CN102600488B - 中枢神经系统的显像 - Google Patents
中枢神经系统的显像 Download PDFInfo
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- CN102600488B CN102600488B CN2012100777571A CN201210077757A CN102600488B CN 102600488 B CN102600488 B CN 102600488B CN 2012100777571 A CN2012100777571 A CN 2012100777571A CN 201210077757 A CN201210077757 A CN 201210077757A CN 102600488 B CN102600488 B CN 102600488B
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- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 150000004654 triazenes Chemical group 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 208000012991 uterine carcinoma Diseases 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3244208P | 2008-02-29 | 2008-02-29 | |
| US61/032,442 | 2008-02-29 | ||
| GBGB0803729.3A GB0803729D0 (en) | 2008-02-29 | 2008-02-29 | Imaging the central nervous system |
| GB0803729.3 | 2008-02-29 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009801067913A Division CN101970017B (zh) | 2008-02-29 | 2009-02-26 | 中枢神经系统的显像 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102600488A CN102600488A (zh) | 2012-07-25 |
| CN102600488B true CN102600488B (zh) | 2013-11-20 |
Family
ID=39315680
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012100777571A Expired - Fee Related CN102600488B (zh) | 2008-02-29 | 2009-02-26 | 中枢神经系统的显像 |
| CN2012100777139A Expired - Fee Related CN102600487B (zh) | 2008-02-29 | 2009-02-26 | 中枢神经系统的显像 |
| CN2009801067913A Expired - Fee Related CN101970017B (zh) | 2008-02-29 | 2009-02-26 | 中枢神经系统的显像 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012100777139A Expired - Fee Related CN102600487B (zh) | 2008-02-29 | 2009-02-26 | 中枢神经系统的显像 |
| CN2009801067913A Expired - Fee Related CN101970017B (zh) | 2008-02-29 | 2009-02-26 | 中枢神经系统的显像 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110027178A1 (enExample) |
| EP (1) | EP2247316B1 (enExample) |
| JP (1) | JP2011513277A (enExample) |
| CN (3) | CN102600488B (enExample) |
| GB (1) | GB0803729D0 (enExample) |
| WO (1) | WO2009106564A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0906274D0 (en) * | 2009-04-09 | 2009-05-20 | Ge Healthcare Ltd | Imaging the central nervous system |
| GB0917611D0 (en) * | 2009-10-08 | 2009-11-25 | Ge Healthcare Ltd | Automated radiosynthesis |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007141267A1 (en) * | 2006-06-06 | 2007-12-13 | Glaxo Group Limited | N- (phenylmethyl) -2- (1h-pyraz0l-4-yl) acetamide derivatives as p2x7 antagonists for the treatment of pain, inflammation and neurodegeneration |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9704546D0 (sv) * | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
| EP1495031A1 (en) * | 2002-04-16 | 2005-01-12 | Pharmacia & Upjohn Company LLC | Labeled oxazinocarbazoles as diagnostic agents |
| EP1556142A4 (en) * | 2002-10-24 | 2006-11-08 | Merck & Co Inc | ALKYN DERIVATIVES AS TRACERS FOR THE METABOTROPE GLUTAMATE RECEPTOR BINDING |
| PA8591801A1 (es) * | 2002-12-31 | 2004-07-26 | Pfizer Prod Inc | Inhibidores benzamidicos del receptor p2x7. |
| AU2004294989B2 (en) * | 2003-12-01 | 2009-03-19 | Ignasi Carrio | Novel differential imaging method |
| AU2007262786B2 (en) * | 2006-06-21 | 2012-12-06 | Ge Healthcare Limited | Radiopharmaceutical products |
| CA2655675A1 (en) * | 2006-07-06 | 2008-01-10 | Glaxo Group Limited | Substituted n-phenylmethyl -5-oxo-proline-2-amides as p2x7-receptor antagonists and their methods of use |
| WO2008064432A1 (en) * | 2006-12-01 | 2008-06-05 | The University Of Sydney | Polycyclic molecular compounds |
-
2008
- 2008-02-29 GB GBGB0803729.3A patent/GB0803729D0/en not_active Ceased
-
2009
- 2009-02-26 US US12/867,914 patent/US20110027178A1/en not_active Abandoned
- 2009-02-26 CN CN2012100777571A patent/CN102600488B/zh not_active Expired - Fee Related
- 2009-02-26 CN CN2012100777139A patent/CN102600487B/zh not_active Expired - Fee Related
- 2009-02-26 WO PCT/EP2009/052280 patent/WO2009106564A2/en not_active Ceased
- 2009-02-26 EP EP09715070.0A patent/EP2247316B1/en not_active Not-in-force
- 2009-02-26 CN CN2009801067913A patent/CN101970017B/zh not_active Expired - Fee Related
- 2009-02-26 JP JP2010548105A patent/JP2011513277A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007141267A1 (en) * | 2006-06-06 | 2007-12-13 | Glaxo Group Limited | N- (phenylmethyl) -2- (1h-pyraz0l-4-yl) acetamide derivatives as p2x7 antagonists for the treatment of pain, inflammation and neurodegeneration |
Non-Patent Citations (6)
| Title |
|---|
| 《Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373》;Stokes L, et. al.;《Br J Pharmacol.》;20061209;第149卷(第7期);880-7 * |
| 《Negative and positive allosteric modulators of the P2X(7) receptor》;Michel AD, Chambers LJ, Walter DS.;《Br J Pharmacol.》;20071210;第153卷(第4期);737-750 * |
| 《Structure-activity relationship studies on a series of novel,substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists 》;Nelson DW, et. al.;《J Med Chem.》;20060101;第49卷(第12期);3659-66 * |
| Michel AD, Chambers LJ, Walter DS..《Negative and positive allosteric modulators of the P2X(7) receptor》.《Br J Pharmacol.》.2007,第153卷(第4期),737-750. |
| Nelson DW, et. al..《Structure-activity relationship studies on a series of novel,substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists 》.《J Med Chem.》.2006,第49卷(第12期),3659-66. |
| Stokes L, et. al..《Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373》.《Br J Pharmacol.》.2006,第149卷(第7期),880-7. |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102600487A (zh) | 2012-07-25 |
| JP2011513277A (ja) | 2011-04-28 |
| US20110027178A1 (en) | 2011-02-03 |
| CN101970017B (zh) | 2012-05-23 |
| EP2247316A2 (en) | 2010-11-10 |
| CN102600487B (zh) | 2013-11-20 |
| CN102600488A (zh) | 2012-07-25 |
| EP2247316B1 (en) | 2013-11-06 |
| WO2009106564A3 (en) | 2010-03-25 |
| WO2009106564A2 (en) | 2009-09-03 |
| GB0803729D0 (en) | 2008-04-09 |
| CN101970017A (zh) | 2011-02-09 |
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