CN102579843A - Formula of health-care pharmaceutical with functions of enhancing immunity and assisting reduction of blood pressure - Google Patents
Formula of health-care pharmaceutical with functions of enhancing immunity and assisting reduction of blood pressure Download PDFInfo
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Abstract
A formula of a health-care pharmaceutical with functions of enhancing immunity and assisting reduction of blood pressure relates to the health-care pharmaceutical. The formula comprises broccoli extractive 9-15 g, eucommia ulmoides 3.5-8 g, gastrodia elata 3-8 g, astragalus mongholicus 3-6 g, folium apocyni veneti 3-8 g, selfheal 4.5-10 g and microcrystalline cellulose 3-9 g by proportion. The preparation process comprises the steps of respectively smashing eucommia ulmoides, gastrodia elata, astragalus mongholicus, folium apocyni veneti and selfheal and sieved by a screen with 60-80 meshes, weighing pharmaceutical power and other raw auxiliary materials proportionally to be mixed evenly for 45-50 minutes, filling mixture into capsules, performing following working procedures including screening, polishing, inner packing and outer packing and finally performing inspection and warehousing according to the inspection standard, wherein filling weight is strictly controlled according to the inner quality standard in filling process. The formula of the health-care pharmaceutical with functions of enhancing immunity and assisting reduction of blood pressure can enhance immunity, assist reduction of blood pressure and improve human body immunity and life quality of hypertensive, is free of side effect and untoward effect, and uses the modern preparation technology and an advanced quality control method to enable products to be safe, stable and controllable in quality.
Description
Technical field:
The present invention relates to a kind of health medicine, be specifically related to a kind of prescription with the health medicine that increases immunity, aided blood pressure-lowering function.
Background technology:
Blood pressure is the main health risk factors of cardiovascular diseases and nephropathy.Study verifiedly, will not shorten life expectancy about 5 years if hypertension is not treated.Though the past over more than 60 year hypertensive Drug therapy become one of the second half in last century the greatest medical science applied achievement: almost each hypertensive patient can be through medicine controlling blood pressure effectively.Yet up to today, global hypertensive patient is still constantly increasing.Although develop the hypertensive active drug of control for a long time, the number that hypertensive patient's blood pressure does not control to normal level is still constantly increasing.The complicated cause of disease of hypertensive pathogeny as yet not the arteriotony of complete clear and definite animal be decided by that cardiac output and the peripheral vascular resistance latter are decided by that then the bore of blood vessel and these control such as autonomic nervous system renin angiotensin-aldosterone systems that determine the factor of blood pressures to receive number of mechanisms again of blood viscosity are the inherent regulation mechanism of hormonal system and smooth muscle etc.Now that the incidence of hypertension is under the influence of various factors regulating blood pressure hypertension dysfunction arising mainly divided into primary hypertension and secondary hypertension, including hypertension, hyperthyroidism, renal hypertension traumatic brain hypertensive drug-induced hypertension but their pathogenesis has not been entirely clear majority of children during hypertension secondary hypertension are present study found that the main cause of kidney disease Pi to acute and chronic glomerulonephritis is more common renal vascular disorders in renal artery stenosis is more common neuroendocrine abnormalities can also cause high blood pressure medicine traditional medicine that the pathogenesis of hypertension and blood fine balance system are related hypertension are Chinese vertigo category.In recent years Here it is so-called " hypertension antinomy " over the year.China is from four ten years of nineteen fifty-nine to 2002 year, and crowd's hypertension prevalence is increasing always more than 15 years old, and wherein in 11 in 1991 to 2002 years, prevalence rises 31%, and number of patients increases more than 7,000 ten thousand.Understand the philtrum of hypertension, effective control rate has only 6.1%, only about 3,230,000 people.Why " hypertension antinomy " can appear? Answer is very clear and definite, and past 30 years social change has brought many unsound influences for our life style and custom.Most of people do not have to form healthy lifestyles and custom is the key that " hypertension antinomy " occur.And do not form healthy lifestyles and custom is closely-related with environment and individual behavior.Can improve successfully at present that more and more whether to have the ability to improve patient's drug compliance relevant with us to hypertensive effective control rate, and little with the accessibility relation of hypertension drug." hypertension antinomy " proves again and exists very complicated relation between health and disease and the multiple factor.Social environment, natural environment and genetic characteristics all can exert an influence to biology and behavioristics's factor of decision personal health.Individual behavior is not simple personal selection, is the result that multiple factor interacts and wields influence on each different aspects of tissue.Therefore, slow sick management light pays close attention to prevention and control biological factor (medicine) is far from being enough, consider to change environment and individual behavior simultaneously, should consider biological factor, also will consider behavioristics's factor.We should come slow patient of Classification Management and slow sick high, medium and low danger crowd through the health risk factors of affirmation and intervention biology-psychology-society-environment various aspects under scientific information instructs.Slow sick infringement and the prevention and control health risk factors to afflicted of prevention and control is of equal importance to the infringement of relative healthy population.
Vascular hypertension has become one of killer who threatens the human life, and therefore developing the health food with aided blood pressure-lowering is vital task of China scientific research personnel and enterprise and responsibility.
Along with the People more and more that day by day seriously makes of social environmental pollution is liked pure natural, pollution-free, the food that do not add synthetics.Adding growth in the living standard also makes people that the quality of life has been had higher pursuit.Thereby pay attention to health more, pay attention to getting rid of illness diseases prevention and slow down aging etc.Under this background, the utilization high-tech means is also arisen at the historic moment with the health food of the free of contamination pure natural animals and plants accent aided blood pressure-lowering that is raw material, and develop rapidly.
Summary of the invention:
The purpose of this invention is to provide a kind of health medicine prescription that increases immunity, aided blood pressure-lowering function that has; It can reduce human blood-pressure, improves people's health level, the various diseases that prevention is caused by hypertension; Have no side effect and untoward reaction; And use modern preparation technique, advanced method of quality control makes product accomplish safety, stable, quality controllable.
In order to solve the existing problem of background technology, the present invention adopts following technical scheme: the prescription ratio of medicine is: Caulis et Folium Brassicae capitatae 9-15g, Cortex Eucommiae 3.5-8g, Rhizoma Gastrodiae 3-8g, Radix Astragali 3-6g, Folium Apocyni Veneti 3-8g, Spica Prunellae 4.5-10g, microcrystalline Cellulose 3-9g.
First optimal way of this medicine is that prescription is than being: Caulis et Folium Brassicae capitatae 9g, Cortex Eucommiae 3.5g, Rhizoma Gastrodiae 3g, Radix Astragali 3g, Folium Apocyni Veneti 3g, Spica Prunellae 4.5g, microcrystalline Cellulose 3g.
Second optimal way of this medicine is that prescription is than being: Caulis et Folium Brassicae capitatae 15g, Cortex Eucommiae 8g, Rhizoma Gastrodiae 8g, Radix Astragali 6g, Folium Apocyni Veneti 8g, Spica Prunellae 10g, microcrystalline Cellulose 9g.
