CN102499261A - Preparation method for antibacterial agent - Google Patents
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- CN102499261A CN102499261A CN2011103661055A CN201110366105A CN102499261A CN 102499261 A CN102499261 A CN 102499261A CN 2011103661055 A CN2011103661055 A CN 2011103661055A CN 201110366105 A CN201110366105 A CN 201110366105A CN 102499261 A CN102499261 A CN 102499261A
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Abstract
The present invention relates to a preparation method for an antibacterial agent. Good dispersity is the premise and the guarantee of the excellent antibacterial performance of the antibacterial agent. According to the method of the invention, inorganic nanoparticles and a basic amino acid are subjected to stirring refluxing for 10-60 minutes in a water bath with a temperature of 25-60 DEG C, such that the basic amino acid is uniformly adsorbed on the surfaces of the inorganic nanoparticles; an inorganic antibacterial active substance is added to the water bath and stirring refluxing is continued, wherein the metal ions in the inorganic antibacterial active substance are uniformly adsorbed on the surfaces of the inorganic nanoparticles by complexing with the amino acid; Na4P2O7.10H2O is added to the water bath and stirring refluxing is continued to further fix the metal ions on the surfaces of the inorganic nanoparticles, and treatments of standing, suction filtration, washing, drying and grinding are performed to obtain the antibacterial agent powder. With the method of the present invention, the antibacterial active substance can be uniformly dispersed on the surfaces of the inorganic nanoparticles so as to improve the antibacterial performance of the antibacterial agent.
Description
Technical field
The invention belongs to the material technology field, relate to a kind of preparation method of antibacterial agent, this antibacterial agent can be used for antibiotic plastic, antibiotic paint and other anti-biotic material.
Background technology
Along with the fast development of industry, environmental problem is increasingly serious, the propagation of noxious bacteria and spread serious threat especially and human beings'health.In Japan nationwide pathogenicity colon bacillus O-157 taking place in 1996 and infected incident, was once causing once that the whole world was panic; The SARS in the first half of the year in 2003 has shocked the world especially.According to ministry of Health of China statistics in 2010; Whole nation class AB infectious disease reports morbidity 3185932 examples altogether; Dead 14289 people; Rank forefront 5 disease kind of report morbidity number is followed successively by virus hepatitis, pulmonary tuberculosis, syphilis, bacillary and amebic dysentery and gonorrhoea, accounts for 95.0% of class AB infection disease notification morbidity sum; Rank forefront five disease kind of report death toll is followed successively by AIDS, pulmonary tuberculosis, rabies, virus hepatitis and Influenza A H1N1, accounts for 96.5% of the dead sum of class AB infection disease notification.This shows that the microorganism that bacterium etc. are caused a disease becomes one of main killer of human health already.Along with human living standard's raising, the enhancing gradually of health perception requires safer living environment naturally.Therefore, the antibacterial agent of development and exploitation high-efficient and lasting is effectively killed and is suppressed Causative virus and bacterium becomes the problem that we press for solution.
The main at present antibacterial agent of using has inorganic, organic and natural three major types.Organic antibacterial agent has instant effect, characteristics that sterilizing ability is strong, but is prone to produce microorganism anti-(resist) property of medicine, and has short, poor heat resistance and shortcomings such as generation secondary pollution action period; Natural antibacterial agent comes from natural extract, like shitosan, Hinokitiol etc., its main antibiotic mechanism be considered to organic quaternary ammonium salts seemingly, but effect is not as organic antibacterial agent, and product is still immature; Compare organic and natural antibacterial agent, inorganic antiseptic is used the most extensive.The main active ingredient of inorganic antiseptic is metal ions such as silver, copper, zinc, and the conclusion of the existing scientific evaluation of their safety in utilization has obtained the allowance of U.S. FDA and EPA, is also checked by human long-term practice simultaneously.Wherein the strongest with the silver-ion antibiotic effect, be that the antibacterial agent of antimicrobial powder is used the most extensive in anti-biotic materials such as antibiotic plastic, antibiotic paint based on silver.Silver ion exists with the form of liquor argenti nitratis ophthalmicus usually, is widely used as antibacterial agent, but silver ion solution has significant limitation on using, and the solid antimicrobial of therefore developing argentiferous and be ion has been the active demand in market.The inorganic antiseptic preparation method mainly is through physical adsorption or ion exchange; Metal ion appendix such as silver, copper, zinc is inner in inorganic carrier surface or duct; To the slow release metal ions of external environment, utilize the antibacterial action of metal ion, reach for a long time, fungistatic effect efficiently.
