CN102512634A - Compound musk soft capsule and preparing method thereof - Google Patents
Compound musk soft capsule and preparing method thereof Download PDFInfo
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- CN102512634A CN102512634A CN2011104425990A CN201110442599A CN102512634A CN 102512634 A CN102512634 A CN 102512634A CN 2011104425990 A CN2011104425990 A CN 2011104425990A CN 201110442599 A CN201110442599 A CN 201110442599A CN 102512634 A CN102512634 A CN 102512634A
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Abstract
The invention discloses a compound musk soft capsule, which is prepared by the following active ingredients with the ratio of part by weight through the following preparing method: (a) taking musk 7.5-16 parts, curcuma aromatica 100-200 parts, pogostemon cablin 100-200 parts, grassleaf sweetflag rhizome 100-200 parts, borneol 1-3 parts and menthol 0.75-1.5 parts; (b) obtaining musk extraction by performing supercritical extraction on the musk with extraction pressure of 20-25 MPa, extraction temperature of 38-42 DEG C and extraction time of 6h-8h; (c) adding steam into the curcuma aromatica, the pogostemon cablin and the grassleaf sweetflag rhizome, distilling the mixture to obtain initially distilled liquid, then performing re-distillation on the initial distilled liquid, and obtaining distilled liquid; (d) grinding the borneol and menthol together into powder, mixing fine powder, the musk extraction and the distilled liquid, adding vegetable oil with total weight 8-20 times that of the mixture, mixing the mixture and the vegetable oil, pressing and forming the soft capsule after evenly grinding through a colloid mill. The compound musk soft capsule is convenient to take, accurate in dosage, good in safety and high in bioavailability.
Description
Technical field
The present invention relates to a kind of pharmaceutical product and preparation method thereof, specifically a kind of have eliminate phlegm for resuscitation, the refreshment and tranquilization effect, cure mainly the pharmaceutical preparation of the apoplectic coma due to closing in the expectorant heat.
Background technology
Compound Moschus injection takes off in Moschus, Radix Curcumae, Herba Pogostemonis, Rhizoma Acori Graminei, Borneolum Syntheticum, Mentholum Six-element Chinese medicine and is prepared from.Its main effect be eliminate phlegm for resuscitation, refreshment and tranquilization.Be widely used in the treatment of the apoplectic coma due to closing in the expectorant heat clinically.Compound Moschus injection composition more complicated, and contain and be prone to cause hemolytic Polysorbate (80), sensitivity response or untoward reaction appear after the intravenous injection easily.In addition, also there are shortcomings such as cost is higher, family's use inconvenience in injection.Therefore, the higher oral formulations of exploitation other biological availability becomes the focus of Chinese medicine research gradually.
Summary of the invention
The object of the invention is exactly the compound musk soft capsule that a kind of bioavailability height, taking convenience will be provided.
The objective of the invention is to realize through following technical scheme:
Compound musk soft capsule provided by the present invention, its active ingredient following weight part ratio, the following method for preparing of employing are prepared from:
(a) Moschus 7.5-16 part, Radix Curcumae 100-200 part, Herba Pogostemonis 100-200 part, Rhizoma Acori Graminei 100-200 part, Borneolum Syntheticum 1-3 part, Mentholum 0.75-1.5 part.
(b) Moschus is through supercritical extraction, and extracting pressure 20-25MPa, extraction temperature are that 38-42 ℃, extraction time are 6h-8h, obtain Moschus extract;
(c) with Herba Pogostemonis, Radix Curcumae, Rhizoma Acori Graminei add steam steam slip first distillate, carry out redistillation again, distillate;
(d) Borneolum Syntheticum, Mentholum are ground altogether, the powder behind the porphyrize, Moschus extract mix with above-mentioned distillate, add the 8-20 vegetable oil doubly of gross weight, mix, and after colloid mill grinding evenly, the compacting soft capsule.
Preferred weight part ratio of active ingredient is among the present invention:
7.5 parts in Moschus, 100 parts of Radix Curcumaes, 100 parts of Herba Pogostemonis, 100 parts of Rhizoma Acori Graminei, 1 part of Borneolum Syntheticum, 0.75 part of Mentholum.