The 3rd optimal way of this medicine is that prescription is than being: Caulis et Folium Brassicae capitatae 10.1g, Cortex Eucommiae 5.3g, Rhizoma Gastrodiae 6.8g, Radix Astragali 4.7g, Folium Apocyni Veneti 6.8g, Spica Prunellae 7.8g, microcrystalline Cellulose 5.5g
The effective ingredient of Caulis et Folium Brassicae capitatae is that sulfur is sweet; The effective ingredient of Cortex Eucommiae extract is that Rabdosia rubescens adds element; The effective ingredient of Rhizoma Gastrodiae extract is a gastrodine, and the effective ingredient of Radix Astragali extract is a total flavones, the effective ingredient Shi Quercetin of dogbane leaf extractive; The effective ingredient of Spica Prunellae extract is a triterpene
The effective ingredient of this medicine distributes as follows: the 100g medicine contains the sweet 800mg of Radix Raphani sulfur, Rabdosia rubescens adds plain 1300mg, total flavones 1100mg 、 Quercetin 350mg, triterpene 3000mg.
The preparation technology of this medicine is: earlier the medicine Cortex Eucommiae, Rhizoma Gastrodiae, the Radix Astragali, Folium Apocyni Veneti, Spica Prunellae are pulverized respectively; The powder of cross the 60-80 mesh sieve, getting them carries out uniform mixing, incorporation time 45-50 minute with the weighing by a certain percentage of other supplementary material; Carrying out capsule again fills; In strict accordance with inner quality standard control filling weight, later process is screened, polishing, inner packing, outer package, at last by touchstone check warehouse-in in the filling process.
The present invention has following beneficial effect: the health medicine prescription that can increase immunity, aided blood pressure-lowering function; It can reduce human blood-pressure, improves people's health level, the various diseases that prevention is caused by hypertension; Have no side effect and untoward reaction; And use modern preparation technique, advanced method of quality control makes product accomplish safety, stable, quality controllable.
The specific embodiment:
This specific embodiment adopts following technical scheme: the prescription ratio of medicine is: Caulis et Folium Brassicae capitatae 9-15g, Cortex Eucommiae 3.5-8g, Rhizoma Gastrodiae 3-8g, Radix Astragali 3-6g, Folium Apocyni Veneti 3-8g, Spica Prunellae 4.5-10g, microcrystalline Cellulose 3-9g.
First optimal way of this medicine is that prescription is than being: Caulis et Folium Brassicae capitatae 9g, Cortex Eucommiae 3.5g, Rhizoma Gastrodiae 3g, Radix Astragali 3g, Folium Apocyni Veneti 3g, Spica Prunellae 4.5g, microcrystalline Cellulose 3g.
Second optimal way of this medicine is that prescription is than being: Caulis et Folium Brassicae capitatae 15g, Cortex Eucommiae 8g, Rhizoma Gastrodiae 8g, Radix Astragali 6g, Folium Apocyni Veneti 8g, Spica Prunellae 10g, microcrystalline Cellulose 9g.
The 3rd optimal way of this medicine is that prescription is than being: Caulis et Folium Brassicae capitatae 10.1g, Cortex Eucommiae 5.3g, Rhizoma Gastrodiae 6.8g, Radix Astragali 4.7g, Folium Apocyni Veneti 6.8g, Spica Prunellae 7.8g, microcrystalline Cellulose 5.5g
The sweet 2.5% 32% 96mg 15.4g2.5% of Caulis et Folium Brassicae capitatae sulfur
The effective ingredient of Cortex Eucommiae extract is that Rabdosia rubescens adds element, and the effective ingredient of Rhizoma Gastrodiae extract is a gastrodine, and the effective ingredient of Radix Astragali extract is a total flavones, the effective ingredient Shi Quercetin of dogbane leaf extractive, and the effective ingredient of Spica Prunellae extract is a triterpene,
The effective ingredient of this medicine distributes as follows: the 100g medicine contains the sweet 800mg of Radix Raphani sulfur, Rabdosia rubescens adds plain 1300mg, total flavones 1100mg 、 Quercetin 350mg, triterpene 3000mg.
The preparation technology of this medicine is: earlier the medicine Cortex Eucommiae, Rhizoma Gastrodiae, the Radix Astragali, Folium Apocyni Veneti, Spica Prunellae are pulverized respectively; The powder of cross the 60-80 mesh sieve, getting them carries out uniform mixing, incorporation time 45-50 minute with the weighing by a certain percentage of other supplementary material; Carrying out capsule again fills; In strict accordance with inner quality standard control filling weight, later process is screened, polishing, inner packing, outer package, at last by touchstone check warehouse-in in the filling process.
This specific embodiment has following beneficial effect: the health medicine prescription that can increase immunity, aided blood pressure-lowering function; It can reduce human blood-pressure, improves people's health level, the various diseases that prevention is caused by hypertension; Have no side effect and untoward reaction; And use modern preparation technique, advanced method of quality control makes product accomplish safety, stable, quality controllable.
Caulis et Folium Brassicae capitatae:
Caulis et Folium Brassicae capitatae raw material in the prescription is processed through alcohol extraction process with our common vegetable Caulis et Folium Brassicae capitatae used in everyday.Caulis et Folium Brassicae capitatae meets " Ministry of Public Health is about the notice of further standard healthy food material management " requirement as the bread and cheese raw material; Caulis et Folium Brassicae capitatae is with its nutrient substance that is rich in and the unique effects that has; Along with progressively going deep into of scientific research; More and more receive people's attention, and beginning has obtained exploitation faster and has used at field of food.Caulis et Folium Brassicae capitatae not only contains protein, sugar, fat, mineral, vitamin C and carotene etc.; Glucosinolate content is very abundant especially; With Radix Raphani sulfur glycosides (4-methylsulfinyl cyclobutenyl thioglycoside) is main, and its catabolite sulforaphen is the strongest active component of finding in the vegetable up to now of anticancer vigor, has the obvious microenvironment of improving human body cell; Can improve body immunity, promote the effect of death of neoplastic cells.
External relevant bibliographical information Caulis et Folium Brassicae capitatae have function of enhancing immunity; P.Thejass for example; Experimental result shows in " probe into the immunocompetence of sulforaphen, a kind of from Brassica oleracea L. var. botrytis L. the isothiocyanate of natural extract " literary composition that G.Kuttan delivers on " plant amedica (magazine) ": sulforaphen has the effect of the peritoneal macrophage that improves activate the phagocytic capacity.The effect of sulforaphen also can significantly reduce the tumor necrosis factor that is increasing in addition--and-a lipopolysaccharide stimulates the macrophage that produces.These results show that sulforaphen has the immunocompetent effect of adjusting.(seeing the 14.3-1 of declaration material for details); According to Thejass P, Kuttan G is in that " " isothiocyanate that sulforaphen is a kind of to derive from the nature of Caulis et Folium Brassicae capitatae increases the cytotoxicity that BALB/c mouse NK cell and antibody rely on through strengthening interleukin II and tumor necrosis factor " literary composition of delivering on immune pharmacology and the immune toxicity journal is reported: sulforaphen is to normally and the research of the influence of the cell-mediated immunity of the BALB/c mouse of Ehrlich ascites inoculated tumour.Sulforaphen significantly increases the NK cytoactive of normal and inoculated tumour animal.NK cytoactive among the intact animal is observed than inoculated tumour cell animal is more Zao.The cytotoxicity that the antibody of the animal of the normal and inoculated tumour that sulforaphen is handled relies on is significantly strengthened than the animal of the inoculated tumour that does not have sulforaphen to handle.In the animal of the normal and inoculated tumour that sulforaphen is handled, observe a kind of cytotoxicity of complementation mediation of early antibody dependence.Sulforaphen is handled interleukin II and tumor necrosis factor-gamma in the animal that has significantly increased normal and inoculated tumour.Sulforaphen is handled and has significantly been promoted splenocyte, medullary cell, thymocyte proliferation in addition.Show that sulforaphen has the effect of raise immunity; According to Thejass P, Kuttan G " deliver on immune pharmacology and the immune toxicity journal " sulforaphen is to B16F-10
MelanomaInductive
MigrationThe property tumor inoculation the adjusting of response of C57BL/6 mouse cell mediation immunity " a literary composition report: sulforaphen is handled and has significantly been strengthened
MigrationThe NK cytoactive of property tumor inoculation animal has significantly increased inoculation
MelanomaAnimal in interleukin II and tumor necrosis factor; Sulforaphen has significantly reduced the toxic level of proinflammatory cytokine in the serum during neoplasm metastasis in addition; Through the response of sulforaphen irritation cell mediation immunity, raise IL-2 and IFN-gamma, downward modulation proinflammatory cytokine toxicity IL-1beta; IL-6, TNF-alpha and GM-CSF.
