CN102488803A - Preparation method for superfine bupleurum powder under normal temperature and special bidirectional airflow sieving machine - Google Patents
Preparation method for superfine bupleurum powder under normal temperature and special bidirectional airflow sieving machine Download PDFInfo
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Abstract
The invention discloses a preparation method for superfine bupleurum powder under a normal temperature; the preparation method comprises the following steps of: firstly selecting radix bupleuri, radix scutellariae, pinellia, dangshen and liquorice, cleaning and cutting the radix bupleuri, the radix scutellariae, the pinellia, the dangshen and the liquorice into sections; drying the sections, and then respectively grinding the sections to obtain crude traditional Chinese medicine powders; uniformly mixing the crude traditional Chinese medicine powders according to proportions of 3:3:2:3:1, then placing the mixed crude traditional Chinese medicine powder in a rod mill to be ground, leading the ground powder to enter a special bidirectional airflow sieving machine through air supply to pass through a sieve with 500 meshes, sieving the ground powder to obtain powder with the particle size of less than or equal to 25 micrometers, conveying the powder into a cyclone material collecting device through air currents generated by a draught fan to be collected, thereby obtaining the superfine bupleurum powder finished product; and collecting and conveying the powder which is not sieved by the sieve with 500 meshes into the rod mill for secondary cyclic grinding. The preparation method has the advantages that the whole preparation process is carried out under the normal temperature, and low temperature or special auxiliary conditions are not needed; the particle size of the prepared medicine finished product is less than or equal to 25 micrometers, and the wall-broken rate of cells and the bioavailability are greatly increased; and the bidirectional airflow sieving machine adopted in the preparation method simplifies the preparation process of the superfine bupleurum powder.
Description
Technical field
The present invention relates to the veterinary drug preparation field, especially relate to superfine powder bupleurum root powder normal temperature preparation method; The invention still further relates to the special-purpose two-way airflow screening machine that is used for this method.
Background technology
Chinese herbal medicine is carrying out having the incomparable superiority of other chemical synthetic drugs aspect the prevention and treatment of diseases: safe, toxic and side effects is little, effective ingredient is many, hazard residue is few, action target spot is many; Can bring into play combined effect; Be difficult for producing drug resistance, scalable immunity of organisms, enhancing body resistance against diseases in anti-bacteria and anti-virus.More and more stress food safety in the our times various countries, call under green, the ecological overall background, apply prevention and the control that herbal medicine carries out Animal diseases and be of great practical significance.
The veterinary drug bupleurum root powder of tradition usefulness is made up of Radix Bupleuri, Radix Scutellariae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Codonopsis and Radix Glycyrrhizae 5 flavor Chinese medicines; Effect with antipyretic and anti-inflammatory, hepatic cholagogic, enhance immunity, remarkable for card effects such as treatment horse sweating syndrome, mule conjunctivitis, faucitis of horses, the antenatal aphagia of donkey bosom mule, cattle epilepsy syndrome, Niu Fengwen folder damp syndrome, cattle puerperal fever and domestic animal low grade fever do not move back.Mostly used bupleurum root powder is the powder of coarse pulverization at present; There are dosage big (horse, cattle 100-250g; Sheep, pig 30-60g), deficiencies such as dosage form thick (particle diameter 250-850 micron), presentation quality and palatability difference; Effective ingredient can not fully discharge, and bioavailability is low, has had a strong impact on Chinese medicine quality and clinical therapeutic efficacy.
