CN102488846A - Medicinal composition for treating diabetes mellitus - Google Patents
Medicinal composition for treating diabetes mellitus Download PDFInfo
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- CN102488846A CN102488846A CN2011104271441A CN201110427144A CN102488846A CN 102488846 A CN102488846 A CN 102488846A CN 2011104271441 A CN2011104271441 A CN 2011104271441A CN 201110427144 A CN201110427144 A CN 201110427144A CN 102488846 A CN102488846 A CN 102488846A
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Abstract
The invention relates to a medicinal composition for treating type II diabetes mellitus. The medicinal composition is prepared from the following raw materials in parts by weight: 18-22 parts of dwarf lilyturf root, 16-20 parts of baikal skullcap root, 16-20 parts of Chinese yam, 14-18 parts of Chinese angelica, 14-17 parts of common anemarrhena, 10-14 parts of polished round-grained rice, 10-14 parts of liquoric root, 8-12 parts of astragalus, 9-11 parts of large-head atractylodes rhizome, 7-9 parts of white paeony root, 6-8 parts of dark plum fruit, 5-7 parts of kudzuvine root, 5-7 parts of prepared rehmannia, 3-5 parts of Chinese magnoliavine fruit and 3-5 parts of ginseng. The medicinal composition has the advantages of short treatment course, high total effective rate, prevention of relapse after curing, simple process, reduction in production cost and lowering of the economic burden of a patient.
Description
Technical field
The invention belongs to the biological medicine technology field, be specifically related to a kind of pharmaceutical composition of treating diabetes and preparation method thereof, relate in particular to pharmaceutical composition of a kind of type and preparation method thereof.
Background technology
Diabetes (diabetes) are to act on that body causes hypoinsulinism, insulin resistant etc. and a series of metabolism disorder syndromes such as the sugar that causes, protein, fat, power and water Xie Zhi by inherited genetic factors, immunologic function disorder, infected by microbes and toxin thereof, free radical toxin, Nervous and Mental Factors or the like various virulence factors; Be main feature clinically with the hyperglycemia; Performance such as polyuria, polydipsia, polyphagia can appear in model case, become thin; I.e. " three-many-one-little " symptom; Diabetes (blood glucose) cause complication in case control bad meeting, cause the depleted pathological changes at positions such as kidney, eye, foot, and can't cure.The clinical observation insulin resistant is prevalent in the type, up to about 90%.Type; Have another name called non-insulin-dependent diabetes mellitus (NIDDM); Characteristics are that human body self can produce insulin; But cell can't be reacted to it, and the effect of insulin is had a greatly reduced quality, and can cause infection, heart change, cerebrovascular disease, renal failure, loses the sight of both eyes, lower limb gangrene etc. and become deadly major cause of morbidity.The diabetes height oozes the serious acute complication that syndrome is diabetes; Starting stage can show as polyuria, polydipsia, fatigue and weakness, bradykinesia etc.; Along with the increase state of an illness of body fluid loss sharply develops; Drowsiness, disorientation appears, epileptic is twitched, the symptom of similar apoplexy such as hemiplegia, even stupor.
Type early stage usually can be through simple diet control, increase physical training or use sulfonylurea drugs and make blood glucose controlled.But unfortunately, the disorder of β cell function causes that insulin secretion is impaired to be the deterioration of carrying out property.The patient will need insulin separately or with the therapeutic strategy of other oral medicine Combined application.Compare with Western medicine, Chinese herbal medicine has good protective effect to stomach, liver, kidney, and effect is steadily effective, and it is wide to be suitable for the crowd, does not more have the toxic and side effects of Western medicine.Chinese medicine is thought, liver controlling conveyance and dispersion concerns that the up-down of human functional activity of vital energy and accent are smooth; Then the defeated cloth of ascending or descending movement of vital Qi is disorderly for irritability stasis; The liver failing to maintain the normal flow of QI then cereal nutrient such as blood glucose can not with the gas of clear sun defeated be distributed in the whole body and stasis in blood, the defeated cloth that hyperglycemia or cereal nutrient occur is disorderly, instead sees blood sugar increasing; Further cause other cereal nutrient such as blood fat, albumen disorderly, cause other complication.Treatment is main with soothing the liver regulating QI, and to recover its physiological function, the irritability bar reaches along liver bar soothing the liver property, and QI movement being in harmonious way precise and tinyly is able to defeated cloth, and sugar is utilized and blood glucose descends naturally.Rational hypoglycemic drug matching has promoting the production of body fluid to quench thirst, recovers patient's the islet function and the affinity of receptor, the effect that blood glucose is fully absorbed.
