CN102552574A - Health-care medicine formula with weight-losing function - Google Patents
Health-care medicine formula with weight-losing function Download PDFInfo
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- CN102552574A CN102552574A CN2011102913218A CN201110291321A CN102552574A CN 102552574 A CN102552574 A CN 102552574A CN 2011102913218 A CN2011102913218 A CN 2011102913218A CN 201110291321 A CN201110291321 A CN 201110291321A CN 102552574 A CN102552574 A CN 102552574A
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Abstract
The invention discloses a health-care medicine, in particular to a health-care product with a function of auxiliary weight-losing and a preparation method thereof. The health-care product can effectively lose weight under the condition of being free of side effects and adverse reactions. The technical scheme is that the health-care product with the auxiliary weight-losing function is characterized by being composed of broccoli extract 3-15g, calcium pyruvate 6-8g, L-carnitine-L-tartrate 7-13g, rhizoma alismatis 3-5g, fiveleaf gynostemma herb 3-5g, lotus leaf extract 3-6g, fructus evodiae 1.5-2.5g and microcrystalline cellulose 3-15g. The preparation method comprises the following steps: 1 weighing rhizoma alismatis, fiveleaf gynostemma herb and fructus evodiae according to formula proportion, crushing the medicines, and screening the medicines through a 80-100 mesh screen; 2 taking powder after screening, and evenly mixing the powder after screening with weighed broccoli extract, calcium pyruvate, L-carnitine-L-tartrate, rhizoma alismatis, lotus leaf extract and microcrystalline cellulose; and 3 filling mixed mixture into capsules, controlling the filling net weight of the capsules to be within the inner quality standard, and then performing selection and polishing.
Description
Technical field
The present invention relates to a kind of health medicine, especially relate to a kind of health product and manufacturing approach thereof with auxiliary weight losing function, these health product can play auxiliary antiobesity action in function of enhancing immunity.
Background technology
Along with many industrializations of the country and development of urbanization and human substance life horizontal raising in the world, the M & M of obesity is also along with rising.Obesity becomes the serious problems that global common fault obesity has become the puzzlement human society.The data that provide according to the WHO website: the whole world has adult more than 1,000,000,000 overweight, wherein has at least 300,000,000 to reach obesity standard.In recent years, occurred the overweight people in some developed countries and accounted for the most situation of population, this is unprecedented on the human history.There is the adult's overweight more than 66% in country-U.S. of " obesity " in the world, and body weight reaches 200 kilograms, and there are plenty of such people.Report, when the fat people who send a body weight to reach 500 kilograms goes to hospital, have to employ crane.And teen-age problem of obesity also goes from bad to worse.Per 10 philtrums of teenager such as between, U.S. 6 years old～17 years old just have an overweight people.According to another the WHO investigation, the prevalence of overweight children nearly 1,760 ten thousand of the whole world below 5 years old.Obesity is very easily brought out multiple disease, and like cardiovascular disease, apoplexy, type ii diabetes and some cancer etc., this type disease is called as noninfectious.According to the WHO statistics, in the 5650 ten thousand routine unusual deaths in the calendar year 2001 whole world, there are 3,300 ten thousand examples to be attributable to this type of disease.WHO studies confirmation, and unsound diet structure, the obesity that lacks motion and cause thus are the major reasons that causes noninfectious.WHO estimates that also to the year two thousand twenty, noninfectious will account for more than 70% of global disease.Only in the U.S., annual just have 300,000 people to die from and fat relevant various diseases.Fat serious with the most expensive disease of the U.S. that become.The Center for Disease Control discovers, because fat, the American needs the medical expense of 93,000,000,000 dollars of pay this extras every year, and that U.S. government has born is wherein half the, and this expense goes out because of the morbific medical expense of smoking is taller much than the U.S. every year.Obesity is common now a kind of Dystrophy, is 10%～20% in the incidence rate of China.And improve development trend with this living standard in several years, and rising year by year, obesity has become and has had a strong impact on the mankind now due to the overnutrition.How to prevent and treat the fat research focus that has become life sciences safely and effectively.
