CN102579878A - Red reed seed granules, as well as preparation method and application thereof - Google Patents
Red reed seed granules, as well as preparation method and application thereof Download PDFInfo
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- CN102579878A CN102579878A CN2012100613340A CN201210061334A CN102579878A CN 102579878 A CN102579878 A CN 102579878A CN 2012100613340 A CN2012100613340 A CN 2012100613340A CN 201210061334 A CN201210061334 A CN 201210061334A CN 102579878 A CN102579878 A CN 102579878A
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- dauci sativae
- rhizoma phragmitis
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Abstract
The invention provides red reed seed granules, which consist of pure natural plant food oat kernel flour, fresh reed rhizome extract which is extracted from plants, carrot extract and celery seed extract. The red reed seed granules are prepared by the steps of: screening the components through a 60-mesh screen; carrying out dry mixing on the fresh reed rhizome extract, the carrot extract and the oat kernel flour; adding proper 80 percent ethanol solution to prepare a soft material; screening and pelletizing, drying and granulating; adding the celery seed extract for uniformly mixing; and sub-packaging with bags. According to the red reed seed granules, the capability of removing uric acid from urine of a human body can be remarkably improved, and deposition of uric acid in the body can be reduced, so that calculus can be dissolved, gout is prevented from relapse, and the red reed seed granules can be applied to preparation of a medicament for preventing and treating gout and hyperuricemia. Pure natural plant foods and plant extract are adopted as raw materials, so that the red reed seed granules have the advantages of unique prescription, reasonable proportion, easily available raw materials, convenience for use, good curative effect, safety and sanitation, proper price and low cost, and has wide market prospect.
Description
Technical field
The invention belongs to pharmaceutical field, relate to red reed seed granule.This red reed seed granule can effectively suppress the activity of xanthine oxidase, uric acid reducing for gout and high hematuria acid disease patient; For not suffering from gout but the higher people of uric acid level can prevent gout.
Background technology
Because dietary structure changes, and high protein and high purine food intake increase, the hyperuricemia and the patient with gout of China day by day increase, and the gesture that directly chases after western countries even surmount is arranged in recent years.
Thereby xanthine oxidase catalysis hypoxanthine changes into xanthine and finally generates uric acid; Uricopoiesis too much with (or) its dysbolismus all can cause the generation of hyperuricemia; And hyperuricemia is the biochemical basis of gout morbidity; Also be the crucial cause of disease that forms gout, generate the too much or hypoecrisia of uric acid in the blood, or other factors all can cause hyperuricemia.In a single day uric acid exceeds normal value, just can form urate, reaches the lower limb far-end with blood flow then and forms deposition, causes gout.Severe patient can cause joint movement disorder or deformity, is called gouty arthritis clinically.The normal value of human body uric acid is 150-420 μ mol/L; Too much uric acid can form uric acid property renal calculus and the infringement of excess of the kidney matter in kidney deposition back; Be called urate nephropathy clinically, be gouty nephropathy again, can cause renal colic outbreak, hematuria, hydronephrosis and renal function injury; Renal failure and uremia can take place in severe patient, are to cause one of gout patient main causes of death.
In nearest 50 years, goat treatment field new product is deficient, and existing medicine all exists patient's intestines and stomach stimulation and damages big defective.The treatment of gout and hyperuricemia at present mainly uses anti-inflammatory agent to alleviate the symptoms such as red, fat, hot, pain of this disease; And on the disease progression different phase, select uricotelic drugs or xanthine oxidase inhibitor to alleviate hyperuricemia, the disease controlling development.
Oatmeal does not contain cholesterol, has the little fat of full cereals.Be rich in soluble fiber.Be rich in vitamin B crowd (especially vitamin B1, B2 and nicotinic acid), vitamin C, E and folic acid.And contain abundant calcium, phosphorus, ferrum, copper, zinc, manganese, silicon.Herba bromi japonici also contains abundant water-soluble fibre, β-polydextrose and plant alkaloid, plant Saponin.
