CN102608308A - Test paper with function of desiccant and method for preparing same - Google Patents
Test paper with function of desiccant and method for preparing same Download PDFInfo
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- CN102608308A CN102608308A CN2012100462919A CN201210046291A CN102608308A CN 102608308 A CN102608308 A CN 102608308A CN 2012100462919 A CN2012100462919 A CN 2012100462919A CN 201210046291 A CN201210046291 A CN 201210046291A CN 102608308 A CN102608308 A CN 102608308A
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- drying agent
- reaction film
- sample pad
- test strips
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Abstract
The invention discloses a test paper with the function of a desiccant, which comprises a sample pad, a reaction film, a desiccant tablet and a lower pressing layer. The sample pad is overlapped on one end of the reaction film, and the desiccant tablet is overlapped on the other end; and the lower pressing layer is adhered to the back surface of the desiccant tablet. The invention further discloses a method for preparing the test paper, which comprises the following steps: (1) spraying latex particles onto the sample pad, and drying; (2) spraying a test line capture antibody and a control line capture antibody onto the reaction film, and drying; (3) curing the desiccant tablet, the dried sample pad and the dried reaction film into pieces; and (4) overlapping the sample pad and the desiccant tablet on the tail ends of the reaction film to form the test paper with the function of the desiccant. The desiccant tablet is overlapped on the tail end of the diagnosing test paper and has the function of the traditional diagnosing products like the water absorption pad and the desiccant, thus the raw material cost and the assembly cost are saved.
Description
[technical field]
The present invention relates to a kind of test strips, relate in particular to a kind of test strips that has the drying agent function, be applied to the quick diagnosis technical field.In addition, the invention still further relates to the preparation method of this test strips.
[background technology]
Test strips is widely used in the quick diagnosis technical field, can be used for detecting the analyte in blood, the urine, both can be used for qualitative detection, also can be used for detection by quantitative.But when test strips is exposed in the air, be prone to the moisture in the absorbing air, thereby change its character, influence testing result.Only under dry environment, preserve test strips, just can make its normal performance detection effect in shelf life.The drying that be to keep test strips, in the packing of quick diagnosis product, the drying agent pouch that adds molecular sieve type or silica gel type reaches this effect usually.The end of tradition fast diagnose test paper bar is superimposed with adsorptive pads usually, and much more more the quick diagnosis product under the syphonic effect of the terminal adsorptive pads of test strips, lets and to detect sample through test strips after adding the detection sample like this, makes the detection signal raising.But; There is following shortcoming in the tradition diagnostic products: need this assembly of drying agent to realize the desiccant dehumidification function in the shelf life in packing; On test strips, need to integrate this assembly of adsorptive pads and realize absorbent function, as far as manufacturer, two assemblies had both increased raw materials cost; Increased assembly process again, the cost and risk of production run is improved.
[summary of the invention]
Technical matters to be solved by this invention is to overcome existing defective in the above-mentioned prior art; A kind of test strips that has the drying agent function is provided; It adopts a kind of drying agent chip, has promptly solved an assembly and has realized problems dry and two kinds of functions of suction, has saved raw materials cost and assembly cost.For this reason, the present invention also provides the preparation method of this test strips.
For solving the problems of the technologies described above, the present invention provides a kind of test strips that has the drying agent function, and said test strips comprises sample pad, reaction film, drying agent chip and presses down layer; One end of said reaction film is superimposed with sample pad, and the other end of reaction film is superimposed with drying agent chip; The said reaction film back side that is superimposed with sample pad, drying agent chip is bonded with and presses down layer.
Said drying agent chip can be fiber drying agent sheet, and this drying agent chip has drying and absorbent function.
The no any overlay film in drying agent chip surface at said drying agent chip and the superimposed place of said reaction film.
Except that said drying agent chip and other parts of drying agent chip surface that said reaction film is superimposed sentencing overlay film can be arranged, the effect of this overlay film is that protection drying agent chip surface does not make moist and not contaminated.
The covering material on said drying agent chip surface is PET.
Said sample pad material is spun glass or filter paper or the product F usion of the medical group of General Electric (China) 5.
Said reaction film material is nitrocellulose filter or nylon membrane or the product F usion of the medical group of General Electric (China) 5.
Said sample pad and reaction film can adopt commaterial.For example, said sample pad and reaction film all adopt the product F usion of the medical group of General Electric (China) 5.
The said reaction film front that is superimposed with sample pad, drying agent chip also is bonded with presses layer.