China is engaged in the research and the production of natural drug; Advantageous condition is arranged; The rarity of Traditional Chinese Medicine, it has clinical experience in several thousand, from present pharmaceutical research trend; Searching new drug or discovery guide are combined to thing and it are carried out the important content that structural modification is a drug development from natural product, add growth in the living standard and also make people that the quality of life has been had higher pursuit.Thereby pay attention to health more, pay attention to getting rid of illness diseases prevention and slow down aging etc.Under this background, this prescription utilization high-tech means and to be aided with other functional components with free of contamination pure natural animals and plants be that the slimming health food of raw material arises at the historic moment, and develop rapidly.
The present invention has carried out useful improvement in order to overcome above-mentioned defective.
Summary of the invention
The objective of the invention is to solve above-mentioned deficiency of the prior art, a kind of health product and manufacturing approach thereof with auxiliary weight losing function is provided.
The purpose of this invention is to provide a kind of prescription for losing weight; It can assist people be lost weight, and improves people's health level, improves overweight people's quality of life; Have no side effect and untoward reaction; And use modern preparation technique, advanced method of quality control makes product accomplish safety, stable, quality controllable.
To achieve these goals; Technical scheme of the present invention is: a kind of health product with auxiliary weight losing function is characterized in that: the consisting of of said health product: Caulis et Folium Brassicae capitatae 3-15g, calcium pyruvate 6-8g, L-carnitine-L-tartrate 7-13g, Rhizoma Alismatis 3-5g, Herb Gynostemmae Pentaphylli 3-5g, Folium Nelumbinis extract 3-6g, Fructus Evodiae 1.5-2.5g microcrystalline Cellulose 3-15g.
Above-mentioned manufacturing approach with health product of auxiliary weight losing function comprise the steps: (1) with Rhizoma Alismatis, Herb Gynostemmae Pentaphylli,, that Fructus Evodiae is pressed the formula proportion weighing is good, pulverizes, and crosses the 80-100 mesh sieve; (2) get sieve back powder and carry out uniform mixing with load weighted Caulis et Folium Brassicae capitatae, calcium pyruvate, L-carnitine-L-tartrate, Folium Nelumbinis extract, microcrystalline Cellulose; (3) mixture that mixes is carried out capsule and fill, the control capsule is filled net content within inner quality standard, screens, polishes.
Beneficial effect of the present invention; Compared with prior art, the present invention can improve people's obesity symptom, improves people's health level, has no side effect and untoward reaction, and uses modern preparation technique, and advanced method of quality control makes product accomplish safety, stable, quality controllable.
The specific embodiment
Below in conjunction with embodiment the present invention is further described.
A kind of health product with auxiliary weight losing function is characterized in that: the composition of said health product is following: Caulis et Folium Brassicae capitatae 3-15g, calcium pyruvate 6-8g, L-carnitine-L-tartrate 7-13g, Rhizoma Alismatis 3-5g, Herb Gynostemmae Pentaphylli 3-5g, Folium Nelumbinis extract 3-6g, Fructus Evodiae 1.5-2.5g microcrystalline Cellulose 3-15g.
Further, each mass percent of forming of said health product is: Caulis et Folium Brassicae capitatae 10%, calcium pyruvate 20%, L-carnitine-L-tartrate 25%, Rhizoma Alismatis 10%, Herb Gynostemmae Pentaphylli 10%, Folium Nelumbinis extract 10%, Fructus Evodiae 5%, microcrystalline Cellulose 10%.
Further, the active ingredient of said Caulis et Folium Brassicae capitatae is that sulfur is sweet, and its mass content is 2.5%; The active ingredient of said L-carnitine-L-tartrate is the L-carnitine, and its mass content is 95%; The active ingredient of said Rhizoma Alismatis is a polysaccharide, and its mass content is 10%; The active ingredient of said Herb Gynostemmae Pentaphylli is a gypenoside, and its mass content is 95%; The active ingredient of said Folium Nelumbinis is a nuciferine; The active ingredient of said Fructus Evodiae is a rutaecarpin.
Say that further the Radix Raphani sulfur glycosides during said sulfur is sweet has the function that improves immunity through the sulforaphen of enzymolysis or hydrolysis generation.
