CN102600490B - Pressurized hot water sterilization process and equipment pipeline configuration of continuous sterilization system for aerobic microbe fermentation culture medium or fed-batch material - Google Patents
Pressurized hot water sterilization process and equipment pipeline configuration of continuous sterilization system for aerobic microbe fermentation culture medium or fed-batch material Download PDFInfo
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- CN102600490B CN102600490B CN201210009179.8A CN201210009179A CN102600490B CN 102600490 B CN102600490 B CN 102600490B CN 201210009179 A CN201210009179 A CN 201210009179A CN 102600490 B CN102600490 B CN 102600490B
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Abstract
The invention relates to a pressurized hot water sterilization process and equipment pipeline configuration of a continuous sterilization system for aerobic microbe fermentation culture mediums or fed-batch materials. The process comprises the following steps that: 1) a pressurized water sterilization tank is fully filled with water, g air in the tank is exhausted, water in the tank is connected with a heat exchanger A through a continuous sterilization pump and the water is heated; 2) hot water returns back to the pressurized water sterilization tank along a culture medium or fed-batch material inlet pipeline through a maintaining tank before the hot water enters a fermentation tank or a fed-batch tank, and after the designated liquid level is reached, inlet water and outlet water enter a closed circulation mode, the water is continuously and cyclically heated, the temperature of the water in the tank is continuously increased and non-condensable gas is continuously exhausted; and 3) when the temperature of the water reaches 100 DEG C, an exhaust valve is closed and corresponding internal pressure of the water sterilization tank is increased with the increase of the temperature of the water, and when the temperature of the water reaches 125-130 DEG C, the inlet water and the outlet water of the system enter a pressurized closed circulation mode and then water sterilization of the system is conducted immediately. The pressurized hot water sterilization process and the equipment pipeline configuration of the continuous sterilization system for aerobic microbe fermentation culture mediums or fed-batch materials have the advantages that the pressurized sterilizing water production process is stable, continuous and reliable, the safety of the continuous sterilization system for culture mediums or fed-batch materials in the fermentation engineering is improved, the heat loss of the pressurized sterilizing water is fewer and the energy consumption is reduced.
Description
Technical field
The present invention relates to microbe industrial fermentation production field, particularly a kind of for fermentation medium or stream being added to technique (claiming again band setting-out to disappear) and the configuration of equipment pipeline that thing continuous sterilization disinfection system (abbreviation continuous sterilizing system) carries out high-temperature-hot-water sterilization with pressure for aerobic microbiological in commercial production
Background technology
Today in the biotechnology taking fermentation engineering as core content at development, carry out production by microorganism culturing and related to medicine, chemical industry, light industry, the energy, the fields such as environmental protection, along with fermentation engineering trend equipment enlarging, efficient and automatization, production technology operation and equipment Design to scale are had higher requirement, wherein a very important production link is exactly the process that the continuous sterilizing systems such as fermentation medium are carried out disinfection, when particularly making good use of oxygen animalcule and carrying out fermenting and producing, it is the success or failure key of sweat that the continuous sterilizing system that culture medium and stream are added to thing carries out disinfection, if continuous sterilizing system sterilization is not thorough, will cause microbiological contamination during the fermentation, thereby can not ensure the quality of fermented product, even cause sweat failure, cause the huge economic loss of manufacturing enterprise.
In the time that fermentation industry manufacturing enterprise adds thing continuous sterilizing system and carries out disinfection fermentation medium or stream, be generally divided into steam (125 DEG C～130 DEG C) sterilization (being called for short vapour disappears) and high-temperature-hot-water (125 DEG C～130 DEG C) sterilization (abbreviation water disappears) two type systematics according to the state of sterilization thermal medium.
