CN102579638A - Traditional Chinese medicine pill for treating gastroenteritis and irritable bowel syndrome as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine pill for treating gastroenteritis and irritable bowel syndrome as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine pill for treating gastroenteritis and irritable bowel syndrome. The traditional Chinese medicine pill is prepared from the following traditional Chinese medicine raw materials in parts by weight: 3500-5500 parts of creeping euphorbia, 5500-7000 parts of goldhair hedyotis herb, 3500-5500 parts of camphor tree roots, 1500-3000 parts of elsholtzia and 1500-3000 parts of maple leaves. The prepared traditional Chinese medicine pill is subjected to a mouse diarrhea relieving observation experiment, the result shows that the delitescence of defecating melena of the mouse is obviously prolonged and the melena quantity is reduced; a mouse small intestine ink propulsion test shows that the small intestine peristalsis of the mouse is reduced; 286 cases of patients with acute gastroenteritis, including 146 cases of male and 140 cases of female, are selected for clinical observation experiment, the result shows that the cure rate of the patients is obviously improved and the total effective rate is 99%; and 76 cases of patients with irritable bowel syndrome take a curative effect observation test, and the total effective rate reaches 97%. The traditional Chinese medicine pill is reasonable in formula, stable in quality, good in safety and convenient for storage, carrying and use; the side effect caused by taking antibiotics is avoided, and the clinical application value is high; and the method is suitable for industrial production.
Description
Technical field
The present invention relates to Chinese medicine, be specifically related to medicine pill, relate in particular to a kind of medicine pill of treating gastroenteritis, irritable bowel syndrome and preparation method thereof and application.
Background technology
Acute gastroenteritis is commonly encountered diseases, the frequently-occurring disease of summer and autumn.How by due to the infected by microbes such as antibacterial and virus, its performance is mainly stomachache, diarrhoea, feels sick, vomiting, heating etc., and severe patient can cause dehydration, electrolyte disturbance, shock etc.That patient shows as more is nauseating, vomiting formerly, continue with diarrhoea, every day 3～5 times, even do not wait for several 10 times, stool is water sample, buff or band are green, stench can be with symptoms such as abdominal colic, heating, systemic pain.The infection of the incidence of acute enteritis (1) antibacterial and toxin: be mainly Salmonella, halophilic bacteria (vibrio parahaemolytious) and infection of staphylococcus aureus.As eaten contaminated poultry, domestic animal, fish, Eriocheir sinensis, spiral shell and eaten contaminated leftovers, leftovers etc. and bring out primary disease.(2) physical chemical factor: take food raw and cold food or some drugs such as salicylic acid salt, sulfanilamide, some antibiotic etc.; Or wrongly take strong acid, highly basic and pesticide etc. and all can cause primary disease.The name of disease that in Chinese medicine, does not have acute enteritis, according to the main clinical manifestation of acute gastroenteritis, such disease belong to the traditional Chinese medical science vomiting, suffer from diarrhoea, have loose bowels, disease category such as cholera, dry cholera, the depletion syndrome.Its cause of disease has the seasonal pathogen of impression, injury due to diet, disorder of emotion and internal organs weakness etc., but main key is spleen and stomach function obstacle and gastrointestinal dysfunction.(1) experience seasonal pathogen: the friendship in autumn in summer, heat-damp in summer is rising, if it is inappropriate to take good care of oneself, experiences the obscene turbid gas of heat-damp in summer; Or sleep in the open because of greedy cold, the cold-damp invasion, cold-evil's oxious gas is strongly fragrantly held back middle Jiao, makes taste impaired, the imbalance of going up and down, clear QI being mixed up with turbid QI is sent out and is primary disease.(2) injury due to diet: hyperalimentation is stagnated and is not changed; Or addiction to greasy and sweet foods, retention of damp-heat in the interior; Or eat the unclean thing of raw food by mistake, and impairing the spleen and stomach causes transformation failure of spleen, and water paddy elite can not absorb, and instead stops being humidity hysteresis, clear QI failing to ascend, turbid QI failing to descend is vomited and diarrhoea to hand over and is done, and sends out primary disease.