Caulis et Folium Brassicae capitatae has another name called broccoli, blue and white Lay, sprouting broccoli etc., belongs to the mutation that the Cruciferae Caulis et Folium Brassicae campestris belongs to brassica specie, is one, the biennial herb plant, originates in Italy.Existing experiment proof Caulis et Folium Brassicae capitatae contains abundant cancer-resisting substance and can lower the formation to the mouse breast tumor, stops the activity of carcinogen.Scientist finds that the anti-cancer material in the brassicaceous vegetables such as Caulis et Folium Brassicae capitatae is the enzymatic hydrolysate or the derivant of thioglycoside, wherein isothiocyanate class most importantly.
Radix Raphani sulfur glycosides is a kind of of thioglycoside, extensively is present in the Caulis et Folium Brassicae capitatae, and Radix Raphani sulfur glycosides produces isothiocyanate through myrosinase enzymolysis or acid hydrolysis: sulforaphen.Sulforaphen is the strongest anti-cancer active matter of finding in the vegetable up to now, because of it finds to gain the name in Radix Raphani.The ocean son professor of Japan nutritionist good fortune man waits and passes through verification experimental verification: contained isothiocyanic acid ester derivant sulforaphen has treatment cancer and the effectiveness of killing leukocyte in the crucifers such as Brassica oleracea L.var.capitata and Caulis et Folium Brassicae capitatae, and this is to confirm that it has the effect of killing the leukaemia for the first time.Show that according to research Radix Raphani sulfur glycosides (3-methylsulfinyl acrylic thioglycoside) and 4-methylsulfinyl cyclobutenyl thioglycoside account for 78% of total glucosinolate content in the fresh Caulis et Folium Brassicae capitatae of freshly harvested.Under common content, Radix Raphani sulfur glycosides has important benefits with its catabolite to health, though Radix Raphani sulfur glycosides is not direct beneficial organism active substance, its hydrolyzate sulforaphen has the defencive function of enhances human body.
The relation of sulforaphen and immunocompetence mainly is: external existing research proof sulforaphen has the function that improves immunity.Experiment shows: gave BALB/c (4-6 age in week) mouse every day (every of 500ug/) feed sulforaphen in continuous 9 days; The total leukocyte counting was strengthened one times of amount in the 9th day; The quantity of medullary cell and esterase A positive cell has also increased by one times; The hemolysis plaque number obviously raises, and the synthetic antibody number obviously increases, and sulforaphen has also improved the activate the phagocytic capacity of peritoneal macrophage.Radix Raphani sulfur greatly reduces the higher leveled TNF-a that stimulates macrophage to produce by LPS (endotoxin) in addition.These results show that it is obvious that sulforaphen raising immunity and auxiliary obesity are improved the interior microenvironment effect of body.
Show through zoopery in addition: sulforaphen is remarkable in the effect of anti-tumor aspect.Sulforaphen is after continuously giving mouse high dose (μ mol/kg every days 100) feed in 4-5 days, and the activity that II separates toxenzyme mutually in mouse liver, lung, mammary gland, pancreas, stomach, small intestinal and colon all has raising [8].Munday etc. [9] have compared six kinds of abilities that ITCs induces QR (quinone reductase), GST Phase II such as (glutathione transferases) to separate toxenzyme in the mouse Different Organs.Test dose is μ mol/kg every days 40, and feeding is 5 days continuously.The result shows that all ITCs have shown the activity of in duodenum, stomach, bladder, inducing QR and GST, and wherein sulforaphen induces the activity of GST the strongest in duodenum and bladder, and the effect with bladder is the most remarkable again in all organs.Jackson etc. [10] discover; F311 breast cancer cell to the BALB/c mouse when sulforaphen reaches 15nmol/L concentration has inhibitory action; Gave BALB/c mouse injection 15nmol/d in continuous 13 days, the sulforaphen of concentration, the F311 breast cancer cell of mouse reduces about 60%.
Above experimental data proof sulforaphen has significant raising immunity and antitumor efficacy; But because sulforaphen itself is very unstable; These article adopt its prerequisite Radix Raphani sulfur glycosides as main component, take Radix Raphani sulfur glycosides through the zoopery proof, become sulforaphen through enzymolysis in animal body; Can reach and directly take the identical effect of sulforaphen, and product is more stable.