The broken technology of Chinese medicine ultra-fine powder is renewal and the development to traditional crushing technology; It had both kept the advantage of Chinese medicine technology of preparing; Injected new vitality for the modern production of Chinese medicine again; Have a extensive future, but in actual production, remain in some problems and a difficult problem: (1) production efficiency is low, the power consumption height is the principal element of restriction Chinese medicine ultra-fine powder large-scale production for animals.Rod mill is in traditional closed circuit method crushing process; When most of material has reached fineness requirement, always there is few part coarse powder to be mixed in wherein, make this part coarse powder further be crushed to the granularity that requires need prolong the pulverizing time significantly; Make crush efficiency reduce, power consumption significantly increases; (2) it is poor that there are the material particular diameter uniformity after the classification in selecting crude drugs with winnower classification and grading wheel classification; Influenced the quality of production of herbal medicine compound recipe superfine powder greatly; Especially when being applied to the use of animal drinking-water, because a small amount of not existence of breaking cellular wall cell is difficult to reach instructions for use.(3) traditional one-way gas flow is sieved, because Chinese medicine is when carrying out micronizing, along with reducing of particle diameter; Material particles surface area and surface energy increase; Adsorptivity increases, and mobile variation is prone to be gathered into bulky grain etc. and causes the sieve classification of crossing that surpasses 200 order fineness medicated powder to be difficult to carry out.The existence of above-mentioned factor has had a strong impact on standardization, the large-scale production of herbal medicine superfine powder, and popularization on veterinary clinic and use.
Summary of the invention
The object of the invention is to provide a kind of rapid-action, good effect, bioavailability is high, the clinical application amount is few superfine powder bupleurum root powder normal temperature preparation method.
Another purpose of the present invention is to provide a kind of special-purpose two-way airflow screening machine that is applied to superfine powder bupleurum root powder normal temperature preparation method.
Superfine powder bupleurum root powder normal temperature preparation method of the present invention comprises the steps:
The first step, choose Radix Bupleuri, Radix Scutellariae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Codonopsis, Radix Glycyrrhizae, choosing is clean, cut into the long section of 3-5cm, through natural drying or dry to moisture≤10%;
Second the step, under 20 ℃～25 ℃ temperature with above-mentioned raw materials medicine pulverize separately, obtain granularity 60～80 purpose Chinese medicine coarse powder;
The 3rd step, with above-mentioned raw materials medicine coarse powder according to Radix Bupleuri: the weight portion ratio mix homogeneously of Radix Scutellariae: Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens): Radix Codonopsis: Radix Glycyrrhizae=3:3:2:3:1;
The 4th step, with the 3rd step gained coarse powder place pulverize in the rod mill after; Be fed into special-purpose two-way airflow screening machine through wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine is transported to collect in the tornado feeder set and promptly gets superfine powder bupleurum root powder finished product; The powder of not crossing 500 mesh sieves arrives circulation pulverizing once more in the said rod mill through the funnel collection and through line transportation.Finished product superfine powder bupleurum root powder is sub-packed in the aluminium foil bag, and every bag weighs 100g, 200g, 500g, 1000g, 2000g etc.
Special-purpose two-way airflow screening machine of the present invention comprises JIKE and sets within it the downward screen drum of chamber intermediate openings, the order number of said screen drum >=500 orders; The nozzle of screen drum is connected with the funnel upper shed that is arranged on the JIKE bottom mutually; Chassis cavity is connected with air-introduced machine through the negative pressure chamber on top; Be provided with the door font rotating spraying trachea that constitutes by transverse tube and standpipe in the zone between screen drum and JIKE; The puff prot of said door font rotating spraying trachea is for axially being opened in the groove on its tube wall along said transverse tube and standpipe respectively; Said groove is offered towards the screen drum direction respectively; The groove width 0.5-2 millimeter of groove, the middle part of transverse tube and drive motors driving coupling; Be provided with blast pipe in the screen drum centre position, the air outlet of said blast pipe passes screen drum and is connected with the transverse tube middle part of door font rotating spraying trachea and is connected through the rolling bearing rolling; The air inlet of blast pipe extends outside the said hopper side walls and is connected with the blast orifice of aerator; In screen drum, be provided with feed pipe, above the discharging opening of said feed pipe, be provided with the buffering umbrella, the charging aperture of feed pipe extends outside the hopper side walls and is communicated with powder conveying fan air outlet through wind stopping device.