(3) disorder of emotion: temper is plain empty, or original dyspepsia, or wet resistance is originally arranged, but does not cause morbidity, and is multiple because of disorder of emotion, melancholy angry, psychentonia, so that the liver failing to maintain the normal flow of QI, and perverse and unreasonable manner takes advantage of spleen to violate stomach, and taste are limited by, and dysfunction of the spleen in transportation and transformation forms primary disease.Said as " Jing Yue's complete work is had loose bowels " piece of writing: " all chance anger person that just do not have loose bowels, being accompanied by dyspepsia in the time of must be angry earlier, the taste of causing injury, so but violate to some extent, promptly with touching and send out, the dirty disease of this liver spleen two is also covered with the liver Wood restricts earth, the spleen being damaged and so." (4) weakness of the spleen and stomach: chronic dietary imbalance, or overstrain internal injury, or prolonged illness is touching, all can cause weakness of the spleen and stomach; and because of The spleen has the function to transport and transform nutrients, it is precise and tiny with fortuneization that stomach receiving food and drink, weakness of the spleen and stomach then can not be taken in Shui Gu, so that the anti-one-tenth of water is wet; Gu Fanwei stagnates, and stops in the humidity hysteresis, and clear QI being mixed up with turbid QI mixes and unsuccessful one-tenth primary disease.Therefore, think that from theory of Chinese medical science the pathogenesis of acute enteritis is: the spleen being the foundation of acquired constitution, source of generating QI and blood, it is dirty to be arranged in burnt dependent territory; It is wet to like dry evil, main the lucid yang sending up gas, and The spleen has the function to transport and transform nutrients water paddy is transferred precise and tiny; Stomach and spleen are the exterior and the interior relation, and the master receives Na Shuigu, and mechanism of qi is for falling preferring moisture to dryness; Two dirty be one dry one wet altogether, one receives a fortune, be total to be good for to transport to be received function.Summer and autumn, heat-damp in summer is handed over steaming, and greedy again the cooling of patient eaten the thing of corrosion by mistake, and it is injured to cause taste, up-down mistake department, and clear QI being mixed up with turbid QI, disorderly causing in gastrointestinal vomits and diarrhoea sends out is primary disease.The syndrome performance: onset is hurried, and feeling sick takes place frequently, the vomiting acid regurgitation, and gastral cavity abdomen paroxysmal pain is rushed down down urgently, and it is not well to defecate, and stool being yellowish-brown is stench, yellowish fur, slippery and rapid pulse.To above-mentioned disease, adopt usually: Qinghua is damp and hot, the intestines and stomach coordinating; Eliminating evilization is turbid, dispelling cold and removing dampness; Regulating the stomach and sending down the abnormal ascending QI, relieving dyspepsia; The spleen invigorating QI invigorating, methods such as stomach function regulating eliminating dampness by diuresis.The chronic inflammation disease of chronic enteritis general reference intestinal, its cause of disease can be infected by microbes such as antibacterial, mycete, virus, protozoon, also can be due to the reasons such as allergy, allergy.Clinical manifestation is diseases such as stomachache, diarrhoea and dyspepsia chronic for a long time or that show effect repeatedly, and weight person can have Mucous Stool or watery stool, and primary disease can or show effect by the acute enteritis delay repeatedly.Overtired for a long time, excited, excessive psychentonia, malnutrition in addition all can become the inducement of chronic enteritis.Usually, the traditional Chinese medical science adopts invigorating the spleen and benefiting QI to the disease of chronic enteritis; Subduing the hyperfunction of the liver is held up spleen; Warming and recuperating the spleen and kidney; Methods such as astringent or styptic treatment for spontaneous sweating antidiarrheal.Dysentery, ancient title intestinal is warded off, dysentery; Be by the caused infectious intestinal disease of dysentery bacterium.Clinical is cardinal symptom with heating, stomachache, tenesmus, stool containing pus and blood.Chinese traditional treatment is detoxified with clearing away heat and eliminating dampness, regulating QI promoting the circulation of blood intestinal stasis relieving; Warming for eliminaring cold-damp, the flavor of circulation of qi promoting cold expelling.