Said have auxiliary weight losing function health product through acute toxicology, nursing experiment in 30 days, any side effect and untoward reaction all do not occur.Said in addition have auxiliary weight losing function health product and adopt ethanol and water from the vegetable Caulis et Folium Brassicae capitatae, to extract, and do not have other pollution.The dosage that adopts is in usual Caulis et Folium Brassicae capitatae vegetable edible range.Show that this prescription is feasible, have good using value.
Further, described calcium pyruvate has the body of raising calcium pyruvate level, stimulates mitochondrion, promotes tricarboxylic acid cycle, increases resting metabolic rate, the effect of effective consumption more energy.
Acetone acid (pyruvate Pyr) is a kind of purposes organic acid very widely, is glycometabolic intermediate product in body, and metabolism has a very important role to bio-energy.Calcium pyruvate (Calcium Pyruvate) is the calcium salt of acetone acid, and is very stable, white crystalline powder, and tasteless, near neutral is slightly soluble in water.Multinomial research shows: calcium pyruvate is cholesterol reducing (TC) significantly, triglyceride (TG) and leptin (Leptin) level; Reduce body weight and body fat content, but do not influence muscle content and motor capacity; Reduce energy stacking, the control lipogenesis.
Calcium pyruvate is at first converted into weak acid by the hydrochloric acid of stomachial secretion after getting into human body---acetone acid.The main metabolic pathway of utilizing glucose in the body is glycolysis and tricarboxylic acid cycle process, can occur in various cells.Glycolytic cycle need just can be decomposed into acetone acid and then under the pyruvate deoxygenase compound action, produce acetyl-CoA participation tricarboxylic acid cycle again through the reaction of 10 steps in the presence of plurality of enzymes.Therefore, when exogenous supply acetone acid, can avoid in the glycolytic cycle key enzyme to the synthetic speed limit effect of acetone acid; It is active to strengthen acetone acid deoxidation complex; Accelerate the conversion of acetone acid, the tricarboxylic acids village is got in return constantly to carry out, discharge lot of energy to NADH and acetyl-CoA.Thereby may suppress hyperabsorption energy from meals and avoid the synthetic of fat.On the other hand, active tricarboxylic acid cycle can quicken lipid mobilization, and glycerol and fatty acid that lipid mobilization produces are supplied with under the competent condition at oxygen and acetone acid, resolves into carbon dioxide and water discharges significant amount of energy.
Simultaneously, also there are some researches show: calcium pyruvate can controlling body weight increase, and reduces content of fatty acid, possibly realize through regulating liver ACC α mRNA transcriptional level and increasing human body energy consumption.
What discoveries such as Cortez gave that the obese rat feed contains Cortez Zucker 60g/L acetone acid (form of calcium pyruvate provides) can reduce the food utilization of animal and the growth of body weight in 5 weeks of feedstuff; Kalman etc. discover that calcium pyruvate can make the losing weight of obese patient, body fat content reduce.The simple additional acetone Stone acid calcium of proof does not have positive effect to the change of body composition.The prompting calcium pyruvate possibly have the effect of fat-reducing and blood fat reducing.In inductive fat rat model calcium pyruvate week of meals, the body weight gain that demonstrates obese rat slows down, and body fat content descends; Blood fat and leptin level also have reduction in various degree, and this possibly be the supply of external source calcium pyruvate, have improved body acetone acid level; Stimulate mitochondrion; Promote tricarboxylic acid cycle, increase resting metabolic rate, due to the effective consumption more energy.Utilizing the main metabolic pathway of glucose in the body is glycolytic cycle, can occur in various cells.This process needs in the presence of multiple regulation and control enzyme, to react through the step, just can be decomposed into acetone acid, then generates acetyl through the pyruvate oxidation