CN102499966B - Medicinal composition for treating recurrent respiratory tract infection (RRTI) - Google Patents
Medicinal composition for treating recurrent respiratory tract infection (RRTI) Download PDFInfo
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Abstract
The invention discloses a medicinal composition for treating recurrent respiratory tract infection (RRTI), belonging to the technical field of traditional Chinese medicine. The medicinal composition is prepared from the following active components by weight part: 14-18 parts of licorice, 8-12 parts of radix astragali, 8-12 parts of paris polyphylla, 12-16 parts of isatis root, 8-12 parts of rehmannia glutinosa libosch, 16-20 parts of rhizoma corydalis, 15-20 parts of dried tangerine peel, 16-20 parts of arctium and 25-30 parts of honey. The medicinal composition disclosed by the invention can effectively enhance the cellular immune function of the human body and correct the low cellular immune function so as to play the normal role of anti-infections immunity and achieve the purpose of preventing and treating the RRTI.
Description
Technical field
The invention belongs to the Chinese medicine technical field, be specifically related to a kind of pharmaceutical composition of treating RRTI.
Background technology
RRTI (RRTI) is a common disease in children, and sickness rate reaches about 20%, and is the most common with 2～6 years old.The children's who suffers from RRI is called for short multiple sense youngster, in 1 year, have more than 7～10 times on lower respiratory infection.Mostly be congenital factor or body's immunity low or trace element and vitamin deficiency; Or feeding patterns is improper; And result of various factor comprehensive action such as heredity, nursing, living environment; If malpractice can cause diseases such as asthma, myocarditis, nephritis, have a strong impact on children's upgrowth and development and healthy.
The traditional Chinese medical science thinks, RRTI is in pathogenic process, in case three deficiency of five ZANG-organs are weak or become estranged; The unstrong then body constitution of function is weak; And repeated infection is difficult to recovery from illness, and the pathogenesis of RRTI, its key are not many in heresy; And be positive QI-insufficiency, it is not enough to show that resistance against diseases lowly reaches ill back self functional rehabilitation.Weakened body resistance is this.Because of children's's this characteristics, there is nursing inappropriate slightly, diet is careless, and the thoughts and feelings exopathogen can be fallen ill.Lung spleen kidney three dirty insufficiency of function are very crucial, and it is marked on lung, the fundamental cause of water disease being in the kidney, duty in spleen.The lung being usually insufficient is easier to feel exopathogen; The spleen being the foundation of acquired constitution, the less than one of the spleen the five internal organs of can not supplementing nutrition, two can not change angry blood makes healthy energy more empty; The kidney being the origin of congenital constitution, and suffering from a deficiency of the kidney can not the store essential substances activating QI, warm lung spleen; The three interacts, and makes healthy energy more empty, not cold-resistant heat and exopathogen invasion and attack.And suffer from a deficiency of the kidney through the overall process of RRTI morbidity, be multiple sense key.Deficiency of the lung instability of surface subjects to heresy, the unable again heresy that reaches, and first the disease being located in the lung, for a long time sick and kidney causes the lung kidney deficiency eventually, and disease is prolonged not to heal.Sense is evil in marking, and RRTI is many to be caused by being invaded by exogenous pathogen.Children's's the lung being usually insufficient, hedge is loose, and is careless slightly, the exopathogen invasion and attack, tender lung hindered then not being easy to recover.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical composition of treating RRTI.This pharmaceutical composition is the cellular immune function of enhancing body significantly, makes body cell immunologic hypofunction state obtain correcting, and with the anti-infectious immunity effect of bringing into normal play, thereby reaches the purpose of preventing and treating RRTI.
The objective of the invention is to realize like this:
A kind of pharmaceutical composition of treating RRTI is processed by following parts by weight of Chinese traditional medicine material: Radix Glycyrrhizae 14-18 part, Radix Astragali 8-12 part, Rhizoma Paridis 8-12 part, Radix Isatidis 12-16 part, Radix Rehmanniae 8-12 part, Rhizoma Corydalis 16-20 part, Pericarpium Citri Reticulatae 15-20 part, Fructus Arctii 16-20 part, Mel 25-30 part.
Preferably; The pharmaceutical composition of said treatment RRTI is processed by following parts by weight of Chinese traditional medicine material: 16 parts in Radix Glycyrrhizae, 10 parts of the Radixs Astragali, 10 parts of Rhizoma Paridis, 14 parts of Radix Isatidis, 10 parts in the Radix Rehmanniae, 18 parts of Rhizoma Corydalis, 18 parts of Pericarpium Citri Reticulataes, 18 parts of Fructus Arctiis, 30 parts of Mel.
Further preferably, the pharmaceutical composition of described treatment RRTI is an oral liquid.
