CN102579491A - Enema for treating intestinal bleeding - Google Patents
Enema for treating intestinal bleeding Download PDFInfo
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- CN102579491A CN102579491A CN2012100448983A CN201210044898A CN102579491A CN 102579491 A CN102579491 A CN 102579491A CN 2012100448983 A CN2012100448983 A CN 2012100448983A CN 201210044898 A CN201210044898 A CN 201210044898A CN 102579491 A CN102579491 A CN 102579491A
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- enema
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Abstract
The invention relates to an enema for treating intestinal bleeding. The enema is prepared from the following raw materials: 40-60g of sodium humate and 1000ml of water. The enema is definite in prescription and can be used for treating chronic colon ulcer and rectum ulcer and treating acute and chronic hemorrhagic proctocolitis.
Description
Technical field
The present invention relates to medical invention field, be specifically related to a kind of enema of treating intestinal bleeding.
Background technology
(Humic Acid is that the residual body of natural plant decomposes the formed product of extraction through decomposition or from coal HA) to humic acids, is a kind of macromole organic monoacid of complicacy, has the wide biological activity of sending out, and the range of application in industry and agricultural production is wider.Modern study is the result show, humic acid substance has multiple pharmacologically active, comprises that antiinflammatory, antiviral, adjusting are immune, antibiotic, antiulcer, antitoxin, free radical resisting, treatment rheumatism or the like.
Sodium humate is the soluble sodium salt of humic acids; Outward appearance is irregular, glossiness granule or black powdery solid; Be alkalescence; Contain hydroxyl, carboxylate isoreactivity group, have ion exchange, absorption, complexation, put together, multiple function such as flocculation, pulverizing, bonding, sodium humate is applied and approves in the various fields of national economy; Especially as ceramic additive, degumming agent, drilling mud adjustment agent, water for industrial use stabilizing agent, cement water reducing agent, boiler detergent, ore floatation agent, waste gas waste water treating agent, water-coal-slurry additive, coal briquette bond and negative battery plate expander etc.; Demonstrate great vitality, obtained the remarkable economical effect, prospect is very wide.Secondly, in agricultural,, can change Soil structure, crops played the effect of disease resistance increasing both production and income as compound fertilizer; As feed additive, as synergist, all have effect and income preferably in the aquaculture in the livestock culture.
Sodium humate mainly is to use as the effective ingredient in single or the compound recipe is for oral administration at field of medicaments, such as the sodium humate sheet of processing tablet, gets sodium humate an amount of (containing humic acids 200g); Be ground into fine powder, it is an amount of to add 8% starch slurry, mixing; Process granule, drying, the adding Pulvis Talci is an amount of; Be pressed into 1000, promptly get.Be mainly used in convergence, hemostasis, antidiarrheal after oral.Cure mainly haematemesis, have blood in stool, have loose bowels, vomiting, epigastric pain, infantile diarrhea, insufficiency of the spleen chronic diarrhea, chronic dysentery; Also have 5% sodium humate liquid enema treatment chronic colitis, 5% humic acid solution is oral or through the report of stomach tube treatment upper gastrointestinal hemorrhage.(disclosing foregoing in the patent application 201110160113.4)
Existing many pieces of bibliographical informations: the light moderate ulcerative colitis of sodium humate retention-enema treatment, (author Zhong Ying is strong etc., " the sick journal of clinical digestion, 2009 the 11st the 2nd phases of volume).
One Chinese patent application 201110160113.4 discloses and has been used for conglutinant sodium humate external preparation, is to add gel, membrane, liniment or the ointment that pharmaceutic adjuvant is processed by sodium humate; In mass fraction, the content of sodium humate is 0.1-20%.
Foregoing discloses the certain applications of sodium humate coloclysis, but the enema that does not disclose sodium humate is formed.
Summary of the invention
The purpose of this invention is to provide a kind of enema of treating the intestinal bleeding disease.
A kind of enema of treating the intestinal bleeding disease provided by the invention, processed by following raw material: the sodium humate of 40-60g, water is supplied 1000ml.
Said sodium humate is directly bought on the market.
