CN102600315B - Medicament composition used for treating rheumatoid arthritis and preparation method thereof - Google Patents
Medicament composition used for treating rheumatoid arthritis and preparation method thereof Download PDFInfo
- Publication number
- CN102600315B CN102600315B CN201110021681.6A CN201110021681A CN102600315B CN 102600315 B CN102600315 B CN 102600315B CN 201110021681 A CN201110021681 A CN 201110021681A CN 102600315 B CN102600315 B CN 102600315B
- Authority
- CN
- China
- Prior art keywords
- pharmaceutical composition
- rheumatoid arthritis
- preparation
- weight portion
- medicament composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a medicament composition used for treating rheumatoid arthritis. The medicament composition comprises monkshood, white atractylodes rhizome, musk, saffron crocus, cassia twig, obscured homalomena rhizome and the like. The medicament composition disclosed by the invention has the effects of dispelling dampness, dredging channels, tonifying kidney, clearing heat, promoting circulation and removing stasis, relaxing tendons and activating channels as well as softening hard mass and dispersing swelling, is effective to joint bone diseases caused by rheumatism and has the advantages of no toxic or side effect, rapid effect and convenience in use.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of pharmaceutical composition for the treatment of rheumatoid arthritis and preparation method thereof.
Background technology
Rheumatic arthritis is a kind of long-term chronic and obstinate commonly encountered diseases, frequently-occurring disease, commonplace.Clinical manifestation is that arthralgia or migration pain, numb limbs and tense tendons, joint deformity, action are obstructed, the even permanent disbility having, serious the healthy of the people that endangering.With medical at present situation, see, this type of patient is on the rise.The traditional Chinese medical science claim to be caused by wind, cold, wet as body pain or numbness be arthromyodynia, be mainly to be taken advantage of a weak point by wind, cold, wet, multiple abscess meridians, joint, hinder QI-blood circulation institute extremely.Wherein rheumatoid is that the autoimmune response being caused by some infectious disease causes take synovitis as basic arthropathy.Should become owner of with dredge the meridian passage, activating blood circulation to dissipate blood stasis, the dehumidifying of method wind, strengthen blood stasis expelling pain relieving, broken become silted up stimulate the menstrual flow, anti inflammatory blood quickening, method wind dampness removing, relieving the exterior syndrome by diaphoresis, the optimal selection of this type of disease of temperature three-way meridian.
Summary of the invention
The object of the invention is to provide a kind of pharmaceutical composition for the treatment of rheumatoid arthritis.
Another object of the present invention is to provide the preparation method of this pharmaceutical composition.
The present invention seeks to be achieved through the following technical solutions:
Pharmaceutical composition crude drug of the present invention consists of:
Radix Aconiti Lateralis Preparata 1-3 weight portion Rhizoma Atractylodis Macrocephalae 1-3 weight portion Moschus 0.5-1.5 weight portion
Stigma Croci 0.5-1.5 weight portion Ramulus Cinnamomi 1.5-4.5 weight portion Rhizoma Homalomenae 2-6 weight portion
Squama Manis 1-3 weight portion Radix Angelicae Sinensis 2-6 weight portion Squama Manis 2-6 weight portion
Herba Erodii 2.5-7.5 weight portion.
The crude drug composition of pharmaceutical composition of the present invention is preferably:
The Radix Aconiti Lateralis Preparata 2 weight portion Rhizoma Atractylodis Macrocephalae 2 weight portion Moschus 1 weight portion Stigma Croci 1 weight portions
Ramulus Cinnamomi 3 weight portion Rhizoma Homalomenae 4 weight portion Squama Manis 2 weight portion Radix Angelicae Sinensis 4 weight portions
Squama Manis 4 weight portion Herba Erodii 5 weight portions.
The crude drug composition of pharmaceutical composition of the present invention is preferably:
The Radix Aconiti Lateralis Preparata 1.2 weight portion Rhizoma Atractylodis Macrocephalae 1.2 weight portion Moschus 1.3 weight portions
Stigma Croci 1.3 weight portion Ramulus Cinnamomi 1.8 weight portion Rhizoma Homalomenae 2.5 weight portions
Squama Manis 2.5 weight portion Radix Angelicae Sinensis 5 weight portion Squama Manis 3 weight portions
Herba Erodii 3 weight portions.
