CN102579874B - Bamboo shoot product for treatment of alcoholic liver disease and preparation method thereof - Google Patents
Bamboo shoot product for treatment of alcoholic liver disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a bamboo shoot product for treatment of alcoholic liver diseases and a preparation method thereof. The preparation method comprises the following steps of: (1) drying bamboo shoots until the water content is below 15 percent, and crushing the bamboo shoots; (2) extracting the bamboo shoots processed in Step (1) with ethanol solution once to four times, mixing filtrate, reducing the pressure to recycle ethanol, and concentrating to prepare concentrated solution; and (3) adding additives into the concentrated solution to prepare the required dosage form. The invention has the following advantages that: (1) raw materials and additives are raw materials and additives for food and are safer than Western medicine and traditional Chinese medicine in treatment, no specific restrictions are needed for the dosage, and the dosage can be adjusted according to specific circumstances of prevention and treatment; (2) the nutritional value of bamboo shoots is fully utilized, and the problems of traditional bamboo shoot food that the astringent cannot be eliminated easily and the food cannot be taken conveniently can be solved; and (3) based on the traditional Chinese medicine theory along with research results of modern pharmacology and drugs, alcoholic liver diseases can be treated effectively, and the bamboo shoot product can also be used as food to prevent alcoholic liver diseases.
Description
[technical field]
The present invention relates to a kind of bamboo-shoot product, specifically a kind of bamboo-shoot product for the treatment of alcoholic liver disease and preparation method thereof.
[background technology]
Alcoholic liver disease (ALD) refers to that drinking in a large number the various liver injury sexually transmitted disease (STD)s that cause containing the beverage of ethanol for a long time becomes.Mainly comprise alcoholic fatty liver, alcoholic hepatitis, alcoholic fibrosis, alcoholic cirrhosis etc.
Can metabolism 120g ethanol in 24 hours bodies of normal person.Drink for a long time and exceed the metabolic capacity of body, can cause alcoholic liver disease, this is main relevant with the toxicity of ethanol and acetaldehyde.After drinking, ethanol becomes acetaldehyde under hepatocellular ethanol dehydrogenase effect.Acetaldehyde is a kind of high-activity compound, can disturb the many-sided function of hepatocyte, by affecting the generation of mitochondrion to ATP, and the biosynthesis of protein and excretion, infringement microtubule, makes albumen and fatty excretion obstacle and accumulates in hepatocyte.When simultaneously ethanol, acetaldehyde are oxidized, produce a large amount of DPNHs, promote on the one hand the synthetic of fat, suppress on the other hand the oxidation of fatty acid in mitochondrion, thereby cause the formation of fatty liver.Having proved has immune factor to participate in alcoholic liver disease morbidity, as self liver antigen and the ethanol hyaline bodies separating, can stimulate patient's lymphocyte transformation and migration migration inhibitory factor vigor; Some cytokines are as relevant with the generation of alcoholic hepatitis in tumor necrosis factor (TNF), interleukin (IL) etc.The hyperlactacidemia that ethanol causes, by stimulating the activity of proline hydroxylase and the oxidation of inhibition proline, can make proline increase, thereby the former formation of liver hose lining is increased, and accelerates liver cirrhosis process.The toxic action of some inflammatory cytokines and ethanol, acetaldehyde can make hepatic stellate cell, hepatocyte, activation of Kupffer cells, secretes some extracellular matrixs, promotes alcoholic cirrhosis to occur.
In the morbidity of alcoholic liver disease, alcoholic fatty liver occurs the earliest, and occurrence rate is also the highest, and clinical symptoms is lighter, has hepatomegaly in various degree, and liver weight significantly increases; Alcoholic hepatitis liver there will be obvious Histological change, and hepatocyte is impaired, abnormal liver function, and with losing weight, the symptom such as inappetence, nausea and vomiting, malaise, abdominal pain diarrhea.Alcoholic liver disease sickness rate is high, large to the infringement of human body, is added with the impact on nervous system, reproductive system after alcoholism, makes it become a kind of disease of serious harm people ' s health.
Approximately there are 1,500 ten thousand-2,000 ten thousand people's excessive drinkings in the whole world, has 10%-20% to have alcoholic liver disease in various degree in these people, and long-term alcoholic has 60-90% to have alcoholic fatty liver.In 20th century of alcoholic liver disease latter stage occurred frequently in American-European countries, but in recent years along with the raising of people's living standard and the change of life style, the sickness rate of China's alcoholic liver disease constantly raises, and has become sick kind of second largest hepatopathy that is only second to viral liver disease.How to prevent and to treat alcoholic liver disease and paid close attention to by people.
