CN102613453B - Marine organism type enteral nutrition preparation for diabetes patients, preparation method of marine organism type enteral nutrition preparation and application - Google Patents
Marine organism type enteral nutrition preparation for diabetes patients, preparation method of marine organism type enteral nutrition preparation and application Download PDFInfo
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Abstract
The invention discloses a marine organism type enteral nutrition preparation for diabetes patients, a preparation method of the marine organism type enteral nutrition preparation and application. The nutrition preparation includes, by weight, from 3 to 15 parts of algal polysaccharides, from 1 to 5 parts of marine edible animal protein peptide powder, from 3 to 5 parts of microalgae oil, from 0.3 to 2 parts of spirulina powder, from0.1 to 1 part of taurine, from 40 to 45 parts of balsam pear polysaccharide or pumpkin polysaccharide, from 10 to 15 parts of soybean protein isolate powder, from 7 to 10 parts of medium chain triglyceride, from 3 to 8 parts of konjac dietary fibers, from 1 to 5 parts of fruit and vegetable powder, from 0.1 to 0.5 part of wheat bran, from 0.1 to 0.5 part of alpha-lipoic acid and a trace of trace element additives. Marine active functional matters with unique pharmacologic bioactivity are reasonably compounded according to needs of nutrition and metabolism of the diabetes patients, and the personal enteral nutrition preparation for the diabetes patients is developed, provides balanced nutrition for the diabetes patients and former diabetes patients, effectively relieves malnutrition, prevents diabetes, assists in regulating blood sugar level, can effectively prevent diabetes complications, and is favorable for increasing the quality of life of the patients and promoting rehabilitation.
Description
Technical field:
The present invention relates to a kind of enteral nutrition preparation and its production and use, what relate to specifically that a kind of diabetic is suitable for contains marine organisms type enteral nutrition preparation of various active material and its production and use.
Background technology:
Diabetes have become a kind of frequently-occurring disease, no matter in developed country or developing country, all or become the third-largest severe chronic NCD after tumour, angiocardiopathy, be called as " not dead cancer ", become the killer who threatens the 21 century human health.According to the WHO statistics, reach 2.16 hundred million to global diabetic in 2010, estimated to reach 300,000,000 by 2025.The a large amount of new patients of diabetes will occur in developing countries such as China, India and Africa.In five populous nations, the incidence of disease of China is only second to India, surpasses 4,000 ten thousand, occupies the whole world the second, and with annual more than 100 ten thousand newly-increased case cumulative year after year, expects 2025, will reach 5,900 ten thousand, but diagnosis has only 35%～40%.In addition, population at risk's enormous amount of diabetes has 4000 all ages to thank syndrome patient and 6,000 ten thousand populations of being obese and may become the diabetic in the future approximately.
Diabetes are all influential to whole enteron aisle, in the clinical investigation of diabetes, have 76% patient to be reflected into rare a kind of gastrointestinal symptom approximately, may cause malnutrition thus and become thin and further infringement digestion, absorption function, cause organism metabolic disorder.Simultaneously, long-term hyperglycemia can be unfavorable for body fluid discrepancy amount balance and damage immunologic function, causes the appearance of complication such as the reduction of patient's immunity, diabetic nephropathy, atherosclerotic, diabetic cataract.Therefore, give the effective EA of diabetic and replenish, energy reverting diabetes patient malnutrition, reduction diabetic complication, auxiliary hyperglycemic improve patient's life and quality of life.Compare with parenteral nutrition, EA is cheap, and the validity height more conforms with psychological need, is easy to keep, and the intestinal mucosa damage that can also avoid the intravenous nutrition infusion to cause simultaneously is the nutritional support approach of diabetic's first-selection.
Commercially available enteral nutrition preparation mainly is to increase dietary fiber at present, the supply that increase indigestibility carbohydrate reduces easy absorbability carbohydrate reaches the reduction postprandial blood sugar and supplies with nutrition, lack the personalized special-purpose enteral nutrition preparation that designs at the diabetic specially, lacking effective nutritional activities in the prescription becomes to assign to alleviate the paathogenic factor of body and regulates organism metabolism, product quality has much room for improvement, to satisfy growing patient's demand.And above-mentioned nutritional preparation raw material is Lu Yuan, easily has potential potential safety hazard.
Summary of the invention:
First purpose of the present invention is to provide a kind of can effectively prevent the marine organisms type enteral nutrition preparation that is used for the diabetic of diabetic complication simultaneously for the diabetic provides effective nutritional support, prevention and auxiliary hyperglycemic.