The crude drug composition of pharmaceutical composition of the present invention is preferably:
The Radix Aconiti Lateralis Preparata 2.5 weight portion Rhizoma Atractylodis Macrocephalae 2.5 weight portion Moschus 0.8 weight portions
Stigma Croci 0.8 weight portion Ramulus Cinnamomi 4 weight portion Rhizoma Homalomenae 5 weight portions
Squama Manis 1.5 weight portion Radix Angelicae Sinensis 3 weight portion Squama Manis 5 weight portions
Herba Erodii 7 weight portions.
Pharmaceutical composition of the present invention adds conventional adjuvant to make the exterior-applied formulation of clinical acceptance by practice of pharmacy, as powder, unguentum, liniment or spray.
The preparation method of medicinal composition powders of the present invention is:
By above-mentioned raw materials medicine, pulverizing is 100 orders, makes powder.
Pharmaceutical composition of the present invention has treatment of arthritis and promoting collateral and channels, the kidney invigorating heat clearing away, and blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons and activating QI and blood in the collateral, softening hardness and disperse swelling, the joint osteopathia that various rheumatisms are caused is all effective, and has no side effect, and instant effect is easy to use.
Following experimental example and embodiment are used for further illustrating the present invention but are not limited to the present invention.
Experimental example:
One, physical data:
Medicine composite for curing group 100 examples of the present invention.
Two, criterion of therapeutical effect:
The Standardization of diagnosis and curative effect > > that cures the desease in the < < implementing for 1994 with reference to State Administration of Traditional Chinese Medicine drafts as follows:
Clinical recovery: tcm clinical practice symptom, sign disappear or substantially disappear;
Effective: tcm clinical practice symptom, sign obviously change;
Effective: tcm clinical practice symptom, sign all take a favorable turn;
Invalid: tcm clinical practice symptom, sign are all not improved.
Three, Therapeutic Method:
Scheme 1:
Radix Aconiti Lateralis Preparata 2g, Rhizoma Atractylodis Macrocephalae 2g, Moschus 1g, Stigma Croci 1g, Ramulus Cinnamomi 3g, Rhizoma Homalomenae 4g, Squama Manis 2g, Radix Angelicae Sinensis 4g, Squama Manis 4g, Herba Erodii 5g.
Scheme 2:
Radix Aconiti Lateralis Preparata 1.2g, Rhizoma Atractylodis Macrocephalae 1.2g, Moschus 1.3g, Stigma Croci 1.3g, Ramulus Cinnamomi 1.8g, Rhizoma Homalomenae 2.5g, Squama Manis 2.5g, Radix Angelicae Sinensis 5g, Squama Manis 3g, Herba Erodii 3g.
Scheme 3:
Radix Aconiti Lateralis Preparata 2.5g, Rhizoma Atractylodis Macrocephalae 2.5g, Moschus 0.8g, Stigma Croci 0.8g, Ramulus Cinnamomi 4g, Rhizoma Homalomenae 5g, Squama Manis 1.5g, Radix Angelicae Sinensis 3g, Squama Manis 5g, Herba Erodii 7g.
Preparation method: it is 100 orders that said medicine is pulverized, and makes powder.
Specification: 30g/ bag.
Function cures mainly: treatment of arthritis and promoting collateral and channels, the kidney invigorating heat clearing away, blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons and activating QI and blood in the collateral, softening hardness and disperse swelling.
Indication: the joint osteopathia that various rheumatisms are caused is all effective.
Contraindication: contraindication in pregnancy.
Usage and dosage: 1 bag/time, boiled water furnishing thick paste external application affected part.
Four, therapeutic outcome (seeing the following form):
| Group | Treatment number | Recovery from illness | Effective | Effectively | Invalid | Total effective rate |
| Treatment group | 100 | 30 | 37 | 24 | 9 | 91％ |
| Matched group | 100 | 28 | 34 | 21 | 17 | 83％ |
Note: three courses for the treatment of of the common ointment for the treatment of group external application (10 days each courses for the treatment of), matched group external application we from three courses for the treatment of of pharmacy.
Five, model case:
Case 1: Wang, 25 years old, female, changed rheumatoid arthritis 3 years.