The advantage of vapour sterilizing system technique is that quick heating, time are short, the efficiency of heating surface is high, operation is relatively simple; Shortcoming is the bad control of sterilization temperature, the residual easy fouling of material in e-quipment and pipe, and the effect of impact sterilization, is the factor that causes sweat microbiological contamination.And the advantage of water sterilizing system is that sterilization temperature control is steady; In sterilization, cleaned e-quipment and pipe, bactericidal effect is more safe and reliable; Shortcoming is that current domestic fermenting and producing enterprise is in the time making water sterilizing system technique, because could not effectively solve, energy reclaims and a difficult problem for system balancing, before high-temperature water is got back to water pot, in order to maintain the balance of system, the mode that can only discharge by flash distillation with directly, the high-temperature-hot-water of 125 DEG C～130 DEG C is dropped to below 100 DEG C, therefore need to be constantly heated to 125 DEG C～130 DEG C with again water the is disappeared water of tank of steam, cause energy waste in circulation disinfecting process.
Based on the feature of above-mentioned two kinds of decontamination systems, current domestic fermenting and producing enterprise fermentation medium or stream added to thing continuous sterilizing system carries out the water problem existing in technique that disappears owing to cannot solve, so what most enterprises adopted is all vapour sterilizing system technique, the water sterilizing system with the feature such as safety, steady, easy control but cannot be widely used in fermentation industry, restrict greatly the promotion and application of this technology in fermentation industry.And how in the feature that keeps water sterilizing system, can reduce again energy resource consumption, this is topic before proposing of the present invention.
Summary of the invention
The object of this invention is to provide and a kind of carry out high-temperature-hot-water sterilization process with pressure and the configuration of equipment pipeline for aerobic microbiological fermentation medium or stream are added to thing continuous sterilization virus killing system, this technique except kept completely water sterilizing system safety, reliable, control the feature such as steady, also greatly reduce energy resource consumption, water sterilizing system is used widely at fermentation industry.
For reaching the object of foregoing invention, the present invention by the following technical solutions:
Thisly carry out the high-temperature-hot-water poison with pressure technique that disappears and comprise the following steps for aerobic microbiological fermentation medium or stream being added to thing continuous sterilization disinfection system:
1) water of the tank that disappears with setting-out is filled it up with, meanwhile, air in drain tank, in tank, water, by the water pump access heat exchanger A that disappears, heats water;
2) hot water adds the feeding pipe of thing along culture medium or stream by maintaining tank, returns to the band setting-out tank that disappears before adding tank entering fermentation tank or stream, arrives and specifies after liquid level, Inlet and outlet water enters closed cycle, constantly circulating-heating water, in tank, water temperature constantly raises, and fixed gas is constantly discharged;
3) in the time that water temperature arrives 100 DEG C, close air bleeding valve, along with the rising water of the water temperature corresponding pressure in tank that disappears is also raising, in the time that water temperature reaches 125 DEG C～130 DEG C, the water corresponding pressure in tank that disappears is gauge pressure 0.14～0.18MPa, and system Inlet and outlet water enters closed cycle state with pressure, the water that carries out immediately system disappears, after the water process of disappearing completes, the water tank water outlet that disappears stops, and opens material inlet valve and makes material enter continuous sterilization disinfection system.
Under closed cycle state with pressure, keep by opening or close feed pump the liquid level of setting in tank.
Under closed cycle state with pressure, regulate the vapor flow rate of heat exchanger A according to the water tank leaving water temperature that disappears.
It is 125 DEG C～130 DEG C with the disappear high-temperature water temperature of tank of setting-out, high-temperature water adds the feeding pipe of thing after maintaining tank along culture medium or stream, return to the water tank that disappears before adding tank entering fermentation tank or stream, add before thing connects and disappear at fermentation medium or stream, the pipeline and the equipment that add to fermentation tank or stream from connecting the pump that disappears the inlet valve of tank are carried out disinfection.After having sterilized, close water disappear tank outlet valve and back-water valve (BWV), open material-compound tank outlet valve and fermentation tank or stream and add tank inlet valve, start material to connect and disappear.
