CN102512712A - 具有梯度结构的丝素蛋白多层功能膜及其制备方法 - Google Patents
具有梯度结构的丝素蛋白多层功能膜及其制备方法 Download PDFInfo
- Publication number
- CN102512712A CN102512712A CN2011104355574A CN201110435557A CN102512712A CN 102512712 A CN102512712 A CN 102512712A CN 2011104355574 A CN2011104355574 A CN 2011104355574A CN 201110435557 A CN201110435557 A CN 201110435557A CN 102512712 A CN102512712 A CN 102512712A
- Authority
- CN
- China
- Prior art keywords
- solution
- phosphate
- fibroin albumen
- fibroin
- silk fibroin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010022355 Fibroins Proteins 0.000 title claims abstract description 56
- 239000012528 membrane Substances 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title abstract description 8
- 230000004888 barrier function Effects 0.000 claims abstract description 21
- 238000000034 method Methods 0.000 claims abstract description 19
- 239000001506 calcium phosphate Substances 0.000 claims abstract description 12
- 229910000389 calcium phosphate Inorganic materials 0.000 claims abstract description 12
- 235000011010 calcium phosphates Nutrition 0.000 claims abstract description 12
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 12
- 239000002131 composite material Substances 0.000 claims abstract description 11
- 238000004132 cross linking Methods 0.000 claims abstract description 10
- 239000011148 porous material Substances 0.000 claims abstract description 4
- 239000004753 textile Substances 0.000 claims abstract description 4
- 239000010408 film Substances 0.000 claims description 34
- 239000000243 solution Substances 0.000 claims description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 19
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 17
- 239000011575 calcium Substances 0.000 claims description 17
- 229910052791 calcium Inorganic materials 0.000 claims description 17
- 238000001035 drying Methods 0.000 claims description 15
- 239000004744 fabric Substances 0.000 claims description 15
- AZKVWQKMDGGDSV-BCMRRPTOSA-N Genipin Chemical compound COC(=O)C1=CO[C@@H](O)[C@@H]2C(CO)=CC[C@H]12 AZKVWQKMDGGDSV-BCMRRPTOSA-N 0.000 claims description 14
- AZKVWQKMDGGDSV-UHFFFAOYSA-N genipin Natural products COC(=O)C1=COC(O)C2C(CO)=CCC12 AZKVWQKMDGGDSV-UHFFFAOYSA-N 0.000 claims description 14
- 239000012460 protein solution Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 10
- 239000011259 mixed solution Substances 0.000 claims description 10
- 239000011574 phosphorus Substances 0.000 claims description 10
- 229910052698 phosphorus Inorganic materials 0.000 claims description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- 229920000642 polymer Polymers 0.000 claims description 9
- 238000006243 chemical reaction Methods 0.000 claims description 8
- 239000012153 distilled water Substances 0.000 claims description 8
- 239000002202 Polyethylene glycol Substances 0.000 claims description 7
- 229920001223 polyethylene glycol Polymers 0.000 claims description 7
- 238000002791 soaking Methods 0.000 claims description 7
- 238000007654 immersion Methods 0.000 claims description 6
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 5
- 238000004108 freeze drying Methods 0.000 claims description 5
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 5
- 238000001291 vacuum drying Methods 0.000 claims description 5
- 238000005406 washing Methods 0.000 claims description 5
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 claims description 4
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 claims description 4
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims description 4
- 229910052586 apatite Inorganic materials 0.000 claims description 3
- 238000005266 casting Methods 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims description 3
- 239000010409 thin film Substances 0.000 claims description 3
- 239000004254 Ammonium phosphate Substances 0.000 claims description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 2
