CN102579448A - 预防并减轻应激相关病症严重程度的方法 - Google Patents
预防并减轻应激相关病症严重程度的方法 Download PDFInfo
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| PT2182960E (pt) * | 2007-07-27 | 2014-06-11 | Galderma Lab Inc | Compostos, formulações e métodos para a redução das rugas, da flacidez e dos sulcos na pele |
| US20090061020A1 (en) * | 2007-08-31 | 2009-03-05 | Theobald Klaus P | Brimonidine Compositions for Treating Erythema |
| US20110269805A1 (en) * | 2007-10-18 | 2011-11-03 | Gil Daniel W | Method of treating sensorimotor disorders with 4-(1-(2,3-dimethylphenyl)ethyl)-1h-imidazole-2(3h)-thione |
| WO2009052073A2 (en) | 2007-10-18 | 2009-04-23 | Allergan, Inc. | Method of treating sensorimotor disorders with alpha-2 adrenergic receptor agonists |
| US8470337B2 (en) * | 2008-03-13 | 2013-06-25 | Allergan, Inc. | Therapeutic treatments using botulinum neurotoxin |
| US20100203165A1 (en) * | 2008-08-01 | 2010-08-12 | Gerald Horn | Compositions and methods for treatment of disorders or conditions of the eye |
| US12246013B2 (en) | 2008-08-01 | 2025-03-11 | Eye Therapies Llc | Vasoconstriction compositions and methods of use |
| US8952011B2 (en) | 2008-08-01 | 2015-02-10 | Eye Therapies Llc | Compositions and methods for the treatment of nasal conditions |
| US8283350B2 (en) | 2008-08-01 | 2012-10-09 | Alpha Synergy Development, Inc. | Compositions and methods for reducing capillary permeability |
| US8987270B2 (en) | 2009-07-27 | 2015-03-24 | Eye Therapies Llc | Formulations of selective alpha-2 agonists and methods of use thereof |
| WO2011028621A1 (en) * | 2009-08-26 | 2011-03-10 | Allergan, Inc. | Method of treating compulsive disorders with alpha-2b adrenergic receptor agonists |
| NZ628266A (en) | 2009-11-09 | 2016-02-26 | Allergan Inc | Compositions and methods for stimulating hair growth |
| EP2329849B1 (en) | 2009-11-18 | 2015-04-29 | Galderma Research & Development | Combination of alpha-2 adrenergic receptor agonist and non-steroidal anti-inflammatory agent for treating or preventing an inflammatory skin disorder |
| US8394800B2 (en) * | 2009-11-19 | 2013-03-12 | Galderma Laboratories, L.P. | Method for treating psoriasis |
| CA2782872A1 (en) * | 2009-12-17 | 2011-06-23 | Alpha Synergy Development, Inc. | Compositions and methods for ophthalmic delivery of nasal decongestants |
| BR112012024289A2 (pt) | 2010-03-26 | 2017-07-18 | Galderma Res & Dev | "método para fornecer um tratamento seguro e efetivo do eritema e composição de gel tópica" |
| RU2535008C2 (ru) | 2010-03-26 | 2014-12-10 | Галдерма Ресерч Энд Девелопмент | Улучшенные способы и композиции для безопасного и эффективного лечения телеангиэктазии |
| US20120073515A1 (en) * | 2010-09-28 | 2012-03-29 | Advanced Bionics Corporation | Intrathecal needle guide apparatus |
| BR112013009578B1 (pt) | 2010-10-21 | 2020-10-20 | Galderma S.A. | composição tópica em gel e uso de uma composição tópica em gel |
| US8053427B1 (en) | 2010-10-21 | 2011-11-08 | Galderma R&D SNC | Brimonidine gel composition |
| US8445526B2 (en) | 2011-02-03 | 2013-05-21 | Glaucoma & Nasal Therapies Llc | Compositions and methods for treatment of glaucoma |
| WO2013010100A1 (en) | 2011-07-14 | 2013-01-17 | Allergan, Inc. | Methods for treatment of incontinence associated with sexual activity |
| JP6511401B2 (ja) | 2013-02-15 | 2019-05-15 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | 持続型薬物送達インプラント |