Marine organisms type enteral nutrition preparation for the diabetic of the present invention; it is characterized in that; according to the mass fraction; comprise: 3～15 parts of algal polysaccharides; 1～5 part in the edible animal protein peptide powder in ocean; 3～5 parts of little algae oil; 0.3～2 part of spirulina powder; 0.1～1 part of taurine, 40～45 parts of bitter melon polysaccharide or squash polyoses, 10～15 parts of soybean isolate protein powders; 7～10 parts of median chain triglyceride oils (MCT); 3～8 parts of Konjak dietary fibers, 1～5 part in fruits and vegetables powder, the micro-additive of 0.1～0.5 part in wheat bran, 0.1～0.5 part of alpha-lipoic acid and trace.
Described algal polysaccharides can be one or more the combination in laminarin, Hijiki polysaccharide, spirulina polysaccharide, laver amylose or the poligeenan, can buy from the market, also can be according to existing method preparation, for example the method for algal polysaccharides is extracted in Chinese patent CN01115981.2 flocculation.
The edible animal protein peptide powder in described ocean can be one or more the combination in shellfish powder, the fish meal, and described shellfish powder can be the one or more combination in ostreae testa pulverata, pearl shell powder, scallop powder, mussel powder, meretrix meretrix powder, paphia undulata powder, a species of small clam living in fresh water powder; Described fish meal can be the one or more combination in the fish meal such as cod powder, anchovy powder, cobio powder, yellow croaker meal, hairtail powder, porgy section powder.These fish meal and Bei Fenke directly buy from the market, also can be prepared by the reference prior art, for example with reference to the preparation method of shellfish enzymolysis powder among the Chinese patent CN200410027304.3.
Described taurine can be bought artificial synthetic or natural extract from the market.
Described its use amount of micro-additive is trace, be preferably the mixture that contains zinc, chromium and selenium compound at least, described zinc compound is zinc gluconate, amino-acid zinc or zinc lactate, the described chromium compound that contains is Cr-enriched yeast, chromium picolinate, nicotinic acid chromium, amino acid chromium or chromium chloride, and described selenium-containing compound is Se-enriched yeast or amino acid selenium.
Described fruits and vegetables powder can be one or more the combination in pumpkin powder, balsam pear powder, carrot meal, lotus root starch, spinach powder, lettuce powder, yam flour, Kiwi berry powder and the apple powder.
Described bitter melon polysaccharide or squash polyoses, soybean isolate protein powder, spirulina powder, little algae oil, median chain triglyceride oil (MCT), Konjak dietary fiber, wheat bran and alpha-lipoic acid all can obtain from the market purchase.
Second purpose of the present invention provides a kind of preparation method of the marine organisms type enteral nutrition preparation for the diabetic, it is characterized in that, each raw material mixed again dry, is crushed to below the particle diameter 125 μ m, obtains through irradiation sterilization.
Described drying, preferred baking temperature is 60～90 ℃.
Described irradiation sterilization, preferred irradiation dose is 6～8kGy, exposure time is 5～10min.
The 3rd purpose of the present invention provides above-mentioned marine organisms type enteral nutrition preparation for the diabetic and provides medicine that nutrition, auxiliary hyperglycemic and/or prevention diabetes and diabetic complication take place or the application on the food being prepared as the diabetic.
The nutritional labeling of the marine organisms type enteral nutrition preparation for the diabetic of the present invention, its analysis result is as shown in table 1.