- LFVGISIMTYGQHF-UHFFFAOYSA-N ammonium dihydrogen phosphate Chemical compound [NH4+].OP(O)([O-])=O LFVGISIMTYGQHF-UHFFFAOYSA-N 0.000 claims description 2
- 229910000387 ammonium dihydrogen phosphate Inorganic materials 0.000 claims description 2
- 229910000148 ammonium phosphate Inorganic materials 0.000 claims description 2
- 235000019289 ammonium phosphates Nutrition 0.000 claims description 2
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 claims description 2
- 239000001639 calcium acetate Substances 0.000 claims description 2
- 235000011092 calcium acetate Nutrition 0.000 claims description 2
- 229960005147 calcium acetate Drugs 0.000 claims description 2
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 2
- 239000011248 coating agent Substances 0.000 claims description 2
- 238000000576 coating method Methods 0.000 claims description 2
- 239000004567 concrete Substances 0.000 claims description 2
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 2
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 2
- 229910000397 disodium phosphate Inorganic materials 0.000 claims description 2
- 235000019800 disodium phosphate Nutrition 0.000 claims description 2
- 235000019837 monoammonium phosphate Nutrition 0.000 claims description 2
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 2
- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 2
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 2
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims description 2
- 229910000160 potassium phosphate Inorganic materials 0.000 claims description 2
- 235000011009 potassium phosphates Nutrition 0.000 claims description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 2
- 239000001488 sodium phosphate Substances 0.000 claims description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 2
- 235000011008 sodium phosphates Nutrition 0.000 claims description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 2
- 238000006731 degradation reaction Methods 0.000 abstract description 9
- 230000015556 catabolic process Effects 0.000 abstract description 8
- 230000010478 bone regeneration Effects 0.000 abstract description 7
- 210000002744 extracellular matrix Anatomy 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 230000001413 cellular effect Effects 0.000 abstract description 2
- 210000002808 connective tissue Anatomy 0.000 abstract description 2
- 235000015097 nutrients Nutrition 0.000 abstract description 2
- 239000010410 layer Substances 0.000 description 51
- 239000000463 material Substances 0.000 description 11
- 238000005516 engineering process Methods 0.000 description 9
- 210000000988 bone and bone Anatomy 0.000 description 8
- 230000008929 regeneration Effects 0.000 description 8
- 238000011069 regeneration method Methods 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 4
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 4
- 239000011229 interlayer Substances 0.000 description 4
- 230000017423 tissue regeneration Effects 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- 239000003643 water by type Substances 0.000 description 3
- ALRHLSYJTWAHJZ-UHFFFAOYSA-N 3-hydroxypropionic acid Chemical compound OCCC(O)=O ALRHLSYJTWAHJZ-UHFFFAOYSA-N 0.000 description 2
- 230000010261 cell growth Effects 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 229920000747 poly(lactic acid) Polymers 0.000 description 2
- 239000004626 polylactic acid Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000255791 Bombyx Species 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 244000043261 Hevea brasiliensis Species 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 230000008512 biological response Effects 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 238000005234 chemical deposition Methods 0.000 description 1