A kind of configuration of the equipment pipeline for described high-temperature-hot-water sterilization process with pressure, it comprises: the band setting-out tank that disappears, on tank, establish inlet valve V1, emptying valve V2, flowing water Valve V4, the company that valve V4 the is connected to each continuous sterilizing system pump inlet that disappears, connect disappear pump inlet also with material-compound tank supply pipe on the outlet of valve V3 join, heat exchanger A connects the water pump discharge that disappears by valve V6, another termination heat exchanger A import of valve V6, heat exchanger A outlet connects and maintains tank, the outlet that maintains tank meets heat exchanger B, the outlet of heat exchanger B meets heat exchanger C, heat exchanger C outlet taps into fermentation tank or stream adds tank valve V9, valve V9 epimere is established water discharging valve V10, the valve V10 other end connects the return pipe of back ingredient tank, heat exchanger C outlet also meets valve V11, and the valve V11 other end connects and rewinds the disappear return pipe of tank of setting-out.
Band setting-out disappears on tank and establishes pop off valve.
The described band setting-out tank that disappears is established liquid-level probe.
Described establish the switch valve on temperature probe and exhaustor with the setting-out tank that disappears.
This technique also can be used for many covers fermentation medium continuous sterilizing system to be with respectively the setting-out operation that disappears;
This technique also can be used for a set of fermentation medium continuous sterilizing system and a set of stream and adds thing continuous sterilizing system and be with the setting-out operation that disappears simultaneously;
This technique also can be used for many cover stream and adds thing continuous sterilizing system and be with the setting-out operation that disappears simultaneously.
Advantage of the present invention is: band setting-out disappears production process operative temperature steadily, continuously, reliably, and pipeline is cleaned, and prevents material fouling on equipment tank skin and tube wall, the safety that has improved system, and heat-energy losses is few, reduces energy resource consumption.
Brief description of the drawings
Fig. 1: the equipment pipeline configuration schematic diagram that band setting-out of the present invention disappears
In Fig. 1, V1 is inlet valve, and V2 is drain tap, and V3 is discharge valve, and V4 is flowing water Valve, and V5 is material inlet valve, and V6 is inlet valve, and V7 is steam valve, and V8 is inlet valve, and V9 is material inlet valve, and V10 is water discharging valve, V11 backwater valve.
Detailed description of the invention
A kind of for this with the disappear equipment pipeline configuration of technique of setting-out, it comprises: the band setting-out tank that disappears, the water inlet valve V1 on tank that disappears, this valve connects workshop feed pipe, the water drain tap V2 on tank that disappears, this valve connects emptying pipeline; The water flowing water Valve V4 on tank that disappears, the company that this valve the is connected to each continuous sterilizing system pump inlet that disappears; Connect disappear pump inlet also with material-compound tank supply pipe on the outlet of discharge valve V3 join.
Equipment pipeline configuration also comprises heat exchanger A (intensification), heat exchanger B (preheating), heat exchanger C (cooling) and maintain tank.Heat exchanger A inlet valve V6, this valve one end connects inlet channel, and the other end connects the import of heat exchanger A material channel; Heat exchanger A steam valve V7, this valve one end connects into jet chimney, and the other end connects the import of heat exchanger A steam channel; Heat exchanger B material inlet valve V5, this valve one end connects feed pipe, and the other end connects the import of heat exchanger B material channel; Heat exchanger C inlet valve V8, this valve one end connects cooling water inlet pipe road, and the other end connects the import of heat exchanger C cooling-water duct.The outlet of heat exchanger B meets heat exchanger C, and heat exchanger C outlet taps into fermentation tank or stream adds tank material inlet valve V9, and this valve one end connects charging (water inlet) pipe, and the other end connects fermentation tank or stream adds tank; Valve V9 epimere water discharging valve V10, this valve one end connects charging (water inlet) pipe, and the other end connects the return pipe of back ingredient tank; Backwater valve V11, this valve one end connects charging (water inlet) pipe, and other end connection rewinds the disappear return pipe of tank of setting-out.