decarboxylation again and participates in tricarboxylic acid cycle.Therefore ought supply with acetone acid exogenously; Can avoid the speed limit effect that key enzyme is grown to acetone acid in the glycolytic cycle, it is active to strengthen pyruvate dehydrogenase complex, accelerates the conversion of acetone acid to NADH and acetyl-CoA; Make tricarboxylic acid cycle be able to constantly carry out, discharge lot of energy.Thereby may suppress hyperabsorption energy from meals and avoid the synthetic of fat.On the other hand, active tricarboxylic acid cycle can quicken lipid mobilization.Glycerol and fatty acid that lipid mobilization produces are supplied with under the competent condition at oxygen and acetone acid, resolve into carbon dioxide and water disengages significant amount of energy.This result of study shows can reduce serum TC and TG, improves the HDL-C level, and blood glucose is not had the significance change.This acetone acid with external report can significantly reduce body weight and food utilization, improves resting metabolic rate, increases lipid metabolism, reduces the oxidation of sugar, makes the unconverted result of blood sugar level more consistent.In addition, after the acetone acid level acquires a certain degree in the body, can increase the substrate circulation (or invalid circulation) of acetone acid.Pyruvate phosphate turns to PEP; Then be acetone acid by dephosphorylation again; Thereby the consumption lot of energy, the accumulation of the excessive increase of controlling body weight and fat, the secreted protein parahormone that the expression product Leptin of ob gene is made up of 167 aminoacid.It is transported to the hypothalamus appetite center mainly by the fatty tissue synthesis secretion through blood, and brings into play appetite-suppressing after the receptors bind, reduces energy and take in, increase energy expenditure, suppress effects such as lipogenesis.Human obese individuals blood Leptin level and fatty tissue obmRNA level all are significantly higher than non-overweight people, and present many scholars think that the opposing of Leptin endogenous possibly be the basis that forms human obesity.
The calcium pyruvate existing exploitation in fat-weight-reducing food aspect at home and abroad. for example at home; Liu Ying etc. are with calcium pyruvate and L one carnitine raw material; With coffee solution is the instant fat-reducing coffee beverage that carrier is developed, and has demonstrated tangible hypolipemic function and certain antiobesity action; Xue Wanli etc. are that the third one of primary raw material development gathers capsule with calcium pyruvate and chitosan, have shown tangible antiobesity action and certain hypolipemic function.
In sum, this product calcium pyruvate uses the interior environmental activity with mediator.Because this product has had the listing product.This product is with reference to the dosage of forefathers' health food, and used dosage is in this scope.
Further, said L-carnitine has the reduction of promotion fatty acid metabolism, the effect of blood fat reducing.
L-carnitine-L-tartrate is a kind of stable salt of L-carnitine, and L-carnitine is a kind of biostearin, biologically active.For understanding L-carnitine to reducing the effect of body fat content, in August, 2004, we take the L-carnitine slimming capsule through giving the fat experimenter, observe its fat-reducing effect.
1, the L-carnitine is to fat model mice food-intake and the influence of body fat
The inductive fat model mice of high fat good deed is given the L-carnitine and carries out swimming exercise after 4 weeks, and the food-intake of 4 groups of mices does not have significant difference; 200, fat mass is starkly lower than matched group (p＜0.05) under the average weight of 400mg/kg group and the abdomen; Liver is heavy to reduce (p＜0.05) than matched group, and its result sees table 1
Table 1L-carnitine influences g to fat model mice food-intake and body fat
2, the L-carnitine is to the influence of blood fat
200,400mg/kg group matched group is compared, triglyceride in the serum, and the LDL-level of cholesterol significantly reduces (p＜0.01); The LDL-level of cholesterol raises (p＜0.05), and the result sees table 2.
