CN102626498B - 治疗慢性胰腺炎的前苓赤金汤 - Google Patents
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Abstract
本发明涉及中药配方领域，具体地说是一种治疗慢性胰腺炎的前苓赤金汤，其技术特征是，原料组成的重量百分比为：车前子6～9％，猪苓4～7％，茯苓6～9％，赤芍4～7％，海金沙6～9％，泽泻3～5％，猫爪草10～13％，猪胆粉0.1～0.2％，白茅根10～13％，延胡索3～6％，苍术3～5％，白术2～5％，栀子3～6％，佛手3～6％，青皮4～6％，川楝子2～5％，三棱2～4％，甘草2～4％，将车前子、猪苓、茯苓、赤芍、海金沙、泽泻、猫爪草、白茅根、延胡索、苍术、白术、栀子、佛手、青皮、川楝子、三棱、甘草用水浸泡，煎熬后去渣得滤液，再将猪胆粉加入滤液中即制得前苓赤金汤。本发明成本低，治疗慢性胰腺炎疗效高，无毒副作用。
Description
技术领域
本发明涉及一种中成药制剂，具体地说是一种治疗慢性胰腺炎的前苓赤金汤。
背景技术
众所周知，慢性胰腺炎是指由于各种不同原因所致的胰腺局部、节段性或弥漫性的慢性进展性炎症，导致胰腺组织和胰腺功能不可逆的损害，临床表现为反复发作性或持续性腹痛、腹泻或脂肪泄、消瘦、黄疸、腹部包块和糖尿病等。慢性胰腺炎无规律性分布于世界各地区，不同地区的发病率相差较大。我国尚无慢性胰腺炎的流行病学调查资料。我国的发病率虽低于西方国家，但呈上升趋势，北京协和医院住院患者中慢性胰腺炎所占的百分率显示，近十年内，住院患者患病率较20世纪50-70年代增加近十倍。我国发病率上升为近年酒精因素上升为主要因素之一，而胆道疾病的长期存在仍为主要危险因素。临床表现为无症状期与症状轻重不等的发作期交替出现，也可无明显症状而发展为胰腺功能不全的表现。典型病例可出现腹痛、胰腺钙化、胰腺假性囊肿、脂肪泄及糖尿病。临床治疗非手术疗法主要为对症处理，缓解症状，不易根治，对病人身心造成极大的伤害。
发明内容
本发明的目的就是为了克服上述现有的技术不足，提供一种治疗慢性胰腺炎的前苓赤金汤，成本低，治疗慢性胰腺炎疗效高，无毒副作用，具有活血化瘀、理气止痛、疏肝利胆、健脾化积、清热利湿、通里攻下，调肠气机等功效，既适用于慢性胰腺炎，对急性胰腺炎也有效。
本发明解决上述技术问题采用的技术方案是：一种治疗慢性胰腺炎的前苓赤金汤，其技术特征是，原料组成的重量百分比为：车前子6～9％，猪苓4～7％，茯苓6～9％，赤芍4～7％，海金沙6～9％，泽泻3～5％，猫爪草10～13％，猪胆粉0.1～0.2％，白茅根10～13％，延胡索3～6％，苍术3～5％，白术2～5％，栀子3～6％，佛手3～6％，青皮4～6％，川楝子2～5％，三棱2～4％，甘草2～4％，将车前子、猪苓、茯苓、赤芍、海金沙、泽泻、猫爪草、白茅根、延胡索、苍术、白术、栀子、佛手、青皮、川楝子、三棱、甘草用水浸泡，煎熬后去渣得滤液，再将猪胆粉加入滤液中即制得前苓赤金汤。
本发明的有益效果是，成本低，治疗慢性胰腺炎疗效高，无毒副作用，具有活血化瘀、理气止痛、疏肝利胆、健脾化积、清热利湿、通里攻下，调肠气机等功效，既适用于慢性胰腺炎，对急性胰腺炎也有效。
具体实施方式