Table 1: the nutritional labeling that is used for diabetic's marine organisms type enteral nutrition preparation
The prescription of the marine organisms type enteral nutrition preparation for the diabetic of the present invention, algal polysaccharides is a kind of effective biological response modifiers, have significantly hypoglycemic, remove oxygen radical, strengthen BAs such as immunologic function, the destruction of diabetes and diabetes patient's pancreatic and islet tissue damage strengthen diabetic's autoimmunity before prevention or the improvement; Be rich in bioactive ingredients such as steroid saponin, class pancreas islet peptide class and alkaloid in the bitter melon polysaccharide, can bring into play hypoglycemic, anti-oxidant, strengthen effect such as immunity; Squash polyoses energy significant stimulation secretion of insulin reduces the level of fasting blood-glucose, and the promotion mononuclear-macrophage phagocytic function is arranged, and strengthens the effect of human body self-protection; Taurine plays an important role to keeping and regulating all of nearly all normal physiological function in the body, itself has ILA, can be combined by the insulin receptor on the body tissue cell, the effect of performance insulin for reducing blood sugar, simultaneously, have direct protective action for beta Cell of islet, have repair for the β cell that damages, and then the promotion insulin secretion, the sensitiveness of raising insulin action; Be rich in DHA (DHA) in little algae oil, belong to omega-3 unsaturated fatty acid, have the 26S Proteasome Structure and Function of biometric safeguard film, regulate immunity, strengthen the sensitiveness of insulin; Trace element plays an important role to synthetic, secretion, storage, activity and the energy substrate utilization of insulin; zinc (Zn) has the effect of para-insulin sample; active component as superoxide dismutase (SOD); the body protective islet cells is played crucial effects; chromium (III) is the active component of GTF (GTF); can increase beta Cell of islet to the sensitiveness of glucose; selenium has the effect of para-insulin in metabolism, copper can play balanced action to insulin and blood sugar.Konjak dietary fiber can effectively reduce postprandial blood sugar rising amplitude and reduce serum insulin or the raising insulin sensitivity; Alpha-lipoic acid is the strongest a kind of of effect in the natural, and the beta cell that can stop radical damage to cause destroys, the protection islet tissue; Spirulina powder in the prescription contains the albumen more than 60%, 8 kinds of amino acid that human body is necessary, particularly vitamin and content of mineral substances are abundant especially, nutrition is abundant, form general equilibrium, can significantly replenish the various nutrition of needed by human body, regulate organism metabolism, strengthen immunity, by beta carotene, vitamin E and trace elements of selenium are the interior powerful antioxidase GSH-PX of body that the activated centre constitutes, and and Fe, Zn, the superoxide dismutase that Cu constitutes (SOD) is formed superpower anti-oxidant defence line in the body jointly, can effectively eliminate radical pair beta cell destruction and islet tissue damage, the function of the generation of prevention diabetes and recovery islet tissue; The edible animal protein peptide powder in ocean in the prescription, have significant anti-oxidant and strengthen biologically active such as immunity, good protein and the Functional Polypeptides that is rich in the edible animal protein peptide powder in ocean and the soybean isolate protein powder simultaneously can provide more excellent nutritive validity for preceding diabetes and diabetic.
The present invention is directed to diabetic's nutrition and metabolism demand, employing has the bioactive marine active functional mass of unique pharmacology and carries out rationally composite, develop the personalized enteral nutrition preparation of diabetic, for diabetic and preceding diabetic provide balanced nutritious, effectively reverse malnutrition, prevention diabetes and auxiliary hyperglycemic, can effectively prevent simultaneously the generation of diabetic complication, therefore be conducive to improve patients ' life quality and promote diabetic's rehabilitation, have broad application prospects.
The specific embodiment:
Following examples are to further specify of the present invention, rather than limitation of the present invention.
Embodiment 1
Buy laminarin 3g from the market, bitter melon polysaccharide 45g, pearl shell peptide powder 5g; soybean isolate protein powder 10g, little algae oil 5g, MCT 7g; taurine 1g, spirulina powder 2g, Konjak dietary fiber 3g; zinc gluconate 2mg; Cr-enriched yeast 0.2mg, Se-enriched yeast 0.1mg, pumpkin powder 3g; carrot meal 2g, wheat bran 0.1g and alpha-lipoic acid 0.1g.
With the pumpkin powder; carrot meal; spirulina powder; Konjak dietary fiber; wheat bran is pre-mixed evenly; all the other raw material laminarins; bitter melon polysaccharide; pearl shell peptide powder; soybean isolate protein powder; little algae oil; MCT; taurine adds in the mixer successively and mixes according to the equivalent mixing method of progressively increasing; add the pumpkin powder that is pre-mixed then; carrot meal; spirulina powder; Konjak dietary fiber; the wheat bran mixed powder carries out secondary to be mixed; add zinc gluconate at last; Cr-enriched yeast; Se-enriched yeast; alpha-lipoic acid mixes mixing for the third time; incorporation time 10min; then after 60 ℃ of dryings; be crushed to below the particle diameter 125 μ m; pack then, 6kGy irradiation sterilization 10min namely gets the marine organisms type enteral nutrition preparation that is used for the diabetic of present embodiment.
