CN102596241A - 生产脑膜炎奈瑟氏菌的人工荚膜多糖的方式和方法 - Google Patents

生产脑膜炎奈瑟氏菌的人工荚膜多糖的方式和方法 Download PDF

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Publication number
CN102596241A
CN102596241A CN2010800483045A CN201080048304A CN102596241A CN 102596241 A CN102596241 A CN 102596241A CN 2010800483045 A CN2010800483045 A CN 2010800483045A CN 201080048304 A CN201080048304 A CN 201080048304A CN 102596241 A CN102596241 A CN 102596241A
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CN
China
Prior art keywords
cps
nucleic acid
capsular polysaccharide
udp
sequence
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Pending
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CN2010800483045A
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English (en)
Chinese (zh)
Inventor
丽塔·热拉尔迪沙恩
马丁纳·米伦霍夫
安德烈亚·贝特
卡塔琳娜·斯图梅尔
弗里德里希·弗赖贝格尔
塞巴斯蒂安·达梅罗
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Medizinische Hochschule Hannover
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Medizinische Hochschule Hannover
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Publication of CN102596241A publication Critical patent/CN102596241A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN2010800483045A 2009-08-26 2010-08-26 生产脑膜炎奈瑟氏菌的人工荚膜多糖的方式和方法 Pending CN102596241A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09168765 2009-08-26
EP09168765.7 2009-08-26
PCT/EP2010/062481 WO2011023764A1 (en) 2009-08-26 2010-08-26 Means and methods for producing artificial capsular polysaccharides of neisseria meningitidis

Publications (1)

Publication Number Publication Date
CN102596241A true CN102596241A (zh) 2012-07-18

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Family Applications (1)

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CN2010800483045A Pending CN102596241A (zh) 2009-08-26 2010-08-26 生产脑膜炎奈瑟氏菌的人工荚膜多糖的方式和方法

Country Status (8)

Country Link
US (1) US20130012471A1 (enExample)
EP (1) EP2470203A1 (enExample)
CN (1) CN102596241A (enExample)
BR (1) BR112012007877A2 (enExample)
CA (1) CA2771672A1 (enExample)
IN (1) IN2012DN01695A (enExample)
RU (1) RU2012111424A (enExample)
WO (1) WO2011023764A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2820898T3 (es) * 2012-05-22 2021-04-22 Glaxosmithkline Biologicals Sa Conjugado del serogrupo X de meningococos
WO2015158898A2 (en) 2014-04-17 2015-10-22 Medizinische Hochschule Hannover Means and methods for producing neisseria meningitidis capsular polysaccharides of low dispersity
AR104469A1 (es) 2014-08-08 2017-07-26 Glycovaxyn Ag Células huésped modificadas para su uso en producción de bioconjugados
ES2846794T3 (es) * 2014-11-18 2021-07-29 Pasteur Institut Anticuerpos policlonales específicos para el serogrupo X de N. meningitidis y usos de los mismos en el diagnóstico
CA2990312A1 (en) * 2015-07-01 2017-01-05 Glaxosmithkline Biologicals S.A. Immunogenic compositions

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1401774A (zh) * 2002-07-19 2003-03-12 大连理工大学 一种尿苷二磷酸葡萄糖焦磷酸化酶基因及其克隆

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
CA1223831A (en) 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5792608A (en) 1991-12-12 1998-08-11 Gilead Sciences, Inc. Nuclease stable and binding competent oligomers and methods for their use
US5525711A (en) 1994-05-18 1996-06-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pteridine nucleotide analogs as fluorescent DNA probes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1401774A (zh) * 2002-07-19 2003-03-12 大连理工大学 一种尿苷二磷酸葡萄糖焦磷酸化酶基因及其克隆

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CLAUS HEIKE ET AL:: ""Amino acid 310 determines the donor substrate specificity of serogroup W-135 and Y capsule polymerases of Neisseria meningitidis"", 《MOLECULAR MICROBIOLOGY》, vol. 71, no. 4, 2 January 2009 (2009-01-02), pages 960 - 971, XP009141601, DOI: doi:10.1111/j.1365-2958.2008.06580.x *
FREIBERGER F ET AL:: ""Biochemical characterization of a Neisseria meningitidis polysialyltransferase reveals novel functional motifs in bacterial sialyltransferases"", 《MOLECULAR MICROBIOLOGY》, vol. 65, no. 2, 27 July 2007 (2007-07-27), pages 1258 - 1275, XP008124960 *
GRIFFISS J M ET AL:: ""SAFETY AND IMMUNOGENICITY OF GROUP Y AND GROUP W-135 MENINGOCOCCAL NEISSERIA-MENINGITIDIS CAPSULAR POLY SACCHARIDE VACCINES IN ADULTS"", 《INFECTION AND IMMUNITY》, vol. 34, no. 3, 31 December 1981 (1981-12-31), pages 725 - 732 *
HARRISON LEE H:: ""Prospects for vaccine prevention of meningococcal infection"", 《CLINICAL MICROBIOLOGY REVIEWS》, vol. 19, no. 1, 31 January 2006 (2006-01-31), pages 142 - 164, XP002611799, DOI: doi:10.1128/CMR.19.1.142-164.2006 *

Also Published As

Publication number Publication date
BR112012007877A2 (pt) 2019-09-24
IN2012DN01695A (enExample) 2015-06-05
RU2012111424A (ru) 2013-10-10
US20130012471A1 (en) 2013-01-10
WO2011023764A1 (en) 2011-03-03
CA2771672A1 (en) 2011-03-03
EP2470203A1 (en) 2012-07-04

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Application publication date: 20120718