The air inducing of said air-introduced machine is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The rotating speed of said drive motors is 155 rev/mins; The blast pressure of said aerator is 33kpa, and the blow rate required is 320m
3/ h; The wind pressure that goes out of said powder conveying fan is 24kpa, and air output is 150m
3/ h; The sidewall of said screen drum and roof respectively with corresponding standpipe and transverse tube between distance be 25 millimeters.
The invention has the advantages that whole process of preparation all carries out at normal temperatures, do not need low temperature or special additional conditions; Final drug particle diameter≤25 micron of preparation; Improve cell wall breaking rate (sporoderm-broken rate reaches more than 95%) and bioavailability greatly, strengthened pharmacological action, thereby reduced treatment disease dosage; Practiced thrift medical material; Also improve simultaneously the abnormal smells from the patient and the mouthfeel of medicine, make and directly adopt the water way administration to be achieved, changed the deficiency that Chinese powder medicine can only spice can not be drunk water and take; The bupleurum root powder of ultra micro powder can evenly stick on the animal pellet feed simultaneously, has solved particulate material and can not mix the problem of using with Chinese medicine; The two-way airflow screening machine that uses in the inventive method has been simplified the preparation technology of superfine powder bupleurum root powder greatly, has realized the purpose that the Chinese powder medicine quality standard is controlled, be suitable for large-scale industrial production.
The clinical therapeutic efficacy of preparation of the present invention obtains checking through following test:
1 materials and methods
1.1 test drug and material
Bupleurum root powder superfine powder: adopt the present invention's preparation.
The bupleurum root powder fine powder: according to two ones of " Chinese veterinary drug allusion quotation " versions in 2010, this laboratory prepares traditionally, 80-100 order, particle diameter 150-190um.
Typhoid fever-paratyphoid fever first and second mixed vaccines: institute of biological products, Ministry of Public Health Zhengzhou provides.
1.2 experimental animal
2-2.5kg/ 80 of healthy livid purple blue state rabbits only, Henan agricultural university Animal Experimental Study center provides.
1.3 test is divided into groups
Table 1Test is divided into groups and medication
| Group | Number of animals (only) | Medicining condition | Usage and dosage |
| 1 | 10 | Do not infect matched group | Do not infect not |
| 2 | 10 | Infect, do not treat group | Infect not medication |
| 3 | 10 | Infect 80-100 order fine powder high-dose therapy group | The 5g/kg spice |
| 4 | 10 | Infect dosage treatment group in the 80-100 order fine powder | The 3g/ |
| 5 | 10 | Infect 80-100 order fine powder low dose treatment group | The 1g/kg spice |
| 6 | 10 | Infect 400-500 order superfine powder high dose group | The 5g/kg spice |
| 7 | 10 | Infect dose groups in the 400-500 order superfine powder | The 3g/kg spice |
| 8 | 10 | Infect 400-500 order superfine powder low dose group | The 1g/kg spice |
Experimental animal is divided into 8 groups at random, and continuous use 4h is every at a distance from body temperature of 1h record.
1.4 test method
Experimental animal is bought back, and begins test behind the 3d.Experimental animal is divided into 8 groups at random, and fasting 12h before the experiment freely drinks water; According to the injection of 1.5ml/kg ear vein, the body temperature of every group of rabbit of record before and after the injection is injected back 30min and is begun to the experimental animal spice then; High dose group is according to the 5g/kg spice, and middle dose groups is according to the 3g/kg spice, and low dose group is according to the 1g/kg spice; 1, the equal spice not of 2 matched groups, logotype 4h observes also the record effect (seeing table 1, table 2) of bringing down a fever.