Irritable bowel syndrome (IBS) is a kind of common functional intestinal disease, usually with mental symptom, also can be considered a kind of functional somatopsychic illness.Clinical manifestation has polytropy because of patient's individual variation, the onset concealment, and the course of disease is longer, is prone to outbreak repeatedly.Pathogenesis does not still have fully and illustrates, and is main relevant with factors such as psychological factor, gastrointestinal motility disorder, visceral paraesthesia, intestinal infection, food anaphylaxis primary stimuli, dysautonomias, and clinical still do not have effective treatment way.Doctor trained in Western medicine mainly is a symptomatic treatment, but is prone to recurrence after the drug withdrawal, is difficult to fundamentally treat.The traditional Chinese medical science has certain advantage in organic unity and the individuation difference of stressing body aspect the treatment IBS.
Acute/chronic gastroenteritis, irritable bowel syndrome are commonly encountered diseases, frequently-occurring disease, at present; Many for such treatment of diseases is main with antibiotics class medicine; Yet antibiotics has certain toxic and side effects more, and long-time application can cause intestinal microbial population disorderly, and is prone to produce drug resistance.The syrupy poor stability of Chinese medicine CHANGYANNING carries, transports inconvenience, and the diabetes patient abstains from.The CHANGYANNING ball is made up of Herba Euphorbiae Humifusae, Herba Hedyotidis Chrysotrichae, Radix litseae rubescentis, Herba Moslae, Folium Evodiae trichotomae Chinese medicine of the five flavours.Has clearing away heat-damp and promoting diuresis, circulation of qi promoting.Be used for acute and chronic gastroenteritis, diarrhoea, bacillary dysentery, infantile dyspepsia.The CHANGYANNING ball has overcome antibiotics, the syrupy shortcoming of CHANGYANNING, these article craft science, and good stability, transportation is carried, taking convenience, the pure natural plant medicine, determined curative effect, toxic and side effects is little, does not contain antiseptic.Be used for acute and chronic gastroenteritis, diarrhoea, the bacillary dysentery irritable bowel syndrome has curative effect preferably.
Summary of the invention
Technical problem to be solved by this invention is to overcome above-mentioned weak point, and the research design good stability transports and carries, the treatment gastroenteritis of taking convenience, the medicine pill of irritable bowel syndrome.
The invention provides a kind of medicine pill (CHANGYANNING ball) of treating gastroenteritis, irritable bowel syndrome.Said medicine pill is pressed row weight portion proportioning by each raw material of Chinese medicine and is processed:
3500 parts～5500 parts of Herba Euphorbiae Humifusaes, 5500 parts～7000 parts of Herba Hedyotidis Chrysotrichaes,
3500 parts～5500 parts of Radix litseae rubescentiss, 1500 parts～3000 parts of Herba Moslaes,
1500 parts～3000 parts of Folium Evodiae trichotomaees.
Preferably, a kind of medicine pill of treating gastroenteritis, irritable bowel syndrome is characterized in that, said medicine pill is pressed column weight amount proportioning by each raw material of Chinese medicine and processed:
Herba Euphorbiae Humifusae 4583.3g Herba Hedyotidis Chrysotrichae 6250g Radix litseae rubescentis 4583.3g
Herba Moslae 2291.7g Folium Evodiae trichotomae 2291.7g.
In the medicine pill of the present invention, the Herba Euphorbiae Humifusae heat-clearing and toxic substances removing, cooling blood for hemostasis is monarch drug, can heat-clearing and toxic substances removing dysentery relieving, pyretic toxicity is let out dysentery, the stool containing pus and blood use be good, the activating blood and eliminatng dampness that can stop blooding again, its effective ingredient Radix seu Caulis Parthenocissi tricuspidatae element has antagonism to various bacteria.Herba Hedyotidis Chrysotrichae heat clearing away, clearing away heat-damp and promoting diuresis, relaxing muscles and tendons to promote blood circulation, relieving stranguria by diuresis, clearing away heat to cure dysentery.The Folium Evodiae trichotomae heat-clearing and toxic substances removing can be controlled enteritis, is ministerial drug.Herba Moslae has relieving the exterior syndrome by diaphoresis and middle dampness removing, can be used for stomachache vomiting and diarrhoea, dysuria.Radix litseae rubescentis removing dampness circulation of qi promoting is for assistant makes it agent.At medicine with having clearing away heat-damp and promoting diuresis, the function of circulation of qi promoting.