In this configuration, heat exchanger A (heating), heat exchanger B (preheating), heat exchanger C (cooling) can adopt spiral-plate heat exchanger.
This is as follows with the disappear concrete operation step of technique of setting-out:
1) open the band setting-out tank inlet valve V1 that disappears, toward the moisturizing in tank that disappears of band setting-out, the tank drain tap 2 that disappears of fetching boiling water, air in drain tank simultaneously;
2) water disappears after tank canful, successively open water disappear tank flowing water Valve 4, connect disappear pump, water intaking valve 6, make the disappear water of tank of water directly enter heat exchanger A by company's pump that disappears, open steam valve 7 simultaneously, make steam enter heat exchanger A, water is heated, open fermentation tank or stream and add tank inlet valve V9 top float water valve V10 and the water tank back-water valve (BWV) V11 that disappears, make hot water maintain tank and heat exchanger B and heat exchanger C by whole, until inlet valve V9 top, it is carried out disinfection, and return to the band setting-out tank that disappears; Now cooling water water intaking valve V8, fermentation tank or the stream of material-compound tank outlet valve V3, heat exchanger B inlet valve V5, heat exchanger C add tank inlet valve V9 and are closed condition;
3) disappear after tank when high-temperature water returns to band setting-out, and the water tank that disappears reaches appointment liquid level, automatically close water intaking valve V1, make system enter closed cycle state;
4) cold water mix that high-temperature water and water disappear in tank can be lowered the temperature, and along with continuous circulating-heating water, water temperature constantly raises in tank, and fixed gas is constantly discharged, and in the time that temperature reaches 100 DEG C of setting, automatically closes air bleeding valve V2; The water water temperature in tank that disappears is greater than after 100 DEG C, along with the rising water of the water temperature corresponding pressure in tank that disappears is also raising, in the time that water temperature reaches 125 DEG C～130 DEG C, with the setting-out corresponding pressure 0.14～0.18MPa (gauge pressure) in tank that disappears, the system Inlet and outlet water of making enters closed cycle state with pressure;
5) connect the pump that disappears and move according to the liquid level of setting in tank, low liquid level turn on pump, high liquid level termination of pumping, ensures liquid level in tank;
6) in the time that heat exchanger A output water temperature reaches 125 DEG C～130 DEG C, start to record circulation time;
7) after the water process of disappearing completes, valve-off V4, the water tank water outlet that disappears stops, and Open valve V3, makes material enter continuous sterilizing system simultaneously; Valve-off V11, valve V10, open valve V9, makes hot water not rewind setting-out and disappear tank and enter in fermentation tank; Valve-off V6 opens valve V5 simultaneously, makes material enter heat exchanger B and carries out preheating; Open valve V8, cooling water enters heat exchanger C, material is carried out cooling, and at this moment material continuous sterilizing system brings into operation, and remaining water in pipeline is pushed up in fermentation tank, starts company that fermentation medium or stream the adds thing process that disappears.
Claims (7)
1. carry out a high-temperature-hot-water sterilization process with pressure for aerobic microbiological fermentation medium or stream are added to thing continuous sterilization disinfection system, it is characterized in that: it comprises the following steps:
1) water of the tank that disappears with setting-out is filled it up with, meanwhile, air in drain tank, in tank, water, by the water pump access heat exchanger A that disappears, heats water;
2) hot water adds the feeding pipe of thing along culture medium or stream by maintaining tank, returns to the band setting-out tank that disappears before adding tank entering fermentation tank or stream, arrives and specifies after liquid level, Inlet and outlet water enters closed cycle, constantly circulating-heating water, in tank, water temperature constantly raises, and fixed gas is constantly discharged;
3) in the time that water temperature arrives 100 DEG C, close air bleeding valve, along with the rising water of the water temperature corresponding pressure in tank that disappears is also raising, in the time that water temperature reaches 125 DEG C～130 DEG C, the water corresponding pressure in tank that disappears is gauge pressure 0.14～0.18MPa, and system Inlet and outlet water enters closed cycle state with pressure, the water that carries out immediately system disappears, after the water process of disappearing completes, the water tank water outlet that disappears stops, and opens material inlet valve and makes material enter continuous sterilization disinfection system.
