CN102631525B - Health care product with function of blood pressure reduction and preparation method thereof - Google Patents

Abstract

The invention discloses a health care product with function of blood pressure reduction and a preparation method of the health care product. The health care product consists of radix scrophulariae, apocynum venetum, chrysanthemum, semen cassiae, safflower, loranthus parasiticus, eucommia ulmoides, gynostemma pentaphylla, onion, celery and carrot. The test proves that compared with the existing health care product with function of blood pressure reduction, the health care product is better in blood pressure reducing effect, completely meets the medicinal and edible theory, and is free of side effects, convenient to take and carry, and quick in absorption. Due to the extraction method adopted in the invention, the temperature is not higher than 100 DEG C, the effective ingredients in the medicine are hard to change caused by high temperature, and the drying under reduced pressure is carried out, so that the damage and the loss of the effective ingredients can be effectively avoided, and the drying is continuously carried out due to the mixing of dry extract, so that the drying is thorough.

Description

A kind of health product with antihypertensive function and preparation method thereof

technical field:

The present invention discloses a kind of health product with antihypertensive function and preparation method thereof, belongs to health product preparation method technical field.

Background technology

Hypertension is a kind of long-term progressive chronic disease, with the heart, and brain, kidney and eye wait organ dysfunction or device matter to change, and as do not treated in time, how its complication can make people disable or lethal.When hypertension occurs, do not there is obvious pathological symptom, and make in the rising along with blood pressure unconsciously, heart and brain, the vitals such as kidney have started to be subject to damage in various degree.Hypertension can cause by multiple pathogenic factors and complicated pathogenesis, and patient, because arterial pressure persistence raises, causes whole body arteriolosclerosis, thereby affects the blood supply of histoorgan, causes various serious consequences.Data shows according to statistics, and in 35 to 75 years old crowd of China, hypertensive sickness rate is up to 27 percent, and patient's number has approached 100,015,000, and newly-increased more than 3,000,000 every year, and hypertension has become the first killer of mankind nowadays health.

At present, although the antihypertensive drug kind of clinical use is more, mostly be Western medicine, when single drug, effect is poor, and side effect is many, and along with the hypertensive Chinese medicine for the treatment of is more and more, although side effect is little compared with Western medicine, how undesirable its therapeutic effect is.Therefore research and development exploitation regulates the health product of blood pressure safely and effectively, can benefit hundreds of millions hyperpietic.

Summary of the invention

The invention provides a kind of health product with antihypertensive function, overcome existing health product and regulated the deficiency existing on blood pressure, meet the theory of integration of edible and medicinal herbs completely, have the effect of good auxiliary treatment and prophylaxis of hypertension.

Another object of the present invention has been to provide the preparation method of these health product.

A kind of health product with antihypertensive function disclosed by the invention, is characterized in that there is following raw materials by weight portion than making:

Radix Scrophulariae 1-6 part, Herba Apocyni veneti 1-6 part, Flos Chrysanthemi 3-10 part, Semen Cassiae 1-6 part, Flos Carthami 2-8 part, Herba Taxilli 1-6 part, Cortex Eucommiae 1-5 part, Herb Gynostemmae Pentaphylli 2-6 part, Bulbus Allii Cepae 1-4 part, Herba Apii graveolentis 1-6 part, Radix Dauci Sativae 1-4 part.

The described health product with antihypertensive function, is characterized in that there is following raw materials by weight portion than making:

1 part of Radix Scrophulariae, 1 part of Herba Apocyni veneti, 5 parts of Flos Chrysanthemis, 1 part of Semen Cassiae, 3 parts, Flos Carthami, 1 part of Herba Taxilli, 1 part of the Cortex Eucommiae, 2 parts of Herb Gynostemmae Pentaphylli, 2 parts of Bulbus Allii Cepaes, 4 parts of Herba Apii graveolentis, 1 part, Radix Dauci Sativae.