Embodiment 2
Buy laminarin 7g from the market, Hijiki polysaccharide 8g, squash polyoses 40g; cod protein peptide powder 1g, soybean isolate protein powder 15g, little algae oil 3g; MCT 10g, taurine 0.1g, Konjak dietary fiber 8g; spirulina powder 0.3g; amino-acid zinc 8mg, chromium picolinate 30ug, amino acid selenium 0.2mg; balsam pear powder 1g, wheat bran 0.5g and alpha-lipoic acid 0.2g.
With balsam pear powder; spirulina powder; Konjak dietary fiber and wheat bran are pre-mixed evenly; all the other raw material laminarins; Hijiki polysaccharide; squash polyoses; the cod protein peptide powder; soybean isolate protein powder; little algae oil; MCT; taurine adds in the mixer successively and mixes according to the equivalent mixing method of progressively increasing; add the balsam pear powder that is pre-mixed then; spirulina powder; Konjak dietary fiber; the wheat bran mixed powder carries out secondary to be mixed; add amino-acid zinc at last; chromium picolinate; amino acid selenium; alpha-lipoic acid carries out mixing three times; incorporation time 10min; after 70 ℃ of dryings; be crushed to below the particle diameter 125 μ m; pack then, 7kGy irradiation sterilization 8min namely gets the marine organisms type enteral nutrition preparation that is used for the diabetic of present embodiment.
Embodiment 3
Getting the edible oyster that meets the relevant marine product food sanitation standard of China shells behind the internal organ, after adding the water homogenate of 3 times of volumes, ultrasonic 10min adds bromelain and papain enzymolysis again, and enzyme concentration is respectively 1500IU/g and 2500IU/g, at pH6.5, enzymolysis 4h under 55 ℃ of conditions of temperature, reaction finishes back 100 ℃ of enzyme 5min that go out, high speed centrifugation 15min, add 1% active carbon and 1% citric acid deodorizing, debitterize, take off raw meat, decolouring, 90 ℃ of vacuum drying 1h namely get oyster enzymolysis protein peptide powder.It is standby to get 3g.
Buy spirulina polysaccharide 5g from the market, poligeenan 5g, bitter melon polysaccharide 42g, soybean isolate protein powder 13g, little algae oil 4g, MCT 8.5g, taurine 0.7g, Konjak dietary fiber 5g, spirulina powder 1g, zinc lactate 5mg, nicotinic acid chromium 0.2mg, Se-enriched yeast 0.1mg, lotus rhizome powder 1g, yam flour 1g, apple powder 1g, wheat bran 0.3g and alpha-lipoic acid 0.5g; Oyster enzymolysis protein peptide powder 3g.
With the lotus rhizome powder; yam flour; the apple powder; spirulina powder; Konjak dietary fiber; wheat bran is pre-mixed evenly; all the other raw material spirulina polysaccharides; poligeenan; bitter melon polysaccharide; oyster enzymolysis protein peptide powder; soybean isolate protein powder; little algae oil; MCT; taurine adds in the mixer successively and mixes according to the equivalent mixing method of progressively increasing; add the lotus rhizome powder that is pre-mixed then; yam flour; the apple powder; spirulina powder; Konjak dietary fiber; the wheat bran mixed powder carries out secondary to be mixed; add zinc lactate at last; nicotinic acid chromium; Se-enriched yeast; alpha-lipoic acid carries out mixing three times; incorporation time 10min; after 90 ℃ of dryings; be crushed to below the particle diameter 125 μ m; pack then, 8kGy irradiation 5min sterilization namely gets the marine organisms type enteral nutrition preparation that is used for the diabetic of present embodiment.
Embodiment 4
Getting the edible oyster that meets the relevant marine product food sanitation standard of China shells behind the internal organ; place broken 30min on the electric blender; take by weighing the oyster meat after a certain amount of fragmentation; the distilled water that adds 10～15 times of volumes; at 30 ℃ of ultrasonic power 400W; ultrasound-enhanced extraction 15min; filter and the negative pressure concentrated extracting solution, use 6～8 times of acetone to mix with concentrated extracting solution, filter behind the stand at low temperature 2h; after the acetone recovery; under 30 ℃ of conditions, use acid highly acid adion exchanger resin fixed bed, the taurine in the separation and Extraction solution; taurine solution pH is adjusted to taurine pI value (5.16); under 60 ℃ of conditions, concentrate 10 times, add the absolute ethyl alcohol of 5 times of volumes; 2～5 ℃ of following crystallizations, obtain the taurine crystal.It is standby to get 0.8g.