2. high-temperature-hot-water sterilization process with pressure according to claim 1, is characterized in that: under closed cycle state with pressure, by opening or the company's of cutting out pump that disappears keeps the liquid level of setting in tank.
3. high-temperature-hot-water sterilization process with pressure according to claim 1, is characterized in that: under closed cycle state with pressure, regulate the vapor flow rate of heat exchanger A according to the water tank leaving water temperature that disappears.
4. the equipment for high-temperature-hot-water sterilization process with pressure claimed in claim 1, it is characterized in that: it comprises: the band setting-out tank that disappears, on tank, establish inlet valve V1, emptying valve V2, flowing water Valve V4, the company that valve V4 the is connected to each continuous sterilizing system pump inlet that disappears, connect disappear pump inlet also with material-compound tank supply pipe on the outlet of valve V3 join, heat exchanger A connects the water pump discharge that disappears by valve V6, another termination heat exchanger A import of valve V6, heat exchanger A outlet connects and maintains tank, the outlet that maintains tank meets heat exchanger B, the outlet of heat exchanger B meets heat exchanger C, heat exchanger C outlet taps into fermentation tank or stream adds tank valve V9, valve V9 epimere is established water discharging valve V10, the valve V10 other end connects the return pipe of back ingredient tank, heat exchanger C outlet also meets valve V11, and the valve V11 other end connects and rewinds the disappear return pipe of tank of setting-out.
5. equipment according to claim 4, is characterized in that: band setting-out disappears on tank and establishes pop off valve.
6. equipment according to claim 4, is characterized in that: the described band setting-out tank that disappears is established liquid-level probe.
7. equipment according to claim 4, is characterized in that: described establish the switch valve on temperature probe and exhaustor with the setting-out tank that disappears.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210009179.8A CN102600490B (en) | 2012-01-12 | 2012-01-12 | Pressurized hot water sterilization process and equipment pipeline configuration of continuous sterilization system for aerobic microbe fermentation culture medium or fed-batch material |
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| CN201210009179.8A CN102600490B (en) | 2012-01-12 | 2012-01-12 | Pressurized hot water sterilization process and equipment pipeline configuration of continuous sterilization system for aerobic microbe fermentation culture medium or fed-batch material |
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| CN102600490B true CN102600490B (en) | 2014-10-29 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201782983U (en) * | 2010-09-14 | 2011-04-06 | 北京东方诚益通工业自动化技术有限公司 | Superheated water sterilizing device for fermentation equipment |
| CN201791122U (en) * | 2010-09-14 | 2011-04-13 | 北京东方诚益通工业自动化技术有限公司 | Automatic control device for continuous sterilization of fermentation base material |
| CN202019699U (en) * | 2011-03-30 | 2011-11-02 | 鹿泽海 | Novel high efficiency dual triple-connected-tank sterilization kettle |
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| WO2007051235A1 (en) * | 2005-11-02 | 2007-05-10 | Packaged Environmental Solutions Pty Ltd | Disinfection system improvements |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201782983U (en) * | 2010-09-14 | 2011-04-06 | 北京东方诚益通工业自动化技术有限公司 | Superheated water sterilizing device for fermentation equipment |
| CN201791122U (en) * | 2010-09-14 | 2011-04-13 | 北京东方诚益通工业自动化技术有限公司 | Automatic control device for continuous sterilization of fermentation base material |
| CN202019699U (en) * | 2011-03-30 | 2011-11-02 | 鹿泽海 | Novel high efficiency dual triple-connected-tank sterilization kettle |
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