Domestic relevant bibliographical information Caulis et Folium Brassicae capitatae have function of enhancing immunity; Show in " sulforaphen extraction, separation and Anticancer Activities in the Caulis et Folium Brassicae capitatae " literary composition that for example Ji Yubin, Chi Wenjie, Zou Xiang, Wang Zhiju deliver that sulforaphen has tangible blocking effect especially obvious to hepatocarcinoma, the esophageal carcinoma, preceding gastric cancer effect to rodent hepatocarcinoma, breast carcinoma, pulmonary carcinoma, the esophageal carcinoma, preceding gastric cancer on " Harbin University of Commerce's journal " (changing the science version over to); Experiment proof they can Phase II (cancerigenic factor detoxifcation) enzyme generation; Thereby play antitumaous effect; These enzymes can be through the active center of destroying cancerigenic factor or the method that they and endogenous aglucon are combined, and acceleration excretes it.Data proves that sulforaphen is through carcinogen metabolic regulation mechanism is worked.The research worker of vast this John Hopkins University of the U.S. is utilized transgenic mouse experiment proof: a kind of system of ubiquity in many animal bodies, the carcinogenesis that is used for resisting toxic chemical substance in food and the environment.The performance of this effect depends on the remarkable increase of Phase II enzyme quantity.This enzyme can be eliminated harmful chemical, suppresses its infringement DNA, thereby reaches anticancer disease effect.Two sulforaphen are the most intensive PhaseII enzyme inducers of finding up to now; Deliver in " purification and the anti-tumor activity of main sulfur glycosides in the Semen Brassicae campestris " literary composition in " applied chemistry " (the 22nd the 10th phase of volume) according to the Zhou Jinlan of department of chemistry of the Central China University of Science and Technology, Yu Kaichao and to show: the sulfur glycosides itself is kind of a more stable chemical compound, but can be become multiple products such as isothiocyanate (ITC), oxazolidine thione (OZT) and nitrile compounds by bacterial enzyme catalytic degradation in myrosase or the gastrointestinal tract.The antibacterial action that these catabolites have stronger inhibition fungus and microbial reproduction etc. reaches through inducing the carcinogenesis of the active blocking-up of ubiquinone reductase carcinogen; According to first middle school, Qinhuangdao, Hebei province, Hebei Normal University chemistry and material science institute Shen tree virtue, Zhang Yingfeng, nightstool river " chemistry teaching " (2009; The 7th phase) shows in " the anticancer pharmacology of thioglycoside in the Caulis et Folium Brassicae capitatae " literary composition of delivering on that Radix Raphani sulfur glycosides can induce body to produce the II type and separate toxenzyme-glutathione transferring enzyme and quinone reductase; This enzyme can produce resistance to many carcinogens, thereby plays antitumaous effect; According to the Beijing University of Technology engineering constraint learn, that The Hong Kong Polytechnic University's applying biological and chemical science and technology is Wang Jiandong, Yuan Qipeng, Qian Zhongming points out that sulforaphen acts on the body process in " sulforaphen progress " literary composition that " food and fermentation industries " delivered is following: (1) enzyme II gene transcription.Transcribe the II type enzyme that only produces the human body beneficial, inhibitory enzyme I produces simultaneously, and enzyme I can produce cooperative effect with carcinogen, quickens cancer and takes place.(2) enzyme II acts on the anticancer system of body self.Through this system, can realize following regulation and control: 1. block carcinogen and produce the required metabolic pathway of carcinogenic effect, stop carcinogen or its metabolite to get into target cell, play the carcinogenic effect of removing simultaneously to metabolism; The division of anticancer and growth, blocking-up circulation approach; But the red carcinogen of the protein secreting ancestral who promotes other kill cancer cell is induced the effect of cancer.2. the hydrolyzate of the sinigrin startup generation effect that possibly play a role to carcinogen; At the cancer formation initial stage gene is undergone mutation; Also have some inhibitory enzymes to have dual resistance cancer or cancer suppressing function in addition, Toxic is degraded, thereby play anticancer effect-become and press down the cancer approach; According to Zhejiang Prov Industrial And Commercial University's food is that Wang Zhongying, Wang Xiangyang show in " thioglycoside and catabolite isothiocyanate thereof " literary composition that " chemistry of life " (rolling up for 4 phases in 2005 25) delivered: the anticancer mechanism of isothiocyanate comprises two parts: (1) is through suppressing the process that the Phase I enzyme stops (comprising cytochrome p450 system) chemocarcinogenesis; Particularly PEITC and BITC can effectively suppress cancerigenic factor-DNA and add the formation with thing; Thereby suppress forming by the inductive tumor of cancerigenic factor; (2) induce the generation Phase to separate toxenzyme; For example glutathione transferase and UDP-glucuronyl transferase etc., thus the overactive carcinogenic intermediate product that cytochrome p450 system produces reduced.Wherein SUL induces and produces Phase to separate the ability of toxenzyme strong especially, is the natural inducer that the most effectively Phase that identifies is up to now separated toxenzyme.Though human body is had certain toxic action for the SUL of high concentration and fragrant alkane isothiocyanate but they (in 0.05～20umol), do not show 200～400 milligrams of the oral suggestions of toxicity human body, can effectively prevent multiple cancer in valid density.
With the Caulis et Folium Brassicae capitatae consumption in this prescription, according to hide naval, Zhang Keying shows in " harm of thioglycoside and detoxification Study on Measures in the dregs of rapeseed cake " literary composition that " feed industry " (2007 the 28th volumes) delivered: pig, rabbit, fowl, fish and ruminant to daily ration in the tolerance level of thioglycoside be respectively 0.78,7.0,5.4,3.6 and 1.5～4.22umol/g; Show in " applied chemistry " (the 20th the 10th phase of volume) " purification and the anti-tumor activity of main sulfur glycosides in the Semen Brassicae campestris " literary composition,, mice sulfur glycosides least action dosage 30mg/kg shows that the sulfur glycosides has obvious inhibitory action to S180 tumor in the mice body; Show in " thioglycoside and catabolite isothiocyanate thereof " literary composition that deliver " chemistry of life " (2005 25 volume 4 phases): though the SUL of high concentration and fragrant alkane isothiocyanate to human body have certain toxic action they in valid density (in 0.05～20umol); Do not show 200～400 milligrams of the oral suggestions of toxicity human body, can effectively prevent multiple cancer.According to above different documents and materials, be test raw material with Radix Raphani sulfur glycosides in this prescription Caulis et Folium Brassicae capitatae raw material, experimentize by adult (50kg weighing machine) 34mg every day.