Table 1Variable concentrations, different process bupleurum root powder superfine powder are to rabbit " fever " observation on effect of bringing down a fever
| Group | Body temperature average before the injection (℃) | Body temperature average behind the injection 30min (℃) | 1h body temperature average after the administration (℃) | 2h body temperature average after the administration (℃) | 3h body temperature average after the administration (℃) | 4h body temperature average after the administration (℃) |
| 1 | 38.8 | 38.9 | 38.9 | 38.8 | 38.8 | 38.8 |
| 2 | 38.9 | 39.5 | 40.1 | 40.3 | 40.5 | 41.0 |
| 3 | 38.8 | 39.4 | 39.7 | 40.1 | 40.3 | 40.6 |
| 4 | 38.8 | 39.5 | 39.9 | 40.2 | 40.4 | 40.8 |
| 5 | 39.0 | 39.6 | 40.0 | 40.3 | 40.5 | 41.0 |
| 6 | 39.0 | 39.5 | 39.7 | 39.9 | 40.1 | 40.3 |
| 7 | 38.9 | 39.5 | 39.7 | 40.0 | 40.3 | 40.5 |
| 8 | 39.0 | 39.6 | 39.9 | 40.2 | 40.4 | 40.7 |
Result of the test shows: the bupleurum root powder superfine powder of different amounts, different process is brought down a fever to rabbit " fever " all has the obvious treatment effect (to infect than matched group; Except the 80-100 order fine powder low dose treatment group); And the big more effect of consumption is good more, and the bupleurum root powder superfine powder of the present invention's preparation is brought down a fever effect more than the bupleurum root powder of traditional handicraft preparation.And draw by statistical calculations: 3,4,8 three groups all with 2 groups of significant differences (P < 0.05); 6,7 liang of groups all extremely remarkable (P < 0.01) with 2 groups of differences; 6 groups with 3 groups of significant differences (P < 0.05); 7 groups with 4 groups of significant differences (P < 0.05), 3 groups with 7 groups of difference not obvious (P>0.05), 5 groups with 2 groups of difference not obvious (P>0.05).Dose groups and the traditional handicraft high dose group effect of bringing down a fever is suitable in the bupleurum root powder superfine powder of the present invention preparation, it is thus clear that the preparation bioavailability that preparation technology of the present invention produces than traditional handicraft is higher, better effects if.
Description of drawings
Fig. 1 is the production equipment system figure of the method for the invention.
Fig. 2 is the structural representation of special-purpose two-way airflow screening machine according to the invention.
The specific embodiment
Like Fig. 1, shown in 2, superfine powder bupleurum root powder normal temperature preparation method of the present invention comprises the steps:
The first step, choose Radix Bupleuri, Radix Scutellariae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Codonopsis, Radix Glycyrrhizae, choosing is clean, cut into the long section of 3-5cm, through natural drying or dry to moisture≤10%;
Second the step, under 20 ℃～25 ℃ temperature with above-mentioned raw materials medicine pulverize separately, obtain granularity 60～80 purpose Chinese medicine coarse powder;
The 3rd step, with above-mentioned raw materials medicine coarse powder according to Radix Bupleuri: the weight portion ratio mix homogeneously of Radix Scutellariae: Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens): Radix Codonopsis: Radix Glycyrrhizae=3:3:2:3:1;
The 4th goes on foot, at first opens powder conveying fan 15, air-introduced machine 5, aerator 11, drive motors 8.The blow pressure of powder conveying fan 15 is 24kpa, and the blowing amount is 150m
3/ h; The air inducing of air-introduced machine 5 is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The blast pressure of aerator 11 is 33kpa, blow rate required 320m
3/ h; The rotating speed of drive motors 8 is 155 rev/mins;
1, with the 3rd step gained coarse powder place pulverize in the rod mill 16 after; Powder body to be fractionated is arranged in the downward screen drum 2 of JIKE 1 inner chamber intermediate openings being brought into by high velocity air through wind stopping device 14, feed pipe 12 under the power of the blowing effect of powder conveying fan 15 in the rod mill 16; And, powder body to be fractionated is disperseed in screen drum 2 through the impulsive force of buffering umbrella 13 reduction powder body to be fractionated in screen drum 2; The order number of screen drum 2 is 500 orders;
2, dispersive powder body to be fractionated carries out classification through screen drum 2 in the screen drum 2 under air-introduced machine 5 effects, and fine powder negative pressure chamber 4 through JIKE 1 top under the negative-pressure air-flow effect that air-introduced machine 5 produces of passing screen drum 2 is transported to collect in the tornado feeder set 17 and promptly gets superfine powder bupleurum root powder finished product.The powder body sinking warp through screen drum 2 is collected with the funnel 3 that screen drum 2 under sheds are connected mutually and is transported in the said rod mill 16 circulation once more through pipeline 18 and pulverizes;