The method for preparing of the Chinese medicine oral liquid that the present invention relates to comprises the steps:
(1) the above-mentioned 8 flavor Chinese crude drugs except that Mel of getting recipe quantity are cleaned roguing, dry, and pulverize; Get the Mel of recipe quantity, temper, filter skimming with slow fire;
(2) more above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull medical material out and put decocte with water secondary in the multi-functional extraction filling; The water that the first time, totalling medical material 8-10 doubly measured decocts 2h, gets decocting liquid; Filter, the water that the second time, totalling medical material 6-8 doubly measured decocts 1h; Get twice decocting liquid and merge, filter, relative density is 1.10 concentrated solution when being concentrated into 90 ℃;
(3) concentrated solution is put 0-5 ℃ of deepfreeze 24h, cold preservation liquid is added 0.3% filter aid kieselguhr, filter; The filtrating reconcentration contains 2-3g crude drug amount to every milliliter, adds the Mel of said filtration skimming again, stirs; Put 0-5 ℃ of deepfreeze 24h, cold preservation liquid is filtered, packing promptly gets oral liquid.
Usage and dosage: the patient takes 20ml every day, once a day.
According to the record of Chinese medicine historical data, the pharmacologically active of above-mentioned Chinese crude drug is following:
Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Select Fisch. for use, Glycyrrhiza inflata Bat. G. inflata Bat., or the root and rhizome of Glycyrrhiza glabra L. G. glabra L. for dicotyledon pulse family Leguminosae Radix Glycyrrhizae Glycyrrhiza uralensis.
The Radix Astragali: have benefiting QI for strengthening the superficies, arresting sweating to take off, hold in the palm the effect of skin ulcer granulation promoting, inducing diuresis to remove edema admittedly.It is weak to be used to treat the deficiency of vital energy, sinking of QI of middle-JIAO, and the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.The invigorating middle warmer of Radix Astragali Preparata QI invigorating is given birth to consolidating superficial resistance holder skin ulcer.
Rhizoma Paridis: heat-clearing and toxic substances removing, reducing swelling and alleviating pain, cool liver arresting convulsion.Be used for the furuncle carbuncle, laryngopharynx swelling and pain, venom falls and pounces on the pain of injury, convulsion with spasms.Be selected from liliaceous plant Rhizoma Paridis Paris yunnanensis Franch. rhizome.
Radix Isatidis: heat clearing away, detoxifcation, removing heat from blood, sore-throat relieving.Cure mainly: maculae caused by violent heat pathogen; The hyperpyrexia headache; Major part pestilence; Crimson tongue is purple dark, scarlet fever; Erysipelas; Mumps; Sore throat; Skin ulcer is swollen, carbuncle; Chickenpox; Measles; Hepatitis; Influenza, epidemic encephalitis, encephalitis b, pneumonia, coma is told nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer rash; Can prevent and treat epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis.Select the root of crucifer ancient name for Chinese cabbage basket and careless Folium Isatidis for use.
The Radix Rehmanniae: clearing away heat and cooling blood, yin nourishing is promoted the production of body fluid.Be used for calentura crimson tongue excessive thirst, interior-heat caused by deficiency of YIN, the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis is sent out the speckle dermexanthesis.Be selected from the fresh or exsiccant tuber of Scrophulariaceae herbaceos perennial Radix Rehmanniae Rehmannia glutinosa Libosch..
Rhizoma Corydalis: blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, be used for pain of each qi depression to blood stasis of whole body, dysmenorrhea, amenorrhea, lump in the abdomen, postpartum stagnation, injury from falling down, hernia is had a pain.Select the tuber of Papaveraceae (Papaveraceae) plant Rhizoma Corydalis or tooth lobe Rhizoma Corydalis for use.
Pericarpium Citri Reticulatae: have regulating qi-flowing for strengthening spleen, in the accent, dampness, expectorant effect.Cure mainly distension and fullness in the abdomen or pain, the dyspepsia of stagnation of QI in spleen and stomach.Abdominal distention uncomfortable in chest, indigestion and loss of appetite loose stool in the turbid damp resistance.Phlegm-damp is stopped up the cough and asthma of lung.Select dry mature skin for use for rutaceae orange and variety thereof.
Fructus Arctii: have the effect of dispelling wind and heat pathogens, lung qi dispersing rash, sore-throat relieving eliminating stagnation, removing toxic substances and promoting subsidence of swelling, cure mainly that cough due to pathogenic wind-heat, laryngopharynx swelling and pain, macule do not pass through, rubella pruritus, sore swollen toxin.Be selected from the dry mature fruit of feverfew Fructus Arctii Arctium lappa L..