Buy laver amylose 9g from the market, squash polyoses 43g, anchovy protein peptide powder 4g, soybean isolate protein powder 12g, little algae oil 3.5g, MCT 9g, spirulina powder 1.5g, Konjak dietary fiber 5g, amino-acid zinc 5mg, Cr-enriched yeast 0.2mg, Se-enriched yeast 0.2mg, spinach powder 1g, Kiwi berry powder 1.5g, lettuce powder 1g, wheat bran 0.4g and alpha-lipoic acid 0.5g; Taurine crystal 0.8g.
With spinach powder; the Kiwi berry powder; lettuce powder; spirulina powder; Konjak dietary fiber; wheat bran is pre-mixed evenly; all the other raw material laver amyloses; squash polyoses; the anchovy protein peptide powder; soybean isolate protein powder; little algae oil; MCT; taurine adds in the mixer successively and mixes according to the equivalent mixing method of progressively increasing; add the spinach powder that is pre-mixed then; the Kiwi berry powder; lettuce powder; spirulina powder; Konjak dietary fiber; the wheat bran mixed powder carries out secondary to be mixed; add amino-acid zinc at last; Cr-enriched yeast; Se-enriched yeast; alpha-lipoic acid carries out mixing three times; incorporation time 10min; after 80 ℃ of dryings; be crushed to below the particle diameter 125 μ m; pack then, 7kGy irradiation 8min sterilization namely gets the marine organisms type enteral nutrition preparation that is used for the diabetic of present embodiment.
Embodiment 5
Marine organisms type enteral nutrition preparation animal functional experiment.According to Ministry of Public Health's " health food check with assessment technique standard (2003 editions) " and carry out the anti-oxidant experiment of invention product.(the marine organisms type enteral nutrition preparation that described sample obtains for embodiment 3.)
1. make the diabetic mice diabetes model
Get 120 of Kunming kind healthy mices, body weight 20 ± 2g, feed after 7 days, randomly draw 10 as the blank group, all the other 110 as making diabetes model, whole mouse fasting (freely drinking water) were weighed after 24 hours before the modeling, according to the mouse body weight, accurately take by weighing a certain amount of alloxan and be mixed with the injection solution of concentration 20mg/ml with physiological saline, disposable celiac injection 160mg/kg, fasting 4h eyeball is got hematometry FBG after 5 days, is higher than 10mmol/L with blood glucose value and is defined as the hyperglycaemia mouse.
2. operating procedure
From the hyperglycemia model animal, filter out 50 mouse by the blood sugar level grouping of fasting 4h, be divided into model control group, the positive (Metformin hydrochloride) control group, basic, normal, high three the dosage groups of marine organisms type enteral nutrition preparation of the present invention at random, 10 every group.Give basic, normal, high three the dosage groups of marine organisms type enteral nutrition preparation (the marine organisms type enteral nutrition preparation that is used for the diabetic of embodiment 3) respectively and irritate stomach with 0.5g/kg.bw, 1.0g/kg.bw, 2.0g/kg.bw, normal control group and model control group give isopyknic physiological saline and irritate stomach, and positive controls is pressed 0.5g/kg.bw Metformin hydrochloride (filling stomach).
After 15 days, fasting 24h before the experiment weighs, and surveys fasting blood-glucose, superoxide dismutase (SOD), MDA (MDA), blood urea nitrogen biochemical indicators such as (BUN).
3. experimental result
3.1 marine organisms type enteral nutrition preparation is to the influence of diabetic mice body weight
Experimental result is shown in Table 2, and when experiment finished, normal control group mouse body weight increased, and all the other are respectively organized body weight and obviously reduce, and along with the raising of dosage, the amplitude that body weight reduces reduces.Compare with model control group, positive controls and the high dose group forebody-afterbody method of double differences are different significantly, and low dose group and middle dosage group do not have significant change.Show that tentatively what can the reverting diabetes patient negative metabolism of marine organisms type enteral nutrition preparation of the present invention caused becomes thin, and recovers patient's normal type gradually.
Table 2: marine organisms type enteral nutrition preparation of the present invention to the influence of diabetic mice body weight (
N=10)
Compare with the normal control group
△ △P＜0.01; Compare with model control group
▲ ▲P＜0.01; Compare with positive controls
*P＜0.05.
3.2 marine organisms type enteral nutrition preparation is to the influence of diabetic mice blood sugar
Experimental result is as shown in table 3, compares with the normal control group, and alloxan diabetes model mice blood sugar obviously raises, and compares with the normal control group to have highly significant difference (P＜0.01).After 15 days, positive controls, middle dosage group, high dose group and model control group comparing difference highly significant (P＜0.01), low dose group and model control group comparing difference be (P＜0.05) significantly; With positive controls relatively, high dose group no significant difference (P＞0.05).Experiment finishes, and positive controls, basic, normal, high dosage group compare with the model control group, and blood sugar reduces obviously.
