CN102639154B - 芳氧基酰苯胺显像剂 - Google Patents

芳氧基酰苯胺显像剂 Download PDF

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Publication number
CN102639154B
CN102639154B CN201080056579.3A CN201080056579A CN102639154B CN 102639154 B CN102639154 B CN 102639154B CN 201080056579 A CN201080056579 A CN 201080056579A CN 102639154 B CN102639154 B CN 102639154B
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CN
China
Prior art keywords
vivo imaging
developer
pbr
limits
imaging agent
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Expired - Fee Related
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CN201080056579.3A
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English (en)
Chinese (zh)
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CN102639154A (zh
Inventor
H.J.瓦德斯沃思
D.奥舍亚
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GE Healthcare Ltd
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GE Healthcare Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/0412—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K51/0423—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/0412—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K51/0419—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/0412—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K51/0425—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin compounds containing methylenedioxyphenol groups, e.g. sesamin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/02—Seven-membered rings
    • C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
CN201080056579.3A 2009-12-17 2010-12-16 芳氧基酰苯胺显像剂 Expired - Fee Related CN102639154B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28723309P 2009-12-17 2009-12-17
US61/287233 2009-12-17
GBGB0921967.6A GB0921967D0 (en) 2009-12-17 2009-12-17 Novel Aryloxyanilide Derivatives
GB0921967.6 2009-12-17
PCT/EP2010/069866 WO2011073304A1 (en) 2009-12-17 2010-12-16 Aryloxyanilide imaging agents

Publications (2)

Publication Number Publication Date
CN102639154A CN102639154A (zh) 2012-08-15
CN102639154B true CN102639154B (zh) 2015-06-17

Family

ID=41717035

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080056579.3A Expired - Fee Related CN102639154B (zh) 2009-12-17 2010-12-16 芳氧基酰苯胺显像剂

Country Status (6)

Country Link
US (2) US8771641B2 (enExample)
EP (1) EP2512525B1 (enExample)
JP (1) JP5744057B2 (enExample)
CN (1) CN102639154B (enExample)
GB (1) GB0921967D0 (enExample)
WO (1) WO2011073304A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114085221A (zh) * 2021-11-29 2022-02-25 暨南大学 含氮杂环化合物、标记的含氮杂环化合物及其制备方法和应用

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201016038D0 (en) * 2010-09-24 2010-11-10 Ge Healthcare Ltd In vivo imaging method

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0115927D0 (en) 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination
GB0115929D0 (en) 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase electrophilic fluorination
US6870069B2 (en) 2003-01-10 2005-03-22 National Institute Of Radiological Sciences Phenyloxyaniline derivatives
JPWO2006092902A1 (ja) 2005-02-28 2008-08-07 大正製薬株式会社 放射性ハロゲン標識フェニルオキシアニリン誘導体
GB0516564D0 (en) * 2005-08-12 2005-09-21 Ge Healthcare Ltd Fluorination process
WO2007036785A2 (en) 2005-09-29 2007-04-05 Ge Healthcare Limited Carbon-isotope monoxide labeling of daa1106 and its analogues to be used as tracers for a peripheral type benzodiazepine binding site
EP1967127A4 (en) 2005-12-27 2013-01-23 Olympus Medical Systems Corp STORAGE DEVICE FOR A MEDICAL DEVICE, DISPOSAL DEVICE AND METHOD FOR USE OF A MEDICAL DEVICE
US20090142264A1 (en) * 2005-12-28 2009-06-04 Bengt Langstrom 18F-Labeled Phenoxyphenyl Nu-benzyl Alkanamid Derivatives for Positron Emission Tomography (PET) Imaging of Peripheral Benzodiazepine Receptor
GB0904715D0 (en) * 2009-03-19 2009-05-06 Ge Healthcare Ltd Aryloxyanilide derivataives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Kinetic Evaluation in Nonhuman Primates of Two New PET Ligands for Peripheral Benzodiazepine Receptors in Brain;MASAO IMAIZUMI，etal;《SYNAPSE》;20071231;第61卷(第8期);第595–605页 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114085221A (zh) * 2021-11-29 2022-02-25 暨南大学 含氮杂环化合物、标记的含氮杂环化合物及其制备方法和应用
CN114085221B (zh) * 2021-11-29 2022-12-09 暨南大学 含氮杂环化合物、标记的含氮杂环化合物及其制备方法和应用

Also Published As

Publication number Publication date
US9186424B2 (en) 2015-11-17
US8771641B2 (en) 2014-07-08
GB0921967D0 (en) 2010-02-03
JP5744057B2 (ja) 2015-07-01
US20140288317A1 (en) 2014-09-25
JP2013514319A (ja) 2013-04-25
WO2011073304A1 (en) 2011-06-23
CN102639154A (zh) 2012-08-15
EP2512525B1 (en) 2017-06-14
US20120244073A1 (en) 2012-09-27
EP2512525A1 (en) 2012-10-24

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