Press layer on said or press down layer to be covered with material, sample pad, reaction film and drying agent chip are bonded together with viscosity with sample pad, reaction film and drying agent chip contact position.
Said laminated or the end length that presses down layer are for can cover the superimposed place of sample pad and reaction film at least; Press down layer to multipotency and all cover sample pad; Last pressure layer will guarantee that sample pad can have part not by its covering; The said laminated or the other end that presses down layer be for covering the superimposed place of reaction film and drying agent chip at least, all covers drying agent chip to multipotency.
Said laminated or press down the layer can form by left and right sides two parts; The starting point of a part is for can cover the superimposed place of sample pad and reaction film at least; One end in contact of this part terminal point and reaction film is bonding; The starting point of another part is that the other end with reaction film is bonding, and terminal point be for covering the superimposed place of reaction film and drying agent chip at least, all covers drying agent chip to multipotency.
In addition, the present invention also provides a kind of above-mentioned preparation method who has the test strips of drying agent function, comprises the steps:
(1) on the sample pad material, spray emulsion particle, spraying finishes material is dried;
(2) spray detection line capture antibody and control line capture antibody on the reaction film material, spraying finishes material is dried;
(3) with drying agent chip, the sample pad material of oven dry and the reaction film of oven dry are cut into tablet;
Sample pad that (4) will cut and reaction film fit together to press down layer, and through pressing down layer that drying agent chip and reaction film end is superimposed, are assembled into the test strips that has the drying agent function.
The present invention compared with prior art has following beneficial effect: the present invention is terminal when superimposed with drying agent chip and diagnosis test paper, can be used as this diagnostic products adsorptive pads and drying agent simultaneously.A kind of like this drying agent chip has been born the adsorptive pads function and the functions/drying of traditional diagnostic products simultaneously, has saved raw materials cost and assembly cost.
[description of drawings]
Fig. 1 is the structural representation that the embodiment of the invention 1 has the test strips of drying agent function;
Fig. 2 is the structural representation that the embodiment of the invention 2 has the test strips of drying agent function;
Fig. 3 is the structural representation that the embodiment of the invention 3 has the test strips of drying agent function;
Fig. 4 is the structural representation that the embodiment of the invention 4 has the test strips of drying agent function;
Fig. 5 is the structural representation that the embodiment of the invention 5 has the test strips of drying agent function;
Fig. 6 is the structural representation that the embodiment of the invention 6 has the test strips of drying agent function;
Fig. 7 is the structural representation that the embodiment of the invention 7 has the test strips of drying agent function;
Fig. 8 is the structural representation that the embodiment of the invention 8 has the test strips of drying agent function;
Description of reference numerals is following among the figure:
The 1st, drying agent chip;
The 2nd, reaction film;
The 3rd, sample pad;
The 4th, the superimposed district of drying agent chip and reaction film;
The 5th, last pressure layer;
The 6th, press down layer.
[embodiment]
Below in conjunction with accompanying drawing and embodiment the present invention is done further detailed explanation:
The drying agent chip that adopts in following examples and the Test Example is a fiber drying agent sheet, available from Shanghai Hengyuan Macromolecular Materials Co., Ltd.; The sample pad and the reaction film that adopt are available from the medical group of General Electric (China).
Referring to Fig. 1-8, spraying concentration is the blue emulsion particle that the pan coating of 4mg/mL has the hCG antibody A on the sample pad material, and diameter of particle is 400nm, and spraying finishes material is placed 50 ℃ of environment oven dry; Spraying concentration is that hCG antibody B and the concentration of 1mg/mL are 1mg/mL control line capture antibody on the reaction film material; HCG antibody B position on the reaction film is the detection line display position; Control line capture antibody spraying position on the reaction film is the control line display position, and spraying finishes material is placed 50 ℃ of environment oven dry; A kind of drying agent chip 1; Be cut into length and be 2 centimetres, wide be 8 millimeters tablet; With the sample pad material be cut into length be 2.5 centimetres, wide be 8 millimeters tablet (referring to sample pad 3 among Fig. 1-8); With reaction film be cut into length be 3.5 centimetres, wide be 8 millimeters tablets (referring to reaction films 2 among Fig. 1-8); The back side of sample pad that cuts 3 and reaction film 2 is fitted together to press down layer 6, and, use again and press layer 5 to be bonded in the front of drying agent chip 1, sample pad 3 and reaction film 2 drying agent chip 1 and reaction film 2 terminal superimposed (can be bonded in drying agent chip 1 and reaction film 2) through pressing down layer 6; Be assembled into the test strips that has the drying agent function, the assembling form can adopt following various ways:
Among the embodiment 1, as shown in Figure 1, press down the whole drying agent chip of layer 6 bonding covering 1, reaction film 2 and sample pad 3, last starting point of pressing layer 5 is for covering the superimposed place of sample pad 3 and reaction film 2, and terminal point is for covering the superimposed place of reaction film 2 and drying agent chip 1.