Table 2L-carnitine is to the mmol/L that influences of blood fat
[0033] sum up: the carnitine (200,400mg/kg) of testing selected dosage can effectively promote fatty acid metabolism; Reduce the amount of body fat, particularly can significantly promote the metabolism of LCFA among Palmic acid and the C20H3402 etc., reduce triglyceride, LDL-cholesterol in the fat model mice serum; Effectively increase the metabolism of acid; More fatty acids that consume impel the fat of deposit in the body to reduce more, cause that the constituent of body changes.Its reason possibly be the supply of external source L-carnitine, directly improves body L-carnitine levels, quickens carnitine transportation acyl CoA and gets in the mitochondrion, increases fatty acid oxidation and decomposes, and finally causes cylinder storage fat to reduce.This L-carnitine with external report can significantly reduce body weight, and results such as raising fatty acid oxidation are more consistent.Transportation system's enzyme at carnitine place is made up of Carnitine palmitoyltransferase (CPT) I, carnitine, acetylcarnitine translocase, CPT II, is positioned different mitochondrion substructures.LCFA that in energy metabolism, plays an important role and coenzyme A thereof have only and could get into mitochondrial matrix through this transportation system and carry out beta-oxidation.CPT I is positioned on the mitochondrial outer membrane, and catalysis long-chain acyl CoA and carnitine synthetic fat acylcarnitine are first rate-limiting reactions of mitochondrion fatty acid oxidation process.Carnitine doses group mice significantly strengthens than the metabolism of matched group Palmic acid; Its reason possibly be the abundant of carnitine, has strengthened the activity of CPT I, thereby the preferential translocation of Palmic acid is strengthened to a certain extent; But its principle is not fully aware of, the further research of still needing.See that through this experiment carnitine can effectively promote obesity mice body fat acid metabolic, blood fat reducing.
Table 3 experiment cross-reference (51 people) and inward turning carnitine group (54 people)
Body weight, waistline, hip circumference, body fat total amount measurement result
This result of study shows that the experimenter is keeping under original life and the dietary habit, takes continuously and is tried thing 35d; Its body weight, waistline, hip circumference, body fat total amount, each point subcutaneous fat thickness all have minimizing; And test back experimenter's exercise tolerance does not descend, experimenter's the equal no abnormality seen of each item clinical symptoms, index before and after the test, and explaining suitably increases L-carnitine content in the human body; Can promote the fatty acyl group transhipment; Thereby promotion lipid metabolism reduces the fat mass of various tissues, reaches the purpose of fat-reducing slimming.
Rhizoma Alismatis has another name called watery diarrhea.For the Alismataceae plant, have promoting diuresis to eliminate damp pathogen, (the Shennong's Herbal exhibition is organized oral Poria Rhizoma Alismatis soup, the oral blood glue capsule of matched group according to two treatments to the effect that expels the heat-evil.The total effective rate of treatment group as a result and matched group is respectively 93.9%, 78.7%, two group relatively, and difference has the significance meaning.Conclusion: the have clear improvement effect of clinical symptoms and blood fat reducing of Poria Rhizoma Alismatis soup; Qian Wenbin utilizes orthogonal test to select that Rhizoma Alismatis water is carried, the preferred plan of alcohol extraction; Pass through pharmacological experimental method; Body weight, liver weight, blood lipids index, LeeShi index with the laboratory animal white mice are testing index, and relatively Rhizoma Alismatis water extract, ethanol extract are to the effect for reducing fat of high fat diet white mice.The result shows that Rhizoma Alismatis water extract, ethanol extract all have certain effect for reducing blood fat to fat white mice, and both effect there was no significant differences (P＞0.05); Rhizoma Alismatis extract has obvious cholesterol reducing to the experimental hypercholesterolemia of rabbit.Its mechanism maybe be relevant with the metabolism of endogenous alcohol with the exogenous absorption of cholesterol of its interference.Rhizoma Alismatis can reduce low density lipoprotein, LDL in the blood (LDL), high density lipoprotein increasing (HDL), thus prevent arteriosclerotic generation and development.Rhizoma Alismatis extract is to also having certain inhibitory action to experimental serum high triglyceride.The main active of Rhizoma Alismatis cholesterol reducing is the amyl acetate of Alisol A and Alisol A, B, C, and is the strongest with alisol 24 1 alisol acetyl A effect for reducing fat especially.Rhizoma Alismatis water extract and ethanol extract can obviously reduce obesity mice serum total cholesterol (TC) and triglyceride (TG), the concentration of high density lipoprotein increasing one cholesterol (HDL-c).Its water extracting alcohol hypostasis (RAE) has obvious functions of blood sugar and effect for reducing blood fat, and can protect islet tissue to avoid damage, and the effect of RAE blood sugar lowering is relevant with the release that promotes the islets of langerhans rope.In addition, Rhizoma Alismatis extract also has antiplatelet aggregation, antithrombotic to form and strengthens effect such as plasmin activity, can be from blood fat reducing, suppress many-side inhibition such as endothelial cell damage, antithrombotic or alleviate atherosclerotic generation, development.