3, door font rotating spraying trachea rotates through rolling bearing 10 under drive motors 8 drives; The wind that aerator 11 is seen off is in blast pipe 9 gets into said transverse tube 6 and standpipe 7; And through be opened in the puff prot ejection that has the groove structure on transverse tube 6 and standpipe 7 tube walls respectively vertically towards screen drum 2 directions; Form the evenly blowback air-flow in screen drum 2 at screen drum 2 end faces and side; Powder body in the screen drum 2 is further atomized, stop powder body on screen drum 2, to lump simultaneously and stop up sieve screen apertures, make the powder body that does not pass through screen drum 2 along with the air-flow whirlpool that forms sinks to getting in the funnel 3.The groove width that is opened in groove on transverse tube 6 and standpipe 7 tube walls is respectively vertically selected between 0.5 millimeter-2 millimeters as required, between the roof of transverse tube 6 and standpipe 7 and corresponding screen drum 2 and the sidewall apart from being respectively 25 millimeters.
The superfine powder bupleurum root powder finished product of preparation is sub-packed in the aluminium foil bag and stores, every bag heavy 500g or 1000g.
Claims (3)
1. a superfine powder bupleurum root powder normal temperature preparation method is characterized in that: comprise the steps:
The first step, choose Radix Bupleuri, Radix Scutellariae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Codonopsis, Radix Glycyrrhizae, choosing is clean, cut into the long section of 3-5cm, through natural drying or dry to moisture≤10%;
Second the step, under 20 ℃～25 ℃ temperature with above-mentioned raw materials medicine pulverize separately, obtain granularity 60～80 purpose Chinese medicine coarse powder;
The 3rd step, with above-mentioned raw materials medicine coarse powder according to Radix Bupleuri: the weight portion ratio mix homogeneously of Radix Scutellariae: Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens): Radix Codonopsis: Radix Glycyrrhizae=3:3:2:3:1;
The 4th step, with the 3rd step gained coarse powder place pulverize in the rod mill (16) after; Be fed into special-purpose two-way airflow screening machine through wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine (5) is transported to collect in the tornado feeder set (17) and promptly gets superfine powder bupleurum root powder finished product; The powder of not crossing 500 mesh sieves is transported to circulation pulverizing once more in the said rod mill (16) through funnel (3) collection and through pipeline (18).
2. according to the special-purpose two-way airflow screening machine of the said superfine powder bupleurum root powder of claim 1 normal temperature preparation method, it is characterized in that: comprise JIKE (1) and the downward screen drum of chamber intermediate openings (2) that sets within it, the order number of said screen drum (2) >=500 orders; The nozzle of screen drum (2) is connected with funnel (3) upper shed that is arranged on JIKE (1) bottom mutually; JIKE (1) inner chamber is connected with air-introduced machine (5) through the negative pressure chamber (4) on top; Zone being positioned between screen drum (2) and the JIKE (1) is provided with the door font rotating spraying trachea that is made up of transverse tube (6) and standpipe (7); The puff prot of said door font rotating spraying trachea is for axially being opened in the groove on its tube wall along said transverse tube (6) and standpipe (7) respectively; Said groove is offered towards screen drum (2) direction respectively; The groove width 0.5-2 millimeter of groove, the middle part of transverse tube (6) and drive motors (8) driving coupling; Be provided with blast pipe (9) in screen drum (2) centre position, the air outlet of said blast pipe (9) passes screen drum (2) and is connected with transverse tube (6) middle part of door font rotating spraying trachea and is connected through rolling bearing (10) rolling; The air inlet of blast pipe (9) extends outside said funnel (3) sidewall and is connected with the blast orifice of aerator (11); In screen drum (2), be provided with feed pipe (12); Be provided with buffering umbrella (13) in the discharging opening of said feed pipe (12) top, the charging aperture of feed pipe (12) extends outside funnel (3) sidewall and is communicated with powder conveying fan (15) air outlet through wind stopping device (14).