The inorganic carrier that inorganic antiseptic adopted mainly comprises silicates, phosphoric acid salt, soluble glass class, silica gel, nm inorganic compound etc.Inorganic carrier has characteristics such as specific surface area is big, porosity height usually, through the fixing antibacterial activity metal ion of physics or chemical method, has significantly improved the stability and the antibiotic property of antibacterial activity metal ions such as silver ion.For example, application number is the Chinese patent of 200810197610.X, discloses a kind of antibacterial plastic sheet-like chopping board and manufacturing approach thereof.The antibacterial agent inorganic carrier that this patent adopted is a kind of inorganic silicate that contains silver ion, and it can be used for the release that the above processing temperature of 500 degree Celsius and silicate can fine control silver ions.The patent No. is 03129255.0 Chinese patent, discloses the stable inorganic powder of a kind of light and has carried silver-colored long acting antibiotic powder and preparation method thereof.The carrier that this patent adopted is the TiO of 5～500nm
2, SiO
2, ZnO, ZrO
2Composite superfine nano inorganic oxide powder, and prepared antibacterial agent has antibacterial effect obviously, lastingly, advantages such as photostability and atmospheric exposure stability.
At present, the preparation method of inorganic antiseptic mainly contains ion-exchange, physisorphtion and chemical fixation etc.For example, application number is 200610024773.9 Chinese patent, discloses a kind of novel Nanometer mesoporous Silver Anti-bacterial Agent And Preparation Method.This patent disperses to be adsorbed in inorganic oxide silica, zeolite, the Al with order mesoporous structure through methods such as physical adsorptions with antibacterial activity component silver
2O
3On carrier, the antibacterial agent that makes has the characteristics of meso-hole structure, bigger serface and even aperture distribution of rule, and this antibacterial agent to colibacillary minimal inhibitory concentration greatly between 10～300ppm.The patent No. is 200410016338.2 Chinese patent, discloses the preparation method of carrying nano silver antimicrobial powder.This patent also is to adopt the method for ultrasonic concussion to make even dispersion of silver ion and physical adsorption in ultra-fine carrier surface, the final antibacterial agent that obtains to contain carrier nano silver powder under the effect of surperficial auxiliary agent and hydrazine hydrate aqueous solution.Application number is 200410022677.1 Chinese patent, discloses a kind of inorganic antiseptic and application thereof.This patent adopt in natural apatite or natural apatite and the natural silicate ore deposit one or more to mix and composite ceramics be carrier; With metal ions such as Ag, Cu, Zn is antibiotic effective ingredient; Adopt to mix again through High temperature diffusion and solid phase reaction and mixed method, effective antibacterial metal ions is loaded in the carrier and produces high performance inorganic antiseptic.
The degree of scatter of antibacterial activity metal ions such as silver ion on the inorganic carrier surface directly determined the antibacterial effect of antibacterial agent, and good dispersiveness is the prerequisite and the guarantee of the superior anti-microbial property of antibacterial agent.Therefore, how improving the dispersion of antibacterial activity metal ion in carrier particle surface, is effectively to improve the antibacterial antiplaque agent performance, reduces the important way of antibacterial agent cost.
Summary of the invention
The objective of the invention is to be to provide a kind of preparation method of antibacterial agent, adopt this method to prepare a kind of stable inorganic particle antibacterial agent.