Table 3: marine organisms type enteral nutrition preparation of the present invention to the influence of diabetic mice blood sugar (
N=10)
Compare with the normal control group
△ △P＜0.01; Compare with model control group
▲P＜0.05,
▲ ▲P＜0.01; Compare with positive controls
*P＜0.05,
*P＜0.01.
3.3 marine organisms type enteral nutrition preparation is to the influence of area under the diabetic mice blood glucose curve
Experimental result is as shown in table 4, compares with the normal control group: model control group, positive controls, area rising highly significant (P＜0.01) under the basic, normal, high dosage group blood glucose curve; Compare with model control group: area reduces highly significant (P＜0.01) under positive controls, the high dose group blood glucose curve, and middle dosage group reduces obviously (P＜0.05), and low dose group does not have significant change; Compare with positive controls: along with the increase of dosage, difference obviously reduces, low dose group highly significant (P＜0.01), and middle dosage group difference is (P＜0.05) obviously, high dose group no significant difference (P＞0.05).Experiment shows that along with the increase of marine organisms type enteral nutrition preparation dosage, area recovers to normal level gradually under diabetic's blood glucose curve.
Table 4: marine organisms type enteral nutrition preparation of the present invention to area effect under the diabetic mice blood glucose curve (
N=10)
Compare with the normal control group
△ △P＜0.01; Compare with model control group
▲P＜0.05,
▲ ▲P＜0.01; Compare with positive controls
*P＜0.05,
*P＜0.01.
3.4 marine organisms type enteral nutrition preparation is to the influence of the anti-oxidant index of diabetic mice serum
Experimental result is as shown in table 5, by experimental result as can be seen, alloxan causes the active highly significant (P＜0.01) that reduces of diabetic mice SOD, compare with model control group, the active utmost point conspicuousness rising of SOD (P＜0.01) in positive controls, middle dosage group, the high dose group serum, the high dose group activity of SOD in serum is near positive controls, no significant difference (P＞0.05).MDA content in the serum, model control group, positive controls, low dose group, middle dosage group, high dose group and normal control group relatively have highly significant difference (P＜0.01), and it is very obvious to raise; Compare with model control group, MDA content reduces extremely significantly (P＜0.01) in positive controls, low dose group, middle dosage group, the high dose group serum, and middle and high dosage group and positive controls be no significant difference (P＞0.05) relatively.With the normal control group relatively, all the other respectively organize in the serum BUN raise extremely significantly (P＜0.01); With the model control group relatively, positive controls, middle dosage group serum BUN content reduce significantly (P＜0.05), and high dose group reduces extremely significantly (P＜0.01); BUN content is near positive controls in the middle and high dosage group serum, no significant difference (P＞0.05).Experiment tentatively shows: marine organisms type enteral nutrition preparation of the present invention can effectively be removed free radical, suppress lipid peroxidation, improves antioxidant ability of organism, and the protection kidney is regulated immunologic function.
Table 5: marine organisms type enteral nutrition preparation of the present invention to the influence of the anti-oxidant index of diabetic mice serum (
N=10)
Compare with the normal control group
△ △P＜0.01; Compare with model control group
▲P＜0.05,
▲ ▲P＜0.01; Compare with positive controls
*P＜0.05,
*P＜0.01.
Embodiment 6
The clinical observation of marine organisms type enteral nutrition preparation (the marine organisms type enteral nutrition preparation that sample obtains for embodiment 3) that is used for the diabetic is as follows:
Choose diabetic's 26 examples, be divided into control group and test-meal group, every group of 13 examples, each group is male 8 examples respectively, woman's 5 examples, control group and test-meal group are edible placebo (protein powder, Guangdong By-Health Biology Science and Technology Co., Ltd) and marine organisms type enteral nutrition preparation of the present invention respectively.According to the normal nutrition intake of patient, the nutriment edible range is 50～100g every day, gives marine organisms type enteral nutrition preparation of the present invention, twice of every day at normal ingest time, viewing duration is adhered to diet control, and former treatment Rezulin species and dosage are constant.After 30 days, use biometrical method that the result is handled, the results are shown in Table 6.Obtain:
(1) fasting blood-glucose: self compares before and after the test-meal of test-meal group, and fasting blood-glucose descends highly significant difference (P＜0.01); Self compares before and after the control group test-meal, and fasting blood-glucose difference does not have conspicuousness (P＞0.05).Compare between group, fasting blood-glucose no significant difference (P＞0.05) before two groups of test-meals, fasting blood-glucose test-meal group and control group compare after the test-meal, and difference highly significant (P＜0.01) illustrates that marine organisms type enteral nutrition preparation of the present invention has the effect that reduces fasting blood-glucose.