Another object of the present invention has provided said a kind of method for preparing of treating the medicine pill of gastroenteritis, irritable bowel syndrome.
The inventive method is: gets Chinese medicine Herba Euphorbiae Humifusae, Herba Hedyotidis Chrysotrichae, Radix litseae rubescentis, Herba Moslae, Folium Evodiae trichotomae, cleans, pulverizes, and after the mixing, the decocte with water secondary; With 10 times of water gagings (W/W) of Chinese medicine gross weight, decocted 2 hours at every turn at every turn, merge decoction liquor, filter; Filtrating 80 ℃ is evaporated to the clear paste that relative density is 1.20 (80 ℃), adds 2 times of amounts of clear paste volume, 95% ethanol (V/V), stirs, and leaves standstill 12 hours; Filter, filtrating 80 ℃ is evaporated to the clear paste that relative density is 1.25 (80 ℃), adds the starch mixing, pill; 60 ℃ of dryings, polishing promptly gets.
Another purpose of the present invention has provided the application of a kind of Chinese medicine in the medicine of preparation treatment gastroenteritis, irritable bowel syndrome.Said Chinese medicine is pressed row weight portion proportioning by each raw material of Chinese medicine and is processed:
3500 parts～5500 parts of Herba Euphorbiae Humifusaes, 5500 parts～7000 parts of Herba Hedyotidis Chrysotrichaes,
3500 parts～5500 parts of Radix litseae rubescentiss, 1500 parts～3000 parts of Herba Moslaes,
1500 parts～3000 parts of Folium Evodiae trichotomaees.
Preferably, said medicine pill is pressed column weight amount proportioning by each raw material of Chinese medicine and is processed:
Herba Euphorbiae Humifusae 4583.3g Herba Hedyotidis Chrysotrichae 6250g Radix litseae rubescentis 4583.3g
Herba Moslae 2291.7g Folium Evodiae trichotomae 2291.7g.
The said Chinese medicine pill that each raw material of Chinese medicine is processed as active component and pharmaceutic adjuvant of serving as reasons.
The medicine pill that the present invention makes carries out mice antidiarrheal observation experiment, and the result shows the incubation period that can obviously prolong mice row melena, reduces melena quantity, reduces intestinal peristalsis promoting.In addition, select acute gastroenteritis patient 286 examples, male 146 examples; Woman's 140 examples are carried out the clinical observation experiment of acute/chronic gastroenteritis, and the result shows that patient's cure rate obviously improves; Total effective rate reaches 99%, is superior to the CHANGYANNING syrup, and has no adverse reaction; Select 76 routine patients to carry out the observation of irritable bowel syndrome, total effective rate reaches 97%, is superior to the CHANGYANNING syrup.Therefore, can be used for preparing the medicine of treatment gastroenteritis, irritable bowel syndrome.
Chinese medicine of the present invention has solved the deficiency of prior art for preparing, prescription rationally, craft science, steady quality, safety is good, is convenient to store carry and use.The Chinese medicine of treating gastroenteritis, irritable bowel syndrome is provided, can have avoided taking the side effect that antibiotic brings, bigger clinical value has been arranged.The inventive method raw material is easy to get, and is easy and simple to handle, is suitable for suitability for industrialized production.
The specific embodiment:
Embodiment 1 pill preparation (CHANGYANNING ball)
Prescription:
Herba Euphorbiae Humifusae 4583.3g Herba Hedyotidis Chrysotrichae 6250g Radix litseae rubescentis 4583.3g
Herba Moslae 2291.7g Folium Evodiae trichotomae 2291.7g
Method for preparing: the above five tastes, the decocte with water secondary adds 10 times of water gagings at every turn, decocts collecting decoction 2 hours; Filter, filtrate 80 ℃ and be evaporated to the clear paste that relative density is about 1.20 (80 ℃), add 95% ethanol 2438ml, stir; Left standstill 12 hours, and filtered, the 80 ℃ of concentrating under reduced pressure of filtrating become relative density to be about the clear paste of 1.25 (80 ℃), add 249g starch; Mixing, with refined honey: water (1: 1) is the binding agent pill, 60 ℃ of dryings, polishing.Pack, packing is processed 1000g altogether, promptly gets.