The present invention adopts technical scheme steps following:
Step (1). inorganic nanoparticles and basic amino acid were refluxed 10～60 minutes 25～60 ℃ of stirred in water bath, make basic amino acid evenly be adsorbed on the inorganic nanoparticles surface;
Described inorganic nanoparticles is nano level TiO
2, SiO
2In one or both;
Described basic amino acid be in lysine, arginine, histidine, the tryptophan one or more;
Inorganic nanoparticles and basic amino acid mass ratio are 100: 1～10;
Step (2). the inorganic antibacterial active substance added in 25～60 ℃ of water-baths continued stirring and refluxing 10～60 minutes, the metal ion in the inorganic antibacterial active substance through with amino acid generation complexing, also evenly be adsorbed on the inorganic nanoparticles surface;
The mass ratio of the inorganic antibacterial active substance that adds and the basic amino acid of adding is 0.06～0.6: 1;
Described inorganic antibacterial active substance is AgNO
3, Zn (NO
3)
2, ZnCl
2, ZnSO
4, Cu (NO
3)
2, CuCl
2, CuSO
4In one or more;
Step (3). with Na
4P
2O
710H
2Continue stirring and refluxing 10～60 minutes in 25～60 ℃ of water-baths of O adding, further metal ion is fixed on the inorganic nanoparticles surface;
The Na that adds
4P
2O
710H
2The mass ratio of the inorganic antibacterial active substance of O and adding is 10～30: 1;
Step (4). left standstill 1～4 hour, and obtained the antibacterial agent powder after suction filtration, deionized water washing, vacuum drying, the grinding.
The inventive method adopts the high natural biological molecule basic amino acid of biological safety as antibacterial activity metal ion dispersant, and antibacterial substance silver ion/zinc ion/copper ion is evenly spread to SiO
2/ TiO
2Nanoparticle surface, the anti-microbial property of raising antibacterial agent.Amino that basic amino acid links to each other with central carbon atom and carboxyl form inner salt, are adsorbed to SiO through interactions such as hydrogen bond/static
2/ TiO
2Nanoparticle surface; Remaining amino then with Ag
+, Zn
2+, Cu
2+Complexing takes place, and silver ion/zinc ion, copper ion evenly are adsorbed onto the inorganic nano-particle sub-surface.The silver ion, zinc ion, copper ion that evenly is adsorbed onto nanoparticle surface through with the complexing of sodium pyrophosphate, form pyrophosphate, be fixed on the carrier nano grain surface.When improving the silver ion photostability, reach Ag
+, Zn
2+, Cu
2+At SiO
2/ TiO
2Deng the inorganic nano-particle sub-surface be uniformly dispersed, the effect of antibacterial ability lasting stability.
Utilize antibacterial agent that the inventive method makes can reach more than 99% to the inhibition kill ratio of bacterial classifications such as Escherichia coli, staphylococcus aureus; Reached antibiotic requirement; Be mainly used in food with fields such as antibiotic utensil, antibiotic commodity, antimicrobial medical apparatus, antibiotic household appliances, antibiotic plastic building materials, be applicable to the processing of most of antibiotic plastics such as PP, PS, HDPE, LDPE, PVC, PC, ABS.
Embodiment
Embodiment 1:
Step (1). with the nano level TiO of 6kg
2The L-histidine of powder and 100g refluxed 50 minutes 30 ℃ of stirred in water bath, made the L-histidine evenly be adsorbed on TiO
2Powder surface;
Step (2). with the Zn (NO of 60g
3)
2Add in 30 ℃ of water-baths and continued stirring and refluxing 60 minutes, Zn (NO
3)
2In Zn
2+Through with L-histidine generation complexing, also evenly be adsorbed on TiO
2Powder surface;
Step (3). with the Na of 600g
4P
2O
710H
2Continued stirring and refluxing 30 minutes in 30 ℃ of water-baths of O adding, further with Zn
2+Evenly be adsorbed on TiO
2Powder surface;
Step (4). left standstill 2 hours, and obtained the antibacterial agent powder after suction filtration, deionized water washing, vacuum drying, the grinding.