(2) 2h blood sugar after the meal: before and after the test-meal of test-meal group self relatively, 2h blood sugar decline difference highly significant (P＜0.01) after the meal; Self compares before and after the control group test-meal, and 2h blood sugar difference does not have conspicuousness (P＞0.05) after the meal.Compare between group, 2h blood sugar no significant difference (P＞0.05) after the meal before two groups of test-meals, after the test-meal after the meal 2h blood sugar test-meal group and control group relatively have highly significant difference (P＜0.01), illustrating that marine organisms type enteral nutrition preparation of the present invention has reduces the effect of 2h blood sugar after the meal.
(3) glucose in urine: self compares before and after the test-meal of test-meal group, and glucose in urine difference does not have conspicuousness (P＞0.05); Self compares before and after the control group test-meal, and glucose in urine difference does not have conspicuousness (P＞0.05).Between group relatively, glucose in urine no significant differences (P＞0.05) before two groups of test-meals, also no significant difference (P＞0.05) of glucose in urine after the test-meal.
(4) glycosylated hemoglobin: self compares before and after the test-meal of test-meal group, glycosylated hemoglobin decline difference highly significant (P＜0.01); Self compares before and after the control group test-meal, glycosylated hemoglobin no significant difference (P＞0.05).Compare between group, glycosylated hemoglobin no significant difference (P＞0.05) before two groups of test-meals, glycosylated hemoglobin test-meal group and control group are relatively after the test-meal, has highly significant difference (P＜0.01), illustrate that marine organisms type enteral nutrition preparation of the present invention has the effect of the glycosylated hemoglobin of reduction, can auxiliary hyperglycemic.
(5) blood fat: relatively, triglycerides, cholesterol decline have significant difference (P＜0.01) before and after the test-meal group; The two no significant change (P＞0.05) before and after the control group test-meal; Compare between group, there was no significant difference (P＞0.05) between group before the test-meal, triglycerides, cholesterol lower significant difference (P＜0.01) after the test-meal, illustrate that marine organisms type enteral nutrition preparation of the present invention can reduce blood fat, and prevention is because hyperlipemia causes the Secondary cases disease of cardiovascular system.
To sum up show: the marine organisms type enteral nutrition preparation for the diabetic of the present invention has significant auxiliary hyperglycemic effect to diabetes, and clinical symptoms have significant improvement.
Table 6: the variation (mmol/L) of diabetic's clinical indices before and after the test-meal (
N=13)
Compare before and after the test-meal group
△ △P＜0.01; Control group and test-meal group are relatively after the test-meal
▲ ▲P＜0.01.
Claims (10)
1. marine organisms type enteral nutrition preparation that is used for the diabetic; it is characterized in that; according to the mass fraction; comprise: 3～15 parts of algal polysaccharides; 1～5 part in the edible animal protein peptide powder in ocean; 3～5 parts of little algae oil; 0.3～2 part of spirulina powder; 0.1～1 part of taurine, 40～45 parts of bitter melon polysaccharide or squash polyoses, 10～15 parts of soybean isolate protein powders; 7～10 parts of median chain triglyceride oils; 3～8 parts of Konjak dietary fibers, 1～5 part in fruits and vegetables powder, the micro-additive of 0.1～0.5 part in wheat bran, 0.1～0.5 part of alpha-lipoic acid and trace.
2. the marine organisms type enteral nutrition preparation for the diabetic according to claim 1, it is characterized in that described algal polysaccharides is one or more the combination in laminarin, Hijiki polysaccharide, spirulina polysaccharide, laver amylose or the poligeenan.
3. the marine organisms type enteral nutrition preparation for the diabetic according to claim 1 is characterized in that, the edible animal protein peptide powder in described ocean is one or more the combination in shellfish powder, the fish meal.