1. 30 times, 10 times of human body recommended amounts are established in ear swelling method experiment, calculate according to formula: promptly every day, Radix Raphani sulfur glycosides 22.48mg/kg, 8.16mg/kg were respectively high low dose group.Actual disposition needs the high low dose group 27.98mg/kg of sample Radix Raphani sulfur glycosides, 9.33mg/kg, dosage 0.4ml/20g Mus weight/d when irritating gastric juice.Every day gastric infusion, experimental result is seen table 1, table 2.
Table 1 Radix Raphani sulfur glycosides immunological enhancement: body weight organ index
Table 2 sulforaphen Radix Raphani sulfur glycosides immunological enhancement: ear swelling
Experimental result compare the high low dosage of Radix Raphani sulfur glycosides with blank control group to not obviously influence of body weight, but the ear swelling experiment shows that high low dose group all has tangible immunological enhancement.
2. humoral immunization serum hemolysin experiment, the high 1.2mg/ml of Radix Raphani sulfur glycosides; Radix Raphani sulfur glycosides hangs down 0.4mg/ml, dosage 0.4ml/20g/d, every day gastric infusion.The result sees table 3 table 4:
Table 3 sulforaphen Radix Raphani sulfur glycosides immunological enhancement: body weight organ index
Table 4 sulforaphen Radix Raphani sulfur glycosides immunological enhancement: serum hemolysin
Experimental result is compared with blank control group, and the positive drug Thymosin alpha 1 is influential to body weight, and the survey experiment of serum hemolysin shows its obviously enhancing body humoral immunization.All the other each groups compare with normal group, and body weight and organ index are not all had remarkable effect.The serum hemolysin and the antibody product of the high low dosage of Radix Raphani sulfur glycosides have raising, p＜0.05, and low metering group also improves with respect to blank control group.The determination experiment of serum hemolysin shows that foretelling just metering group of sulfur glycosides has certain enhancing immunity effect.
The Cortex Eucommiae
The Cortex Eucommiae has another name called thinks celestial, silk cotton tree, belongs to the peculiar section of China Eucommiaceae.Mainly be distributed in provinces such as Shaanxi, Henan, Hubei, Hunan, Sichuan, Yunnan, Guizhou, Zhejiang, Gansu.Its skin stem, Ye Junke are used as medicine, and have invigorating the liver and kidney, bone and muscle strengthening, blood pressure lowering, antiabortive, the anti-effect of waiting for a long time of making light of one's life by commiting suicide.Modern study shows that the Cortex Eucommiae contains the various active composition, has effects [17 such as blood pressure lowering, diuresis, antibiotic, antiinflammatory, calmness, hemostasis, analgesia.This paper has summarized the antihypertensive compositions and the hypotensive effect mechanism of the Cortex Eucommiae.Water extract: water extract is to be a kind of mixture that solvent extracts from the Cortex Eucommiae with water.Zoopery proof Cortex Eucommiae water extract has tangible hypotensive effect, and untoward reaction is little.In recent years research thinks that water extract possibly produce hypotensive effect through vasodilator.The vasodilator effect of water extract has endothelium-dependent relaxation; After removing vascular endothelial cell; Vasodilator effect complete obiteration [8] water extract of water extract is different to elasticity large artery trunks and the arteriolar diastole mechanism of flesh type: main through promoting the synthetic nitric oxide (NO) of endotheliocyte in large artery trunks; Thereby activate bird former times cyclase of acid (GC) concentration of cycli phosphate bird former times (cGMP) in the cell is increased, cGMP is as the second message,second messenger, and then the enzyme that activates other reaches vasodilatory effect; And water extract comes the vasodilator except that synthesizing NO through the promotion endotheliocyte in small artery, also come vasodilator through promoting endotheliocyte to discharge endothelium derived hyperpolarizing factor (EDHF), and this approach is the arteriolar main path of diastole.Discover that further the vasodilatory effect of water extract is irrelevant with the M receptor and relevant with the activation of K ten passages.Kwan etc. add people's atropine in experiment; The vasodilator effect of water extract does not have obvious change; And the K+ channel inhibitor can significantly suppress its diastole effect, and this possibly be because NO that water extract vasoactive endothelium is produced and EGHF all can cause VSMC hyperpolarization and diastole through activating this approach of potassium-channel.In recent years discover that Cortex Eucommiae Cheng Fen Quercetin can bring high blood pressure down through number of ways.Quercetin has vasodilator effect, and according to the height of concentration, the concrete mechanism of its diastole effect is also different.The vasodilator effect of low concentration Shi ， Quercetin has endothelium-dependent relaxation, and is main through promoting endotheliocyte to discharge the NO vasodilator; And when high concentration, it is mainly through suppressing the approach vasodilators [131 such as Ca2+ passage of VSMC.Research Biao Ming Quercetin 1-100 μ mol/L can be dose dependent ground and suppress the interior calcium concentration rising of VSMC that high potassium depolarization causes, and is similar with the verapamil effect, but is weaker than verapamil; Quercetin 1-100 μ mol/L increases through the receptor-mediated calcium concentration that causes norepinephrine and Angiotensin II and also has the obvious suppression effect, but the smooth muscle calcium concentration of quiescent condition is not had obvious influence.The Gu Quercetin maybe be through the double inhibition effect to VSMC voltage dependent channel and receptor operated calcium channel; Reduce the endocellular liberation calcium level; Thereby vasodilator, falling the hypotension Quercetin has persistent inhibitory action to arterial smooth muscle cell (ASMC) Angiotensin-Converting (ACE) activity and angiotensin (Ang I) generation.As everyone knows; Blood vessel local organization renin-angiotensin system (RAS) plays an important role in the hypertension incidence and development; This effect of ， Quercetin of playing a crucial role in the balance of ACE between vasoconstriction and vasodilation also can cause vasodilation, produces the effect that brings high blood pressure down.Quercetin also can bring high blood pressure down through the hypertrophy approach that suppresses VSMC (VSMC).Hypertension belongs to cell proliferation disorders, and its cytology is in the nature VSMC propagation and migration, causes luminal stenosis, causes hypertension.Proto-oncogene.Expression increase with VSMC propagation and move closely related.Quercetin can suppress transcribing of c-myc DNA in the smooth muscle cell, thereby can suppress the VSMC hypertrophy that its translation albumen promotes.Simultaneously ， generates the AngI of ASMC Yin Quercetin has inhibitory action, and AngI can promote cardiac muscle and levicellular propagation reconstruct, so this effect of quercetin also can suppress the VSMC hypertrophy.Hypertensive generation is except that outside the Pass having with cardiovascular system, and is also relevant with other multiple factors, absorbs and heavily absorbs like Na+.It is the essential condition of keeping regular liquid measure and blood pressure that normal N a+ absorbs with heavily absorbing, and distal convoluted renal tubule epithelium sodium channel (ENaC) plays a part crucial in the heavily absorption of Na+.Recently find that the ， Quercetin can reduce the inductive ENaC expression of high salt diet institute and increase, thereby reduce the caused hypertension of high salt diet.