Described gypenoside has blood lipid regulation and suppresses fat effect; Gynostemma is in qi-restoratives medicine; The traditional Chinese medical science thinks to have replenishing QI to invigorate the spleen, preventing phlegm from forming and stopping coughing, the effect of heat-clearing and toxic substances removing; Modern pharmacology research confirms, many-sided effects such as Herb Gynostemmae Pentaphylli has enhancing immunity, blood lipid regulation, protects the liver, slow down aging, anti-hypoxia, resisting fatigue, cold-resistant, tranquilizing soporific, analgesia, anticancer, antiulcer, blood pressure lowering, increase heart coronary artery flow and cerebral blood flow.
The effective ingredient of Herb Gynostemmae Pentaphylli is a gypenoside.Domestic and international many pharmacological testings all prove, gypenoside scalable blood fat, fat-reducing.Herb Gynostemmae Pentaphylli blood lipid regulation and the mechanism of action that suppresses obesity mainly contain two aspects: the first, and it can suppress adipose cell and produce free fatty, synthetic simultaneously neutral fat.The second, it can stop intestinal tube to sucrose with fat absorption, prevent the effect of hepatic tissue endoperoxides.
Described microcrystalline Cellulose is as antiplastering aid; Consider that Caulis et Folium Brassicae capitatae, Rhizoma Alismatis, Herb Gynostemmae Pentaphylli etc. contain sugar and the higher characteristics of vitamin; And the operability of the course of processing we selected the food additive microcrystalline Cellulose for use, show in " one one kinds of multi-functional macromolecular materials of microcrystalline Cellulose " literary composition of on " Guangzhou chemical industry " 1993 the 21st the 3rd phases of volume, delivering according to the Zhu Yu of Guangzhou Inst of Chemistry, Chinese Academy of Sciences qin, Tang Liegui, Pan Songhan: microcrystalline Cellulose can be used as antiplastering aid.The microcrystalline Cellulose addition meets GB2760 " food additive use sanitary standard " for 15% of prescription, and microcrystalline Cellulose toxicity property ADI does not do particular provisions (FAO/WHO, 1994), makes its whole prescription have more reasonability and science like this.
Several kinds of raw materials are assisted mutually in whole prescription and are deposited mutually more than this specific embodiment, bring out the best in each other, and make full side present effect preferably, and product has tangible antiobesity action through these article of function test proof.
The above embodiment has only been expressed one embodiment of the present invention, but can not therefore be interpreted as limitation of the scope of the invention.Should be pointed out that for the person of ordinary skill of the art under the prerequisite that does not break away from the present invention's design, can also make some distortion and improvement, these all belong to protection scope of the present invention.
Claims (6)
1. health product with auxiliary weight losing function, it is characterized in that: the composition of said health product is following:
Caulis et Folium Brassicae capitatae 3-15g,
Calcium pyruvate 6-8g,
L-carnitine-L-tartrate 7-13g,
Rhizoma Alismatis 3-5g,
Herb Gynostemmae Pentaphylli 3-5g,
Folium Nelumbinis extract 3-6g,
Fructus Evodiae 1.5-2.5g,
Microcrystalline Cellulose 3-15g.
2. a kind of health product with auxiliary weight losing function according to claim 1 is characterized in that: each mass percent of forming of said health product is:
Caulis et Folium Brassicae capitatae 10%,
Calcium pyruvate 20%,
L-carnitine-L-tartrate 25%,
Rhizoma Alismatis 10%,
Herb Gynostemmae Pentaphylli 10%,
Folium Nelumbinis extract 10%,
Fructus Evodiae 5%,
Microcrystalline Cellulose 10%.