Embodiment 2
Prescription:
Herba Euphorbiae Humifusae 4590g Herba Hedyotidis Chrysotrichae 6250g Radix litseae rubescentis 4590g
Herba Moslae 2285g Folium Evodiae trichotomae 2285g
Method for preparing: the above five tastes, the decocte with water secondary adds 10 times of water gagings at every turn, decocts collecting decoction 2 hours; Filter, filtrate 80 ℃ and be evaporated to the clear paste that relative density is about 1.20 (80 ℃), add 95% ethanol 2438ml,, stir; Left standstill 12 hours, and filtered, the 80 ℃ of concentrating under reduced pressure of filtrating become relative density to be about the clear paste of 1.25 (80 ℃), add 249g starch; Mixing, with refined honey: water (1: 1) is the binding agent pill, 60 ℃ of dryings, polishing.Process 1000g altogether, pack, packing promptly gets.
Promptly get.
Embodiment 3
Preparation technology parameter research experiment of the present invention:
1, the extraction of different amount of water experiment:
Take by weighing Herba Euphorbiae Humifusae 687.50g, Herba Hedyotidis Chrysotrichae 937.5g, Radix litseae rubescentis 687.50g, Herba Moslae 343.75g, Folium Evodiae trichotomae 343.75g, be total to 3000g, totally 5 parts; Add not commensurability water respectively; According to basic extraction process decoct, decoction liquor is evaporated to the thick paste shape, in 60～70 ℃ of drying under reduced pressure, weighing; Calculate paste-forming rate, confirm amount of water according to the paste-forming rate situation of change.The result sees table 1:
The extraction test of the different amount of water of table 1
| Test | Amount of water (doubly) | Paste volume (g) | Paste-forming rate (%) |
| 1 | 6 | 302.20 | 10.49 |
| 2 | 8 | 355.83 | 12.35 |
| 3 | 10 | 365.20 | 12.68 |
| 4 | 12 | 370.35 | 12.85 |
| 5 | 14 | 375.71 | 13.05 |
The above results shows, cuts down the consumption of energy for making big production, and it is comparatively reasonable that amount of water is decided to be 10 times of amounts.
2, definite research of thickening temperature:
Take by weighing Herba Euphorbiae Humifusae 6875g, Herba Hedyotidis Chrysotrichae 9375g, Radix litseae rubescentis 6875g, Herba Moslae 3437.5g, Folium Evodiae trichotomae 3437.5g by above parts by weight, 30Kg adds 10 times of water gagings and decocts 2 times altogether, and each 2 hours, merge decoction liquor, filter, filtrating is divided into 3 parts.Respectively at 70 ℃, 80 ℃, 90 ℃ of clear paste that are evaporated to relative density 1.25 (80 ℃).The content of high effective liquid chromatography for measuring Quercetin.The result sees table 2
The extraction result of the test of the different thickening temperatures of table 2
| Thickening temperature (℃) | Clear paste amount (L) | Quercetin content (mg/g) |
| 70 | 40 | 0.69 |
| 80 | 40 | 0.70 |
| 90 | 40 | 0.62 |
According to result of the test, the present invention confirm the concentrating under reduced pressure temperature fix on 80 ℃ comparatively suitable.
3, definite test of precipitate with ethanol time:
Take by weighing Herba Euphorbiae Humifusae, Herba Hedyotidis Chrysotrichae, Radix litseae rubescentis, Herba Moslae, Folium Evodiae trichotomae 30Kg altogether by above parts by weight, add 10 times of water gagings and decoct 2 times, each 2 hours, merge decoction liquor, filter, the 80 ℃ of clear paste that are evaporated to relative density 1.25 (80 ℃) of filtrating are divided into 3 parts.Add the ethanol of 2 times of amounts, stir.Room temperature is placed different time, observes the clarity of solution, confirms the time of precipitate with ethanol.The result sees table 3
Table 3 precipitate with ethanol result of the test
| Sequence number | Time (h) | The result |
| 1 | ?6 | Solution is muddy |
| 2 | ?8 | Solution is slightly muddy |
| 3 | ?12 | The solution clarification |
Result of the test shows, precipitate with ethanol 12h, and hour clarity of solution is preferable, so the precipitate with ethanol time of the present invention is confirmed as 12 hours.