Disclose the pharmaceutical composition of some treatment type in the prior art, but there are many defectives in number average mostly, complicated process of preparation, the effect of expensive raw materials and pathology virulence test is relatively poor, is not suitable for most of people and uses or the like; How preparing a kind of Chinese medicine composition with low cost, evident in efficacy is the technical barrier that the world of medicine needs to be resolved hurrily.
Summary of the invention
The pure Chinese medicine composition and the fabricating technology thereof that the purpose of this invention is to provide a kind of with low cost, evident in efficacy, safe ready.
The application inventor combines secret prescription handed down in the family from generation to generation according to forefathers' experience and oneself practice of practising medicine for many years, through the research to Chinese medicine, and combines dialectical demonstration; In many ways collect the length of many families, seek therapeutic regimen, by the theory of Chinese medical science prescription; Adopt the natural Chinese medicines raw material; Through systematic study, science compatibility, be mixed with the Chinese medicine composition of treatment type of the present invention meticulously in conjunction with traditional lunar physics technique, type there is preferable effect.
For realizing above-mentioned purpose, the technical scheme that the present invention adopts is following:
A kind of pharmaceutical composition of treating type, it is got by following feedstock production,
Radix Ophiopogonis 18-22, Radix Scutellariae 16-20, Rhizoma Dioscoreae 16-20, Radix Angelicae Sinensis 14-18, Rhizoma Anemarrhenae 14-17, Semen oryzae sativae 10-14, Radix Glycyrrhizae 10-14, Radix Astragali 8-12, Rhizoma Atractylodis Macrocephalae 9-11, Radix Paeoniae Alba 7-9, Fructus Mume 6-8, Radix Puerariae 5-7, Radix Rehmanniae Preparata 5-7, Fructus Schisandrae Chinensis 3-5, Radix Ginseng 3-5.
A kind of pharmaceutical composition of treating type, it is preferably got by following weight proportioning feedstock production,
Radix Ophiopogonis 20, Radix Scutellariae 18, Rhizoma Dioscoreae 18, Radix Angelicae Sinensis 16, the Rhizoma Anemarrhenae 15, Semen oryzae sativae 12, Radix Glycyrrhizae 12, the Radix Astragali 10, the Rhizoma Atractylodis Macrocephalae 9, the Radix Paeoniae Alba 8, Fructus Mume 7, Radix Puerariae 6, Radix Rehmanniae Preparata 6, Fructus Schisandrae Chinensis 4, Radix Ginseng 4.
Pharmaceutical composition of the present invention can adopt respectively the distinguish the flavor of medical material of conventional method in will writing out a prescription to carry out compatibility in proportion, processes various clinical suitable dosage forms by existing preparation process, and the used medical material of respectively distinguishing the flavor of is the Chinese crude drug that commercially available process is up to the standards.
Preparation of pharmaceutical compositions method of the present invention comprises the steps:
(1) it is subsequent use to get above-mentioned each bulk drugs;
(2) add 3 times of water gagings and decocted 2 hours, filter and collect filtrating, filtrating is condensed into the extractum that density is 1.2g/ml;
After (3) 60 ℃ of dryings, be crushed to 80 purpose medicated powder, incapsulate, sterilization makes capsule preparations.
Dosage form and usage: our pharmaceutically dosage form is a capsule formulation, and three times on the one, take half an hour ante cibum, and each 2, two weeks were a course of treatment.
Period in a medicine avoids pungent food and cold and cool food, avoids feelings will to stimulate, and life is regular.
The excellent results of Chinese medicine composition of the present invention and preparation method thereof is:
1. medicament of the present invention is processed by pure Chinese medicine, and each component meets pharmacopeia method relevant regulations, utilizes the compatibility effect of the Chinese medicine of respectively distinguishing the flavor of, and does not contain chemical components, does not contain hormone, has no side effect, and treating both the principal and secondary aspects of a disease reaches better hypoglycemic effect;
2. this medicament short treating period, total effective rate is high, and more the back is difficult for recurrence;
3. technology of the present invention is simple, has reduced production cost, has alleviated patient's financial burden.
The specific embodiment
Below come detailed explanation the present invention through concrete embodiment, but as restriction to content of the present invention.