Preferably, enema provided by the invention, prepared by following method: formula ratio 1/3 sodium humate is dissolved in the 500ml water, progressively adds remaining water and sodium humate according to the equivalent method of progressively increasing then, promptly gets.
Further preferred, enema provided by the invention is by following method preparation:
1) sodium humate is ground into fine powder, behind the 40-800 order, subsequent use excessively;
2) sodium humate of formula ratio 1/3 being dissolved in 500ml, temperature is 50-60 ℃ water, with adding with stirring; When solution is even suspension state, add the hot water of remaining sodium humate fine powder and 50-60 ℃ again by the equivalent method of progressively increasing, add to capacity gradually, promptly get enema.
After said sodium humate is ground into fine powder, the preferred 60-400 mesh sieve of crossing.
The present invention also provides the application of above-mentioned enema in preparing the medicine of treating chronic colonic ulcer, rectal ulcer and treating acute and chronic hemorrhagic proctocolitis.
Enema provided by the invention has the following advantages:
1, the active ingredient of enema of the present invention is a sodium humate; This medicine has outstanding hemostasis convergence effect; Can be used for wound healing though prior art discloses it, do not mention the application aspect anal and intestinal disease, the inventor find sodium humate be prepared into enema after coloclysis can be attached to the intestinal wall affected part rapidly; Promote the healing of intestinal wall ulcer surface, alleviate hemorrhage and pain symptom.
2, enema provided by the invention has solved that enteral illness oral medicine onset is slow, difficult to be absorbed and common enema is difficult for being attached to the defective of intestinal wall, and easy to use, do not decrease body.
3, the present invention is inventor's summary of clinical experience for many years; The enema that provides has convergence moisture absorption, hemostasis astringing intestine to stop diarrhea, alleviate intestinal bleeding has specially good effect; That, colonic acute and chronic inflammation straight for treatment, ulcerative hemorrhage all have is evident in efficacy, easy to use, onset rapidly, advantage such as safety is painless, effective percentage reaches 100%.
4, sodium humate enema of the present invention is concentration dependent and increases, but surpasses 60% or when being lower than 30%, the effect reduction when concentration.
The specific embodiment
Following examples are used to explain the present invention, but are not used for limiting scope of the present invention.
Embodiment 1: the enema of treatment intestinal bleeding
1, raw material: sodium humate 40g complements to 1000ml with purified water.
2, method for preparing:
1) sodium humate is ground into fine powder, behind 60 mesh sieves, subsequent use excessively;
2) it is in 50 ℃ the purified water that the sodium humate that takes by weighing 13.3g is dissolved in 500ml, temperature; With adding with stirring; When solution is even suspension state, add sodium humate fine powder and 50 ℃ of purified water of residue 26.7g again by the equivalent method of progressively increasing, finally be supplemented to capacity; And, promptly get enema with adding with stirring.
Embodiment 2: the enema of treatment intestinal bleeding
1, raw material: sodium humate 50g complements to 1000ml with purified water.
2, method for preparing:
1) sodium humate is ground into fine powder, behind 80 mesh sieves, subsequent use excessively;
2) it is in 50 ℃ the purified water that the sodium humate that takes by weighing 16.7g is dissolved in 500ml, temperature; With adding with stirring; When solution is even suspension state, add residue 33.3g sodium humate fine powder and 50 ℃ of purified water by the equivalent method of progressively increasing again, finally be supplemented to capacity; And, promptly get enema with adding with stirring.
Embodiment 3: the enema of treatment intestinal bleeding
1, raw material: sodium humate 60g complements to 1000ml with purified water.
2, method for preparing:
1) sodium humate is ground into fine powder, behind 120 mesh sieves, subsequent use excessively;
2) it is in 60 ℃ the purified water, with adding with stirring that the sodium humate that takes by weighing 20g is dissolved in 500ml, temperature; When solution is even suspension state, add sodium humate fine powder and 60 ℃ of purified water of residue 60g again by the equivalent method of progressively increasing, finally be supplemented to capacity, and, promptly get enema with adding with stirring.
Embodiment 4: the enema of treatment intestinal bleeding
1, raw material: sodium humate 55g complements to 1000ml with purified water.