Symptom: the enlargement of the symmetry of shutting down between patient's both hands refer to shuttle shape, daystart is stiff, bends, stretches difficulty, right side of head paroxysmal pain, and have an enclosed mass.Check: RF becomes positive.
Analyze: due to blockage of meridian, QI-blood circulation is not smooth, thus muscle, muscles and bones, joint are ached, numbness, weighing, joint stuffiness.
Treatment: blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons and activating QI and blood in the collateral, softening hardness and disperse swelling.
By the external application embodiment of the present invention 1 powder, treat 1 the course for the treatment of whole body arthralgia take an evident turn for the better.Continual cure recovers normal 3 courses for the treatment of on inspection substantially.
Case 2: Liu, man, 67 years old, retired veteran cadre.
Symptom: conscious whole body arthralgia is risen one after another, and joint is wasted time.The pain increased in recent months, slows down that it is impractical to see, pale simple and unadorned, aversion to cold and cold limbs, and two handss are swollen like steamed bread, refer to, wrist, ankle swelling be stiff, and especially left knee joint bending is ineffective, walks with difficulty.Red tongue, white and thin fur, the root of the tongue is greasy, thready and hesitant pulse number.
Analyze: yang-energy virtual loss, expectorant becomes silted up to hand over and coagulates, and gos deep into bone thigh.
Treatment: treatment of arthritis and promoting collateral and channels, blood circulation promoting and blood stasis dispelling.
By the external application embodiment of the present invention 2 unguentum, 1 stiff being clearly better of the arthralgia course for the treatment of of external application, left knee joint function obviously improves, and continual cure recovers normal 4 courses for the treatment of on inspection substantially.
Following embodiment all can realize the effect of above-mentioned experimental example.
The specific embodiment
Embodiment 1: the preparation of powder
Radix Aconiti Lateralis Preparata 2kg Rhizoma Atractylodis Macrocephalae 2kg Moschus 1kg Stigma Croci 1kg
Ramulus Cinnamomi 3kg Rhizoma Homalomenae 4kg Squama Manis 2kg Radix Angelicae Sinensis 4kg
Squama Manis 4kg Herba Erodii 5kg.
Get above-mentioned raw materials medicine, pulverizing is 100 orders, makes powder.
Embodiment 2: the preparation of unguentum
Radix Aconiti Lateralis Preparata 1.2kg Rhizoma Atractylodis Macrocephalae 1.2kg Moschus 1.3kg Stigma Croci 1.3kg
Ramulus Cinnamomi 1.8kg Rhizoma Homalomenae 2.5kg Squama Manis 2.5kg Radix Angelicae Sinensis 5kg
Squama Manis 3kg Herba Erodii 3kg.
Above-mentioned raw materials medicine adds conventional adjuvant to make the unguentum of clinical acceptance by practice of pharmacy.
Embodiment 3: the preparation of liniment
Radix Aconiti Lateralis Preparata 2.5kg Rhizoma Atractylodis Macrocephalae 2.5kg Moschus 0.8kg Stigma Croci 0.8kg
Ramulus Cinnamomi 4kg Rhizoma Homalomenae 5kg Squama Manis 1.5kg Radix Angelicae Sinensis 3kg
Squama Manis 5kg Herba Erodii 7kg.
Above-mentioned raw materials medicine adds conventional adjuvant to make the liniment of clinical acceptance by practice of pharmacy.
Embodiment 4: the preparation of spray
Radix Aconiti Lateralis Preparata 2kg Rhizoma Atractylodis Macrocephalae 2kg Moschus 1kg Stigma Croci 1kg
Ramulus Cinnamomi 3kg Rhizoma Homalomenae 4kg Squama Manis 2kg Radix Angelicae Sinensis 4kg
Squama Manis 4kg Herba Erodii 5kg.
Above-mentioned raw materials medicine adds conventional adjuvant to make the spray of clinical acceptance by practice of pharmacy.
Claims (9)
1. treat a pharmaceutical composition for rheumatoid arthritis, it is characterized in that the crude drug of this pharmaceutical composition consists of:
2. pharmaceutical composition as claimed in claim 1, is characterized in that the crude drug of this pharmaceutical composition consists of:
3. pharmaceutical composition as claimed in claim 1, is characterized in that the crude drug of this pharmaceutical composition consists of:
4. pharmaceutical composition as claimed in claim 1, is characterized in that the crude drug of this pharmaceutical composition consists of:
5. the pharmaceutical composition as described in as arbitrary in claim 1-4, is characterized in that this pharmaceutical composition adds conventional adjuvant to make the exterior-applied formulation of clinical acceptance by pharmaceutics method.