Fresh Rhizoma Phragmitis is cold in nature, and sweet in the mouth has the effect of diuresis antidotal.Rhizoma Phragmitis ability lithodialysis, it is edible to be suitable for uric acid property illness and gout person.Many with bright article in ancient prescription.Fresh Rhizoma Phragmitis is mashed the strand juice person of being used as medicine, claim fresh Rhizoma Phragmitis juice, also claim pharagmitis rhizoma juice.The power of YIN nourishing and the production of body fluid promoting is stronger, and the effect of detoxifcation is speed more, is particularly useful for the calentura excessive thirst, vomiting; Stomach is weak and difficulty is advanced the child and the poisoning emergency case person of medicine food.The result proves according to modern study, contains a large amount of vitamin B1s, B2 and vitamin C in the Rhizoma Phragmitis, only can keep the vitamin content loss minimum with aquatic foods article or the bright juice person of being used as medicine.
Radix Dauci Sativae belongs to basic food; It is a kind of vegetable that is substantially free of purine; Effect with blood fat reducing, cholesterol, stabilizing blood pressure contains abundant organized enzyme in the Radix Dauci Sativae, eat the metabolism that can effectively promote purine raw; Also contain materials such as a large amount of potassium, phosphorus, calcium, ferrum, vitamin K, Vc in the Radix Dauci Sativae, so just can improve blood quality effectively, blood and diuresis, litholytic effect are arranged alkalizes.In addition, Radix Dauci Sativae is rich in potassium, is several times even tens times of other Radix Raphani.Well-known potassium can be regulated the osmotic pressure suitable in the cell and the acid-base balance of body fluid, participates in endocellular sugar and proteinic metabolism, and this adjusting to patient with gout hematuria acid number is very favourable.
The contained blood pressure lowering of celery seed, blood fat reducing composition are 50 times of Herba Apii graveolentis, and short-term is taken and played blood pressure lowering, and the effect of blood fat reducing is taken for a long time and is far superior to other Pharmaceuticalss, and is without any side effects.Celery seed has specially good effect to hypertension.The effect of blood pressure lowering, blood fat reducing is arranged.Celery seed all alleviates effect to pathogenic wind-warm disease, rheumatic arthritis, gout, metabolic arthritis disease etc.
Summary of the invention
The purpose of this invention is to provide a kind of red reed seed granule, its component comprises pure natural plant food oatmeal, the fresh Rhizoma Phragmitis extract, Radix Dauci Sativae extract and the Apium graveolens Linnaeus extract that from plant, extract.
Above-mentioned red reed seed granule; The weight proportion of each component is an oatmeal: fresh Rhizoma Phragmitis extract: Radix Dauci Sativae extract: Apium graveolens Linnaeus extract is 26.1～31.9:9.9～10.1:0.9～1.1:1.8～2.2, and wherein proportion optimization is an oatmeal: fresh Rhizoma Phragmitis extract: Radix Dauci Sativae extract: Apium graveolens Linnaeus extract is 29:10:1:2.
Another object of the present invention is to provide red reed seed particulate method for preparing: above-mentioned each component is crossed 60 mesh sieves respectively; Subsequent use; Take by weighing pretreated raw material by formula ratio; Fresh Rhizoma Phragmitis extract, Radix Dauci Sativae extract, Herba bromi japonici dried bean noodles were mixed 10～15 minutes, add 80% alcoholic solution and prepare soft material in right amount; Granulate through 12～16 mesh sieves; In 50 ℃～55 ℃ oven dry; Granulate; Add Apium graveolens Linnaeus extract as essence; Mixing; Be distributed into bag; Promptly get.
A further object of the present invention provides the above-mentioned red reed seed granule that makes and prevents and treats the application in gout and the high hematuria acid disease drug in preparation, and its instructions of taking is: one day two bags, each one bag sooner or later, brew with hot boiled water when taking and drink.
Under normal circumstances, the ability of human body eliminating uric acid from urine is about 5% of total uric acid level; If take red reed seed granule of the present invention, the amount of getting rid of uric acid just can obviously improve, uric acid reducing deposition in vivo, thus dissolve calculus, the recurrence of control gout.
Through actual taking, proved that its effect is obvious among the high crowd of red reed seed granule of the present invention uric acid in blood, can prevent and treat gout.