Used rubber is made up of gelatin, glycerol, water, and its each plant demand optimum ratio is counted 1: 0.7: 0.3 with weight part ratio.
Described Moschus is through supercritical extraction, and optimizing technology parameters is that extracting pressure 20MPa, extraction temperature are that 40 ℃, extraction time are 6h, obtains Moschus extract.
Described vegetable oil can be Semen Maydis oil, soybean oil and palmitic a kind of.
The used rubber of soft capsule is made up of gelatin, glycerol, water, wherein also can add iron oxide brown, ethyl hydroxybenzoate according to routine dose, the optimum ratio 1: 0.7～1.2: 0.3～0.6 of gelatin, water and glycerol wherein, most preferably 1: 0.7: 0.3.
The present invention is wrapped in the soft capsule shell the active constituents of medicine mixed liquor is airtight through pressing, and medicine is hedged off from the outer world, and the soft capsule that makes is exquisite appearance not only, taking convenience, and dosage is accurate, and safety is good, and bioavailability is high.
Compound musk soft capsule provided by the present invention has overcome shortcomings such as in use easy sensitization of compound Moschus injection, inconvenience, dangerous, cost height; In addition; In preparation Moschus extract process, introduced process for super-critical extracting, its better efficacy, the cost of preparation is lower.The compound musk soft capsule is that clinical application provides new selection.
Beneficial effect of the present invention has obtained checking through pharmacodynamic experiment.
Test method:
Get Kunming mouse (body weight 18-22g) and be divided into normal saline matched group, prepared compound musk soft capsule 3 dose groups (20mg/kg, 10mg/kg, the 5mg/kg of the present invention at random; By content) and totally 5 groups of positive drug control group (compound Moschus injection); Every group 10, male and female half and half.Each organizes medicine after calculating dilution, and all with the dosed administration of 0.2ml/10g, 15min's every Mus fast breaks end at mice two ear line places behind the single administration, writes down the persistent period of the action of dehiscing behind each mice broken end to breathe.Experimental result is seen table 1.The result shows that the compound musk soft capsule is dehisced the time of breathing after can obviously prolonging the mice broken end, and presents certain dose dependent, and the maximum extension percentage rate is 25.1%.The result shows that the compound musk soft capsule has protective effect to the ischemic hypoxia brain injury.
Table 1 compound musk soft capsule is to the protective effect
of mice hypoxic-ischemic brain injury
| Group | Dosage | Dehisce the time of breathing | Prolong percentage rate/% |
| Normal saline | - | 18.7±1.26 | - |
| The compound Moschus injection group | 0.2ml/kg | 22.6±1.34 ** | 20.85 |
| Compound musk soft capsule high dose group | 20mg/kg | 23.4±1.45 ** | 25.13 |
| Dose groups in the compound musk soft capsule | 10mg/kg | 22.4±1.21 ** | 19.79 |
| Compound musk soft capsule low dose group | 5mg/kg | 20.8±1.01 * | 11.23 |
Annotate: compare * P＜0.05, * * P＜0.01 with the normal saline group
The specific embodiment
Below in conjunction with embodiment the present invention is done further description:
Embodiment 1:
Prescription: Moschus 7.5g, Radix Curcumae 100g, Herba Pogostemonis 100g, Rhizoma Acori Graminei 100g, Borneolum Syntheticum 1g, Mentholum 0.75g
Method for making:, Moschus obtains Moschus extract through supercritical extraction, extracting pressure 20MPa; Extraction temperature is 40 ℃, and the extraction time is 6h, with Herba Pogostemonis, Radix Curcumae, Rhizoma Acori Graminei add steam steam slip first distillate; Carry out redistillation again, Borneolum Syntheticum, Mentholum are ground altogether, the powder behind the porphyrize, Moschus extract mix with above-mentioned distillate; 10 times of amounts of pressing principal agent (except that Borneolum Syntheticum, Mentholum, other medical materials are by extract) gross weight take by weighing Semen Maydis oil mixes with it, grinds the gained mixture after fully evenly with colloid mill; Be pressed into soft capsule, promptly get, result of the test is seen table 2.