2, method for preparing:
1) sodium humate is ground into fine powder, behind 400 mesh sieves, subsequent use excessively;
2) it is in 60 ℃ the purified water, with adding with stirring that the sodium humate that takes by weighing 18.3g is dissolved in 500ml, temperature; When solution is even suspension state, add sodium humate fine powder and 60 ℃ of purified water of 31.7g again by the equivalent method of progressively increasing, finally be supplemented to capacity, and, promptly get enema with adding with stirring.
Comparative Examples 1: the enema of treatment intestinal bleeding
1, raw material: sodium humate 30g complements to 1000ml with purified water.
2, method for preparing:
1) sodium humate is ground into fine powder, behind 400 mesh sieves, subsequent use excessively;
2) it is in 50 ℃ the purified water, with adding with stirring that the sodium humate that takes by weighing 10g is dissolved in 500ml, temperature; When solution is even suspension state, add sodium humate fine powder and 50 ℃ of purified water of residue 20g again by the equivalent method of progressively increasing, finally be supplemented to capacity, and, promptly get enema with adding with stirring.
Comparative Examples 2: the enema of treatment intestinal bleeding
1, raw material: sodium humate 70g complements to 1000ml with purified water.
2, method for preparing:
1) sodium humate is ground into fine powder, behind 100 mesh sieves, subsequent use excessively;
2) it is in 50 ℃ the purified water, with adding with stirring that the sodium humate that takes by weighing 23.33g is dissolved in 500ml, temperature; When solution is even suspension state, add sodium humate fine powder and 50 ℃ of purified water of remaining 46.67g again by the equivalent method of progressively increasing, finally be supplemented to capacity, and, promptly get enema with adding with stirring.
Experimental example: treatment rectum, colonic ulcer, hemorrhage clinical observation
1, clinical data:
540 examples; Be divided into six groups at random, treat 1 group of 90 example (adopting embodiment 1 coloclysis), treat 2 group of 90 example (adopting embodiment 2 coloclysis); Treat 3 group of 90 example (adopting embodiment 3 coloclysis); Treat 4 group of 90 example (adopting embodiment 4 coloclysis), contrast 1 group of 90 example (Comparative Examples 1 coloclysis), contrast 2 group of 90 example (Comparative Examples 2 coloclysis).
2, intend research method and the technology path that adopts
1) include the case standard in:
A. realize clear, the patient that can clearly express operating position;
B. the age is at 18-65 between year;
C. the patient knows the inside story and agrees
2) get rid of the case standard:
A. the enteropathy patient who merges malignant tumor;
B. suffers from serious skin disease patient;
C. can't take care of oneself, the slurred speech patient.
3) therapeutic evaluation standard:
(version in 2006) efficacy evaluation is as the criterion execution by " up-to-date hospital clinical medical diagnosis on disease foundation and healing improvement manual of standards ":
Produce effects: patient's rectum, colonorrhagia transference cure, symptom of diarrhea disappears; Mirror is observed the enteral ulcer surface down and is obviously healed, and ulcer point obviously reduces.
Effectively: patient's rectum, colonorrhagia sx, symptom of diarrhea alleviates; Mirror is observed the most healings of enteral ulcer surface down, and ulcer point reduces.
Invalid: treatment back above-mentioned symptom does not have improvement.
3, test method:
The treatment group: according to the enema that embodiment 1-4 in the test method prepares, slowly pour into enemator every day and get rid of after stopping 10 minutes to enteral, 1 time on the one, 1 time 30 milliliters, logotype 7 days.
Matched group: according to the enema that Comparative Examples in the test method 1,2 prepares, slowly pour into enemator every day and get rid of after stopping 10 minutes to enteral, 1 time on the one, 1 time 30 milliliters, logotype 7 days.
4, result of the test: treatment group and matched group Comparison of therapeutic are seen table 1-6.