It is raw material that the present invention adopts pure natural plant food and plant extract, and prescription is unique, reasonable mixture ratio, and raw material is easy to get, and is easy to use, good effect, safety and sanitation, price is suitable, and cost is lower, has vast market prospect.
The specific embodiment
The present invention combines embodiment to be further described.Present invention is described for following examples, and these examples only are can not be interpreted as limitation of the scope of the invention for explanation.
Among the following embodiment, the oatmeal of use, fresh Rhizoma Phragmitis extract, Radix Dauci Sativae extract and Apium graveolens Linnaeus extract make by following method:
The method for preparing of oatmeal is: naked oats removed the peel, taken off fine hair, baked and banked up with earth 4 hours for 85 ℃, and afterwards through mechanical activation comminution, check, steam sterilization promptly gets.
The fresh Rhizoma Phragmitis preparation method of extract is: fresh Rhizoma Phragmitis pulverized, extracted 2 times for 80 ℃ with 10 times of water gagings, and 2h/ time, the extracting solution concentrating under reduced pressure, spray drying is pulverized, and sieves, and promptly gets.
The method for preparing of Radix Dauci Sativae extract is: Radix Dauci Sativae is pulverized, and water extracts 3 times for 80 ℃, and 10 times of water gagings extract 2h for the first time; 8 times of water gagings extract 1.5h for the second time; 6 times of water gagings extract 1.0h for the third time, filter, and concentrate, and spray drying is pulverized, and sieves, and promptly gets.
The method for preparing of Apium graveolens Linnaeus extract is: celery seed extracts 2 times for 80 ℃ with 10 times of water gagings, and 2h/ time, the extracting solution concentrating under reduced pressure, spray drying is pulverized, and sieves, and promptly gets.
Embodiment 1 (oatmeal: fresh Rhizoma Phragmitis extract: Radix Dauci Sativae extract: the Apium graveolens Linnaeus extract weight ratio is 29:10:1:2)
With oatmeal 2900 grams, fresh Rhizoma Phragmitis extract 1000 grams, Radix Dauci Sativae extract 100 grams, Apium graveolens Linnaeus extract 200 grams are crossed 60 mesh sieves respectively, and are subsequent use.With the raw material after sieving: fresh Rhizoma Phragmitis extract 1000 grams, Radix Dauci Sativae extract 100 grams, oatmeal 2900 grams are done and were mixed 10～15 minutes, add 80% alcoholic solution and prepare soft material in right amount; Granulate through 12～16 mesh sieves; In 50 ℃～55 ℃ oven dry; Granulate; Add Apium graveolens Linnaeus extract 200 grams after sieving again; Mixing; Be distributed into bag, every packed 4.2 gram dried granules, totally 1000 bags; Promptly get.
Embodiment 2 (oatmeal: fresh Rhizoma Phragmitis extract: Radix Dauci Sativae extract: the Apium graveolens Linnaeus extract weight ratio is 27:9:1.1:2)
With oatmeal 2700 grams, fresh Rhizoma Phragmitis extract 900 grams, Radix Dauci Sativae extract 110 grams, Apium graveolens Linnaeus extract 200 grams are crossed 60 mesh sieves respectively, and are subsequent use.With the raw material after sieving: fresh Rhizoma Phragmitis extract 900 grams, Radix Dauci Sativae extract 110 grams, oatmeal 2700 grams are done and were mixed 10～15 minutes, add 80% alcoholic solution and prepare soft material in right amount; Granulate through 12～16 mesh sieves; In 50 ℃～55 ℃ oven dry; Granulate; Add Apium graveolens Linnaeus extract 200 grams after sieving again; Mixing; Be distributed into bag, every packed 3.91 gram dried granules, totally 1000 bags; Promptly get.
Embodiment 3 (oatmeal: fresh Rhizoma Phragmitis extract: Radix Dauci Sativae extract: the Apium graveolens Linnaeus extract weight ratio is 28:10:0.9:1.9)
With oatmeal 2800 grams, fresh Rhizoma Phragmitis extract 1000 grams, Radix Dauci Sativae extract 90 grams, Apium graveolens Linnaeus extract 190 grams are crossed 60 mesh sieves respectively, and are subsequent use.With the raw material after sieving: fresh Rhizoma Phragmitis extract 1000 grams, Radix Dauci Sativae extract 90 grams, oatmeal 2800 grams are done and were mixed 10～15 minutes, add 80% alcoholic solution and prepare soft material in right amount; Granulate through 12～16 mesh sieves; In 50 ℃～55 ℃ oven dry; Granulate; Add Apium graveolens Linnaeus extract 190 grams after sieving again; Mixing; Be distributed into bag, every packed 4.08 gram dried granules, totally 1000 bags; Promptly get.
