CN103768451B - 治疗慢性胰腺炎的中药 - Google Patents
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Abstract
本发明涉及中药配方领域，具体地说是一种治疗慢性胰腺炎的中药，其特征在于由如下重量百分比的原料药组成，八月札6～9%，半边莲4～7%，元胡6～9%，薏苡仁4～7%，龙胆草6～9%，苦楝皮3～5%，瓜蒌10～13%，王不留行0.1～0.2%，白芍10～13%，紫花地丁3～6%，芦根3～5%，泽兰叶2～5%，川椒3～6%，茵陈3～6%，黄芩4～6%，白毛藤2～5%，白屈菜2～4%，厚朴2～4%，将上述原料药用水浸泡，煎熬后去渣得滤液。本发明成本低，治疗慢性胰腺炎疗效高，无毒副作用。
Description
技术领域
本发明涉及一种中成药制剂，具体地说是一种治疗慢性胰腺炎的中药。
背景技术
众所周知，慢性胰腺炎是指由于各种不同原因所致的胰腺局部、节段性或弥漫性的慢性进展性炎症，导致胰腺组织和胰腺功能不可逆的损害，临床表现为反复发作性或持续性腹痛、腹泻或脂肪泄、消瘦、黄疸、腹部包块和糖尿病等。慢性胰腺炎无规律性分布于世界各地区，不同地区的发病率相差较大。我国尚无慢性胰腺炎的流行病学调查资料。我国的发病率虽低于西方国家，但呈上升趋势，北京协和医院住院患者中慢性胰腺炎所占的百分率显示，近十年内，住院患者患病率较20世纪50-70年代增加近十倍。我国发病率上升为近年酒精因素上升为主要因素之一，而胆道疾病的长期存在仍为主要危险因素。临床表现为无症状期与症状轻重不等的发作期交替出现，也可无明显症状而发展为胰腺功能不全的表现。典型病例可出现腹痛、胰腺钙化、胰腺假性囊肿、脂肪泄及糖尿病。临床治疗非手术疗法主要为对症处理，缓解症状，不易根治，对病人身心造成极大的伤害。
发明内容
本发明的目的就是为了克服上述现有的技术不足，提供一种治疗慢性胰腺炎的中药，成本低，治疗慢性胰腺炎疗效高，无毒副作用，具有活血化瘀、理气止痛、疏肝利胆、健脾化积、清热利湿、通里攻下，调肠气机等功效，既适用于慢性胰腺炎，对急性胰腺炎也有效。
本发明解决上述技术问题采用的技术方案是：一种治疗慢性胰腺炎的中药，其特征在于由如下重量百分比的原料药组成，八月札6～9%，半边莲4～7%，元胡6～9%，薏苡仁4～7%，龙胆草6～9%，苦楝皮3～5%，瓜蒌10～13%，王不留行0.1～0.2%，白芍10～13%，紫花地丁3～6%，芦根3～5%，泽兰叶2～5%，川椒3～6%，茵陈3～6%，黄芩4～6%，白毛藤2～5%，白屈菜2～4%，厚朴2～4%，将上述原料药用水浸泡，煎熬后去渣得滤液。
本发明的有益效果是，成本低，治疗慢性胰腺炎疗效高，无毒副作用，具有活血化瘀、理气止痛、疏肝利胆、健脾化积、清热利湿、通里攻下，调肠气机等功效，既适用于慢性胰腺炎，对急性胰腺炎也有效。
具体实施方式
下面结合实施例对本发明作进一步的描述：
实施例1：
采用八月札、半边莲、元胡、薏苡仁、龙胆草、苦楝皮、瓜蒌、王不留行、白芍、紫花地丁、芦根、泽兰叶、川椒、茵陈、黄芩、白毛藤、白屈菜、厚朴为原料药制备而成。其组分（重量%）每副为八月札8.3、半边莲6.2、元胡8.1、薏苡仁6.1、龙胆草8.1、苦楝皮4.6、瓜蒌10.8、王不留行0.2、白芍11.3、紫花地丁4.4、芦根4.6、泽兰叶3.9、川椒4.4、茵陈4.9、黄芩4.3、白毛藤3.9、白屈菜3.1、厚朴2.8。取上述18味中草药原料，总重量为202克，加水1100～1300ml，浸泡2～3小时，然后用武火煮沸，文火煎熬60～70分钟，去渣得滤液200ml左右，药渣再加水300～400ml，煎熬30分钟左右，去渣得滤液100ml左右，共得300ml左右药汁，装入无菌玻璃瓶内，密封瓶盖备用。每日1剂分2次口服，每次空腹服150ml左右。一个月为一疗程。注意病人饮食指导，戒酒及避免暴饮暴食。