| US8999938B2 (en) | 2013-06-21 | 2015-04-07 | Gnt Llc | Ophthalmic lipophilic drug delivery vehicle formulations |
| JP2017536421A (ja) | 2014-12-01 | 2017-12-07 | アケリオス セラピューティクス，インコーポレーテッド | 片頭痛及び疼痛に関連する状態を処置するための方法及び組成物 |
| MX2021001645A (es) * | 2018-08-29 | 2021-05-12 | Cellix Bio Private Ltd | Metodos y composiciones oftalmicas para el tratamiento de trastornos del ojo y enfermedades de la piel. |
| WO2020222188A1 (en) | 2019-05-01 | 2020-11-05 | Clexio Biosciences Ltd. | Methods of treating pruritus |
| CN120938924B (zh) * | 2025-10-17 | 2025-12-16 | 杭州云柏医药科技有限公司 | 一种盐酸乌拉地尔注射液及其制备方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5380754A (en) * | 1988-02-29 | 1995-01-10 | Virotex Corporation | Topical composition enhancing healing of viral lesions |
| AU688380B2 (en) * | 1993-10-13 | 1998-03-12 | Allergan, Inc. | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives |
| US6323204B1 (en) * | 1993-10-13 | 2001-11-27 | Allergan | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives |
| US6462077B1 (en) * | 1993-12-28 | 2002-10-08 | Allergan, Inc. | Thromboxane ligands without blood clotting side effects |
| GB9425211D0 (en) * | 1994-12-14 | 1995-02-15 | Ucb Sa | Substituted 1H-imidazoles |
| WO1996025163A1 (en) | 1995-02-14 | 1996-08-22 | Board Of Supervisors Or Louisiana State Universityof Agricultural And Mechanical College Through Itsmedical Center | Treatment of herpes simplex viruses |
| US6194415B1 (en) * | 1995-06-28 | 2001-02-27 | Allergan Sales, Inc. | Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury |
| US6576636B2 (en) | 1996-05-22 | 2003-06-10 | Protarga, Inc. | Method of treating a liver disorder with fatty acid-antiviral agent conjugates |
| US5795909A (en) | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
| AU1827799A (en) | 1997-12-15 | 1999-07-05 | Axia Therapeutics, Inc. | Oral delivery formulation |
| US20030059471A1 (en) | 1997-12-15 | 2003-03-27 | Compton Bruce Jon | Oral delivery formulation |
| EP1124535B1 (en) | 1998-10-27 | 2002-12-11 | Alcon Laboratories, Inc. | Preservative system for topically administrable pharmaceutical compositions containing a fatty acid/amino acid soap |
| MXPA01012187A (es) * | 1999-05-28 | 2002-06-21 | Jeffrey Berlant | Compuestos y metodos para el tratamiento del trastorno por estres postraumatico. |
| AU5331200A (en) | 1999-06-11 | 2001-01-02 | Ohio State University Research Foundation, The | Methods and compositions for treating raynaud's phenomenon and scleroderma |
| KR100331529B1 (ko) | 1999-06-16 | 2002-04-06 | 민경윤 | 난용성 항진균제의 경구투여용 조성물 및 그의 제조 방법 |
| US7160890B2 (en) | 1999-12-02 | 2007-01-09 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
| IN188750B (enExample) | 1999-12-04 | 2002-11-02 | Khamar Bakulesh Dr Mafatlal | |
| US6294553B1 (en) * | 2000-02-15 | 2001-09-25 | Allergan Sales, Inc. | Method for treating ocular pain |
| US6444681B1 (en) | 2000-06-09 | 2002-09-03 | The Ohio State University Research Foundation | Methods and compositions for treating Raynaud's Phenomenon and scleroderma |
| WO2002005853A2 (en) * | 2000-07-14 | 2002-01-24 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
| US6673802B2 (en) | 2000-12-01 | 2004-01-06 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
| DE60234118D1 (de) | 2001-11-30 | 2009-12-03 | Osi Pharm Inc | Verbindungen, die für Adenosin A1 und A3 Rezeptoren spezifisch sind, und deren Anwendungen |