- 210000001608 connective tissue cell Anatomy 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 239000002346 layers by function Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 229920003052 natural elastomer Polymers 0.000 description 1
- 229920001194 natural rubber Polymers 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 210000000963 osteoblast Anatomy 0.000 description 1
- 230000001582 osteoblastic effect Effects 0.000 description 1
- 210000004409 osteocyte Anatomy 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229950000845 politef Drugs 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Images
Landscapes
- Materials For Medical Uses (AREA)
Abstract
Description
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201110435557.4A CN102512712B (zh) | 2011-12-22 | 2011-12-22 | 具有梯度结构的丝素蛋白多层功能膜及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201110435557.4A CN102512712B (zh) | 2011-12-22 | 2011-12-22 | 具有梯度结构的丝素蛋白多层功能膜及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102512712A true CN102512712A (zh) | 2012-06-27 |
CN102512712B CN102512712B (zh) | 2014-12-10 |
Family
ID=46283952
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201110435557.4A Active CN102512712B (zh) | 2011-12-22 | 2011-12-22 | 具有梯度结构的丝素蛋白多层功能膜及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102512712B (zh) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103628119A (zh) * | 2013-12-03 | 2014-03-12 | 苏州大学 | 一种仿生多孔结构磷酸八钙/丝素蛋白复合膜层的制备方法 |
CN104383598A (zh) * | 2014-12-04 | 2015-03-04 | 湖北赛罗生物材料有限责任公司 | 一种生物活性材料、其制备方法及应用 |
CN107596448A (zh) * | 2017-11-14 | 2018-01-19 | 四川大学 | 可梯度降解的生物膜支架材料及其制备方法 |
CN107812248A (zh) * | 2017-10-26 | 2018-03-20 | 锡山区东港玉英家电经营部 | 一种改善骨折愈合的三层尖型复合膜的w模型制作方法 |
CN110721348A (zh) * | 2019-10-24 | 2020-01-24 | 湖南师范大学 | 一种天然蚕丝增强羟基磷灰石/壳聚糖复合膜及制备方法 |
CN115501396A (zh) * | 2022-09-13 | 2022-12-23 | 四川大学 | 可降解组织支架及其制备方法与用途 |
CN115779152A (zh) * | 2022-12-07 | 2023-03-14 | 诺一迈尔(山东)医学科技有限公司 | 一种可降解生物型韧带及其制备方法 |
CN116103933A (zh) * | 2023-02-21 | 2023-05-12 | 现代纺织技术创新中心(鉴湖实验室) | 一种高牢度双层组合丝素蛋白涂层织物的制备方法 |
WO2023179418A1 (zh) * | 2022-03-25 | 2023-09-28 | 上海工程技术大学 | 具有取向结构的肩袖补片及其制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101066470A (zh) * | 2007-05-25 | 2007-11-07 | 浙江大学 | 一种膜状组织工程支架及其应用 |
WO2009156226A2 (en) * | 2008-06-25 | 2009-12-30 | Spintec Engineering Gmbh | A silk membrane for bone graft material and a method for manufacture thereof |
CN101628130A (zh) * | 2009-08-20 | 2010-01-20 | 华中科技大学 | 一种纳米仿生骨材料及其制备方法 |
CN101891962A (zh) * | 2010-07-22 | 2010-11-24 | 苏州大学 | 丝素蛋白多孔三维材料的制备方法 |
WO2011156586A2 (en) * | 2010-06-09 | 2011-12-15 | Trustees Of Tufts College | Multilayered silk scaffolds for meniscus tissue engineering |
-
2011
- 2011-12-22 CN CN201110435557.4A patent/CN102512712B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101066470A (zh) * | 2007-05-25 | 2007-11-07 | 浙江大学 | 一种膜状组织工程支架及其应用 |
WO2009156226A2 (en) * | 2008-06-25 | 2009-12-30 | Spintec Engineering Gmbh | A silk membrane for bone graft material and a method for manufacture thereof |
CN101628130A (zh) * | 2009-08-20 | 2010-01-20 | 华中科技大学 | 一种纳米仿生骨材料及其制备方法 |
WO2011156586A2 (en) * | 2010-06-09 | 2011-12-15 | Trustees Of Tufts College | Multilayered silk scaffolds for meniscus tissue engineering |
CN101891962A (zh) * | 2010-07-22 | 2010-11-24 | 苏州大学 | 丝素蛋白多孔三维材料的制备方法 |
Non-Patent Citations (3)
Title |
---|
RIKAKO KINO等: "Preparation and Characterization of Multilayered Hydroxyapatite/Silk Fibroin Film", 《JOURNAL OF BIOSCIENCE AND BIOENGINEERING》, vol. 103, no. 6, 30 June 2007 (2007-06-30), pages 514 - 520 * |
江芸等: "构建用于骨再生引导膜的多层丝素自增强复合膜", 《2011年全国高分子学术论文报告会》, 28 September 2011 (2011-09-28), pages 647 * |
程新等: "预处理对构建丝素蛋白纤维/磷灰石仿生骨修复材料的影响", 《无机材料学报》, vol. 26, no. 1, 31 January 2011 (2011-01-31), pages 43 - 48 * |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103628119A (zh) * | 2013-12-03 | 2014-03-12 | 苏州大学 | 一种仿生多孔结构磷酸八钙/丝素蛋白复合膜层的制备方法 |
CN104383598A (zh) * | 2014-12-04 | 2015-03-04 | 湖北赛罗生物材料有限责任公司 | 一种生物活性材料、其制备方法及应用 |