6. pharmaceutical composition as claimed in claim 5, is characterized in that described dosage form is powder, unguentum, liniment or spray.
7. the preparation method of pharmaceutical composition as claimed in claim 6, is characterized in that wherein the preparation method of powder is:
By above-mentioned raw materials medicine, pulverizing is 100 orders, makes powder.
8. as the application of the pharmaceutical composition of claim 1-4 or 6 as described in arbitrary in the medicine of preparation treatment rheumatoid arthritis.
9. the application of pharmaceutical composition as claimed in claim 5 in the medicine of preparation treatment rheumatoid arthritis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110021681.6A CN102600315B (en) | 2011-01-19 | 2011-01-19 | Medicament composition used for treating rheumatoid arthritis and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110021681.6A CN102600315B (en) | 2011-01-19 | 2011-01-19 | Medicament composition used for treating rheumatoid arthritis and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102600315A CN102600315A (en) | 2012-07-25 |
| CN102600315B true CN102600315B (en) | 2014-04-30 |
Family
ID=46518334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110021681.6A Expired - Fee Related CN102600315B (en) | 2011-01-19 | 2011-01-19 | Medicament composition used for treating rheumatoid arthritis and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102600315B (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895642A (en) * | 2005-07-12 | 2007-01-17 | 侯保君 | Traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain and preparation method thereof |
-
2011
- 2011-01-19 CN CN201110021681.6A patent/CN102600315B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN102600315A (en) | 2012-07-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102940853B (en) | Navel paste for treating mammary gland hyperplasia diseases | |
| CN103191383B (en) | Traditional Chinese medicine composition for treating rheumatoid arthritis | |
| CN104398982A (en) | Traditional Chinese medicine composition for treating traumatic injury and joint pain and swelling | |
| CN101905006B (en) | External medicament for treating traumatic injury | |
| CN100998656A (en) | Medicated wine for tonifying bone and removing obstruction in channels | |
| CN101396541B (en) | Traditional Chinese medicine for treating the cervical vertebra disease | |
| CN104906368A (en) | Traditional Chinese medicine composition for treating systemic lupus erythematosus | |
| CN101721651B (en) | Traditional Chinese medicine capsule for treating scapulohumeral periarthritis | |
| CN101647878A (en) | Traditional Chinese medicine preparation for treating rheumatism and numbness | |
| CN103845429A (en) | Traditional Chinese medicine for treating chronic hepatitis | |
| CN103211886A (en) | Medicament for treating rheumatic arthritis | |
| CN105327313A (en) | Traditional Chinese medicine composition with pain eliminating and bone strengthening functions | |
| CN104491775A (en) | Tradtional Chinese medicament for treating post cerebral hemorrhage depressions | |
| CN103861004A (en) | Traditional Chinese medicine external application agent for treating knee osteoarthritis and nursing method | |
| CN102600315B (en) | Medicament composition used for treating rheumatoid arthritis and preparation method thereof | |
| CN102327524A (en) | Traditional Chinese medicine composition for curing erysipelas | |
| CN102018815A (en) | Chinese medicine preparation for treating tuberculosis of lumbar spine | |
| CN103191229B (en) | Traditional Chinese medicine for treating swelling of knee joints | |
| CN102078432A (en) | Medicament for treating skin itch | |
| CN102342976B (en) | Pharmaceutical composition for treating rheumatoid arthritis | |
| CN103127349B (en) | Medicine for treating traumatic injury | |
| CN101954043A (en) | Medicament for treating hyperosteogeny and preparation method thereof | |
| CN106389943A (en) | Traditional Chinese medicinal composition for treating back myofascitis | |
| CN104524528A (en) | Chinese herb preparation treating anemofrigid-damp arthralgia syndrome | |
| CN105194411A (en) | Formula of traditional Chinese medicine for treating scapulobumeral periarthritis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140430 Termination date: 20160119 |
|
| EXPY | Termination of patent right or utility model |