3. special-purpose two-way airflow screening machine according to claim 2 is characterized in that: the air inducing of said air-introduced machine (5) is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The rotating speed of said drive motors (8) is 155 rev/mins; The blast pressure of said aerator (11) is 33kpa, and the blow rate required is 320m
3/ h; The wind pressure that goes out of said powder conveying fan (15) is 24kpa, and air output is 150m
3/ h; The sidewall of said screen drum (2) and roof respectively with corresponding standpipe (7) and transverse tube (6) between distance be 25 millimeters.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102397163A (en) * | 2011-11-28 | 2012-04-04 | 河南省康星药业有限公司 | Method for preparing ultrafine medicine terminalia fruit, gardenia and szechwan chinaberry fruit powder at normal temperature and special bidirectional airflow screening machine for method |
| CN102406675A (en) * | 2011-11-28 | 2012-04-11 | 河南省康星药业有限公司 | Room-temperature preparation method of ultramicro powder angelica and special two-way airflow screening machine |
| CN102406688A (en) * | 2011-11-28 | 2012-04-11 | 河南省康星药业有限公司 | Normal-temperature preparation method of codonopsis pilosula submicron powder and special bidirectional airflow sieving machine used by same |
| CN102423333A (en) * | 2011-11-28 | 2012-04-25 | 河南省康星药业有限公司 | Ultramicro powder epimedium constant-temperature preparation method and dedicated bidirectional air flow screening machine thereof |
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2011
- 2011-11-28 CN CN2011103829130A patent/CN102488803B/en active Active
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102397163A (en) * | 2011-11-28 | 2012-04-04 | 河南省康星药业有限公司 | Method for preparing ultrafine medicine terminalia fruit, gardenia and szechwan chinaberry fruit powder at normal temperature and special bidirectional airflow screening machine for method |
| CN102406675A (en) * | 2011-11-28 | 2012-04-11 | 河南省康星药业有限公司 | Room-temperature preparation method of ultramicro powder angelica and special two-way airflow screening machine |
| CN102406688A (en) * | 2011-11-28 | 2012-04-11 | 河南省康星药业有限公司 | Normal-temperature preparation method of codonopsis pilosula submicron powder and special bidirectional airflow sieving machine used by same |
| CN102423333A (en) * | 2011-11-28 | 2012-04-25 | 河南省康星药业有限公司 | Ultramicro powder epimedium constant-temperature preparation method and dedicated bidirectional air flow screening machine thereof |
| CN102423333B (en) * | 2011-11-28 | 2013-12-04 | 河南省康星药业股份有限公司 | Ultramicro powder epimedium constant-temperature preparation method |
| CN102406688B (en) * | 2011-11-28 | 2013-12-04 | 河南省康星药业股份有限公司 | Normal-temperature preparation method of codonopsis pilosula submicron powder |
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Address after: 451464, No. 2, Hing Road, Baisha Industrial Park, Zhongmu County, Henan, Zhengzhou Applicant after: Henan Health Star Pharmaceutical Co., Ltd. Address before: 451464, No. 2, Hing Road, Baisha Industrial Park, Zhongmu County, Henan, Zhengzhou Applicant before: Henan Kangxing Pharmaceutical Co., Ltd. |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Xing Yujuan Inventor after: Liu Haixin Inventor after: Li Rongyu Inventor after: Yang Caixia Inventor after: Zhang Yongchang Inventor after: Huang Wenhua Inventor before: Liu Haixin Inventor before: Li Rongyu Inventor before: Yang Caixia Inventor before: Zhang Yongchang Inventor before: Huang Wenhua |