下面结合实施例对本发明作进一步的描述：
实施例1：
采用车前子、猪苓、茯苓、赤芍、海金沙、泽泻、猫爪草、猪胆粉、白茅根、延胡索、苍术、白术、栀子、佛手、青皮、川楝子、三棱、甘草为原料制备而成。其组分(重量％)每副为车前子8.3、猪苓6.2、茯苓8.1、赤芍6.1、海金沙8.1、泽泻4.6、猫爪草10.8、猪胆粉0.2、白茅根11.3、延胡索4.4、苍术4.6、白术3.9、栀子4.4、佛手4.9、青皮4.3、川楝子3.9、三棱3.1、甘草2.8。取上述18味中草药原料，总重量为201.6克。先将猪胆粉包后单放。余17味中草药加水1100～1300ml，浸泡2～3小时，然后用武火煮沸，文火煎熬60～70分钟，去渣得滤液200ml左右，药渣再加水300～400ml，煎熬30分钟左右，去渣得滤液100ml左右，共得300ml左右药汁，装入无菌玻璃瓶内，再将单包单放的猪胆粉倒入瓶内摇匀，密封瓶盖备用，即制得“前苓赤金汤”。每日1剂分2次口服，每次空腹服150ml左右。一个月为一疗程。注意病人饮食指导，戒酒及避免暴饮暴食。
本发明主药车前子药理作用有利尿作用，并能增加尿素、氯化钠及尿酸的排泄，能使气管及支气管分泌物增强，呼吸运动加深变慢，而有祛痰止咳功效。其性味甘、寒，归肝、肾、肺、小肠经。具有清热利尿、祛痰、凉血、解毒功效，用于水肿尿少，热淋涩痛，暑湿泻痢，痰热咳嗽，吐血衄血，痈肿疮毒。猪苓性味甘、淡、平，归肾、膀胱经。具有利水渗湿功效，用于小便不利，水肿，泄泻，淋浊，带下。茯苓性味甘、淡、平，归心、肺、脾、肾经。具有利水渗湿，健脾宁心功效，用于水肿尿少，痰饮眩悸，脾虚食少，便溏泄泻，心神不宁，惊悸失眠。赤芍性味苦、微寒，归肝经。具有清热凉血，散瘀止痛功效，用于温毒发斑，吐血衄血，目赤肿痛，肝郁胁痛，经闭痛经，跌扑损伤，痈肿疮疡。海金沙性味甘、咸、寒，归膀胱、小肠经。具有湿热利湿，通淋止痛功效，用于热淋，砂淋，石淋，血淋，膏淋，尿道涩痛。泽泻性味甘、寒，归肾、膀胱经。具有利小便，清湿热功效，用于小便不利，水肿胀满，泄泻尿少，痰饮眩晕，热淋涩痛，高血脂。猫爪草性味甘、辛、温，归肝、肺经。具有散结、消肿功效，用于瘰疬未溃，淋巴结结核。猪胆粉性味苦、寒，归肝、胆、肺、大肠经。具有清热，润燥，解毒，止咳，平喘功效，用于热病烦渴，目赤，喉痹，黄疸，百日咳，哮喘，泄泻，痢疾等。白茅根性味甘、寒，归肺、胃、膀胱经。具有凉血止血，清热利尿功效，用于血热吐血，衄血，尿血，热病烦渴，黄疸，水肿，热淋涩痛等。延胡索性味辛、苦、温，归肝、脾经，具有活血、利气，止痛功效，用于胸胁，脘腹疼痛，经闭痛经，产后瘀阻，跌扑肿痛。苍术性味辛、苦、温，归脾、胃、肝经。具有燥湿健脾，祛风散寒，明目功效，用于脘腹胀满，泄泻，水肿，脚气痿蹙，风湿痹痛，风寒感冒，夜盲。白术性味苦、甘、温，归脾、胃经。具有健脾益气，燥湿利水，止汗，安胎功效，用于脾虚食少，腹胀泄泻，痰饮眩悸，水肿，自汗，胎动不安。栀子性味苦、寒，归心、肺、三焦经。具有泻火除烦，清热利尿，凉血解毒功效，用于热病心烦，黄疸尿赤，血淋涩痛，血热吐衄，目赤肿痛，火毒疮疡。佛手性味辛、苦、酸、温，归肝、脾、肺经。具有疏肝理气，和胃止痛功效，用于肝胃气滞，胸胁胀痛，胃脘痞满，食少呕吐。