Embodiment 4 (oatmeal: fresh Rhizoma Phragmitis extract: Radix Dauci Sativae extract: the Apium graveolens Linnaeus extract weight ratio is 30:9.5:1:1.8)
With oatmeal 3000 grams, fresh Rhizoma Phragmitis extract 950 grams, Radix Dauci Sativae extract 100 grams, Apium graveolens Linnaeus extract 180 grams are crossed 60 mesh sieves respectively, and are subsequent use.With the raw material after sieving: fresh Rhizoma Phragmitis extract 950 grams, Radix Dauci Sativae extract 100 grams, oatmeal 3000 grams are done and were mixed 10～15 minutes, add 80% alcoholic solution and prepare soft material in right amount; Granulate through 12～16 mesh sieves; In 50 ℃～55 ℃ oven dry; Granulate; Add Apium graveolens Linnaeus extract 180 grams after sieving again; Mixing; Be distributed into bag, every packed 4.23 gram dried granules, totally 1000 bags; Promptly get.
Embodiment 5 detects the particulate biological activity of the red reed seed of the present invention
Below to the particulate biological activity of the prepared red reed seed of embodiment 1-4, promptly the inhibitory action of xanthine oxidase is tested.Test as follows:
A, experiment material:
Xanthine, xanthine oxidase, Na
2HPO
4.12H
2O (AR), NaH
2PO
42H
2O (AR), embodiment 1 prepared red reed seed granule, Febuxostat (molecular weight 316).
B, experimental procedure:
1) preparation of 0.2M PH7.5 phosphate buffer (PBS)
Take by weighing Na
2HPO
4.12H
2O 15.6g (or NaH
2PO
42H
2O 13.8g) adds redistilled water and dissolve to 500ml, get the NaH of 16ml 0.2mol/L
2PO
4Na with 160ml 0.2mol/L
2HPO
4.12H
2O fully mixes the PBS that is 0.2mol/L.
2) preparation of xanthine solution
It is an amount of to get xanthine, adds above-mentioned phosphate buffer and is diluted to 75Mm/L.Leave standstill 15min.
3) preparation of need testing solution
Get each about 0.3g+ water/DMSO solution 20ml of the prepared red reed seed particulate samples of embodiment 1-4, ultrasonic heating makes dissolving or DL, and 10000r/min is centrifugal, gets supernatant.Get the about 26mg of Febuxostat (comparison) and add the DMSO2ml heating for dissolving, 10000r/min is centrifugal, gets supernatant.
4) preparation of xanthine oxidase
Get xanthine oxidase and add above-mentioned phosphate buffer configuration written treaty 0.009U/ml in right amount.
5) application of sample and grouping
Blank pipe: add xanthine 3ml, survey the A value, add DMSO 20ul, the vortex mixing is surveyed the A value.
Model pipe: add xanthine 3ml, survey the A value, add DMSO 20ul, the vortex mixing is surveyed the A value.
Control tube: add xanthine 3ml, survey the A value, add the red reed granule of 20ul, the vortex mixing is surveyed the A value.
Sample cell: add xanthine 3ml, survey the A value, add the 20ul Febuxostat, the vortex mixing is surveyed the A value.
After below respectively managing the application of sample mixing, put into 37 ℃ of water-bath environment at once, behind the 20min.
6) enzymolysis and detection
More than except that the blank pipe, each the pipe all add the 50ul xanthine oxidase, hatch 30min for 37 ℃.With the zeroing of 0.2M PH7.5 phosphate buffer, under 270nm, measure each developmental tube absorbance and change, and compare enzyme inhibition rate difference then.