1, the Cortex Eucommiae is seen table 5 to the influence of WBV, plasma viscosity, packed cell volume value.The result shows, the Cortex Eucommiae can reduce in various degree stasis syndrome card rat low cut (10/S), in cut (40/S) and height is cut whole blood viscosity and blood plasma viscosity under (120/S) 3 shear rates.
2, the Cortex Eucommiae is seen table 6 to whole blood reduced viscosity, erythrocyte aggregation index, the exponential influence of electrophoresis.The result shows that the Cortex Eucommiae can reduce stasis syndrome card rat whole blood reduced viscosity, erythrocyte aggregation index, electrophoresis index in various degree.
Table 5 Cortex Eucommiae is to the influence of WBV, plasma viscosity, packed cell volume value
Model compares with blank control group: ※ P＜0.01, and ※ ※ P＜0.001, medicine and model group compare: △ △＜0.05, △ △ P＜0.005
Table 6 Cortex Eucommiae is to whole blood reduced viscosity, erythrocyte aggregation index, the exponential influence of electrophoresis
Model compares with blank control group: ※ P＜0.01, and ※ ※ P＜0.001, medicine and model group compare: △ P＜0.05, △ △ P＜0.005
In a word, although hypertension has very big progress in theory with in the treatment, have masses of work to do aspect many at new drug development etc.Epidemiologic data confirm the hyperpietic often some hemorheology indexs be higher than the normal person, this variation to the generation of hypertension, develop and lapse to the important clinical meaning is all arranged.
Rhizoma Gastrodiae
Rhizoma Gastrodiae is famous and precious orchidaceae medicinal plant, has realized artificial growth at present and obtained large tracts of land promoting.Clinically cure mainly dizzy, headache, extremity spasm, numbness, neurasthenia etc.The pharmacology of the relevant Rhizoma Gastrodiae of modern medicine mainly contains the following aspects, anticonvulsant action; Calm, syngignoscism; Analgesic activity; Delaying senility function etc.Pharmacological evaluation proof gastrodine and gastrodin unit-p-Hydroxybenzylalcohol all have biological activity, think that at present the main active of Rhizoma Gastrodiae is a gastrodine.This prescription uses its blood pressure lowering principle, the auxiliary Hypertensive Population blood pressure that reduces.
1, gastrodia elata polysaccharide right＜influence of H＜rat body weight and urine amount
Write down respectively body weight before and after the rat administration cycle variation and administration week after date urine amount as shown in table 8 with amount of drinking water ratio, body weight no significant difference before administration of each group in the table, the body weight of each model group all is starkly lower than normal group before the experiment end.The ratio of urine amount and amount of drinking water does not have notable difference between each group.
Table 7 is given gastrodia elata polysaccharide front and back body weight and urine quantitative changeization
Negative control: medicament not; Positive control: captopril 10mg/kg; Compare with normal group a:P＜0.01
2, gastrodia elata polysaccharide is to the influence of RHR rat blood pressure and heart rate
Record rat blood pressure value and heart rate value behind the arterial cannulation, the result sees table 8, and is visible by table, heart rate does not have evident difference between each group; Compare with the normal group pressure value, the systolic pressure and the diastolic pressure of negative control group obviously raises (P＜0.01), and systolic pressure and the diastolic pressure that the administration group is respectively organized rat is than negative control group all decrease (P＜0.05); Pressure value by the visible gastrodia elata polysaccharide height of table 8, middle dose groups and positive controls is compared obvious reduction (P＜0.01) with negative control group, and each group of gastrodia elata polysaccharide is the dose dependent reduction in the dosage scope.
Table 8 gastrodia elata polysaccharide is right＜influence of H＜rat blood pressure and heart rate
Compare with normal group a:P＜0.01; B:P＜0.05, compare with negative control group c:P＜0.01
3, gastrodia elata polysaccharide is to the influence of RHR rat plasma ET, Ang II and NO content
Visible by table 9, negative control group rat plasma ET, AngII, all obviously raise (P＜0.01) than normal group, NO content obviously reduces (P＜0.01) than normal group.The administration group is respectively organized blood plasma ET content, Ang II content all decreases than negative control group, NO content raise to some extent (P＜0.05); All obviously reduce RHR rat plasma ET, Ang II content (P＜0.01) by visible wherein gastrodia elata polysaccharide height, middle dose groups and Captopril group in the table 9; The gastrodia elata polysaccharide senior middle school dose groups NO content in plasma that can significantly raise.Gastrodia elata polysaccharide is to the reduction of blood plasma ET, Ang II content, and the rising of NO content all is dose dependent.
Table 9 gastrodia elata polysaccharide is to the content of RHR rat plasma ET, Ang II and NO content
Negative control: medicament not; Positive control: captopril 10mg/kg;
Compare with normal group a:P＜0.01; B:P＜0.05, compare with negative control group c:P＜0.01
In antihypertensive drugs research, hypertension animal model establish several different methods, like salt hypertension, SH (SHR), neuroendocrine type hypertension, renal artery stenosis type hypertension, the outer wrapping type of kidney hypertension etc.Wherein the modeling principle of renal artery stenosis type method is that narrow renal artery causes the kidney ischemia, causes feritin formation in the kidney, and then increases the nervous plain content of blood medium vessels, makes hypertension.This mode changes similar with the pathophysiology of clinical hypertension especially secondary hypertension.The success rate of operation of the method is higher, can reach more than 80%, and the postoperative rat blood pressure increases steadily, to the stable hypertension of 4 weeks back formation.In this experiment, with compared with normal, the systolic pressure and the diastolic pressure of negative control group obviously raises (P＜0.01), shows RHR rat modeling success.Each model group was than compared with normal before experiment finished, and body weight all decreases, show modeling after, rat blood pressure raises, and the normal growth of rat is grown exert a certain influence.Administration January, systolic pressure and diastolic pressure that the administration group is respectively organized rat obviously reduce (P＜0.01) than negative control group, and in the dosage scope, are dose dependent and reduce.Show that gastrodia elata polysaccharide and captopril all have good hypotensive activity after administration.
The Radix Astragali
The Radix Astragali is the Chinese medicine of using always; Being recorded in the existing monograph on materia medica Shennong's Herbal the earliest of China first. Chinese Pharmacopoeia version regulation in 2005 medicinal Astragalis is the dry root of leguminous plant Radix Astagali or Radix Astragali; Property is sweet; Tepor is returned spleen, lung meridian, and traditional Chinese medical science ancient books is classified as the Qi-tonifying drug in the tonic to it mostly.It has the effect that tonifying Qi and lifting yang, benefit are defended consolidating superficial resistance, inducing diuresis to remove edema, holder skin ulcer granulation promoting; Contain trace element such as astragalus polysaccharides, aminoacid, Radix Astragali saponin, flavonoid, alkaloid, protein, vitamin and selenium, silicon, cobalt, molybdenum; Ability enhancing human body immunity function, diuresis, defying age; Protect the liver hypotensive effect.. the modern pharmacology result of study shows that the Radix Astragali has effects such as protection heart kidney, two-phase blood pressure regulation and blood glucose, antitumor, anti-hypoxia, antioxidation, defying age and adjusting immunologic function.