The preparation method of the health product with antihypertensive function of the present invention, comprises the following steps:

(1) take in proportion Radix Scrophulariae, Semen Cassiae, Herba Taxilli 3 taste crude drug, with 70% ethanol extraction twice, each 1 hour, merge extractive liquid, concentrating under reduced pressure obtained dry extract A;

(2) take in proportion Herba Apocyni veneti, Flos Chrysanthemi, Herb Gynostemmae Pentaphylli, Flos Carthami, the Cortex Eucommiae 5 taste crude drug, use distilled water extraction 2 times, each 1 hour, merge extractive liquid, concentrating under reduced pressure obtained dry extract B;

(3) take in proportion Bulbus Allii Cepae, Herba Apii graveolentis, Radix Dauci Sativae, use distillation extraction 1 time, extracting solution concentrating under reduced pressure is obtained to dry extract C;

(4) after merging dry extract A, dry extract B, dry extract C, at 60-70 DEG C, be dried 2 hours, be ground into 200 order powder, be active component, make according to a conventional method capsule.

Good effect of the present invention is: prove to have the effect of better blood pressure lowering than the health product of existing blood pressure lowering through repetition test, meet integration of edible and medicinal herbs theory completely, have no side effect, take with easy to carry, absorb rapidly.The extracting method temperature adopting in the present invention is not higher than 100 DEG C, and the effective ingredient in medicine is difficult for Yin Gaowen and changes, and adopts drying under reduced pressure simultaneously, avoided the failure loss of effective ingredient, mix simultaneously continue after dry extract dry, thoroughly dry.

The prepared active component of the present invention can be prepared different dosage form, as pill, and tablet, capsule, oral liquid etc., the capsule that the present invention adopts, caters to modern life rhythm, easy to carry, absorbs rapidly.

Detailed description of the invention

embodiment 1

Following raw materials according by weight, Radix Scrophulariae 100g, Herba Apocyni veneti 100g, Flos Chrysanthemi 500g, Semen Cassiae 100g, Flos Carthami 300g, Herba Taxilli 100g, Bulbus Allii Cepae 200g, Herba Apii graveolentis 400g, Radix Dauci Sativae 100g, Cortex Eucommiae 100g, Herb Gynostemmae Pentaphylli 200g.

Preparation method: (1) takes Radix Scrophulariae, Semen Cassiae, Herba Taxilli 3 taste crude drug in proportion, and with 70% ethanol extraction twice, each 1 hour, merge extractive liquid, concentrating under reduced pressure obtained dry extract A;

(2) take in proportion Herba Apocyni veneti, Flos Chrysanthemi, Herb Gynostemmae Pentaphylli, Flos Carthami, the Cortex Eucommiae 5 taste crude drug, use distilled water extraction 2 times, each 1 hour, merge extractive liquid, concentrating under reduced pressure obtained dry extract B;

(3) take in proportion Bulbus Allii Cepae, Herba Apii graveolentis, Radix Dauci Sativae, use distillation extraction 1 time, extracting solution concentrating under reduced pressure is obtained to dry extract C;

After merging dry extract A, dry extract B, dry extract C, at 60-70 DEG C, be dried 2 hours, be ground into 200 order powder, be active component, make according to a conventional method capsule, each capsule is containing active component 700mg.

embodiment 2

Following raw materials according by weight, Radix Scrophulariae 200g, Herba Apocyni veneti 200g, Flos Chrysanthemi 800g, Semen Cassiae 200g, Flos Carthami 500g, Herba Taxilli 200g, Bulbus Allii Cepae 300g, Herba Apii graveolentis 600g, Radix Dauci Sativae 200g, Cortex Eucommiae 300g, Herb Gynostemmae Pentaphylli 400g.

Its preparation method and embodiment 1 are same.

embodiment 3

Following raw materials according by weight, Radix Scrophulariae 300g, Herba Apocyni veneti 300g, Flos Chrysanthemi 10000g, Semen Cassiae 300g, Flos Carthami 800g, Herba Taxilli 400g, Bulbus Allii Cepae 400g, Herba Apii graveolentis 600g, Radix Dauci Sativae 300g, Cortex Eucommiae 400g, Herb Gynostemmae Pentaphylli 600g.