Embodiment 1
A kind of pharmaceutical composition of treating type, it is got by following weight proportioning feedstock production:
Radix Ophiopogonis 20, Radix Scutellariae 18, Rhizoma Dioscoreae 18, Radix Angelicae Sinensis 16, the Rhizoma Anemarrhenae 15, Semen oryzae sativae 12, Radix Glycyrrhizae 12, the Radix Astragali 10, the Rhizoma Atractylodis Macrocephalae 9, the Radix Paeoniae Alba 8, Fructus Mume 7, Radix Puerariae 6, Radix Rehmanniae Preparata 6, Fructus Schisandrae Chinensis 4, Radix Ginseng 4.
It is subsequent use that the aforementioned pharmaceutical compositions method for preparing comprises the steps: to get above-mentioned each bulk drugs; Add 3 times of water gagings and decocted 2 hours, filter and collect filtrating, filtrating is condensed into the extractum that density is 1.2g/ml; After 60 ℃ of dryings, be crushed to 80 purpose medicated powder, incapsulate, sterilization makes capsule preparations.
Dosage form and usage: our pharmaceutically dosage form is a capsule formulation, and three times on the one, take half an hour ante cibum, each 2, and every of 0.5g, two weeks were a course of treatment.
Embodiment 2
Experiment of Zoology
Experimental animal: 40 of SD rats, male and female half and half, 160-180g, Linyi City the People's Hospital animal center provides.Rat is randomly drawed 8 and feeds with the common feedstuff of keeping as the normal control group after Animal House adapt to be fed 5 days.High glucose and high fat feed formula: rat normal feedstuff 68%, sucrose 10%, yolk powder 9%, Adeps Sus domestica 8%, cholesterol 1%, cholate 0.2%.
Embodiment: all the other 32 are adopted high glucose and high fat 4 weeks of forage feed.4 week back rats behind fasting 24h, streptozotocin (STZ) intravenous injection 20mg/Kg, per two days once, uses twice after, the high person of blood pressure and blood lipoid is successful for modeling.Choose 24 of the successful rats of modeling; Be divided into 3 groups at random, 8 every group, i.e. model group (not using any medicine), the embodiment of the invention 1 drug group 10mg/Kg, control drug group: use metformin hydrochloride (10mg/kg); Method of application is oral, and every day, ante cibum, half was taken.Take continuously after 10 days and detect.
Statistical analysis: data information adopts x ± s to represent, uses the SPSS17.0 statistical software to carry out data analysis, relatively adopts variance analysis between many groups, relatively adopts the t check between two groups.There is statistical significance P＜0.05.
Therapeutic effect: detected fasting glucose (fasting plasma glucose is abbreviated as FPG), 2h blood glucose (2hPG) biochemical indicator after the meal, unit is mmol/L.
| Group | FPG | 2hPG |
| Normal group | 5.15±0.13 | 7.67±0.42 |
| Simulating groups | 18.19±3.45 | 25.24±4.21 |
| The control drug group | 7.26±1.87 | 8.65±1.03 |
| Drug group of the present invention | 6.73±0.61 | 7.89±0.21 |
Conclusion: the influence to FPG and 2hPG is visible by last table, and except that normal group, model group FPG, 2hPG all obviously raise; Compare than model group, control drug group and drug group FPG of the present invention, 2hPG all have obvious decline (P＜0.01), and medicine of the present invention obviously is better than control drug group (P＜0.05).
Embodiment 3
Clinical trial:
Data and method: physical data outpatient service type ii diabetes patient is totally 120 examples, wherein male 72 examples, women 48 examples, patient age 48～76 years old, fasting glucose (FPG) and all significantly risings of 2h blood glucose (2hPG) after the meal.The medicine of taking the embodiment of the invention 1 preparation detects above-mentioned biochemical indicator after two courses of treatment.Cure: FPG＜6.1mmol/L, 2h blood glucose (2hPG)＜8.0mmol/L.Invalid: fasting glucose (FPG) and after the meal 2h blood glucose (2hPG) all do not have obviously and change.Effectively: fasting glucose (FPG) and after the meal 2h blood glucose (2hPG) change to some extent, but do not reach normal index.
Therapeutic effect: cure 87 examples, effective 26 examples, invalid 7 examples, total effective rate is 94%.
Above-mentioned data specific embodiments of the invention has been carried out detailed description; But be not restriction to protection domain of the present invention; One of ordinary skill in the art should be understood that; On the basis of technical scheme of the present invention, those skilled in the art need not pay various modifications that creative work can make or distortion still in protection scope of the present invention.