本发明八月札舒肝理气，活血止痛，除烦利尿。治肝胃气痛，胃热食呆，烦渴；半边莲利水，消肿，解毒，治黄疸，水肿，臌胀，泄泻，痢疾，蛇伤，疔疮，肿毒，湿疹，癣疾，跌打扭伤肿痛；元胡性温、味辛、苦。入心、肝、脾经，有活血、行气、止痛之功效；薏苡仁利水渗湿最在行，可以去湿除风、清热排脓、除痹止痛，对小便不利、水肿、脚气和风湿疼痛等效果显著；龙胆草具有清热、泻肝、定惊之功效；苦楝皮有清热，燥湿，杀虫的功效，体弱及肝肾功能障碍；瓜蒌清热涤痰，宽胸散结，润燥滑肠。用于肺热咳嗽，痰浊黄稠，胸痹心痛，结胸痞满，乳痈，肺痈，肠痈肿痛，大便秘结；王不留行味苦，性平。归肝，胃经。有活血通经，下乳消痈，利尿通淋的功效。用于血瘀经闭，痛经，难产，产后乳汁不下，乳痈肿痛，热淋，血淋，石淋；白芍养血柔肝，缓中止痛，敛阴收汗。治胸腹胁肋疼痛，泻痢腹痛，自汗盗汗，阴虚发热，月经不调，崩漏，带下；紫花地丁味苦、微辛，性寒，归心、肝经，气微散泄，具有清热解毒，凉血消肿的功效；芦根清热生津、除烦、止呕、利尿的功效，主治热病烦渴、胃热呕吐、肺热咳嗽、肺痈吐脓、热淋涩痛；泽兰叶主要作用是活血化瘀，行水消肿。用于月经不调、经闭、痛经、产后瘀血腹痛、水肿等功效；川椒健胃，温中散寒，除湿止痛，杀虫解毒，止痒解腥之功效，主要治疗呕吐，风寒湿痹，齿痛等；茵陈清热利湿，退黄。主治:黄疸，小便不利，湿疮瘙痒等。有利胆，保护肝功能，解热，抗炎，降血脂，降压；黄芩有清热燥湿，凉血安胎，解毒功效。主治温热病、上呼吸道感染、肺热咳嗽、湿热黄胆、肺炎、痢疾、咳血、目赤、胎动不安、高血压、痈肿疖疮等症；白毛藤清热，利湿，祛风，解毒。治疟疾，黄疸，水肿，淋病，风湿关节痛，丹毒，疔疮；白屈菜镇痛，止咳，平喘，消肿。用于胃痛、慢性支气管炎、百日咳；厚朴温中，下气，燥湿，消痰。治胸腹痞满胀痛，反胃，呕吐，宿食不消，痰饮喘咳，寒湿泻痢。18种中草药巧妙组方，药物相互协调作用，共奏慢性胰腺炎之功效。
本发明各原料还可按下表所列比例（重量百分比）混合的实施例来实现，其煎熬程序、口服方法与实施例1相同，其含量如下表所示。
| 实施例 | 八月札 | 半边莲 | 元胡 | 薏苡仁 | 龙胆草 | 苦楝皮 | 瓜蒌 | 王不留行 | 白芍 | 紫花地丁 | 芦根 | 泽兰叶 | 川椒 | 茵陈 | 黄芩 | 白毛藤 | 白屈菜 | 厚朴 |
| 二 | 6 | 7 | 9 | 7 | 7.8 | 5 | 10 | 0.2 | 10 | 6 | 3 | 5 | 3 | 6 | 4 | 5 | 2 | 4 |
| 三 | 9 | 6.9 | 9 | 4 | 9 | 3 | 13 | 0.1 | 13 | 3 | 5 | 2 | 6 | 3 | 6 | 2 | 4 | 2 |
| 四 | 9 | 4 | 6 | 7 | 6 | 5 | 12 | 0.2 | 11 | 5 | 4 | 5 | 5 | 5 | 6 | 4 | 2.8 | 3 |
| 五 | 8 | 6 | 8 | 6 | 8 | 4 | 13 | 0.2 | 12 | 4 | 4 | 3 | 5.8 | 4 | 5 | 4 | 3 | 2 |
下面结合我院进行的临床试验对本发明作进一步详细地描述：
1、病例选择：所选病例为临床诊断为慢性胰腺炎患者63例，其诊断符合陆再英、钟南山主编的《内科学》第7版诊断标准，其中男46例，女17例；年龄29～66岁，平均45.8岁；病程1～3年，排除重症病情凶险恶化及癌变患者。
2、诊断标准：中医诊断标准参照标准国家中医药管理局发布的《中医病证诊断疗效标准》。
3、治疗方法：每日1剂分2次口服，每次空腹服150ml左右药汁，一个月为一疗程。注意病人饮食指导，戒酒及避免暴饮暴食。
4、疗效判断：显效：患者口服本发明汤剂一个疗程后，患者腹痛，腹胀，腹肌紧张，恶心呕吐与发热等临床症状体征均消失；实验室检查80分钟内胰液分泌＞2ml/kg，碳酸氢钠浓度＞90mmol/L；B超或CT检查胰腺大小形态恢复正常。有效：患者口服一个疗程后，患者腹痛，腹胀，腹肌紧张，恶心呕吐与发热等临床症状体征明显减轻，偶有腹痛；实验室检查80分钟内胰液分泌等于2ml/kg，碳酸氢钠浓度等于90mmol/L；B超或CT检查胰腺大小形态明显恢复。无效：患者口服一个疗程后，患者腹痛，腹胀，腹肌紧张，恶心呕吐与发热等临床症状体征无改变；实验室检查80分钟内胰液分泌＜2ml/kg，碳酸氢钠浓度＜90mmol/L。
治疗效果：使用本发明63例慢性胰腺炎患者治疗一个疗程后，应用疗效评价标准进行治疗效果评价；显效29例，有效26例，无效8例，总有效率为87.3%。显效加有效为总有效率。
Claims (1)
1.一种治疗慢性胰腺炎的中药，其特征在于由如下重量百分比的原料药制成，八月札6～9%，半边莲4～7%，元胡6～9%，薏苡仁4～7%，龙胆草6～9%，苦楝皮3～5%，瓜蒌10～13%，王不留行0.1～0.2%，白芍10～13%，紫花地丁3～6%，芦根3～5%，泽兰叶2～5%，川椒3～6%，茵陈3～6%，黄芩4～6%，白毛藤2～5%，白屈菜2～4%，厚朴2～4%，将上述原料药用水浸泡，煎熬后去渣得滤液。
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