1, the Radix Astragali is to the influence of immunocyte
1.1 influence to T lymphocyte and bone-marrow-derived lymphocyte
Thin and the B cell of T can further be divided into some subgroups.These lymphocyte populations and subgroup be common in the immune response process accomplishes identification to antigenic substance, reply and remove, and keeps the stable of organismic internal environment.Mao Suping is through studying Th1/Th2 cytokine levels before and after the 106 routine Patients with Herpes Simplex Keratitis MAO Radix Astragali treatments; Find it and can regulate the imbalance state of Th1/Th2 cytokine; Raise the Th2 cell, suppress the Th1 cell, improve the disorderly situation of patient's body's immunity.Cai Xiaoyan is through the influence of the research Radix Astragali to systemic lupus erythematosus (sle) apoptosis and t lymphocyte subset crowd; Find the antigenic down-regulated expression of Fas on the PBLC of Radix Astragali treatment group treatment back; Bcl one 2 antigenic expression and CD4+/CD8+ ratio rise remarkable than matched group; Think that the Radix Astragali has increased the inhibitory action of hormone/immunosuppressant pair cell apoptosis to a certain extent, regulate t lymphocyte subset crowd ratio and be tending towards normal.The Radix Astragali also has potentiation to the bone-marrow-derived lymphocyte function.Zoopery shows that astragalus polysaccharides can improve the breeder reaction of mice bone-marrow-derived lymphocyte.
1.2 influence to NKT (NK) cell
The NK cell has functions such as antitumor, infection, immunomodulating.Zhang Xiaomings etc. find that through the isotope method for releasing IL-2 and astragalus polysaccharides all have stimulation to NK cell activity and propagation.IL-2 and APS are collaborative stronger than single effect to the stimulation of NK cytoactive and propagation.
1.3 influence to macrophage
Macrophage is immunomodulating and the effector lymphocyte that body weight for humans is wanted, and participates in numerous physiology and the pathological reaction processes of body.As macrophage phagocytic with eliminate pathogenic microorganism, offer antigen, start specific immune response and macrophage and remove the infective pathogen body engulfed etc. through apoptosis through processed.Climax utilization RT-PCR method is measured the influence of the Radix Astragali to the mice after burn macrophage function.Behind continuous five days of the lumbar injection Radix Astragali, the phagocytic function of macrophage significantly raises.Gao Peng [7] inquires into Radix Astragali injection through the RT-PCR method effect of macrophage phagocytic tubercule bacillus is found that the Radix Astragali injection of 1.5g/L concentration has obvious facilitation to the macrophage phagocytic tubercule bacillus; And have two-phase property, have the effect that suppresses the macrophage phagocytic tubercule bacillus during excessive concentration.
1.4 the influence of the pair cell factor
Father-in-law's tinkling of pieces of jade result of study shows; Mice behind the injection astragalus polysaccharides injectable powder; Its splenocyte is IL-3 after canavaline stimulates, and the secretory volume of IL-4 and IL-6 significantly increases, and the secretory volume of II.-2 reduces to some extent; Point out yellow late-maturing polysaccharide powder injection that the ability of normal mouse boosting cell secrete cytokines is had certain regulating action, some autoimmune disease or infectious disease are had certain influence.Cheng Peng etc. give the hepatitis intravenous injection yellow late-maturing injection, after measuring discovery Radix Astragali treatment chronic hepatitis patient, can reduce serum TG F-pI and improve the activity that PMBC produces IFN 1, the control hepatic fibrosis.The Radix Astragali can not only promote the leukocyte of mice and human peripheral that new castle disease virus or Sendai virus are induced IFN-a in addition; Promote cycloheximide; Radiating streptozotocin D causes the reaction of IFN one 8 superinductions on people's lung diploid cell, and the Radix Astragali is from mouse cell is cultivated, inducing IFN-γ.It is thus clear that the Radix Astragali has the ability that promotes virus induction and self inducement interferon.
1.5 water extraction of astragalus membranaceus is to the influence of kidney type hypertensive rat blood pressure and heart rate
In 3 weeks of postoperative, each modeling group rat SBP and heart rate obviously raise, and with compared with normal utmost point significant difference (P＜0.01) are arranged.Each administration group is low through the pressure drops of continuous 3 weeks treatment bleeding from anus, with model group with treat before compared utmost point significant difference (P＜0.01); Heart rate reduces, with model group with treat before compared significant difference (P＜0.05); The Radix Astragali large, medium and small dosed administration group blood pressure and heart rate are through statistical procedures, with the relatively more equal no significant difference (P＞0.05) of positive controls.The result sees table 10.
Table 10 water extraction of astragalus membranaceus is to the influence of kidney type hypertensive rat blood pressure and heart rate
Annotate: model group: medicament not; Positive control: captopril 10mg/kg and normal group compare, * * P＜0.01; Compare #P＜0.05, ##P＜0.01 with model group; Relatively preceding with treatment, △ P＜0.05, △ △ P＜0.01; Compare * P＞0.05 with positive controls.
1.5, Radix Astragali the water extracted immersing paste is to the influence of kidney type Hypertensive Rats plasma A ng II, ET
Visible by table 11, model group rat plasma ET, AngII all obviously raise (P＜0.01) than normal group, and the large, medium and small dose groups blood plasma of Radix Astragali ET content, Ang II content are all than model group decrease (P＜0.05); The result sees table 11.
Table 11 water extraction of astragalus membranaceus is to RHR rat plasma ET, Ang II
Annotate: model group: medicament not; Positive control: captopril 10mg/kg and normal group compare, * * P＜0.01; Compare ##P＜0.01, * P＞0.05 with model group.
Endothelium derived contracting factor has important role in the propagation of regulating vascular smooth muscle in contraction and the organic blood flow volume.ET knows vasoconstrictive factor the strongest in the body at present, in hypertensive generation, development, plays an important role, and the structure of vascular endothelial cell and function change during hypertension, the synthetic or release increase of ET.Exist to interact between Ang 1I, the ET, ET has hypertensin conversion enzyme activity, but the synthetic AngII of catalysis, but and Ang II inducing endothelial cell ET gene expression strengthens, so ET and AngU are the relations of mutually promoting.This experiment is studied the pharmacological action of the Radix Astragali, discovers that the water extract of the Radix Astragali has good hypotensive effect to kidney type Hypertensive Rats.This experimental result shows; The Radix Astragali can reduce Ang II, ET level in kidney type Hypertensive Rats heart rate and the blood plasma; Show that this medical material has decreased heart rate and the effect that reduces Ang 1I, ET, thus infer, the mechanism of this medical material treatment hypertension maybe for: 1. make the cardiac output minimizing through decreased heart rate; Thereby make blood flow volume reduce blood pressure drops.2. the content of ET in the content through reducing plasma A ng II and the blood plasma makes the blood vessel of contraction be able to diastole, Peripheral resistance reduction, blood pressure drops.
Folium Apocyni Veneti
Apocynum Apocynaceae Apocynum; China just names " Apocynum "; The each place is claimed " bluish dogbane ", " wild tea ", " tea fruit " etc. again, fine quality is arranged and name " Herba Apocyni veneti ", research title thereafter to use till today always since nineteen fifty-two Dong Zhengjun discovers its fiber; Comprising ambary, in 3 kinds of grey fiber crops, Flos Caryophylli hemp etc.According to record, Folium Apocyni Veneti sweet in the mouth, slightly bitter, cool in nature is returned Liver Channel, cures mainly " liver-yang, dizzy, cardiopalmus, insomnia, edema oliguria, hypertension, neurasthenia, nephritis edema ".States such as the external former Soviet Union, Japan further investigate the chemical constituent and the medical mechanism aspect of Folium Apocyni Veneti, have found many new pharmacologically actives.