3. a kind of health product according to claim 1 and 2 with auxiliary weight losing function,, it is characterized in that:
The active ingredient of said Caulis et Folium Brassicae capitatae is that sulfur is sweet, and its mass content is 2.5%;
The active ingredient of said L-carnitine-L-tartrate is the L-carnitine, and its mass content is 95%;
The active ingredient of said Rhizoma Alismatis is a polysaccharide;
The active ingredient of said Herb Gynostemmae Pentaphylli is a gypenoside;
The active ingredient of said Folium Nelumbinis is a nuciferine;
The active ingredient of said Fructus Evodiae is a rutaecarpin.
4. a kind of health product according to claim 3 with auxiliary weight losing function,, it is characterized in that:
Radix Raphani sulfur glycosides during said sulfur is sweet has the function that improves immunity through the sulforaphen of enzymolysis or hydrolysis generation;
Described calcium pyruvate has the body of raising calcium pyruvate level, stimulates mitochondrion, promotes tricarboxylic acid cycle, increases resting metabolic rate, the effect of effective consumption more energy.
5. a kind of health product according to claim 3 with auxiliary weight losing function,, it is characterized in that:
Said L-carnitine has the reduction of promotion fatty acid metabolism, the effect of blood fat reducing;
Described gypenoside has blood lipid regulation and suppresses fat effect;
Described microcrystalline Cellulose is as antiplastering aid.
6. according to claim 1,2 or 3 described method for preparinies, it is characterized in that, comprise the steps: with auxiliary weight losing function health product
(1) with Rhizoma Alismatis, Herb Gynostemmae Pentaphylli,, that Fructus Evodiae is pressed the formula proportion weighing is good, pulverizes, and crosses the 80-100 mesh sieve;
(2) get sieve back powder and carry out uniform mixing with load weighted Caulis et Folium Brassicae capitatae, calcium pyruvate, L-carnitine-L-tartrate, Folium Nelumbinis extract, microcrystalline Cellulose;
(3) mixture that mixes is carried out capsule and fill, the control capsule is filled net content within inner quality standard, screens, polishes.
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| CN (1) | CN102552574A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103478632A (en) * | 2013-09-17 | 2014-01-01 | 江西宇骏生物工程有限公司 | Fruit and vegetable health tablets and method for preparing same |
| CN103610054A (en) * | 2013-11-27 | 2014-03-05 | 营养屋(成都)生物医药有限公司 | Healthcare food with effects of reducing weight and facilitating feces excretion and preparation method thereof |
| CN103690819A (en) * | 2013-12-31 | 2014-04-02 | 庞会心 | Traditional Chinese medicinal composition capable of preventing and treating cardiovascular and cerebrovascular diseases and with weight reducing function |
| CN104415188A (en) * | 2013-08-19 | 2015-03-18 | 宣城柏维力生物工程有限公司 | L-carnitine tea polyphenol capsule and preparation method thereof |
| CN110464010A (en) * | 2019-08-14 | 2019-11-19 | 中国农业大学 | A kind of weight-reducing cereal meal replacement powder |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1168279A (en) * | 1997-01-17 | 1997-12-24 | 西安博仁中医药研究所 | Glossy ganoderma-Eighteen treasure oral liquid |
-
2011
- 2011-09-30 CN CN2011102913218A patent/CN102552574A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1168279A (en) * | 1997-01-17 | 1997-12-24 | 西安博仁中医药研究所 | Glossy ganoderma-Eighteen treasure oral liquid |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104415188A (en) * | 2013-08-19 | 2015-03-18 | 宣城柏维力生物工程有限公司 | L-carnitine tea polyphenol capsule and preparation method thereof |
| CN103478632A (en) * | 2013-09-17 | 2014-01-01 | 江西宇骏生物工程有限公司 | Fruit and vegetable health tablets and method for preparing same |
| CN103610054A (en) * | 2013-11-27 | 2014-03-05 | 营养屋(成都)生物医药有限公司 | Healthcare food with effects of reducing weight and facilitating feces excretion and preparation method thereof |
| CN103690819A (en) * | 2013-12-31 | 2014-04-02 | 庞会心 | Traditional Chinese medicinal composition capable of preventing and treating cardiovascular and cerebrovascular diseases and with weight reducing function |
| CN110464010A (en) * | 2019-08-14 | 2019-11-19 | 中国农业大学 | A kind of weight-reducing cereal meal replacement powder |
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Application publication date: 20120711 |