Embodiment 4 pharmacodynamic experiments:
1, to the influence of mice defecation: the preparation (CHANGYANNING ball) that is made by embodiment 1 carries out mice antidiarrheal observation experiment.Mice, male and female half and half are divided 4 groups: CHANGYANNING ball group, CHANGYANNING syrup group, berberine hydrochloride group, normal saline group at random.Gastric infusion 6 days, every day 1 time (CHANGYANNING 8g crude drug/kg, i.e. CHANGYANNING ball 2.5 balls that make of embodiment 1/kg).The berberine hydrochloride group gives berberine hydrochloride sheet solution (0.70g/kg body weight).The normal saline group gives the equal-volume normal saline.Fasting 12h behind the successive administration 5 times behind the last administration 30min, irritates stomach and gives 35% Radix Et Rhizoma Rhei liquid 1ml/20g body weight (Radix Et Rhizoma Rhei liquid is prepared with 15% activated carbon suspension), observes the incubation period and the fecal grains of arranging melena in 8 hours.CHANGYANNING ball group and CHANGYANNING syrup group and normal saline group relatively can obviously prolong the incubation period of mice row melena, reduce melena quantity, have tangible anti-diarrhea effect.The result sees table 4.
The influence of table 4 pair mice defecation
The influence of 2, mouse small intestine being wriggled
Mice, male and female half and half are divided into 4 groups at random: CHANGYANNING ball group, CHANGYANNING syrup group, berberine hydrochloride group, normal saline group.Mouse stomach administration 6 days, every day 1 time, dosage (CHANGYANNING 8g crude drug/kg).Fasting 24h after the 5th administration, 1h behind the last medicine, each group is irritated the normal saline (0.3ml/10g) that stomach contains 15% carbon element prepared Chinese ink.15min takes off neck execution after the administration, opens clip upper end, abdominal cavity to pylorus, and the intestinal tube of lower end to ileocecus places on the pallet.Gently small intestinal is pulled into straight line, measure intestinal tube length.Distance from pylorus to the prepared Chinese ink forward position as prepared Chinese ink at the enteral advance distance.Calculate prepared Chinese ink propelling rate with formula.
Prepared Chinese ink propelling rate (%)=prepared Chinese ink is at enteral advance distance (cm)/small intestinal total length (cm) * 100%
The influence of table 5 pair mouse small intestine wriggling
The result shows that the CHANGYANNING ball can effectively reduce the small intestinal peristalsis frequency, and effect is superior to CHANGYANNING syrup group.
Embodiment 5 clinical experimental studies:
1, the clinical research of acute/chronic gastroenteritis:
The CHANGYANNING ball that is made by embodiment 1 carries out the clinical observation experiment of acute/chronic gastroenteritis.Select acute gastroenteritis patient's 286 examples that in June, 2008 to 2009, year December was accepted for medical treatment, male 146 examples, women 140 examples, 45.12 years old mean age.The patient gets rid of gastrointestinal cancer and other systemic disease all through medical history investigation, routine physical examination and lab testing before the treatment.At random the patient is divided into observation group and matched group, every group 143 example, 2 groups of patients compare not statistically significant (0.05) at aspects such as age, the cause of disease, health and clinical manifestations, have comparability.
(1) research method
The patient of observation group adopts the smelting of oral CHANGYANNING ball to treat scheme: the CHANGYANNING ball is oral, one time 9 ball (the CHANGYANNING ball 1.44g that embodiment 1 makes), and 3 times on the one, 3d was 1 course of treatment.The matched group patient then adopts oral norfloxacin in treatment scheme: norfloxacin 0.4g, every day 3 times, 3d is 1 course of treatment.Can suitably adjust dosage kimonos medication journey according to the conditions of patients weight for 2 groups, after 2 courses of treatment, carry out electrocardiogram, routine blood test, routine urinalysis, liver function, kidney function test, observe and compare 2 groups of curative effects and untoward reaction.