1, hypotensive effect
[day]/Tian Chuanzhi favour ... //YAKUGAKUZASSHI.-2004,124 (11) one 851～856 use rat mesenteric artery vascular bed, have inquired into the vasorelaxation action and the mechanism of action thereof of dogbane leaf extractive (LLE).Materials and methods: (1) material: prepare LLE by reported method once.(2) laboratory animal be 9～11 age in week Wistar be male rat (280～3509), under the condition of room temperature (23 ± 2) ℃, humidity (45 ± 5) %, raise, freely ingest and drink water.(3) Mesenteric artery vascular specimen perfusion: with opening abdomen behind the rat anesthesia, press the method extraction rat mesenteric artery vascular bed of Kawasaki etc., make the perfusion BIAO and BEN.After BIAO and BEN placed perfusion device, with peristaltic pump perfusion Krebs liquid (5mL/min), with the variation of perfusion pressure variation as vascular tone.(4) chemical method is removed vascular endothelial cell: under static state, and sodium deoxycholate (SD, 1.8mg/mL) perfusion 30s, perfusion pressure one property crossed rising (2.67～4.00kPa).Clean BIAO and BEN 60rnin with the Krebs liquid that does not contain SD, the Krebs liquid with hydrochloric methoxamine (29M) raises perfusion pressure again, injects ACh (1nM) and makes the disappearance of endothelium-dependent relaxation relaxation response and confirm to have removed endotheliocyte.(5) experiment flow: 1. endothelium-denuded BIAO and BEN not: (every mL contains 100Pg with the Krebs liquid of hydrochloric methoxamine (79M) LLE to be mixed with multiple concentration; 1,3,10,30,100,300ng; 1,3,10gg), be 15min the blanking time of each concentration perfusion, observes the blood vessel relaxation response.The blood vessel relaxation response is that the maximum slackness that causes with last perfusion papaverine (100 μ m) is 100%, estimates relaxation rate.2. endothelium-denuded BIAO and BEN: by with the same method of endothelium-denuded BIAO and BEN not, with each concentration solution of LLE 15min perfusion at interval, observe relaxation response.Result and discussion: the 1. positive blood vessel relexation of u: behind the positive perfusion of U, the reduction of concentration dependent perfusion pressure does not appear in the endothelium-denuded BIAO and BEN, promptly is the blood vessel relaxation response, and its relax level shows that to the obviously increase of taking a picture LLE contains certain material of lax blood vessel.But, then by obvious inhibition, compare relax level with contrast and obviously weaken for the relexation of endothelium-denuded BIAO and BEN LLE.Thereby think, be endothelium-dependent relaxation in the relexation of the LLE of rat mesenteric artery vascular bed blood vessel.2. various endothelium relaxation factor depressants are to the influence of LLE blood vessel relexation: the blood vessel relaxation response due to the LLE can strengthen because of adding L one nitroso-group arginine methyl ester (L-NAME).In the presence of high K ten Krebs liquid, the relaxation response due to the LLE is obviously suppressed, but the relaxation response due to the high concentration LLE is then suppressed fully.Therefore infer that the positive endothelium-dependent relaxation blood vessel relexation of u is relevant with the deutero-hyperpolarization factor of endotheliocyte (EDHF), thinks that u is just mediating EDHF generation relaxation response.The blood vessel relexation of LLE can strengthen because of adding Cycloxygenase depressant indomethacin, shows the positive relexation of prostaglandins U capable of blocking.Add KCl and L-NAME the relexation of LLE is disappeared, the reaction during high concentration is also suppressed fully.Think that thus mediation NO produces relaxation response during the LLE high concentration.When adding Ca dependency K+ carrier frequency channel break medicine etamon (TEA), obviously suppress the relexation of LLE, but the then not influence fully of relexation during to the LLE high concentration.3. antimuscarinic drug is to the influence of the positive blood vessel relexation of U: LLE and anticholinergic agent atropine simultaneously during perfusion, the basic no change of the relexation of LLE.Therefore infer, do not contain cholinergic agent class material among the LLE.Conclusion: LLE has the relexation of endothelium-dependent relaxation blood vessel, and this effect is concentration dependent.Its mechanism of action is that at rat mesenteric artery, the EDHF of mediation K+ passage then produces the blood vessel relexation through EDHF and NO during high concentration during low concentration.
Different quercetin glycosides, quercetin is Apocynum hypotensive main active substances.Zoopery and the 800 routine hyperpietic's Clinical results done according to units such as northwest plant institute, Suzhou Medical College, Beijing's dogbane tea cooperative groups show that the Folium Apocyni Veneti efficacy of antihypertensive treatment is definite, action temperature with, effective percentage reaches 88.6%.Especially improving aspect the symptoms such as dizzy, cardiopalmus, insomnia evident in efficacyly, it is fast to prove effective.Folium Apocyni Veneti does not reduce normal arterial pressure, and person on the low side can also play the regulating action of boosting for blood pressure.These characteristics are that other all antihypertensive drugs can not be compared.The present test of the decompression principle of Folium Apocyni Veneti thinks that hypotensive effect is relevant with histamine, possibly be that effective ingredient causes that some organizes release tissue amine or directly act on histamine's receptor, distends the blood vessels, and blood pressure reduces.Japan's scholar Kim research shows that the extract of Folium Apocyni Veneti obviously reduces the diastolic pressure of kidney type Hypertensive Rats, increases the discharge of urine amount and K+, Na+, minimizing hematuria nitrogen (BUN) level, possibly be through improve renal function be used for bring high blood pressure down.Folium Apocyni Veneti blood pressure lowering mechanism produces relevant with the enhancing of release with NO.
2, the effect of raise immunity
Result of the tests such as Hang Bingqian show that the water-soluble alcohol-insoluble substances of Folium Apocyni Veneti water soluble ingredient contained with it all can make mice spleen heavily increase, and explains immunologic function influential.Water soluble ingredient 50 1 100mgkg can significantly alleviate the atrophy effect of immunosuppressant cyclophosphamide (CY) to mouse spleen; Prompting is under immunity of organism suppresses; Water soluble ingredient has raise immunity and strengthens the Turnover of Mouse Peritoneal Macrophages phagocytosis; Also show and lower the CY toxic action, explain and to play some protective effects body.Ditch between fields clinical observation result such as Liu Lifu show, drink dogbane tea 10g for each person every day, continue 5 months, and immunoglobulin content has rising in various degree more.
Spica Prunellae
Spica Prunellae is the dry fruit ear of Labiatae perennial plant Spica Prunellae hemisphere.% bitter in the mouth cold in nature is hot, return spleen, gallbladder meridian.Have effects such as clearing away liver-fire, Disperse hepatic depression, blood pressure lowering.We use modern scientific method, from the Spica Prunellae ethanol extract, extract an effective site, find that through preliminary pharmacological tests this extract has hypoglycemic activity.In order to verify its hypoglycemic activity, we have made epinephrine and the alloxan zoic model with hyperglycemia is observed the influence of Spica Prunellae extract to laboratory animal blood glucose.