Embodiment 2:
Step (1). with the nano level SiO of 10kg
2The D-histidine of powder and 500g refluxed 10 minutes 60 ℃ of stirred in water bath, made the D-histidine evenly be adsorbed on SiO
2Powder surface;
Step (2). with the CuCl of 30g
2Add in 60 ℃ of water-baths and continued stirring and refluxing 10 minutes, CuCl
2In Cu
2+Through with D-histidine generation complexing, also evenly be adsorbed on SiO
2Powder surface;
Step (3). with the Na of 500g
4P
2O
710H
2Continued stirring and refluxing 10 minutes in 60 ℃ of water-baths of O adding, further with Cu
2+Evenly be adsorbed on SiO
2Powder surface;
Step (4). left standstill 3 hours, and obtained the antibacterial agent powder after suction filtration, deionized water washing, vacuum drying, the grinding.
Embodiment 3:
Step (1). with the nano level TiO of 8kg
2The nano level SiO of powder, 8kg
2The L-lysine of powder and 1kg refluxed 60 minutes 25 ℃ of stirred in water bath, made L-lysine evenly be adsorbed on TiO
2Powder and SiO
2The surface of powder;
Step (2). with the AgNO of 200g
3Add in 25 ℃ of water-baths and continued stirring and refluxing 60 minutes, AgNO
3In Ag
+Through with L-lysine generation complexing, also evenly be adsorbed on TiO
2Powder and SiO
2The surface of powder;
Step (3). with the Na of 1kg
4P
2O
710H
2Continued stirring and refluxing 60 minutes in 25 ℃ of water-baths of O adding, further with Ag
+Evenly be adsorbed on TiO
2Powder and SiO
2The surface of powder;
Step (4). left standstill 1 hour, and obtained the antibacterial agent powder after suction filtration, deionized water washing, vacuum drying, the grinding.
Embodiment 4:
Step (1). with the nano level TiO of 10kg
2The D-lysine of powder and 100g refluxed 30 minutes 40 ℃ of stirred in water bath, made D-lysine evenly be adsorbed on TiO
2Powder surface;
Step (2). with the ZnSO of 30g
4Add in 40 ℃ of water-baths and continued stirring and refluxing 30 minutes, ZnSO
4In Zn
2+Through with D-lysine generation complexing, also evenly be adsorbed on TiO
2Powder surface;
Step (3). with the Na of 500g
4P
2O
710H
2Continued stirring and refluxing 30 minutes in 40 ℃ of water-baths of O adding, further with Zn
2+Evenly be adsorbed on TiO
2Powder surface;
Step (4). left standstill 1 hour, and obtained the antibacterial agent powder after suction filtration, deionized water washing, vacuum drying, the grinding.
Embodiment 5:
Step (1). with the nano level SiO of 10kg
2The L-tryptophan of powder and 1kg refluxed 40 minutes 30 ℃ of stirred in water bath, made the L-tryptophan evenly be adsorbed on SiO
2Powder surface;
Step (2). with the ZnCl of 60g
2Add in 30 ℃ of water-baths and continued stirring and refluxing 40 minutes, ZnCl
2In Zn
2+Through with L-tryptophan generation complexing, also evenly be adsorbed on SiO
2Powder surface;
Step (3). with the Na of 1kg
4P
2O
710H
2Continued stirring and refluxing 40 minutes in 30 ℃ of water-baths of O adding, further with Zn
2+Evenly be adsorbed on SiO
2Powder surface;
Step (4). left standstill 1.5 hours, and obtained the antibacterial agent powder after suction filtration, deionized water washing, vacuum drying, the grinding.
Embodiment 6:
Step (1). with the nano level TiO of 5kg
2The nano level SiO of powder, 5kg
2The D-tryptophan of powder and 800g refluxed 20 minutes 50 ℃ of stirred in water bath, made the acid of D-tryptophan evenly be adsorbed on TiO
2Powder and SiO
2The surface of powder;
Step (2). with the Cu (NO of 400g
3)
2Add in 50 ℃ of water-baths and continued stirring and refluxing 20 minutes, Cu (NO
3)
2In Cu
2+Through with D-tryptophan generation complexing, also evenly be adsorbed on TiO
2Powder and SiO
2The surface of powder;
Step (3). with the Na of 8kg
4P
2O
710H
2Continued stirring and refluxing 20 minutes in 50 ℃ of water-baths of O adding, further with Cu
2+Evenly be adsorbed on TiO
2Powder and SiO
2The surface of powder;
Step (4). left standstill 2.5 hours, and obtained the antibacterial agent powder after suction filtration, deionized water washing, vacuum drying, the grinding.