The western medical treatment medicine of alcoholic liver disease mainly contains corticosteroid hormone, colchicine, propylthiouracil, insulin and glucagon, antiendotoxin agent, antioxidant, SAM, lipid lowerers etc.Modern study is found the effects such as bamboo sprout have antioxidation, anti-diabetic, protect the liver, regulate gastrointestinal function, anti-anemia, antitumor.Thereby bamboo sprout can act on treatment alcoholic liver disease by its antioxidation, protect the liver etc.
Though the record of alcohol-free hepatopathy in the traditional Chinese medical science, successive dynasties document has clearly record to the harm of drinking and caused clinical symptoms thereof, as " alcoholic jaundice ", " alcoholophilia ", " wine drum ", " flatulence due to immoderate drinking ", " getting sick from drinking too much wine " " hypochondriac pain " etc.Vinosity hardship, sweet, pungent, large heat is poisonous.Long-term or excessive consumption of alcohol is " wet ", " heat " tire out, damp is stopped up Sheng and is become phlegm retention to block human functional activity of vital energy, occurs the stagnation of QI, stasis, and causes that internal organs are deficient; , there is the syndromes such as Tianjin is few in the pyretic toxicity cloudy liquid of burning.Control and work as with heat-clearing and toxic substances removing, clearing away heat-damp and promoting diuresis, removing dampness by means of aromatics, blood circulation promoting and blood stasis dispelling, nourishing YIN and benefiting blood tonifying speen and tonifying kidney.Bamboo sprout have removing heat-phlegm, QI invigorating stomach function regulating, control quench one's thirst, the effect such as dredging water passages, the refreshing stomach of sharp diaphragm, can stop up for inappetence, gastral cavity abdomen feeling of fullness, constipation, sputum stagnant etc.Bamboo sprout can, for " wetting " and " heat " of causing " alcoholic liver disease ", to remove the cause of disease, to encourage healthy trends, provide theoretical foundation thereby treat alcoholic liver disease for bamboo sprout by QI invigorating stomach function regulating by removing heat-phlegm, diuretic the turbid descending.
[summary of the invention]
The object of the present invention is to provide have can Qinghua heat-phlegm, dampness removing the turbid descending, QI invigorating stomach function regulating, directly effective a kind of bamboo-shoot product for the treatment of alcoholic liver disease for the treatment of and prevention alcoholic simple fatty liver and ethanol hepatopathy.
Another object of the present invention is to provide a kind of preparation method of bamboo-shoot product for the treatment of alcoholic liver disease.
For achieving the above object, technical scheme of the present invention is: a kind of bamboo-shoot product for the treatment of alcoholic liver disease, made by bamboo sprout extract and adjuvant,
The step that the preparation method of described bamboo sprout extract comprises is as follows:
(1) get bamboo sprout (preferred fresh Radix Crotalariae szemoensis are shelled) and be dried to water content below 15%, pulverized 10 orders and sieve below, for subsequent use;
(2) get bamboo sprout after (1) step process and add alcoholic solution and extract 1-4 time, merging filtrate, decompression recycling ethanol, and be concentrated into the relative density of regulation, and make concentrated solution, for subsequent use.
In described (2) step, filtrate recycling ethanol to be concentrated into 60 DEG C of relative densities be 1.32-1.40.
In described (2) step, the bamboo sprout after (1) step process add its weight 4-12 doubly to measure the alcoholic solution that volume by volume concentration is 30-80%.
Get the concentrated solution that above (2) step obtains, add additive and water, after allotment, filtration, fill and sterilizing, make oral liquid.
Get the concentrated solution that above (2) step obtains and dry, pulverize 60-120 mesh sieve, add proper auxiliary materials, mix homogeneously, adds adhesive soft material processed, granulates in 14-20 mesh sieve, dry, granulate, fill as requested, tank capsule or tabletting make solid articles.
Described bamboo sprout solid articles can be made tablet, granule and capsule etc.Described tablet comprises ordinary tablet, coated tablet, chewable tablet, buccal tablet etc.