Mel: have harmonizing the spleen and stomach; Relieving spasm to stop pain; Nourishing the lung to arrest cough; Loosening bowel to relieve constipation; The skin moistening granulation promoting; The antidotal effect.Cure mainly the empty pain of gastral cavity abdomen; The xeropulmonary cough; The dryness of the intestine constipation; Conjunctival congestion; Aphtha; Ulcer being unable to heal; The rubella pruritus; Burn due to hot liquid or fire; Rhagadia manus et pedis.Select the Mel of making for the close honeybee of Apidae animal China or apis mellifera for use.
Discover that through animal experiment Chinese medicine composition of the present invention is the cellular immune function of enhancing body significantly, make body cell immunologic hypofunction state obtain correcting,, thereby reach the purpose of preventing and treating RRTI with the anti-infectious immunity effect of bringing into normal play.
The specific embodiment
Below be specific embodiment of the present invention, technical scheme of the present invention is done further to describe, but protection scope of the present invention be not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
The preparation of embodiment 1 Chinese medicine oral liquid
Crude drug prescription: Radix Glycyrrhizae 160g, Radix Astragali 100g, Rhizoma Paridis 100g, Radix Isatidis 140g, Radix Rehmanniae 100g, Rhizoma Corydalis 180g, Pericarpium Citri Reticulatae 180g, Fructus Arctii 180g, Mel 300g.
Oral liquor:
(1) the above-mentioned 8 flavor Chinese crude drugs except that Mel of getting recipe quantity are cleaned roguing, dry, and pulverize; Get the Mel of recipe quantity, temper, filter skimming with slow fire;
(2) more above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull medical material out and put decocte with water secondary in the multi-functional extraction filling; The water of 10 times of amounts of totalling medical material decocts 2h for the first time, gets decocting liquid; Filter, the water of 8 times of amounts of totalling medical material decocts 1h for the second time; Get twice decocting liquid and merge, filter, relative density is 1.10 concentrated solution when being concentrated into 90 ℃;
(3) concentrated solution is put 2 ℃ of deepfreeze 24h, cold preservation liquid is added 0.3% filter aid kieselguhr, filter; The filtrating reconcentration contains 2.5g crude drug amount to every milliliter, adds the Mel of said filtration skimming again, stirs; Put 2 ℃ of deepfreeze 24h, cold preservation liquid is filtered, packing promptly gets oral liquid.
Radix Glycyrrhizae 14-18 part, Radix Astragali 8-12 part, Rhizoma Paridis 8-12 part, Radix Isatidis 12-16 part, Radix Rehmanniae 8-12 part, Rhizoma Corydalis 16-20 part, Pericarpium Citri Reticulatae 15-20 part, Fructus Arctii 16-20 part, Mel 25-30 part.
The preparation of embodiment 2 Chinese medicine oral liquid
Crude drug prescription: Radix Glycyrrhizae 180g, Radix Astragali 100g, Rhizoma Paridis 120g, Radix Isatidis 120g, Radix Rehmanniae 120g, Rhizoma Corydalis 200g, Pericarpium Citri Reticulatae 150g, Fructus Arctii 160g, Mel 250g
Oral liquor:
(1) the above-mentioned 8 flavor Chinese crude drugs except that Mel of getting recipe quantity are cleaned roguing, dry, and pulverize; Get the Mel of recipe quantity, temper, filter skimming with slow fire;
(2) more above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull medical material out and put decocte with water secondary in the multi-functional extraction filling; The water of 8 times of amounts of totalling medical material decocts 2h for the first time, gets decocting liquid; Filter, the water of 8 times of amounts of totalling medical material decocts 1h for the second time; Get twice decocting liquid and merge, filter, relative density is 1.10 concentrated solution when being concentrated into 90 ℃;
(3) concentrated solution is put 2 ℃ of deepfreeze 24h, cold preservation liquid is added 0.3% filter aid kieselguhr, filter; The filtrating reconcentration contains 2.5g crude drug amount to every milliliter, adds the Mel of said filtration skimming again, stirs; Put 2 ℃ of deepfreeze 24h, cold preservation liquid is filtered, packing promptly gets oral liquid.