Embodiment 7:
Step (1). with the nano level SiO of 10kg
2The L-arginine of powder and 600g refluxed 25 minutes 45 ℃ of stirred in water bath, made the L-arginine evenly be adsorbed on SiO
2Powder surface;
Step (2). with the CuSO of 100g
4Add in 45 ℃ of water-baths and continued stirring and refluxing 25 minutes, CuSO
4In Cu
2+Through with L-arginine generation complexing, also evenly be adsorbed on SiO
2Powder surface;
Step (3). with the Na of 3kg
4P
2O
710H
2Continued stirring and refluxing 25 minutes in 45 ℃ of water-baths of O adding, further with Cu
2+Evenly be adsorbed on SiO
2Powder surface;
Step (4). left standstill 2 hours, and obtained the antibacterial agent powder after suction filtration, deionized water washing, vacuum drying, the grinding.
Embodiment 8:
Step (1). with the nano level TiO of 8kg
2The nano level SiO of powder, 2kg
2The D-arginine of powder and 300g refluxed 45 minutes 35 ℃ of stirred in water bath, made the D-arginine evenly be adsorbed on TiO
2Powder and SiO
2The surface of powder;
Step (2). with the AgNO of 18g
3Add in 35 ℃ of water-baths and continued stirring and refluxing 45 minutes, AgNO
3In Ag
+Through with D-arginine generation complexing, also evenly be adsorbed on TiO
2Powder and SiO
2The surface of powder;
Step (3). with the Na of 500g
4P
2O
710H
2Continued stirring and refluxing 45 minutes in 35 ℃ of water-baths of O adding, further with Ag
+Evenly be adsorbed on TiO
2Powder and SiO
2The surface of powder;
Step (4). left standstill 3.5 hours, and obtained the antibacterial agent powder after suction filtration, deionized water washing, vacuum drying, the grinding.
Embodiment 9:
Step (1). with the nano level TiO of 10kg
2DL ± tryptophan of powder and 1kg refluxed 15 minutes 60 ℃ of stirred in water bath, made DL ± tryptophan evenly be adsorbed on TiO
2Powder surface;
Step (2). with the ZnSO of 30g
4Zn (NO with 30g
3)
2Add in 60 ℃ of water-baths and continued stirring and refluxing 15 minutes, ZnSO
4And Zn (NO
3)
2In Zn
2+Through with DL ± tryptophan generation complexing, also evenly be adsorbed on TiO
2Powder surface;
Step (3). with the Na of 500g
4P
2O
710H
2Continued stirring and refluxing 15 minutes in 60 ℃ of water-baths of O adding, further with Zn
2+Evenly be adsorbed on TiO
2Powder surface;
Step (4). left standstill 2.5 hours, and obtained the antibacterial agent powder after suction filtration, deionized water washing, vacuum drying, the grinding.
Embodiment 10:
Step (1). with the nano level SiO of 10kg
2DL ± lysine of powder and 500g refluxed 20 minutes 55 ℃ of stirred in water bath, made DL ± lysine evenly be adsorbed on SiO
2Powder surface;
Step (2). with the ZnCl of 20g
2CuCl with 10g
2Add in 55 ℃ of water-baths and continued stirring and refluxing 20 minutes, ZnCl
2And CuCl
2In Zn
2+And Cu
2+Through with DL ± lysine generation complexing, also evenly be adsorbed on SiO
2Powder surface;
Step (3). with the Na of 900g
4P
2O
710H
2Continued stirring and refluxing 20 minutes in 55 ℃ of water-baths of O adding, further with Zn
2+And Cu
2+Evenly be adsorbed on SiO
2Powder surface;
Step (4). left standstill 2 hours, and obtained the antibacterial agent powder after suction filtration, deionized water washing, vacuum drying, the grinding.