Table 1: treat 1 group of experimental result
Table 2: treat 2 groups of experimental results
Table 3: treat 3 groups of experimental results
Table 4: treat 4 groups of experimental results
Table 5: contrast 1 group of experimental result
Table 6: contrast 2 groups of experimental results
Conclusion: shown in table 1-6, from clinical observation, treatment group and matched group have notable difference on total effective rate; Compare with contrast 1,2 group (concentration of sodium humate is respectively 30%, 70%), the concentration of sodium humate is obvious in hemostasis, short wound healing effect in the treatment group of 40-60%.
Though, used general explanation, the specific embodiment and test in the preceding text, the present invention has been done detailed description, on basis of the present invention, can to some modifications of do or improvement, this will be apparent to those skilled in the art.Therefore, these modifications or the improvement on the basis of not departing from spirit of the present invention, made all belong to the scope that requirement of the present invention is protected.
Claims (6)
1. an enema of treating intestinal bleeding is characterized in that, this enema is processed by following raw material: the sodium humate of 40-60g, water is supplied 1000ml.
2. enema according to claim 1 is characterized in that, this enema is prepared by following method: formula ratio 1/3 sodium humate is dissolved in the 500ml water, progressively adds remaining water and sodium humate according to the equivalent method of progressively increasing then, promptly gets.
3. enema according to claim 1 and 2 is characterized in that, this enema is by following method preparation:
1) sodium humate is ground into fine powder, behind the 40-800 mesh sieve, subsequent use excessively;
2) sodium humate of formula ratio 1/3 being dissolved in 500ml, temperature is in 50-60 ℃ the water, when solution is even suspension state, adds the hot water of remaining sodium humate fine powder and 50-60 ℃ again by the equivalent method of progressively increasing, and adds to capacity gradually, promptly gets enema.
4. enema according to claim 3 is characterized in that, after this sodium humate is ground into fine powder, crosses the 60-400 mesh sieve.
5. method for preparing for preparing each described enema of claim 1-4; It is characterized in that this method may further comprise the steps: formula ratio 1/3 sodium humate is dissolved in the 500ml water, stirs; Progressively add remaining water and sodium humate according to the equivalent method of progressively increasing then, promptly get.
6. the application of each described enema of claim 1-4 in preparing the medicine of treating chronic colonic ulcer, rectal ulcer and treating acute and chronic hemorrhagic proctocolitis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100448983A CN102579491A (en) | 2012-02-24 | 2012-02-24 | Enema for treating intestinal bleeding |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100448983A CN102579491A (en) | 2012-02-24 | 2012-02-24 | Enema for treating intestinal bleeding |
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| CN102579491A true CN102579491A (en) | 2012-07-18 |
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| CN2012100448983A Pending CN102579491A (en) | 2012-02-24 | 2012-02-24 | Enema for treating intestinal bleeding |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998066A (en) * | 2016-06-28 | 2016-10-12 | 俞瑞山 | Application method of sodium humate serving as orally taken medicine for curing stomach illness and gynecological inflammation |
-
2012
- 2012-02-24 CN CN2012100448983A patent/CN102579491A/en active Pending
Non-Patent Citations (6)
| Title |
|---|
| 《中兽医学杂志》 19960525 王建树 "腐植酸钠在兽医临床上应用举隅" 第35-36页 , * |
| 《中国现代药物应用》 20100713 戴君妹 "腐殖酸钠保留灌肠治疗溃疡性结肠炎40例临床观察" 第65-66页 6 第4卷, 第13期 * |
| 《基层医学论坛》 20070201 杜文贞，于天霞 "腐植酸钠液灌肠治疗慢性结肠炎87例临床观察" 第169-170页 1-5 第11卷, 第2期 * |
| 戴君妹: ""腐殖酸钠保留灌肠治疗溃疡性结肠炎40例临床观察"", 《中国现代药物应用》 * |
| 杜文贞，于天霞: ""腐植酸钠液灌肠治疗慢性结肠炎87例临床观察"", 《基层医学论坛》 * |
| 王建树: ""腐植酸钠在兽医临床上应用举隅"", 《中兽医学杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998066A (en) * | 2016-06-28 | 2016-10-12 | 俞瑞山 | Application method of sodium humate serving as orally taken medicine for curing stomach illness and gynecological inflammation |
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Application publication date: 20120718 |