Treat a preparation method for the bamboo-shoot product of alcoholic liver disease, it step comprising is as follows:
(1) get bamboo sprout (preferred fresh Radix Crotalariae szemoensis are shelled) and be dried to water content below 15%, pulverized 10 orders and sieve below, for subsequent use;
(2) get bamboo sprout after (1) step process and add alcoholic solution and extract 1-4 time, merging filtrate, decompression recycling ethanol, and be concentrated into the relative density of regulation, and make concentrated solution, for subsequent use.
(3) in concentrated solution, add adjuvant and make required dosage form.
In described (2), filtrate recycling ethanol to be concentrated into 60 DEG C of relative densities be 1.32-1.40.
In described (2) step, the bamboo sprout after (1) step process add its weight 4-12 doubly to measure the alcoholic solution that volume by volume concentration is 30-80%.
A preparation method for the treatment of the bamboo sprout oral liquid of alcoholic liver disease, its step comprises: get the concentrated solution that above (2) step obtains, add additive and water, after allotment, filtration, fill and sterilizing, make.
A kind of preparation method of bamboo sprout solid articles for the treatment of alcoholic liver disease, its step comprises: its step comprises: get the concentrated solution that above (2) step obtains dry, pulverized 60-120 mesh sieve, add proper auxiliary materials, mix homogeneously, adds adhesive soft material processed, granulate in 14-20 mesh sieve, dry, granulate, fill as requested, tank capsule or tabletting make.
The present invention is from Chinese medical theory, many because of wet after drinking, hot cohesion for alcoholic simple fatty liver and alcoholic liver disease, retardance human functional activity of vital energy, so that QI and blood is not smooth, forms phlegm retention and blood stasis, and with the passing of time phlegm retention and stagnation of blood stasis must cause the deficiency syndrome of internal organs; With removing dampness the turbid descending, blood circulation promoting and blood stasis dispelling, and according to internal organs deficiency syndrome; Make full use of bamboo sprout energy Qinghua heat-phlegm, dampness removing the turbid descending, QI invigorating stomach function regulating, can be directly wet and hot for the heresy of causing a disease of alcoholic simple fatty liver and ethanol hepatopathy, adopt modern extraction and preparation process that bamboo sprout are processed into multiple product simultaneously, play good effect and there is huge economic benefit.
Compared with prior art, the present invention has the following advantages:
(1) supplementary material is raw-food material or food additive, has more security advantages compared with Western medicine and Traditional Chinese Medicine treatment; And amount, without concrete restriction, can be adjusted according to the concrete condition of prevention, treatment;
(2) adopt modern science and technology processing bamboo shoot, both taken full advantage of the nutritive value of bamboo sprout, solved again the astringent taste existing during bamboo sprout tradition is edible difficult except, edible inconvenient problem;
(3), taking Chinese medical theory as guidance, in conjunction with modern pharmacology, medicine achievement in research, can effectively treat alcoholic liver disease, for the food therapy of alcoholic liver disease provides thinking.
[detailed description of the invention]
Below in conjunction with specific embodiment, the present invention will be described in detail.
Embodiment 1
Treat a preparation method for the bamboo-shoot product of alcoholic liver disease, it step comprising is as follows:
(1) get bamboo sprout (preferred fresh Radix Crotalariae szemoensis are shelled) and be dried to water content below 15%, pulverized 10 orders and sieve below, for subsequent use;
(2) get bamboo sprout after (1) step process and add the alcoholic solution that volumetric concentration that its weight 4-8 doubly measures is 45-75% and extract 2-4 time, merging filtrate, decompression recycling ethanol, and to be concentrated into 60 DEG C of relative densities be 1.32-1.40, makes concentrated solution; The above alcoholic solution preferred concentration is 50-65%.
(3) in concentrated solution, add adjuvant and make required dosage form, described adjuvant comprises water, Icing Sugar, lactose, mannitol, starch, dextrin, flour, egg, vegetable oil and sodium bicarbonate etc.
Wherein, the step of the preparation method of the bamboo sprout oral liquid for the treatment of alcoholic liver disease comprises: get the concentrated solution that above (2) step obtains, add additive and water, after allotment, filtration, fill and sterilizing, make.Described additive is conventional edible additive.
The step of preparation method of the bamboo sprout solid articles for the treatment of alcoholic liver disease comprises: get the concentrated solution that above (2) step obtains dry, pulverized 60-120 mesh sieve, add proper auxiliary materials, mix homogeneously, add adhesive soft material processed, granulate in 14-20 mesh sieve, dry, granulate, fill as requested, tank capsule or tabletting make.