Embodiment 11:
Step (1). with the nano level TiO of 5kg
2The nano level SiO of powder, 5kg
2DL ± arginine of powder and 200g refluxed 45 minutes 35 ℃ of stirred in water bath, made DL ± arginine evenly be adsorbed on TiO
2Powder and SiO
2The surface of powder;
Step (2). with the Cu (NO of 50g
3)
2CuSO with 50g
4Add in 35 ℃ of water-baths and continued stirring and refluxing 45 minutes, Cu (NO
3)
2And CuSO
4In Cu
2+Through with DL ± arginine generation complexing, also evenly be adsorbed on TiO
2Powder and SiO
2The surface of powder;
Step (3). with the Na of 3kg
4P
2O
710H
2Continued stirring and refluxing 45 minutes in 35 ℃ of water-baths of O adding, further with Cu
2+Evenly be adsorbed on TiO
2Powder and SiO
2The surface of powder;
Step (4). left standstill 2 hours, and obtained the antibacterial agent powder after suction filtration, deionized water washing, vacuum drying, the grinding.
Embodiment 12:
Step (1). with the nano level TiO of 10kg
2DL ± histidine of powder and 400g refluxed 45 minutes 35 ℃ of stirred in water bath, made DL ± histidine evenly be adsorbed on TiO
2Powder and SiO
2The surface of powder;
Step (2). with the AgNO of 100g
3Add in 35 ℃ of water-baths and continued stirring and refluxing 45 minutes, AgNO
3In Ag
+Through with DL ± histidine generation complexing, also evenly be adsorbed on TiO
2Powder and SiO
2The surface of powder;
Step (3). with the Na of 1kg
4P
2O
710H
2Continued stirring and refluxing 45 minutes in 35 ℃ of water-baths of O adding, further with Ag
+Evenly be adsorbed on TiO
2Powder and SiO
2The surface of powder;
Step (4). left standstill 1 hour, and obtained the antibacterial agent powder after suction filtration, deionized water washing, vacuum drying, the grinding.
Embodiment 13:
Step (1). with the nano level SiO of 10kg
2The L-tryptophan of powder and 500g, the L-lysine of 500g refluxed 40 minutes 30 ℃ of stirred in water bath, made L-tryptophan and L-lysine evenly be adsorbed on SiO
2Powder surface;
Step (2). with the ZnCl of 60g
2Add in 30 ℃ of water-baths and continued stirring and refluxing 40 minutes, ZnCl
2In Zn
2+Through with L-tryptophan and L-lysine generation complexing, also evenly be adsorbed on TiO
2Powder surface;
Step (3). with the Na of 1kg
4P
2O
710H
2Continued stirring and refluxing 40 minutes in 30 ℃ of water-baths of O adding, further with Zn
2+Evenly be adsorbed on SiO
2Powder surface;
Step (4). left standstill 1.5 hours, and obtained the antibacterial agent powder after suction filtration, deionized water washing, vacuum drying, the grinding.
Embodiment 14:
Step (1). with the nano level TiO of 5kg
2The nano level SiO of powder, 5kg
2The D-histidine of powder and 300g, the D-arginine of 500g refluxed 20 minutes 50 ℃ of stirred in water bath, made D-histidine and D-arginine evenly be adsorbed on TiO
2Powder and SiO
2The surface of powder;
Step (2). with the Cu (NO of 400g
3)
2Add in 50 ℃ of water-baths and continued stirring and refluxing 20 minutes, Cu (NO
3)
2In Cu
2+Through with D-histidine and D-arginine generation complexing, also evenly be adsorbed on TiO
2Powder and SiO
2The surface of powder;
Step (3). with the Na of 8kg
4P
2O
710H
2Continued stirring and refluxing 20 minutes in 50 ℃ of water-baths of O adding, further with Cu
2+Evenly be adsorbed on TiO
2Powder and SiO
2The surface of powder;
Step (4). left standstill 2.5 hours, and obtained the antibacterial agent powder after suction filtration, deionized water washing, vacuum drying, the grinding.