(2) evaluation index
Efficacy assessment standard: (1) recovery from illness: clinical symptom disappearance, result of laboratory test is normal, and ordinary circumstance is good, and (2) produce effects: clinical symptom disappearance is fast, and chemical examination is near normal; (3) effective: clinical symptoms reduces gradually, and result of laboratory test alleviates; (4) invalid: clinical symptoms does not have change with stool, and uses other medicine instead.Total effective rate is cure rate, obvious effective rate and effective percentage sum.
(3) statistical procedures
The data SPSS12.0 software carries out statistical procedures and analysis, and wherein measurement data adopts the t check, and enumeration data adopts) the c check.There is statistical significance P＜0.05 for difference
(4) result
The comparison of 2 groups of patient treatment effects is compared with matched group, and the patient's of observation group cure rate obviously improves, and difference has statistical significance (0.05), and the result sees table 7.
Table 7 clinical observation general curative effect is analyzed
Annotate: compare expression P＜0.05 with matched group
The comparison of 2 groups of adverse reactions of patients situation
Compare with matched group, the patient of observation group has no adverse reaction, matched group generation abdominal distention, stomachache, feel sick, the ratio of vomiting and general malaise is all higher, difference has statistical significance (P＜0.05), the result sees table 8.
The comparison of table 82 group adverse reactions of patients situation
1, the curative effect of irritable bowel syndrome
The CHANGYANNING ball that is made by embodiment 1 carries out acute gastroenteritis patient's 76 examples that the clinical observation experiment of irritable bowel syndrome is accepted for medical treatment, male 36 examples, women 40 examples, 40.5 years old mean age.The patient gets rid of gastrointestinal cancer and other systemic disease all through medical history investigation, routine physical examination and lab testing before the treatment.At random the patient is divided into observation group and matched group, every group 38 example, 2 groups of patients compare not statistically significant (0.05) at aspects such as age, the cause of disease, health and clinical manifestations, have comparability
(1) research method
The patient of observation group adopts the smelting of oral CHANGYANNING ball to treat scheme: the CHANGYANNING ball is oral; One time 9 ball (the CHANGYANNING ball 1.44g that embodiment 1 makes), 3 times on the one, the matched group patient then adopts oral CHANGYANNING syrup therapeutic scheme: CHANGYANNING syrup 10ml; Every day 3 times, observed for 4 weeks.Carry out electrocardiogram, routine blood test, routine urinalysis, liver function, kidney function test, observe and compare 2 groups of curative effects and untoward reaction.
(2) result
The general curative effect analysis of 2 groups of tcm symptoms before and after table 9 treatment
The result shows that the CHANGYANNING ball is superior to the CHANGYANNING syrup to the curative effect of irritable bowels syndrome.
Claims (6)
1. a medicine pill of treating gastroenteritis, irritable bowel syndrome is characterized in that, said medicine pill is pressed row weight portion proportioning by each raw material of Chinese medicine and processed:
3500 parts～5500 parts of Herba Euphorbiae Humifusaes, 5500 parts～7000 parts of Herba Hedyotidis Chrysotrichaes,
3500 parts～5500 parts of Radix litseae rubescentiss, 1500 parts～3000 parts of Herba Moslaes,
1500 parts～3000 parts of Folium Evodiae trichotomaees.
2. a medicine pill of treating gastroenteritis, irritable bowel syndrome is characterized in that, said medicine pill is pressed column weight amount proportioning by each raw material of Chinese medicine and processed:
Herba Euphorbiae Humifusae 4583.3g Herba Hedyotidis Chrysotrichae 6250g Radix litseae rubescentis 4583.3g
Herba Moslae 2291.7g Folium Evodiae trichotomae 2291.7g.
3. a method for preparing of treating the medicine pill of gastroenteritis, irritable bowel syndrome according to claim 1 or claim 2 is characterized in that, this method is: get Chinese medicine Herba Euphorbiae Humifusae, Herba Hedyotidis Chrysotrichae, Radix litseae rubescentis, Herba Moslae, Folium Evodiae trichotomae, clean, pulverize; After the mixing, the decocte with water secondary is used 10 times of water gaging W/W of Chinese medicine gross weight at every turn, decocts 2 hours at every turn; Merge decoction liquor, filter, filtrate 80 ℃ and being evaporated to relative density is 1.2080 ℃ clear paste, adds the clear paste volume and measures 95% ethanol V/V for 2 times; Stir, left standstill 12 hours, filter, the 80 ℃ of concentrating under reduced pressure of filtrating become relative density to be about 1.2580 ℃ clear paste; The starch that adds clear paste weight 40%, mixing, with refined honey: water is to make binding agent pill, 60 ℃ of dryings at 1: 1; Polishing, pack promptly gets.