1, blood pressure lowering
Spica Prunellae extract can effectively bring high blood pressure down.H1 such as Sun Shi discover that the rabbit thoracic aorta shrinkage curve that Spica Prunellae chloroform extract, n-butanol extract and ethyl acetate extract can make norepinephrine cause moves to right, and its maximum shrinkage amplitude is diminished.Wang Shi etc. face 1 and from Spica Prunellae, extract the Spica Prunellae total saponins and carry out intravenous injection, and the result shows.The diastolic pressure of anesthetized rat and contraction are pressed with remarkable decline.Clinically, the Spica Prunellae compound preparation is used to treat hypertension and has obtained good effect.Three careless blood pressure lowering soup with obvious pressure reduction effect are clapped 1 (Spica Prunellae, Herba Leonuri, Radix Gentianae), blood pressure drops promptly occurs at the back 1h that takes medicine, and in 1～4h, keep more stable antihypertensive effect.
2, antiinflammatory reaches the immune system effect
Spica Prunellae has significant inhibitory effect to early stage inflammatory reaction.New Chinese medicine preparation---the Spica Prunellae oral liquid that Chen Shi etc. process according to the Pharmacopoeia of the People's Republic of China " Spica Prunellae cream " dosage changing form; Give mouse stomach 7d continuously with it; All can significantly suppress Oleum Tiglii induced mice ear swelling, rat angle justice dish colloidality and Ovum Gallus domesticus album property foot swelling model and rat granuloma are swollen all has the obvious suppression effect.Domestic research thinks that Spica Prunellae is an immunomodulator.With Spica Prunellae injection subcutaneous injection, can make animal thymus, the obvious atrophy of spleen, the adrenal gland obviously increases; Behind the lumbar injection, level of plasma cortisol significantly raises." draw and can treat ulcerative colitis, its mechanism of action possibly be to regulate immunization through raising the mute crowd of periphery blood T lymphocyte value to the Spica Prunellae capsule that Spica Prunellae and brown sugar are formed.Abroad also discover; The ursolic acid that from Spica Prunellae, extracts, 2Q monohydroxy ursolic acid, belulinic acid Betulinic acid and 2d; 3d one dihydroxy Usu-12 alkene-28 acid has tangible antiallergic, anti-inflammatory activity; Wherein the latter has significant inhibitory effect to the release of 13 1 hexosaminidases in the RBL-2H3 cell of cultivating, and demonstrates dose-effect relationship.
Microcrystalline Cellulose
Consider the course of processing operability and medicine mouthfeel we selected for use food additive microcrystalline Cellulose, Sorbitol, mannitol, sucralose as antiplastering aid and flow aid, sweeting agent, show in " microcrystalline Cellulose---a kind of multi-functional macromolecular material " literary composition of on " Guangzhou chemical industry " 1993 the 21st the 3rd phases of volume, delivering according to the Zhu Yu of Guangzhou Inst of Chemistry, Chinese Academy of Sciences qin, Tang Liegui, Pan Songhan: microcrystalline Cellulose can be used as antiplastering aid.The microcrystalline Cellulose addition meets GB2760 " food additive use sanitary standard " for 11% of prescription, and microcrystalline Cellulose toxicity property ADI does not do particular provisions (FAO/WHO, 1994), makes its whole prescription have more reasonability and science like this.
Several kinds of raw materials are assisted mutually in whole prescription and are deposited mutually more than this specific embodiment, bring out the best in each other, and make full side present effect preferably, and product has tangible increase immunity, aided blood pressure-lowering function through these article of function test proof.
Claims (6)
1. the health medicine of an antihypertensive function, it is filled a prescription than being: Caulis et Folium Brassicae capitatae 9-15g, Cortex Eucommiae 3.5-8g, Rhizoma Gastrodiae 3-8g, Radix Astragali 3-6g, Folium Apocyni Veneti 3-8g, Spica Prunellae 4.5-10g, microcrystalline Cellulose 3-9g.
2. health medicine according to claim 1 is characterized in that, it is filled a prescription than being: Caulis et Folium Brassicae capitatae 9g, Cortex Eucommiae 3.5g, Rhizoma Gastrodiae 3g, Radix Astragali 3g, Folium Apocyni Veneti 3g, Spica Prunellae 4.5g, microcrystalline Cellulose 3g.
3. health medicine according to claim 1 is characterized in that, it is filled a prescription than being: Caulis et Folium Brassicae capitatae 15g, Cortex Eucommiae 8g, Rhizoma Gastrodiae 8g, Radix Astragali 6g, Folium Apocyni Veneti 8g, Spica Prunellae 10g, microcrystalline Cellulose 9g.
4. health medicine according to claim 1 is characterized in that, it is filled a prescription than being: Caulis et Folium Brassicae capitatae 10.1g, Cortex Eucommiae 5.3g, Rhizoma Gastrodiae 6.8g, Radix Astragali 4.7g, Folium Apocyni Veneti 6.8g, Spica Prunellae 7.8g, microcrystalline Cellulose 5.5g.
5. health medicine according to claim 1 is characterized in that, the effective ingredient of this medicine distributes as follows: the 100g medicine contains the sweet 800mg of Radix Raphani sulfur, Rabdosia rubescens adds plain 1300mg, total flavones 1100mg 、 Quercetin 350mg, triterpene 3000mg.
6. method for preparing each said health medicine of claim 1-5; It is characterized in that, earlier the medicine Cortex Eucommiae, Rhizoma Gastrodiae, the Radix Astragali, Folium Apocyni Veneti, Spica Prunellae are pulverized respectively that the powder of cross the 60-80 mesh sieve, getting them is with the weighing by a certain percentage of other supplementary material; Carry out uniform mixing; Incorporation time 45-50 minute, carry out capsule again and fill, control filling weight in strict accordance with inner quality standard in the filling process; Later process is screened, polishing, inner packing, outer package, at last by touchstone check warehouse-in.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1546097A (en) * | 2003-12-09 | 2004-11-17 | 君 李 | Health tea capable of reducing blood lipid, blood viscosity and blood pressure |
| CA2520757A1 (en) * | 2005-09-16 | 2007-03-16 | Peter Sun | Method and composition for treatment of diabetes mellitus and impaired glucose tolerance |
| CN101085044A (en) * | 2007-06-18 | 2007-12-12 | 邵延年 | Hypertension medicine containing eucommia ulmoides, red sage root and other four ingredients |
| CN101947248A (en) * | 2010-10-28 | 2011-01-19 | 江西中医学院 | Apocynum venetum pulsatile tablet |
| WO2011077163A2 (en) * | 2009-12-23 | 2011-06-30 | Plant Bioscience Limited | Use |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1546097A (en) * | 2003-12-09 | 2004-11-17 | 君 李 | Health tea capable of reducing blood lipid, blood viscosity and blood pressure |
| CA2520757A1 (en) * | 2005-09-16 | 2007-03-16 | Peter Sun | Method and composition for treatment of diabetes mellitus and impaired glucose tolerance |
| CN101085044A (en) * | 2007-06-18 | 2007-12-12 | 邵延年 | Hypertension medicine containing eucommia ulmoides, red sage root and other four ingredients |
| WO2011077163A2 (en) * | 2009-12-23 | 2011-06-30 | Plant Bioscience Limited | Use |
| CN101947248A (en) * | 2010-10-28 | 2011-01-19 | 江西中医学院 | Apocynum venetum pulsatile tablet |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107029014A (en) * | 2017-06-16 | 2017-08-11 | 江苏省农业科学院 | Prevent and treat Chinese herb compound powder of pig bacterial endotoxin disease and its preparation method and application |
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Application publication date: 20120718 |