Among the embodiment 2, as shown in Figure 2, press down the whole drying agent chip of layer 6 bonding covering 1, reaction film 2 and sample pad 3; Last pressure layer 5 is divided into two parts, and a part covers the superimposed place of sample pad 3 and reaction film 2, and another part covers the superimposed place of reaction film 2 and drying agent chip 1.
Among the embodiment 3, as shown in Figure 3, press down the whole drying agent chip of layer 6 bonding covering 1, reaction film 2 and sample pad 3; Last pressure layer 5 is divided into two parts, and a part covers the superimposed place of sample pad 3 and reaction film 2, and the starting point of another part is for covering the superimposed place of reaction film 2 and drying agent chip 1, and terminal point is for all covering drying agent chip 1.
Among the embodiment 4, as shown in Figure 4, press down the whole drying agent chip of layer 6 bonding covering 1, reaction film 2 and sample pad 3; Last starting point of pressing layer 5 is for covering the superimposed place of sample pad 3 and reaction film 2, and terminal point is for all covering drying agent chip 1.
Among the embodiment 5, as shown in Figure 5, press down layer 6 and be divided into two parts, a part, a part covers the superimposed place of sample pad 3 and reaction film 2, and another part covers the superimposed place of reaction film 2 and drying agent chip 1; Last starting point of pressing layer 5 is for covering the superimposed place of sample pad 3 and reaction film 2, and terminal point is for covering the superimposed place of reaction film 2 and drying agent chip 1.
Among the embodiment 6, as shown in Figure 6, press down layer 6 and be divided into two parts, a part all covers sample pad 3 and covers sample pad 3 and the superimposed place of reaction film 2, and another part all covers drying agent chip 1 and covers reaction film 2 and the superimposed place of drying agent chip 1; Last starting point of pressing layer 5 is for covering the superimposed place of sample pad 3 and reaction film 2, and terminal point is for covering the superimposed place of reaction film 2 and drying agent chip 1.
Among the embodiment 7, as shown in Figure 7, press down layer 6 and cover total overall reaction film 2 and cover part sample pad 3 and part drying agent chip 1; Last starting point of pressing layer 5 is for covering the superimposed place of sample pad 3 and reaction film 2, and terminal point is for covering the superimposed place of reaction film 2 and drying agent chip 1.
Among the embodiment 8, need not adopt and press layer, only adopt to press down layer, as shown in Figure 8, press down the whole drying agent chip of layer 6 bonding covering 1, reaction film 2 and sample pad 3.
After being assembled into the test strips that has the drying agent function, in the product storage life, this drying agent chip 1 can play the effect of drying agent, makes the relative humidity in the packing reach 0%RH.When this test strips product is used; Adding concentration is the hCG solution of 25mIU/mL; After 3 minutes, with the signal value of NES Camera readout instrument read test line and control line, the detection line signal value of test strips is 11.71; The signal value of control line is 51.03, and this drying agent chip 1 can play the effect of adsorptive pads.Fig. 1-8 has indicated the relative position of drying agent chip 1 and reaction film 2, and how superimposed indicated both is, after this drying agent chip 1 and reaction film 2 are superimposed, can be used as drying agent and adsorptive pads simultaneously.
The present invention uses a kind of drying agent chip, be cut into behind the suitable dimension and the reaction film end superimposed, be assembled into diagnostic products after, in the product storage life, this drying agent chip can play the effect of the drying agent of desiccant dehumidification.When product was used, this drying agent chip can play the effect of adsorptive pads.
Further beneficial effect of the present invention is set forth below through Test Example:
Test Example
1. in two same diagnostic products packings, the miniature hygrograph that write down the place ambient humidity in per 15 minutes of respectively packing in two packings wherein reinstalls a slice molecular sieve type drying agent (tradition) in a packing; In another packing, reinstall drying agent chip (the present invention), both sealings are placed under the ambient temperature and moisture environment, unpack behind the 24h; Derive the data of TR; Data see the following form 1, and the result shows that the drying agent of molecular sieve type and drying agent chip are done the time spent at the performance drying agent; Can make the relative air humidity in the packing reach 0%RT, both are equal to effect.