Clinical trial:
1 experiment equipment
The healthy Wistar male rat of 1.1 laboratory animals, body weight 180-220g, is provided by Guangdong Province's Experimental Animal Center.
1.2 medicines and reagent bamboo sprout extracting solution, liver-protecting tablet (Heilongjiang Kuihua Yaoye Co.Ltd Co., Ltd), edible ethanol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglyceride (TG) test kit.
1.3 instrument semi-automatic biochemical analyzers, centrifuge, thermostat water bath, electronic balance.
2 experimental techniques
Rat is divided at random 6 groups by 2.1 groupings, and 10 every group, i.e. blank group, model group, positive controls, high dose group, middle dosage group and low dose group.
2.2 modelings except blank group, every group all in afternoon 4 gavages give 40% ethanol (8g/kg* days, continue 6 weeks), since the 7th week, concentration of alcohol is brought up to 50% (9g/kg* days until the 12nd weekend).
2.3 administration blank groups and model control group 8 o'clock of every morning gavage give distilled water 10mL/kg, positive controls tank every day is with the liver-protecting tablet suspension (10mL/kg) of 0.5g/kg weight, high dose group tank gives 2g/mL bamboo sprout extracting solution (10mL/kg), middle dosage group tank gives 1g/mL bamboo sprout extracting solution (10mL/kg), and low dose group tank gives 0.5g/mL bamboo sprout extracting solution (10mL/kg).
2.4 detect index and method
2.4.1 sample disposal tested for 12 weekends, and fasting after last 1 administration, in second day weighed weight.Adopt femoral artery to get blood, blood sample low-temperature centrifugation, gets serum in-20 DEG C of cold preservations.Rat is got liver after putting to death immediately, uses normal saline washed blood, and filter paper blots, and weighs.After weighing, get 0.5cm place, the maximum blde pitch edge of liver and get 0.5cm × 0.5cm size hepatic tissue.Fix with 4% paraformaldehyde.Separately get appropriate hepatic tissue, with the normal saline flushing of pre-cooling, filter paper blots, and takes 0.3g left and right, and adds the normal saline of pre-cooling, makes 10% homogenate in ice bath, in 4 DEG C of centrifugal 10min of 4000r/min, gets supernatant, in-20 DEG C of cold preservations.
2.4.2 level of fibrosis is learned to observe and is taken the fixing hepatic tissue of 4% paraformaldehyde, routine paraffin wax embedded section, hematoxylin-eosin (HE) dyeing, electron microscope observation.
2.4.3TG, the mensuration of AST and ALT is got serum and on semi-automatic biochemical analyzer, is measured TG, AST and ALT.
2.4.4 data represent with x ± s, and application SPSS12.0 statistical package is processed.Between group, relatively adopt variance analysis.
3 results
3.1 rat liver morphological changes of various tissue components
3.1.1 perusal blank group liver outward appearance is bronzing, soft high resilience; Model group liver volume increases, and edge is blunt and thick, and surface and inside are all lark, the obvious greasy feeling of tool; Between each medication group, perusal difference is not obvious, and color and luster is dimmer, and quality, elasticity are all between model group and normal group.
3.1.2 electron microscopic observation normal rats lobules of liver structure is normal, and central vein is large and wall is thin, and hepatocyte is arranged in liver rope, around central vein, radially distributes, and cell is polygon, and without cloudy swelling, necrosis, endochylema drips without fat, without inflammatory cell infiltration; Model group rats'liver leaflet structure is unclear, hepatic cords disorder, and sinus hepaticus narrows, most hepatocyte cloudy swellings, obvious steatosis, fat drips taking large alveolitoid as main, visible spotty necrosis and inflammatory cell infiltration; Each medication group rats'liver leaflet structure is clear, and hepatic cell fattydegeneration is clearly better, hepatocyte marshalling, and sinus hepaticus recovers normally substantially, and a small amount of hepatocyte cloudy swelling, without cell infiltration and necrosis.
3.2 impacts of bamboo sprout extracting solution on Rats with Fatty Liver liver coefficient
Liver coefficient=liver weight/rat body weight (g) x100%.Significantly increase (P < 0.05) with blank group comparison model group liver coefficient, all little and model group of each administration group increasing degree, specifically sees the following form.
Note: (n=10) with model group contrast,
*p < 0.05;
*p < 0.01.