Wherein, rubber is formulated by a certain percentage by gelatin, glycerol, iron oxide brown, ethyl hydroxybenzoate, water, and the ratio of gelatin, water and glycerol is 1: 0.7: 0.3.
Embodiment 2:
Prescription: Moschus 7.5g, Radix Curcumae 100g, Herba Pogostemonis 100g, Rhizoma Acori Graminei 100g, Borneolum Syntheticum 1g, Mentholum 0.75g
Method for making: Moschus obtains Moschus extract through supercritical extraction, extracting pressure 20MPa, and extraction temperature is 40 ℃; The extraction time is 6h, with Herba Pogostemonis, Radix Curcumae, Rhizoma Acori Graminei add steam steam slip first distillate, carry out redistillation again; Borneolum Syntheticum, Mentholum are ground altogether, and the powder behind the porphyrize, Moschus extract mix with above-mentioned distillate, press principal agent (except that Borneolum Syntheticum, Mentholum; Other medical materials are by extract) 12 times of amounts of gross weight take by weighing Semen Maydis oil and mix with it, grind the gained mixture after fully evenly with colloid mill, are pressed into soft capsule; Promptly get, result of the test is seen table 2.
Wherein, rubber is formulated by a certain percentage by gelatin, glycerol, water, and the ratio of gelatin, water and glycerol is 1: 1.2: 0.3.
Embodiment 3:
Prescription: Moschus 7.5g, Radix Curcumae 100g, Herba Pogostemonis 100g, Rhizoma Acori Graminei 100g, Borneolum Syntheticum 1g, Mentholum 0.75g
Method for making:, Moschus obtains Moschus extract through supercritical extraction, extracting pressure 20MPa; Extraction temperature is 40 ℃, and the extraction time is 6h, with Herba Pogostemonis, Radix Curcumae, Rhizoma Acori Graminei add steam steam slip first distillate; Carry out redistillation again, Borneolum Syntheticum, Mentholum are ground altogether, the powder behind the porphyrize, Moschus extract mix with above-mentioned distillate; 10 times of amounts of pressing principal agent (except that Borneolum Syntheticum, Mentholum, other medical materials are by extract) gross weight take by weighing soybean oil mixes with it, be milled to fully evenly with colloid barreling gained mixture after; Be pressed into soft capsule, promptly get, result of the test is seen table 2.
Wherein, rubber is formulated by a certain percentage by gelatin, glycerol, iron oxide brown, ethyl hydroxybenzoate, water, and the ratio of gelatin, water and glycerol is 1: 1.2: 0.6.
Embodiment 4:
Prescription: Moschus 16g, Radix Curcumae 150g, Herba Pogostemonis 150g, Rhizoma Acori Graminei 150g, Borneolum Syntheticum 2g, Mentholum 1.5g
Method for making: Moschus obtains Moschus extract through supercritical extraction, extracting pressure 25MPa, and extraction temperature is 38 ℃; The extraction time is 8h, with Herba Pogostemonis, Radix Curcumae, Rhizoma Acori Graminei add steam steam slip first distillate, carry out redistillation again; Borneolum Syntheticum, Mentholum are ground altogether, and the powder behind the porphyrize, Moschus extract mix with above-mentioned distillate, press principal agent (except that Borneolum Syntheticum, Mentholum; Other medical materials are by extract) 20 times of amounts of gross weight take by weighing Petiolus Trachycarpi oil and mix with it, be milled to fully evenly with colloid barreling gained mixture after, be pressed into the soft capsule grain; Promptly get, result of the test is seen table 2.
Wherein, rubber is formulated by a certain percentage by gelatin, glycerol, iron oxide brown, ethyl hydroxybenzoate, water, and the ratio of gelatin, water and glycerol is 1: 0.7: 0.6.