Computing formula:
Suppression ratio (%)=(model difference meansigma methods-sample difference meansigma methods)/model difference meansigma methods * 100
Table 1 has been enumerated the data of embodiment 1-4 prepared red reed seed particulate samples gained in xanthine oxidase is suppressed to detect, in this experiment with Febuxostat thing as a comparison.
Table the-2nd, the prepared red reed seed granule of embodiment 1-4 is to the inhibiting detection of xanthine oxidase.
Data can draw from table; Prepared red reed seed granule of embodiment 1-4 and Febuxostat all can suppress the activity of xanthine oxidase; Wherein the red reed seed granule that makes of embodiment 1 (optimum ratio) is the highest to the suppression ratio of xanthine oxidase, equally with Febuxostat is 100%.
Claims (4)
1. red reed seed granule; Be made up of oatmeal, fresh Rhizoma Phragmitis extract, Radix Dauci Sativae extract and Apium graveolens Linnaeus extract, the weight proportion of each component is an oatmeal: fresh Rhizoma Phragmitis extract: Radix Dauci Sativae extract: Apium graveolens Linnaeus extract is 26.1～31.9:9.9～10.1:0.9～1.1:1.8～2.2.
2. a kind of red reed seed granule according to claim 1, it is characterized in that the weight proportion of each component is an oatmeal: fresh Rhizoma Phragmitis extract: Radix Dauci Sativae extract: Apium graveolens Linnaeus extract is 29:10:1:2.
3. the particulate method for preparing of a kind of red reed seed according to claim 1 is characterized in that realizing through following steps: oatmeal, fresh Rhizoma Phragmitis extract, Radix Dauci Sativae extract and Apium graveolens Linnaeus extract are crossed 60 mesh sieves respectively, and subsequent use; Take by weighing pretreated raw material by weight ratio, fresh Rhizoma Phragmitis extract, Radix Dauci Sativae extract, Herba bromi japonici dried bean noodles were mixed 10～15 minutes, add 80% alcoholic solution and prepare soft material in right amount; Granulate through 12～16 mesh sieves, in 50 ℃～55 ℃ oven dry, granulate; Add Apium graveolens Linnaeus extract; Mixing is distributed into bag, promptly gets.
4. a kind of red reed seed granule according to claim 1 is prevented and treated the application in gout and the high hematuria acid disease drug in preparation.
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| CN201210061334.0A CN102579878B (en) | 2012-03-09 | 2012-03-09 | Red reed seed granules, as well as preparation method and application thereof |
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| CN102579878B CN102579878B (en) | 2014-03-26 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103181595A (en) * | 2013-04-03 | 2013-07-03 | 刘银松 | Health drink of carrot juice capable of lowering UA |
Citations (3)
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|---|---|---|---|---|
| CN1362859A (en) * | 1999-04-23 | 2002-08-07 | 陈昭妃 | Ginseng berry health products |
| CN101322552A (en) * | 2007-06-11 | 2008-12-17 | 刘金忠 | Food prescription for regulating blood sugar and processing technique thereof |
| CN101810336A (en) * | 2010-04-30 | 2010-08-25 | 广东仙乐制药有限公司 | Chewable soft capsules and method for preparing same |
-
2012
- 2012-03-09 CN CN201210061334.0A patent/CN102579878B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1362859A (en) * | 1999-04-23 | 2002-08-07 | 陈昭妃 | Ginseng berry health products |
| CN101322552A (en) * | 2007-06-11 | 2008-12-17 | 刘金忠 | Food prescription for regulating blood sugar and processing technique thereof |
| CN101810336A (en) * | 2010-04-30 | 2010-08-25 | 广东仙乐制药有限公司 | Chewable soft capsules and method for preparing same |
Non-Patent Citations (2)
| Title |
|---|
| 《山西农业科学》 20081231 李蕊倩 "西葫芦根腐病病原菌（Phytophthora nicotianae）的生物学特性研究" 第74-76页 1-4 第36卷, 第12期 * |
| 李蕊倩: ""西葫芦根腐病病原菌（Phytophthora nicotianae）的生物学特性研究"", 《山西农业科学》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103181595A (en) * | 2013-04-03 | 2013-07-03 | 刘银松 | Health drink of carrot juice capable of lowering UA |
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