Table 1
2. be example with the very early pregnancy detection, spraying concentration is the blue emulsion particle that the pan coating of 4mg/mL has the hCG antibody A on the sample pad material, and diameter of particle is 400nm, and spraying finishes material is placed 50 ℃ of environment oven dry; Spray concentration is that hCG antibody B and the concentration of 1mg/mL are 1mg/mL control line capture antibody on the reaction film material; HCG antibody B position on the reaction film is the detection line display position; Control line capture antibody spraying position on the reaction film is the control line display position, and spraying finishes material is placed 50 ℃ of environment oven dry; A kind of drying agent chip 1; Be cut into length and be 2 centimetres, wide be 8 millimeters tablet; With the sample pad material be cut into length be 2.5 centimetres, wide be 8 millimeters tablet (referring to sample pad among Fig. 1 3); With reaction film be cut into length be 3.5 centimetres, wide be that 8 millimeters tablets are referring to reaction film among Fig. 1 2); Sample pad that cuts 3 and reaction film 2 are fitted together with bottom laminated material 6, and, be assembled into the test strips that has the drying agent function drying agent chip 1 and reaction film 2 terminal superimposed (can through bottom laminated material 6 bonding drying agent chips 1 and reaction films 2).Diagnostic products (test strips of the present invention) is at the performance diagnostic function when detecting, and the hCG solution that adds concentration and be 25mIU/mL is after 3 minutes, with the signal value of NES Camera readout instrument read test line and control line; Discovery with the drying agent chip of test strips of the present invention as adsorptive pads; The average signal value that makes p-wire rises to 11.68 from 10.89, has raise 7.2%, makes the signal value of control line rise to 52.04 from 50.03; Raise 4%; Data see the following form 2, explain when using test strips of the present invention, and this drying agent chip makes effectively during as adsorptive pads and increases through p-wire zone and the regional sample size of control line; Let the antibody capture of p-wire and control line arrive more particulate, thereby played the effect that signal strengthens through this regional band signal.
Table 2
3. this drying agent chip not only makes signal value strengthen at application of sample after 3 minutes; Can also in long-time, keep signal value and not descend, data see the following form 3, behind application of sample 20 minutes; Signal value with NES Camera readout instrument read test line and control line; Signal value with reference to paper slip drops to 7.41, and end still can maintain 11.66 with the superimposed test strips of drying agent chip, than high by 57.35% with reference to the signal value of test strips.
Table 3
The fiber drying agent sheet that the result of above Test Example proves test strips of the present invention both can success as drying agent, again can success as adsorptive pads.
Claims (14)
1. a test strips that has the drying agent function is characterized in that, said test strips comprises sample pad, reaction film, drying agent chip and presses down layer; One end of said reaction film is superimposed with sample pad, and the other end of reaction film is superimposed with drying agent chip; The said reaction film back side that is superimposed with sample pad, drying agent chip is bonded with and presses down layer.
2. the test strips that has the drying agent function according to claim 1 is characterized in that, said drying agent chip is a fiber drying agent sheet, and this drying agent chip has drying and absorbent function.
3. the test strips that has the drying agent function according to claim 1 is characterized in that, the no any overlay film in drying agent chip surface at said drying agent chip and the superimposed place of said reaction film.
4. according to claim 1 or the 3 described test strips that have the drying agent function, it is characterized in that, except that said drying agent chip and other parts of drying agent chip surface that said reaction film is superimposed sentencing overlay film can be arranged.
5. the test strips that has the drying agent function according to claim 4 is characterized in that, the covering material on said drying agent chip surface is PET.
6. the test strips that has the drying agent function according to claim 1 is characterized in that, said sample pad material is spun glass or filter paper or the product F usion of the medical group of General Electric (China) 5.
7. the test strips that has the drying agent function according to claim 1 is characterized in that, said reaction film material is nitrocellulose filter or nylon membrane or the product F usion of the medical group of General Electric (China) 5.
8. according to claim 1 or the 6 or 7 described test strips that have the drying agent function, it is characterized in that said sample pad and reaction film can adopt commaterial.
9. the test strips that has the drying agent function according to claim 8 is characterized in that, said sample pad and reaction film all adopt the product F usion of the medical group of General Electric (China) 5.
10. the test strips that has the drying agent function according to claim 1 is characterized in that, the said reaction film front that is superimposed with sample pad, drying agent chip also is bonded with presses layer.
11. according to claim 1 or the 10 described test strips that have the drying agent function; It is characterized in that; Press layer on said or press down layer to be covered with material, sample pad, reaction film and drying agent chip are bonded together with viscosity with sample pad, reaction film and drying agent chip contact position.