4. the application of Chinese medicine in preparation treatment gastroenteritis, irritable bowel syndrome is characterized in that said Chinese medicine is pressed row weight portion proportioning by each raw material of Chinese medicine and processed:
3500 parts～5500 parts of Herba Euphorbiae Humifusaes, 5500 parts～7000 parts of Herba Hedyotidis Chrysotrichaes,
3500 parts～5500 parts of Radix litseae rubescentiss, 1500 parts～3000 parts of Herba Moslaes,
1500 parts～3000 parts of Folium Evodiae trichotomaees.
5. the application of Chinese medicine in preparation treatment gastroenteritis, irritable bowel syndrome is characterized in that said Chinese medicine is pressed column weight amount proportioning by each raw material of Chinese medicine and processed:
Herba Euphorbiae Humifusae 4583.3g Herba Hedyotidis Chrysotrichae 6250g Radix litseae rubescentis 4583.3g
Herba Moslae 2291.7g Folium Evodiae trichotomae 2291.7g.
6. according to claim 4 or 5 described application, it is characterized in that the said Chinese medicine pill that each raw material of Chinese medicine is processed as active component and pharmaceutic adjuvant of serving as reasons.
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Effective date of registration: 20180612 Address after: 712000 No. 1, Han Cang Nan Road, high-tech zone, Qin Du District, Xianyang, Shaanxi Patentee after: Shaanxi Mo Mei Qi blood and Pharmaceutical Co., Ltd. Address before: 712000 No. 1, Han Cang Nan Road, high-tech zone, Qin Du District, Xianyang, Shaanxi Patentee before: Shaanxi Mo Mei get pharmaceutical Co. Ltd |
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Denomination of invention: Traditional Chinese medicine pill for treating gastroenteritis and irritable bowel syndrome as well as preparation method and application thereof Effective date of registration: 20181225 Granted publication date: 20140402 Pledgee: Xianyang Rural Commercial Bank of Shaanxi Qin Limited by Share Ltd Pledgor: Shaanxi Mo Mei Qi blood and Pharmaceutical Co., Ltd. Registration number: 2018610000237 |
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Assignee: Shaanxi Mo Mei Qi blood and Pharmaceutical Co., Ltd. Assignor: Shaanxi Mo Mei get pharmaceutical Co. Ltd Contract record no.: 2018610000011 Date of cancellation: 20190813 |
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Date of cancellation: 20200330 Granted publication date: 20140402 Pledgee: Xianyang Rural Commercial Bank of Shaanxi Qin Limited by Share Ltd Pledgor: SHAANXI MOMENTUM QIXUEHE PHARMACEUTICAL Co.,Ltd. Registration number: 2018610000237 |
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Denomination of invention: Traditional Chinese medicine pill for treating gastroenteritis and irritable bowel syndrome as well as preparation method and application thereof Effective date of registration: 20200428 Granted publication date: 20140402 Pledgee: Xianyang Rural Commercial Bank of Shaanxi Qin Limited by Share Ltd Pledgor: SHAANXI MOMENTUM QIXUEHE PHARMACEUTICAL Co.,Ltd. Registration number: Y2020990000395 |
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Date of cancellation: 20220530 Granted publication date: 20140402 Pledgee: Xianyang Rural Commercial Bank of Shaanxi Qin Limited by Share Ltd. Pledgor: SHAANXI MOMENTUM QIXUEHE PHARMACEUTICAL CO.,LTD. Registration number: Y2020990000395 |
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Denomination of invention: A traditional Chinese medicine pill for treating gastroenteritis and irritable bowel syndrome and its preparation method and Application Effective date of registration: 20220606 Granted publication date: 20140402 Pledgee: Xianyang Rural Commercial Bank of Shaanxi Qin Limited by Share Ltd. Pledgor: SHAANXI MOMENTUM QIXUEHE PHARMACEUTICAL CO.,LTD. Registration number: Y2022980007093 |
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