CN107812248A (zh) * | 2017-10-26 | 2018-03-20 | 锡山区东港玉英家电经营部 | 一种改善骨折愈合的三层尖型复合膜的w模型制作方法 |
CN107596448A (zh) * | 2017-11-14 | 2018-01-19 | 四川大学 | 可梯度降解的生物膜支架材料及其制备方法 |
CN107596448B (zh) * | 2017-11-14 | 2020-06-05 | 四川大学 | 可梯度降解的生物膜支架材料及其制备方法 |
CN110721348A (zh) * | 2019-10-24 | 2020-01-24 | 湖南师范大学 | 一种天然蚕丝增强羟基磷灰石/壳聚糖复合膜及制备方法 |
CN110721348B (zh) * | 2019-10-24 | 2021-10-01 | 湖南师范大学 | 一种天然蚕丝增强羟基磷灰石/壳聚糖复合膜及制备方法 |
WO2023179418A1 (zh) * | 2022-03-25 | 2023-09-28 | 上海工程技术大学 | 具有取向结构的肩袖补片及其制备方法 |
CN115501396A (zh) * | 2022-09-13 | 2022-12-23 | 四川大学 | 可降解组织支架及其制备方法与用途 |
CN115501396B (zh) * | 2022-09-13 | 2024-03-22 | 长春达康园医疗器械有限公司 | 可降解组织支架及其制备方法与用途 |
CN115779152A (zh) * | 2022-12-07 | 2023-03-14 | 诺一迈尔(山东)医学科技有限公司 | 一种可降解生物型韧带及其制备方法 |
CN116103933A (zh) * | 2023-02-21 | 2023-05-12 | 现代纺织技术创新中心(鉴湖实验室) | 一种高牢度双层组合丝素蛋白涂层织物的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN102512712B (zh) | 2014-12-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102512712B (zh) | 具有梯度结构的丝素蛋白多层功能膜及其制备方法 | |
Chen et al. | New forms of electrospun nanofiber materials for biomedical applications | |
CN101214393B (zh) | 纳米纤维组织工程血管及其制备方法 | |
Huang et al. | Silk scaffolds with gradient pore structure and improved cell infiltration performance | |
Shabafrooz et al. | Electrospun nanofibers: from filtration membranes to highly specialized tissue engineering scaffolds | |
CN102430155B (zh) | 一种蜂窝状丝素蛋白多孔支架及制备方法 | |
Yixiang et al. | Degradation of electrospun nanofiber scaffold by short wave length ultraviolet radiation treatment and its potential applications in tissue engineering | |
JP5179124B2 (ja) | 骨再生誘導膜、およびその製造方法 | |
CN103736153A (zh) | 单层及双层聚己内酯基引导组织再生膜及其制备方法 | |
Yang et al. | Bioinspired porous octacalcium phosphate/silk fibroin composite coating materials prepared by electrochemical deposition | |
CN102940907A (zh) | 氧化石墨烯和丝素蛋白复合膜及其制备方法 | |
Zhang et al. | Applications of electrospun scaffolds with enlarged pores in tissue engineering | |
CN109876186B (zh) | 一种用于神经修复的生物医用可降解双层支架及其制备方法 | |
Su et al. | Biomimetic 3D hydroxyapatite architectures with interconnected pores based on electrospun biaxially orientated PCL nanofibers | |
Zhao et al. | In vitro biomimetic construction of hydroxyapatite–porcine acellular dermal matrix composite scaffold for MC3T3-E1 preosteoblast culture | |
US9956711B2 (en) | Facile methods for fabricating a uniformly patterned and porous nanofibrous scaffold | |
Shalumon et al. | Fabrication of three-dimensional nano, micro and micro/nano scaffolds of porous poly (lactic acid) by electrospinning and comparison of cell infiltration by Z-stacking/three-dimensional projection technique | |
CN110585487B (zh) | 一种负载离子和几何图案信号的医用骨膜支架及其构建方法 | |
Qian et al. | Biomedical applications of Janus membrane | |
CN107213529A (zh) | 一种用于提高成骨细胞粘附和成骨性能的可降解医用高分子三维材料的制备方法 | |
Zulkifli et al. | Cross-linking effect on electrospun hydroxyethyl cellulose/poly (vinyl alcohol) nanofibrous scaffolds | |
Song et al. | Assembling of electrospun meshes into three-dimensional porous scaffolds for bone repair | |
CN106012297B (zh) | 一种医用复合纤维三维结构敷料的制备方法 | |
CN102949750B (zh) | 双层电纺仿生骨膜及其制备 | |
Ullah et al. | Impact of structural features of acetylated bacterial cellulose on cell-scaffold and scaffold-blood interactions in vitro |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C53 | Correction of patent of invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Li Yanbao Inventor after: Jiang Yun Inventor after: Shi Yuhao Inventor after: Cheng Xin Inventor after: Lu Chunhua Inventor after: Xu Zhongzi Inventor before: Li Yanbao Inventor before: Jiang Yun Inventor before: Cheng Xin Inventor before: Lu Chunhua Inventor before: Xu Zhongzi |
|
COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: LI YANBAO JIANG YUN CHENG XIN LU CHUNHUA XU ZHONGZI TO: LI YANBAO JIANG YUN SHI YUHAO CHENG XIN LU CHUNHUA XU ZHONGZI |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant |