts the animal head in the lump then, let the nook closing member end gently be pressed in the destination organization surface.A/C is extracted nook closing member, and sampling tube is inserted conduit.Light press sampling tube and fast rotational a few, cut tunicle.Continue gently to press and rotate sampling tube it is moved down, behind the emplacement depth arrival brain target position by spacing head, rotate sampling tube 3-10 circle again, let the target cerebral tissue managed female thread and push in the pipe.With spacing the uncovered insertion sampling tube of rotary-cut cutter from sampling tube, rotate rotary-cut cutter 2-3 circle, cut off getting in touch of interior tissue of female thread and following tissue.Conduit, sampling tube and rotary-cut cutter are together slowly taken out, take out the rotary-cut cutter, can go out sampling tissue from spacing uncovered water filling of sampling tube.
If need make cavity at the specific part of brain; Then let catheter retaining in brain; Thereby the cavity that the stifled core insertion of conduit conduit stays sampling area is blocked up, extracted the stifled core of conduit after several days, the conduit below can form a cylindrical cavity; Can supply the implantable neural stem cell, or put into particular chemicals and wait research experiment.
The beneficial effect of apparatus of the present invention: a kind of microcomponent's sampler that can be used for brain is provided, processing ease, tissue injury is little; Precision is high; Simple in structure, low cost of manufacture can be used for carrying out the foundation of the sampling analysis of live body nucleic acid, pathologic finding and special damage model.
Description of drawings:
Below in conjunction with accompanying drawing and embodiment the present invention is further described, but the invention is not restricted to shown in the accompanying drawing.
Fig. 1 is the main TV structure sketch map of conduit among the embodiment.
Fig. 2 is the main TV structure sketch map of nook closing member among the embodiment.
Fig. 3 is the main TV structure band partial cutaway schematic of sampling tube among the embodiment.
Fig. 4 is the main TV structure sketch map of rotary-cut cutter among the embodiment.
Fig. 5 is the main TV structure band partial cutaway schematic behind the rotary-cut cutter insertion sampling tube among the embodiment.
Fig. 6 is the main TV structure sketch map of the stifled core of conduit among the embodiment.
The specific embodiment
See the embodiment of Fig. 1～6.The parts that the present embodiment device is processed by following rustless steel are formed:
It is crown that nook closing member 2, one ends are ellipsoid, and the other end is established spacing 3 that can limit the degree of depth of inserting conduit 1,0.8 millimeter of nook closing member 2 bar portion diameter, and the length that does not contain spacing 3 part is 36 millimeters.
Rotary-cut cutter 8; One end is a blade 11, and the other end is established spacing 9 that can limit the degree of depth of inserting sampling tube 4, establishes handle 10 on spacing 9; The vertical length that rotary-cut cutter 8 can insert sampling tube 4 is identical with spacing 7 total length with sampling tube 4, and the diameter of rotary-cut cutter 8 bar portions is 0.35 millimeter.
Stifled core 12, one ends of one conduit are cylindric, and the other end is established spacing 13 of the degree of depth that can limit insertion conduit 1, and conduit blocks up core 12, and not contain the length of spacing 13 part identical with the length that sampling tube 4 does not contain spacing 7 part.
The present embodiment device is used to carry out the position sampling analysis of macaque brain stem inferior colliculus and makes cavity work, and result of use is fine.
Claims (2)
1. brain microcomponent sampler is characterized in that including:
One conduit;
One inserts the nook closing member that can move behind the conduit, and nook closing member one end is spherical crown or ellipsoid is crown, and the other end is established the spacing head that can limit the degree of depth of inserting conduit;
One inserts the sampling tube that can move behind the conduit, and sampling tube one end band saw dentation blade and inside pipe wall are threaded, the other end establish the degree of depth that can limit the insertion conduit, hollow and open spacing head, this cavity of spacing docks perforation with the sampling tube cavity;
The one rotary-cut cutter that behind spacing insertion sampling tube of sampling tube, can rotate, rotary-cut cutter one end is a blade, the other end is established the spacing head that can limit the degree of depth of inserting sampling tube, establishes the hands handle on this spacing head;
Nook closing member and sampling tube do not contain the length of spacing head part all greater than catheter length, and the length that the rotary-cut cutter can insert sampling tube is identical with the total length of the spacing head of sampling pipe racks.
2. like the said brain of claim 1 microcomponent sampler; It is characterized in that: can paste the stifled core of conduit that pipe inner wall moves after also comprising an insertion conduit; Stifled core one end of conduit is cylindric; The other end is established the spacing head that can limit the degree of depth of inserting conduit, and the length that the stifled core of conduit does not contain spacing head part is identical with the length that sampling tube does not contain spacing head part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210110829 CN102652682B (en) | 2012-04-16 | 2012-04-16 | Micro brain-tissue sampler |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210110829 CN102652682B (en) | 2012-04-16 | 2012-04-16 | Micro brain-tissue sampler |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102652682A true CN102652682A (en) | 2012-09-05 |
| CN102652682B CN102652682B (en) | 2013-10-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201210110829 Expired - Fee Related CN102652682B (en) | 2012-04-16 | 2012-04-16 | Micro brain-tissue sampler |
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| CN (1) | CN102652682B (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006345A (en) * | 2012-12-17 | 2013-04-03 | 中国人民解放军第四军医大学 | Brain taking device for simulating surgical injury |
| CN103284980A (en) * | 2013-06-18 | 2013-09-11 | 中国科学院昆明动物研究所 | Method for establishing animal model for senile dementia, special liquid medicine and dosing device |
| CN103340859A (en) * | 2013-06-04 | 2013-10-09 | 中国科学院昆明动物研究所 | Method for establishing non-human primate animal model of parkinson disease by lateral ventricle administration of MPP<+> |
| CN103417538A (en) * | 2013-06-28 | 2013-12-04 | 云南中科灵长类生物医学重点实验室 | Dedicated liquid medicine, dedicated tool and method for building animal model of parkinson's disease through intracerebral administration |
| CN103598924A (en) * | 2013-12-03 | 2014-02-26 | 菏泽学院 | Experiment rat central nervous sucking and pulling device |
| CN104783919A (en) * | 2015-04-29 | 2015-07-22 | 桂林医学院 | Brain tissue damage experimental facility |
| CN106448402A (en) * | 2016-10-26 | 2017-02-22 | 中国人民解放军第三军医大学 | Balloon model device for simulating encephalic space occupying effect |
| CN111397943A (en) * | 2020-04-20 | 2020-07-10 | 山东中医药大学附属医院 | Focal sampler for sampling adenomyosis specimen and sampling method |
| CN115530889A (en) * | 2022-11-08 | 2022-12-30 | 西安交通大学 | Tumor sampling equipment convenient for separating tumors |
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| CN2274944Y (en) * | 1996-05-14 | 1998-02-25 | 张希真 | Multifunctional casing encephalopuncture needle |
| WO1999023950A1 (en) * | 1997-11-12 | 1999-05-20 | Stereotaxis, Inc. | Method and apparatus for obtaining tissue samples |
| CN2533808Y (en) * | 2002-03-08 | 2003-02-05 | 郝振海 | Device for taking out bone phyma sample for biopsy |
| WO2005110602A1 (en) * | 2004-05-11 | 2005-11-24 | Inpro Biotechnology, Inc. | Device, system and method for extracting and preparing animal tissue |
| CN2857833Y (en) * | 2005-12-02 | 2007-01-17 | 顾永成 | Deep tissue aspiration pathological biopsy needle |
| CN201139587Y (en) * | 2008-01-11 | 2008-10-29 | 王卫国 | Ring tection inhalation type soft tissue biopsy sampling needle |
| US20080312554A1 (en) * | 2005-08-05 | 2008-12-18 | Garrison William A | Biopsy Device with Manually Rotated Sample Barrel |
| CN202096228U (en) * | 2011-06-02 | 2012-01-04 | 桂林医学院 | Brain tissue locating and taking device |
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2012
- 2012-04-16 CN CN 201210110829 patent/CN102652682B/en not_active Expired - Fee Related
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2274944Y (en) * | 1996-05-14 | 1998-02-25 | 张希真 | Multifunctional casing encephalopuncture needle |
| WO1999023950A1 (en) * | 1997-11-12 | 1999-05-20 | Stereotaxis, Inc. | Method and apparatus for obtaining tissue samples |
| CN2533808Y (en) * | 2002-03-08 | 2003-02-05 | 郝振海 | Device for taking out bone phyma sample for biopsy |
| WO2005110602A1 (en) * | 2004-05-11 | 2005-11-24 | Inpro Biotechnology, Inc. | Device, system and method for extracting and preparing animal tissue |
| US20080312554A1 (en) * | 2005-08-05 | 2008-12-18 | Garrison William A | Biopsy Device with Manually Rotated Sample Barrel |
| CN2857833Y (en) * | 2005-12-02 | 2007-01-17 | 顾永成 | Deep tissue aspiration pathological biopsy needle |
| CN201139587Y (en) * | 2008-01-11 | 2008-10-29 | 王卫国 | Ring tection inhalation type soft tissue biopsy sampling needle |
| CN202096228U (en) * | 2011-06-02 | 2012-01-04 | 桂林医学院 | Brain tissue locating and taking device |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006345A (en) * | 2012-12-17 | 2013-04-03 | 中国人民解放军第四军医大学 | Brain taking device for simulating surgical injury |
| CN103006345B (en) * | 2012-12-17 | 2015-07-29 | 中国人民解放军第四军医大学 | What a kind of sham operated damaged gets brain device |
| CN103340859A (en) * | 2013-06-04 | 2013-10-09 | 中国科学院昆明动物研究所 | Method for establishing non-human primate animal model of parkinson disease by lateral ventricle administration of MPP<+> |
| CN103284980A (en) * | 2013-06-18 | 2013-09-11 | 中国科学院昆明动物研究所 | Method for establishing animal model for senile dementia, special liquid medicine and dosing device |
| CN103417538A (en) * | 2013-06-28 | 2013-12-04 | 云南中科灵长类生物医学重点实验室 | Dedicated liquid medicine, dedicated tool and method for building animal model of parkinson's disease through intracerebral administration |
| CN103598924A (en) * | 2013-12-03 | 2014-02-26 | 菏泽学院 | Experiment rat central nervous sucking and pulling device |
| CN103598924B (en) * | 2013-12-03 | 2015-09-09 | 菏泽学院 | Experimental rat nervus centralis draws drawing device |
| CN104783919A (en) * | 2015-04-29 | 2015-07-22 | 桂林医学院 | Brain tissue damage experimental facility |
| CN106448402A (en) * | 2016-10-26 | 2017-02-22 | 中国人民解放军第三军医大学 | Balloon model device for simulating encephalic space occupying effect |
| CN111397943A (en) * | 2020-04-20 | 2020-07-10 | 山东中医药大学附属医院 | Focal sampler for sampling adenomyosis specimen and sampling method |
| CN115530889A (en) * | 2022-11-08 | 2022-12-30 | 西安交通大学 | Tumor sampling equipment convenient for separating tumors |
| CN115530889B (en) * | 2022-11-08 | 2023-10-31 | 西安交通大学第二附属医院 | Tumor sampling equipment convenient for separating tumor |
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| Publication number | Publication date |
|---|---|
| CN102652682B (en) | 2013-10-16 |
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Granted publication date: 20131016 Termination date: 20160416 |