Its preparation method is with embodiment 1.

The present invention is raw materials used is the allowance of Ministry of Public Health, national Bureau of Drugs Supervision files specify for the raw material of health product.

in order further to explain the blood pressure lowering effect of health product of the present invention, carry out following laboratory observation:

Experimental principle gives tested material (health product that embodiment 1 ~ 3 makes) to the hypertension animal model that method causes by experiment, observes the impact of the index such as blood pressure, heart rate of tested material on hypertension animal model, determines the hypotensive activity of tested material.

Laboratory animal Hypertensive Rats (SHR), 8 ~ 10 week age, body weight 160 ~ 200g, male and female are double purchases 150,10 of each dosage groups.

Dosage grouping and given the test agent give time experiment and establish embodiment 1, embodiment 2,3 three dosage groups of embodiment and 1 blank group, tested material is with adult's recommended amounts oral 700mg/d every day, by adult 60kg weighing machine, being 5 times of 12mg/ (kg body weight) is embodiment 1 wherein, 10 times is that 2,15 times of embodiment are embodiment 3.Matched group adopts blank.Tested material gives time totally 4 weeks 30d.

Result is as shown in table 1.

Conclusion: per os gives this health care position three weeks of SHR rat various dose, and compared with hypertension model matched group, tested material can reduce rat blood pressure (P < 0.05) in high dose group.Per os gives the antihypertensive function health product examination thing 4th week of SHR rat various dose, and compared with blank group, tested material can reduce rat blood pressure (P < 0.05) in embodiment group.Result shows, experimental group animal blood pressure is starkly lower than matched group, and on experimental group animal heart rate and intact animal's blood pressure and heart rate without impact, determine the antihypertensive function results of animal positive of the present invention.

Claims (3)

1. there are health product for antihypertensive function, it is characterized in that by following raw materials by weight portion than making:

Radix Scrophulariae 1-6 part, Herba Apocyni veneti 1-6 part, Flos Chrysanthemi 3-10 part, Semen Cassiae 1-6 part, Flos Carthami 2-8 part, Herba Taxilli 1-6 part, Cortex Eucommiae 1-5 part, Herb Gynostemmae Pentaphylli 2-6 part, Bulbus Allii Cepae 1-4 part, Herba Apii graveolentis 1-6 part, Radix Dauci Sativae 1-4 part.

2. there are according to claim 1 the health product of antihypertensive function, it is characterized in that by following raw materials by weight portion than making:

1 part of Radix Scrophulariae, 1 part of Herba Apocyni veneti, 5 parts of Flos Chrysanthemis, 1 part of Semen Cassiae, 3 parts, Flos Carthami, 1 part of Herba Taxilli, 1 part of the Cortex Eucommiae, 2 parts of Herb Gynostemmae Pentaphylli, 2 parts of Bulbus Allii Cepaes, 4 parts of Herba Apii graveolentis, 1 part, Radix Dauci Sativae.

3. the method described in preparation claim 1 or 2 with the health product of antihypertensive function, comprises the following steps:

(1) take in proportion Radix Scrophulariae, Semen Cassiae, Herba Taxilli 3 taste crude drug, with 70% ethanol extraction twice, each 1 hour, merge extractive liquid, concentrating under reduced pressure obtained dry extract A;

(2) take in proportion Herba Apocyni veneti, Flos Chrysanthemi, Herb Gynostemmae Pentaphylli, Flos Carthami, the Cortex Eucommiae 5 taste crude drug, use distilled water extraction 2 times, each 1 hour, merge extractive liquid, concentrating under reduced pressure obtained dry extract B;

(3) take in proportion Bulbus Allii Cepae, Herba Apii graveolentis, Radix Dauci Sativae, use distillation extraction 1 time, extracting solution concentrating under reduced pressure is obtained to dry extract C;

(4) after merging dry extract A, dry extract B, dry extract C, at 60-70 DEG C, be dried 2 hours, be ground into 200 order powder, be active component, make according to a conventional method capsule.