The preparation of embodiment 3 Chinese medicine oral liquid
Crude drug prescription: Radix Glycyrrhizae 140g, Radix Astragali 80g, Rhizoma Paridis 80g, Radix Isatidis 160g, Radix Rehmanniae 120g, Rhizoma Corydalis 160g, Pericarpium Citri Reticulatae 200g, Fructus Arctii 200g, Mel 300g
Oral liquor:
(1) the above-mentioned 8 flavor Chinese crude drugs except that Mel of getting recipe quantity are cleaned roguing, dry, and pulverize; Get the Mel of recipe quantity, temper, filter skimming with slow fire;
(2) more above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull medical material out and put decocte with water secondary in the multi-functional extraction filling; The water of 10 times of amounts of totalling medical material decocts 2h for the first time, gets decocting liquid; Filter, the water of 10 times of amounts of totalling medical material decocts 1h for the second time; Get twice decocting liquid and merge, filter, relative density is 1.10 concentrated solution when being concentrated into 90 ℃;
(3) concentrated solution is put 2 ℃ of deepfreeze 24h, cold preservation liquid is added 0.3% filter aid kieselguhr, filter; The filtrating reconcentration contains 3g crude drug amount to every milliliter, adds the Mel of said filtration skimming again, stirs; Put 2 ℃ of deepfreeze 24h, cold preservation liquid is filtered, packing promptly gets oral liquid.
Embodiment 4 Chinese medicine compositions of the present invention are to the influence of RRTI model mice
60 of cleaning level male ICR mouses, body weight 16～18g.Reserve 15 mices as the normal control group, other mice is used for modeling.RRTI (RRTI) model copy: with reference to the method for " practical tcm syndrome model is learned " use.Method is 0.04mL/ of a mouse peritoneal injection hydrocortisone, and 12d causes the immunologic hypofunction mouse model continuously.Model mice is divided into following 4 groups at random: model control group, positive controls, Chinese medicine high dose group, Chinese medicine low dose group, 15 every group.Beginning in the 2nd day after modeling, normal control group, model control group are only all irritated stomach normal saline 0.5mL/; Chinese medicine high dose group, Chinese medicine low dose group are irritated Chinese medicine oral liquid 50mL/kg/d, the 25mL/kg/d of the stomach embodiment of the invention 1 preparation respectively.Continue to irritate stomach after 3 weeks, after plucking eyeball and getting blood, the cervical vertebra dislocation method is put to death mice, surveys mice serum CD4, CD8.Table 1 is seen in statistical result.
Table 1 Chinese medicine oral liquid is to the influence of model RRTI mice CD4, CD8
| Group | n | CD4（%） | CD8（%） | CD4/ CD8 |
| The normal control group | 15 | 23.56±1.96 | 11.73±2.84 | 2.10±0.15 |
| Model control group | 13 | 17.95±2.21 | 17.28±3.28 | 1.08±0.16 |
| The Chinese medicine low dose group | 14 | ?20.03±2.07 * | ? 13.24±1.54 ** | 1.50±0.30 * |
| The Chinese medicine high dose group | 15 | ? 21.29±3.30 ** | ?12.43±2.36 ** | 1.71±0.22 ** |
Compare * with model control group
P＜0.05, * *
P＜0.01
Result of the test according to table 1 can find out, Chinese medicine high and low dose group of the present invention and model group relatively can obviously improve mice CD4 level, reduce the CD8 level, have significant difference (
P＜0.05) or utmost point significant difference (
P＜0.01).Simultaneously, Chinese medicine high and low dose group of the present invention and model group relatively can obviously improve mice CD4/CD8 ratio, have significant difference (
P＜0.05) or utmost point significant difference (
P＜0.01).
This shows that Chinese medicine composition of the present invention is the cellular immune function of enhancing body significantly, make body cell immunologic hypofunction state obtain correcting,, thereby reach the purpose of preventing and treating RRTI with the anti-infectious immunity effect of bringing into normal play.
Claims (2)
1. a pharmaceutical composition of treating RRTI is characterized in that: processed by following parts by weight of Chinese traditional medicine material: 16 parts in Radix Glycyrrhizae, 10 parts of the Radixs Astragali, 10 parts of Rhizoma Paridis, 14 parts of Radix Isatidis, 10 parts in the Radix Rehmanniae, 18 parts of Rhizoma Corydalis, 18 parts of Pericarpium Citri Reticulataes, 18 parts of Fructus Arctiis, 30 parts of Mel.
2. the pharmaceutical composition of treatment RRTI according to claim 1 is characterized in that: said pharmaceutical composition is an oral liquid.
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| CN102499966B true CN102499966B (en) | 2012-10-03 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1317004C (en) * | 2005-10-18 | 2007-05-23 | 滕焕昭 | Chinese medicine prepn for treating infantile respiratory tract infection |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1317004C (en) * | 2005-10-18 | 2007-05-23 | 滕焕昭 | Chinese medicine prepn for treating infantile respiratory tract infection |
Non-Patent Citations (2)
| Title |
|---|
| 健儿清补汤治疗小儿反复呼吸道感染76例;朱南方等;《陕西中医》;20031125;第24卷(第11期);第990-991页 * |
| 朱南方等.健儿清补汤治疗小儿反复呼吸道感染76例.《陕西中医》.2003,第24卷(第11期),第990-991页. |
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