青皮性味苦、辛、温，归肝、胆、胃经。具有疏肝破气，消积化滞功效，用于胸胁胀满，疝气，乳核，乳痈，食积腹痛。川楝子性味苦、寒，有小毒，归肝、小肠、膀胱经。具有疏肝行气止痛，驱虫功效，用于胸胁脘腹胀痛，疝痛，虫积腹痛。三棱性味辛、苦、平，归肝、脾经。具有破血行气，消积止痛功效，用于癥瘕痞块，瘀血经闭，食积胀痛。甘草性味甘、平，归心、肺、脾、胃经。具有补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药功效，用于脾胃虚弱，倦怠无力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。18种中草药巧妙组方，药物相互协调作用，共奏慢性胰腺炎之功效。
本发明各原料还可按下表所列比例(重量百分比)混合的实施例来实现，其煎熬程序、口服方法与实施例1相同，其含量如下表所示。
下面结合我院，即山东省威海市文登中心医院进行的临床试验对本发明作进一步详细地描述：
1、病例选择：所选病例为临床诊断为慢性胰腺炎患者63例，其诊断符合陆再英、钟南山主编的《内科学》第7版诊断标准，其中男46例，女17例；年龄29～66岁，平均45.8岁；病程1～3年，排除重症病情凶险恶化及癌变患者。
2、诊断标准：中医诊断标准参照标准国家中医药管理局发布的《中医病证诊断疗效标准》。
3、治疗方法：每日1剂分2次口服，每次空腹服150ml左右药汁，一个月为一疗程。注意病人饮食指导，戒酒及避免暴饮暴食。
4、疗效判断：显效：患者口服“前苓赤金汤”一个疗程后，患者腹痛，腹胀，腹肌紧张，恶心呕吐与发热等临床症状体征均消失；实验室检查80分钟内胰液分泌＞2ml/kg，碳酸氢钠浓度＞90mmol/L；B超或CT检查胰腺大小形态恢复正常。有效：患者口服“前苓赤金汤”一个疗程后，患者腹痛，腹胀，腹肌紧张，恶心呕吐与发热等临床症状体征明显减轻，偶有腹痛；实验室检查80分钟内胰液分泌等于2ml/kg，碳酸氢钠浓度等于90mmol/L；B
5、超或CT检查胰腺大小形态明显恢复。无效：患者口服“前苓赤金汤”一个疗程后，患者腹痛，腹胀，腹肌紧张，恶心呕吐与发热等临床症状体征无改变；实验室检查80分钟内胰液分泌＜2ml/kg，碳酸氢钠浓度＜90mmol/L。
治疗效果：使用本发明63例慢性胰腺炎患者治疗一个疗程后，应用疗效评价标准进行治疗效果评价；显效29例，有效26例，无效8例，总有效率为87.3％。显效加有效为总有效率。
Claims (1)
1.一种治疗慢性胰腺炎的前苓赤金汤，其技术特征是：原料组成的重量百分比为，车前子6～9％，猪苓4～7％，茯苓6～9％，赤芍4～7％，海金沙6～9％，泽泻3～5％，猫爪草10～13％，猪胆粉0.1～0.2％，白茅根10～13％，延胡索3～6％，苍术3～5％，白术2～5％，栀子3～6％，佛手3～6％，青皮4～6％，川楝子2～5％，三棱2～4％，甘草2～4％，将车前子、猪苓、茯苓、赤芍、海金沙、泽泻、猫爪草、白茅根、延胡索、苍术、白术、栀子、佛手、青皮、川楝子、三棱、甘草用水浸泡，煎熬后去渣得滤液，再将猪胆粉加入滤液中即制得前苓赤金汤。
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