Claims (3)
1. a pharmaceutical composition of treating type is characterized in that, it is got by the preparation of following weight proportion raw material:
Radix Ophiopogonis 18-22, Radix Scutellariae 16-20, Rhizoma Dioscoreae 16-20, Radix Angelicae Sinensis 14-18, Rhizoma Anemarrhenae 14-17, Semen oryzae sativae 10-14, Radix Glycyrrhizae 10-14, Radix Astragali 8-12, Rhizoma Atractylodis Macrocephalae 9-11, Radix Paeoniae Alba 7-9, Fructus Mume 6-8, Radix Puerariae 5-7, Radix Rehmanniae Preparata 5-7, Fructus Schisandrae Chinensis 3-5, Radix Ginseng 3-5.
2. pharmaceutical composition as claimed in claim 1 is characterized in that, said pharmaceutical composition is got by following weight proportioning feedstock production:
Radix Ophiopogonis 20, Radix Scutellariae 18, Rhizoma Dioscoreae 18, Radix Angelicae Sinensis 16, the Rhizoma Anemarrhenae 15, Semen oryzae sativae 12, Radix Glycyrrhizae 12, the Radix Astragali 10, the Rhizoma Atractylodis Macrocephalae 9, the Radix Paeoniae Alba 8, Fructus Mume 7, Radix Puerariae 6, Radix Rehmanniae Preparata 6, Fructus Schisandrae Chinensis 4, Radix Ginseng 4.
3. according to claim 1 or claim 2 preparation of drug combination method is characterized in that, gets raw material for standby; Add 3 times of water gagings and decocted 2 hours, filter and collect filtrating, filtrating is condensed into the extractum that density is 1.2g/ml; After 60 ℃ of dryings, be crushed to 80 purpose medicated powder, incapsulate, sterilization makes said pharmaceutical composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110427144 CN102488846B (en) | 2011-12-20 | 2011-12-20 | Medicinal composition for treating diabetes mellitus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110427144 CN102488846B (en) | 2011-12-20 | 2011-12-20 | Medicinal composition for treating diabetes mellitus |
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| CN102488846A true CN102488846A (en) | 2012-06-13 |
| CN102488846B CN102488846B (en) | 2013-06-19 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201110427144 Expired - Fee Related CN102488846B (en) | 2011-12-20 | 2011-12-20 | Medicinal composition for treating diabetes mellitus |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103223087A (en) * | 2013-05-13 | 2013-07-31 | 谭格铭 | Food therapy formula for treating diabetes mellitus |
| CN104173857A (en) * | 2014-09-17 | 2014-12-03 | 济南高天机械设备有限公司 | Traditional Chinese medicine for treating yin-yang-deficiency diabetes mellitus II and preparation method of traditional Chinese medicine |
| CN104587337A (en) * | 2014-12-31 | 2015-05-06 | 李玉宾 | Traditional Chinese medicine composition for treating diabetes and preparation method of traditional Chinese medicine composition |
| CN105168873A (en) * | 2015-08-14 | 2015-12-23 | 兰为民 | Traditional Chinese medicine composition conditioning diabetes and preparation method therefor |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101120971A (en) * | 2006-08-08 | 2008-02-13 | 芮育健 | New use of traditional Chinese medicines radix astragali, white peony root and purearia root for kidney-tonifying qi-replenishing and treating diabetes |
-
2011
- 2011-12-20 CN CN 201110427144 patent/CN102488846B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101120971A (en) * | 2006-08-08 | 2008-02-13 | 芮育健 | New use of traditional Chinese medicines radix astragali, white peony root and purearia root for kidney-tonifying qi-replenishing and treating diabetes |
Non-Patent Citations (2)
| Title |
|---|
| 段启等: "白术的研究进展", 《中草药》 * |
| 车敏等: "消渴病的治疗用药与治法的探讨", 《甘肃中医》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103223087A (en) * | 2013-05-13 | 2013-07-31 | 谭格铭 | Food therapy formula for treating diabetes mellitus |
| CN104173857A (en) * | 2014-09-17 | 2014-12-03 | 济南高天机械设备有限公司 | Traditional Chinese medicine for treating yin-yang-deficiency diabetes mellitus II and preparation method of traditional Chinese medicine |
| CN104587337A (en) * | 2014-12-31 | 2015-05-06 | 李玉宾 | Traditional Chinese medicine composition for treating diabetes and preparation method of traditional Chinese medicine composition |
| CN105168873A (en) * | 2015-08-14 | 2015-12-23 | 兰为民 | Traditional Chinese medicine composition conditioning diabetes and preparation method therefor |
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| CN102488846B (en) | 2013-06-19 |
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Granted publication date: 20130619 Termination date: 20131220 |