Embodiment 15:
Step (1). with the nano level TiO of 5kg
2The nano level SiO of powder, 5kg
2The L-arginine of powder and 100g, the D-tryptophan of 100g refluxed 50 minutes 25 ℃ of stirred in water bath, made L-arginine and D-tryptophan evenly be adsorbed on TiO
2Powder and SiO
2The surface of powder;
Step (2). with the Cu (NO of 50g
3)
2CuSO with 50g
4Add in 25 ℃ of water-baths and continued stirring and refluxing 50 minutes, Cu (NO
3)
2And CuSO
4In Cu
2+Through with L-arginine and D-tryptophan generation complexing, also evenly be adsorbed on TiO
2Powder and SiO
2The surface of powder;
Step (3). with the Na of 3kg
4P
2O
710H
2Continued stirring and refluxing 50 minutes in 25 ℃ of water-baths of O adding, further with Cu
2+Evenly be adsorbed on TiO
2Powder and SiO
2The surface of powder;
Step (4). left standstill 4 hours, and obtained the antibacterial agent powder after suction filtration, deionized water washing, vacuum drying, the grinding.
Claims (3)
1. the preparation method of an antibacterial agent is characterized in that the concrete steps of this method are:
Step (1). inorganic nanoparticles and basic amino acid were refluxed 10～60 minutes 25～60 ℃ of stirred in water bath, make basic amino acid evenly be adsorbed on the inorganic nanoparticles surface;
Described inorganic nanoparticles is nano level TiO
2, SiO
2In one or both;
Inorganic nanoparticles and basic amino acid mass ratio are 100:1～10;
Step (2). the inorganic antibacterial active substance added in 25～60 ℃ of water-baths continued stirring and refluxing 10～60 minutes, the metal ion in the inorganic antibacterial active substance through with amino acid generation complexing, also evenly be adsorbed on the inorganic nanoparticles surface;
The mass ratio of the inorganic antibacterial active substance that adds and the basic amino acid of adding is 0.06～0.6:1;
Step (3). with Na
4P
2O
710H
2Continue stirring and refluxing 10～60 minutes in 25～60 ℃ of water-baths of O adding, further metal ion is fixed on the inorganic nanoparticles surface;
The Na that adds
4P
2O
710H
2The mass ratio of the inorganic antibacterial active substance of O and adding is 10～30:1;
Step (4). left standstill 1～4 hour, and obtained the antibacterial agent powder after suction filtration, deionized water washing, vacuum drying, the grinding.
2. the preparation method of a kind of antibacterial agent as claimed in claim 1 is characterized in that: described basic amino acid be in lysine, arginine, histidine, the tryptophan one or more.
3. the preparation method of a kind of antibacterial agent as claimed in claim 1, it is characterized in that: described inorganic antibacterial active substance is AgNO
3, Zn (NO
3)
2, ZnCl
2, ZnSO
4, Cu (NO
3)
2, CuCl
2, CuSO
4In one or more.
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| CN104004375A (en) * | 2014-06-12 | 2014-08-27 | 东莞市金富实业有限公司 | Technology for manufacturing antibacterial and bacteriostatic plastic bottle caps |
| CN104472537A (en) * | 2014-11-11 | 2015-04-01 | 南京工程学院 | Eggshell-type antibacterial microspheres and preparation method thereof |
| CN105603410A (en) * | 2015-12-22 | 2016-05-25 | 唐艺峰 | Manufacturing method of bacteriostatic stainless steel dish |
| CN106172493A (en) * | 2016-07-28 | 2016-12-07 | 东莞市雄林新材料科技股份有限公司 | A kind of nano-photo catalytic antibacterial and preparation method thereof |
| CN106489991A (en) * | 2016-11-01 | 2017-03-15 | 山东理工大学 | A kind of preparation method of high-efficient antibacterial agent |
| CN112853755A (en) * | 2020-12-23 | 2021-05-28 | 南通雅文纺织品有限公司 | Antibacterial fabric for sofa cushion and production process thereof |
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| CN101292667A (en) * | 2008-06-18 | 2008-10-29 | 山西农业大学 | Farming veterinarian disinfectant liquid and its preparation |
| CN101744001A (en) * | 2009-12-29 | 2010-06-23 | 浙江理工大学 | Silver-containing silicon-based mesoporous antibacterial agent and preparation method thereof |
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