4. the marine organisms type enteral nutrition preparation for the diabetic according to claim 3, it is characterized in that described shellfish powder is the one or more combination in ostreae testa pulverata, pearl shell powder, scallop powder, mussel powder, meretrix meretrix powder, paphia undulata powder, a species of small clam living in fresh water powder; Described fish meal is the one or more combination in cod powder, anchovy powder, cobio powder, yellow croaker meal, hairtail powder, the porgy section powder.
5. the marine organisms type enteral nutrition preparation for the diabetic according to claim 1 is characterized in that, described micro-additive is for containing the mixture of zinc, chromium and selenium compound at least.
6. the marine organisms type enteral nutrition preparation for the diabetic according to claim 5 is characterized in that described zinc compound is zinc gluconate, amino-acid zinc or zinc lactate; The described chromium compound that contains is Cr-enriched yeast, chromium picolinate, nicotinic acid chromium, amino acid chromium or chromium chloride; Described selenium-containing compound is Se-enriched yeast or amino acid selenium.
7. the marine organisms type enteral nutrition preparation for the diabetic according to claim 1, it is characterized in that described fruits and vegetables powder is one or more the combination in pumpkin powder, balsam pear powder, carrot meal, lotus root starch, spinach powder, lettuce powder, yam flour, Kiwi berry powder and the apple powder.
8. the preparation method of the described marine organisms type enteral nutrition preparation for the diabetic of a claim 1, it is characterized in that, mix again each raw material of claim 1 dry, be crushed to below the particle diameter 125 μ m, obtain marine organisms type enteral nutrition preparation for the diabetic through irradiation sterilization.
9. preparation method according to claim 8 is characterized in that, described drying, and its baking temperature is 60～90 ℃, and described irradiation sterilization, irradiation dose are 6～8kGy, and exposure time is 5～10min.
10. the described marine organisms type enteral nutrition preparation for the diabetic of claim 1 provides medicine that nutrition, auxiliary hyperglycemic and/or prevention diabetes and diabetic complication take place or the application on the food being prepared as the diabetic.
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| CN103284042B (en) * | 2013-06-03 | 2015-09-09 | 吉林大学 | A kind of enteral nutrition preparation containing egg-white protein peptide and preparation method thereof |
| CN103584083B (en) * | 2013-10-15 | 2015-11-11 | 中国科学院南海海洋研究所 | A kind of enteral nutrition preparation for gestational diabetes mellitus women and its production and use |
| CN104187606A (en) * | 2014-07-18 | 2014-12-10 | 吴自伟 | A composite nutritive food and a preparing method thereof |
| CN109567208A (en) * | 2019-01-04 | 2019-04-05 | 广东海洋大学 | Enteral nutrition preparation and its preparation method and application containing marine bioactivity polysaccharide |
| CN113170898A (en) * | 2021-05-06 | 2021-07-27 | 海南蛛王生物科技有限公司 | Health-care composition assisting in reducing blood sugar and blood fat and health-care product thereof |
| CN113647629A (en) * | 2021-07-31 | 2021-11-16 | 华南理工大学 | Seaweed health food base material for resisting diabetes and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101278736A (en) * | 2008-03-28 | 2008-10-08 | 西安力邦制药有限公司 | Balanced enteral total nutrient preparation suitable for nutrition support of Asian population |
| CN101703248A (en) * | 2009-10-23 | 2010-05-12 | 中国科学院南海海洋研究所 | Enteral nutritional preparation containing marine bioactivity polysaccharide as well as preparation method and application thereof |
| CN102077936A (en) * | 2010-09-20 | 2011-06-01 | 王强 | Special sea dietary food for diabetics |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101278736A (en) * | 2008-03-28 | 2008-10-08 | 西安力邦制药有限公司 | Balanced enteral total nutrient preparation suitable for nutrition support of Asian population |
| CN101703248A (en) * | 2009-10-23 | 2010-05-12 | 中国科学院南海海洋研究所 | Enteral nutritional preparation containing marine bioactivity polysaccharide as well as preparation method and application thereof |
| CN102077936A (en) * | 2010-09-20 | 2011-06-01 | 王强 | Special sea dietary food for diabetics |
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Effective date of registration: 20230509 Address after: Room 1004, Unit 2, Building 2, No. 11 Spectral Middle Road, Huangpu District, Guangzhou City, Guangdong Province, 510663 Patentee after: GUANGDONG SHINYEE MARINE BIOLOGY ENGINEERING Corp. Address before: 510301 No. 164 West Xingang Road, Guangdong, Guangzhou Patentee before: SOUTH CHINA SEA INSTITUTE OF OCEANOLOGY, CHINESE ACADEMY OF SCIENCES |