| IL147921A0 (en) * | 2002-01-31 | 2002-08-14 | Abdulrazik Mohammad | A method for treating central nervous system disorders by ocular dosing |
| US7345065B2 (en) * | 2002-05-21 | 2008-03-18 | Allergan, Inc. | Methods and compositions for alleviating pain |
| US7439241B2 (en) | 2003-05-27 | 2008-10-21 | Galderma Laboratories, Inc. | Compounds, formulations, and methods for treating or preventing rosacea |
| US20050020600A1 (en) | 2003-07-23 | 2005-01-27 | Scherer Warren J. | Methods of treating cutaneous flushing using selective alpha-2-adrenergic receptor agonists |
| MXPA06013649A (es) | 2004-05-25 | 2007-07-09 | Sansrosa Pharmaceutical Dev In | Compuestos, formulaciones, y metodos para tratar o prevenir desordenes inflamatorios de la piel. |
-
2003
- 2003-06-25 US US10/607,439 patent/US20040266776A1/en not_active Abandoned
-
2004
- 2004-06-22 BR BRPI0411826-0A patent/BRPI0411826A/pt not_active IP Right Cessation
- 2004-06-22 AU AU2004253500A patent/AU2004253500A1/en not_active Abandoned
- 2004-06-22 ES ES04755981T patent/ES2376878T3/es not_active Expired - Lifetime
- 2004-06-22 KR KR1020057024881A patent/KR20060023575A/ko not_active Withdrawn
- 2004-06-22 WO PCT/US2004/020194 patent/WO2005002580A1/en not_active Ceased
- 2004-06-22 AT AT04755981T patent/ATE539751T1/de active
- 2004-06-22 CA CA2530487A patent/CA2530487C/en not_active Expired - Fee Related
- 2004-06-22 MX MXPA05013900A patent/MXPA05013900A/es active IP Right Grant
- 2004-06-22 EP EP04755981A patent/EP1638569B1/en not_active Expired - Lifetime
- 2004-06-22 CN CNA2004800178422A patent/CN1812791A/zh active Pending
- 2004-06-22 JP JP2006517594A patent/JP2007524625A/ja active Pending
- 2004-06-22 CN CN2011104449533A patent/CN102579448A/zh active Pending
- 2004-06-22 DK DK04755981.0T patent/DK1638569T3/da active
- 2004-06-25 TW TW093118660A patent/TWI371276B/zh not_active IP Right Cessation
-
2008
- 2008-05-02 US US12/114,727 patent/US7977335B2/en not_active Expired - Lifetime
- 2008-05-02 US US12/114,719 patent/US20080207627A1/en not_active Abandoned
-
2010
- 2010-11-18 AU AU2010241513A patent/AU2010241513B9/en not_active Ceased
-
2011
- 2011-12-13 JP JP2011272494A patent/JP2012092123A/ja active Pending
-
2012
- 2012-06-01 US US13/486,847 patent/US20120302574A1/en not_active Abandoned
- 2012-10-15 US US13/652,179 patent/US20130102612A1/en not_active Abandoned
-
2013
- 2013-02-15 US US13/768,901 patent/US20130217694A1/en not_active Abandoned
Non-Patent Citations (2)
| Title |
|---|
| DILLS C V ET AL: "Evidence for analgesia mediated by the alpha-2A adrenergic receptor using two models of chemical allodynia in alpha-2 knockout mice", 《BIOSIS》 * |
| 陆建华等: "应激时NMDA受体活性变化对HPA轴兴奋性的影响研究进展", 《西南国防医药》 * |
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| EP1638569A1 (en) | 2006-03-29 |
| US20080207628A1 (en) | 2008-08-28 |
| US20130102612A1 (en) | 2013-04-25 |
| US20130217694A1 (en) | 2013-08-22 |
| BRPI0411826A (pt) | 2006-08-08 |
| TW200524611A (en) | 2005-08-01 |
| AU2004253500A1 (en) | 2005-01-13 |
| MXPA05013900A (es) | 2006-02-24 |
| US20080207627A1 (en) | 2008-08-28 |
| ATE539751T1 (de) | 2012-01-15 |
| ES2376878T3 (es) | 2012-03-20 |
| US7977335B2 (en) | 2011-07-12 |
| DK1638569T3 (da) | 2012-04-02 |
| AU2010241513A1 (en) | 2010-12-09 |
| KR20060023575A (ko) | 2006-03-14 |
| CN1812791A (zh) | 2006-08-02 |
| TWI371276B (en) | 2012-09-01 |
| EP1638569B1 (en) | 2012-01-04 |
| JP2012092123A (ja) | 2012-05-17 |
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