The impact of 3.3 bamboo sprout extracting solution on Rats with Alcoholic Liver Disease TG, AST and ALT content
Result shows, each group of administration all can reduce TG, AST, the ALT value of Rats with Alcoholic Liver Disease preferably, and wherein with positive controls the best, the effect of bamboo sprout extracting solution is slightly poor compared with positive drug, and better with dosage increasing effect, and concrete outcome sees the following form.
Each group TG, AST and ALT comparison (n=10) table
Note: with model group contrast,
*p < 0.05;
*p < 0.01.
Alcoholic simple fatty liver in alcoholic liver disease and the main clinical manifestation of alcoholic hepatitis are that hepatocyte is impaired, and liver weight in wet base increases, and triglyceride increases, and with abnormal liver function.Experimental result demonstration bamboo sprout extracting solution can be alleviated the liver morphological change of experimental Rats with Alcoholic Liver Disease; The indexs such as the liver coefficient of the experimental Rats with Alcoholic Liver Disease of remarkable reduction and TG, AST, ALT.Show that hepatic injury and abnormal liver function that bamboo sprout extracting solution causes alcoholic simple fatty liver and alcoholic hepatitis have good therapeutical effect.Because each treatment group shifts to an earlier date administration intervention, show the liver damage that bamboo sprout extracting solution energy antagonism potable spirit causes simultaneously.
As described above, it is only preferred embodiment of the present invention, when not limiting scope of the invention process with this, the simple equivalence of generally doing according to the present patent application the scope of the claims and invention description content changes and modifies, and all still remains within the scope of the patent.
Claims (4)
1. the application of bamboo-shoot product in the medicine of preparation treatment alcoholic liver disease, described bamboo-shoot product is made up of bamboo sprout extract and adjuvant,
The step that the preparation method of described bamboo sprout extract comprises is as follows:
(1) get bamboo sprout and be dried to water content below 15%, pulverized 10 orders and sieve below;
(2) getting bamboo sprout after (1) step process, to add its weight 4-12 doubly to measure volume by volume concentration be that the alcoholic solution of 50-65% extracts 1-4 time, merging filtrate, decompression recycling ethanol, and to be concentrated into 60 DEG C of relative densities be 1.32-1.40, makes concentrated solution.
2. application according to claim 1, is characterized in that, gets the concentrated solution that above (2) step obtains, and adds additive and water, after allotment, filtration, fill and sterilizing, makes oral liquid.
3. application according to claim 1, is characterized in that, gets the concentrated solution that above (2) step obtains and dry, pulverize 60-120 mesh sieve, add adjuvant, mix homogeneously, adds adhesive soft material processed, granulate in 14-20 mesh sieve, dry, after granulate, make solid articles.
4. application according to claim 3, is characterized in that, described solid articles is made to tablet, granule and capsule; Described tablet is selected from coated tablet, chewable tablet and buccal tablet.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101166538A (en) * | 2005-05-02 | 2008-04-23 | 希杰株式会社 | Composition for preventing and treating hangover |
| CN102133349A (en) * | 2011-03-07 | 2011-07-27 | 李雪松 | Bitter bamboo shoot extract with anti-inflammatory activity and applications thereof |
| CN102357209A (en) * | 2011-10-25 | 2012-02-22 | 广州蓝韵医药研究有限公司 | Extraction method of bamboo shoot flavonoid and tannin |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101166538A (en) * | 2005-05-02 | 2008-04-23 | 希杰株式会社 | Composition for preventing and treating hangover |
| CN102133349A (en) * | 2011-03-07 | 2011-07-27 | 李雪松 | Bitter bamboo shoot extract with anti-inflammatory activity and applications thereof |
| CN102357209A (en) * | 2011-10-25 | 2012-02-22 | 广州蓝韵医药研究有限公司 | Extraction method of bamboo shoot flavonoid and tannin |
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Address after: 510663 Guangdong city of Guangzhou province high tech Industrial Development Zone of Guangzhou Science City skim Springs Road No. 3, Guangzhou international business incubator District B Room 301 Patentee after: Guangzhou Yun Yun medicine Polytron Technologies Inc Address before: 510663 Guangdong city of Guangzhou province high tech Industrial Development Zone of Guangzhou city science and technology innovation base on Road No. 80 D District fourth floor unit 410-412 Patentee before: Guangzhou Lanyun Medicine Research Co., Ltd. |
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