12. according to claim 1 or the 10 described test strips that have the drying agent function; It is characterized in that; Said laminated or the end length that presses down layer press down layer to multipotency and all cover sample pad for covering the superimposed place of sample pad and reaction film at least, and last pressure layer will guarantee that sample pad can have partly not by its covering; The said laminated or the other end that presses down layer be for covering the superimposed place of reaction film and drying agent chip at least, all covers drying agent chip to multipotency.
13. according to claim 1 or the 10 described test strips that have the drying agent function; It is characterized in that, said laminated or press down layer and can form by left and right sides two parts, the starting point of a part is to cover at least the superimposed place of sample pad and reaction film; One end in contact of this part terminal point and reaction film is bonding; The starting point of another part is that the other end with reaction film is bonding, and terminal point be for covering the superimposed place of reaction film and drying agent chip at least, all covers drying agent chip to multipotency.
14. one kind like each described preparation method who has the test strips of drying agent function of claim 1-13, it is characterized in that, comprises the steps:
(1) on the sample pad material, spray emulsion particle, spraying finishes material is dried;
(2) spray detection line capture antibody and control line capture antibody on the reaction film material, spraying finishes material is dried;
(3) with drying agent chip, the sample pad material of oven dry and the reaction film of oven dry are cut into tablet;
Sample pad that (4) will cut and reaction film fit together to press down layer, and through pressing down layer that drying agent chip and reaction film end is superimposed, are assembled into the test strips that has the drying agent function.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100462919A CN102608308A (en) | 2012-02-27 | 2012-02-27 | Test paper with function of desiccant and method for preparing same |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012100462919A CN102608308A (en) | 2012-02-27 | 2012-02-27 | Test paper with function of desiccant and method for preparing same |
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2263074Y (en) * | 1996-07-19 | 1997-09-24 | 桂林市医疗电子仪器厂 | Test paper slip packing barrel with drying agent |
| CN2329621Y (en) * | 1998-06-29 | 1999-07-21 | 姚崇德 | Test paper sealing packing piece |
| EP1019457B1 (en) * | 1998-07-31 | 2006-05-31 | Multisorb Technologies, Inc. | Desiccant deposit |
| EP1885795B1 (en) * | 2005-06-02 | 2008-12-31 | CSP Technologies, Inc. | Desiccant plastic composition for a shaped article |
| CN201819907U (en) * | 2010-04-17 | 2011-05-04 | 北京庄笛浩禾生物医学科技有限公司 | Duplex detection card |
| CN201945590U (en) * | 2010-08-06 | 2011-08-24 | 艾博生物医药(杭州)有限公司 | A detecting device with immune test paper strip |
| CN102253211A (en) * | 2011-06-13 | 2011-11-23 | 清华大学深圳研究生院 | Immune chromatography test paper for detecting clenbuterol hydrochloride and preparation method thereof |
| CN202533435U (en) * | 2012-02-27 | 2012-11-14 | 美艾利尔（上海）诊断产品有限公司 | Test strip with function of desiccating agent |
-
2012
- 2012-02-27 CN CN2012100462919A patent/CN102608308A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2263074Y (en) * | 1996-07-19 | 1997-09-24 | 桂林市医疗电子仪器厂 | Test paper slip packing barrel with drying agent |
| CN2329621Y (en) * | 1998-06-29 | 1999-07-21 | 姚崇德 | Test paper sealing packing piece |
| EP1019457B1 (en) * | 1998-07-31 | 2006-05-31 | Multisorb Technologies, Inc. | Desiccant deposit |
| EP1885795B1 (en) * | 2005-06-02 | 2008-12-31 | CSP Technologies, Inc. | Desiccant plastic composition for a shaped article |
| CN201819907U (en) * | 2010-04-17 | 2011-05-04 | 北京庄笛浩禾生物医学科技有限公司 | Duplex detection card |
| CN201945590U (en) * | 2010-08-06 | 2011-08-24 | 艾博生物医药(杭州)有限公司 | A detecting device with immune test paper strip |
| CN102253211A (en) * | 2011-06-13 | 2011-11-23 | 清华大学深圳研究生院 | Immune chromatography test paper for detecting clenbuterol hydrochloride and preparation method thereof |
| CN202533435U (en) * | 2012-02-27 | 2012-11-14 | 美艾利尔（上海）诊断产品有限公司 | Test strip with function of desiccating agent |
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Application publication date: 20120725 |