Table 2 result of the test
Claims (7)
1. compound musk soft capsule, it is characterized in that it the active ingredient of following weight part ratio, adopt following method for preparing to be prepared from:
(a) 7.5-16 parts in Moschus, Radix Curcumae 100-200 part, Herba Pogostemonis 100-200 part, Rhizoma Acori Graminei 100-200 part, Borneolum Syntheticum 1-3 part, Mentholum 0.75-1.5 part.
2. (b) Moschus is through supercritical extraction, and extracting pressure 20-25MPa, extraction temperature are that 38-42 ℃, extraction time are 6h-8 h, obtain Moschus extract;
(c) with Herba Pogostemonis, Radix Curcumae, Rhizoma Acori Graminei add steam steam slip first distillate, carry out redistillation again, distillate;
(d) Borneolum Syntheticum, Mentholum are ground altogether, the powder behind the porphyrize, Moschus extract mix with above-mentioned distillate, add the 8-20 vegetable oil doubly of gross weight, mix, and after colloid mill grinding evenly, the compacting soft capsule.
3. compound musk soft capsule according to claim 1 is characterized in that the described weight part ratio of active ingredient down is:
7.5 parts in Moschus, 100 parts of Radix Curcumaes, 100 parts of Herba Pogostemonis, 100 parts of Rhizoma Acori Graminei, 1 part of Borneolum Syntheticum, 0.75 part of Mentholum.
4. compound musk soft capsule according to claim 1 is characterized in that described soft capsule, and its used rubber is made up of gelatin, glycerol, water, its separately consumption proportion count 1:0.7 ~ 1.2:0.3 ~ 0.6 with weight part ratio.
5. compound musk soft capsule according to claim 1 is characterized in that described soft capsule, and its used rubber is made up of gelatin, glycerol, water, its separately consumption proportion count 1:0.7:0.3 with weight part ratio.
6. compound musk soft capsule according to claim 1 is characterized in that described Moschus through supercritical extraction, and its extracting pressure 20MPa, extraction temperature are that 40 ℃, extraction time are 6h, obtain Moschus extract.
7. compound musk soft capsule according to claim 1 is characterized in that described vegetable oil is Semen Maydis oil, soybean oil and palmitic a kind of.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014187945A1 (en) * | 2013-05-24 | 2014-11-27 | Nestec S.A. | Treatment or prevention of non-inflammatory neuronal damage from brain trauma and strokes using menthol, linalool and/or icilin |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1686385A (en) * | 2005-04-11 | 2005-10-26 | 北京正大绿洲医药科技有限公司 | Compound musk drip pill and its preparation method |
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- 2011-12-26 CN CN2011104425990A patent/CN102512634A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1686385A (en) * | 2005-04-11 | 2005-10-26 | 北京正大绿洲医药科技有限公司 | Compound musk drip pill and its preparation method |
Non-Patent Citations (1)
| Title |
|---|
| 徐国兵: "HS-GC测定复方麝香注射液中龙脑和薄荷脑的含量", 《中药新药与临床药理》, vol. 19, no. 04, 25 July 2008 (2008-07-25), pages 294 - 296 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014187945A1 (en) * | 2013-05-24 | 2014-11-27 | Nestec S.A. | Treatment or prevention of non-inflammatory neuronal damage from brain trauma and strokes using menthol, linalool and/or icilin |
| CN105228601A (en) * | 2013-05-24 | 2016-01-06 | 雀巢产品技术援助有限公司 | Use menthol, linalool and/or ice extract for treating or prevention by cerebral trauma and in wind-induced non-inflammatory neuronal damage |
| JP2016520588A (en) * | 2013-05-24 | 2016-07-14 | ネステク ソシエテ アノニム | Treatment or prevention of non-inflammatory neuronal injury from brain trauma and stroke using menthol, linalool and / or icilin |
| JP2020011985A (en) * | 2013-05-24 | 2020-01-23 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | Treatment or prevention of non-inflammatory neuronal damage from brain trauma and strokes using menthol, linalool and/or icilin |
| US10799502B2 (en) | 2013-05-24 | 2020-10-13 | Societe Des Produits Nestle S.A. | Treatment or prevention of non-inflammatory neuronal damage from brain trauma and strokes using Menthol, Linalool and/or Icilin |
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Application publication date: 20120627 |