CN102430089B - Method for preparing ultrafine powder Qiangzhuang San at normal temperature - Google Patents

Method for preparing ultrafine powder Qiangzhuang San at normal temperature Download PDF

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CN102430089B
CN102430089B CN 201110382926 CN201110382926A CN102430089B CN 102430089 B CN102430089 B CN 102430089B CN 201110382926 CN201110382926 CN 201110382926 CN 201110382926 A CN201110382926 A CN 201110382926A CN 102430089 B CN102430089 B CN 102430089B
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powder
screen drum
air
normal temperature
sieving
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CN102430089A (en
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李荣誉
曹凌杰
于瑞
马长宇
王伟伟
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HENAN HEALTH STAR PHARMACEUTICAL CO Ltd
Henan Kangxing Pharmaceutical Co Ltd
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HENAN HEALTH STAR PHARMACEUTICAL CO Ltd
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Abstract

The invention discloses a method for preparing ultrafine powder Qiangzhuang San at normal temperature, which comprises the following steps of: selecting Chinese herbal medicine decoction pieces such as pilose asiabell root, medicated leaven, malt, stir-fried hawthorn fruit, astragalus, tuckahoe, largehead atractylodes rhizome and katsumade galangal seed; cleaning, and drying until water content is less than or equal to 10 percent; grinding the Chinese herbal medicines at normal temperature to obtain coarse powder with the particle size of 60 to 120 meshes; uniformly mixing the obtained coarse powder in a ratio, putting into a rod mill for grinding, feeding into a special bidirectional airflow sieving machine through air, sieving with a 500-mesh screen, conveying powder which is obtained by sieving and has the particle size of less than or equal to 25 micrometers to a cyclone collector through airflow generated by a draught fan, and collecting to obtain a finished ultrafine powder Qiangzhuang San product; and collecting powder which does not pass through the 500-mesh screen by using a funnel, conveying to the rod mill through a pipeline, and performing cyclic grinding. The method has the advantages that: the whole preparation process is performed at normal temperature, the particle size of the prepared finished product medicine is less than or equal to 25 micrometers, and the cell wall breaking rate and bioavailability are greatly improved; and by the bidirectional airflow sieving machine used in the method, the preparation process for the ultrafine powder Qiangzhuang San is simplified.

Description

The strong loose normal temperature preparation method of superfine powder
Technical field
The present invention relates to the veterinary drug preparation field, especially relate to the strong loose normal temperature preparation method of superfine powder.
Background technology
Strong loose major function is replenishing QI to invigorate the spleen, and gastrointestinal function is namely regulated in the relieving dyspepsia that helps digestion, and facilitating digestion absorbs, enhancing immunity.Be applied at present the strong loose powder that mostly is coarse pulverization of domestic animal, have that dosage is large, dosage form thick, appearance poor, effective ingredient can not fully discharge, and bioavailability is low to be waited not enoughly, has had a strong impact on Chinese medicine quality and therapeutic effect.
The Study on Supermicro-pulverization of Traditional Chinese Drugs technology is to the renewal of traditional crushing technology and development; it had both kept the advantage of Chinese medicine technology of preparing; injected new vitality for the modern production of Chinese medicine again; have a extensive future, but remain in actual production in some problems and a difficult problem: (1) production efficiency is low, the power consumption height is the principal element of restriction veterinary Chinese medicine superfine powder large-scale production.Rod mill is in traditional closed circuit method crushing process, when most of material has reached fineness requirement, always there is the small part coarse powder to be mixed in wherein, make this part coarse powder further be crushed to the granularity that requires and need to significantly extend grinding time, make crush efficiency reduce, power consumption significantly increases; (2) it is poor that there are the material particular diameter uniformity after classification in selecting crude drugs with winnower classification and grading wheel classification, greatly affected the quality of production of herbal medicine compound recipe superfine powder, especially when being applied to the drinking water for animals use, due to a small amount of not existence of breaking cellular wall cell, be difficult to reach instructions for use.(3) traditional one-way gas flow screening, due to Chinese medicine when carrying out micronizing, along with reducing of particle diameter, material particles surface area and surface can increase, adsorptivity increases, and the mobility variation easily is gathered into bulky grain etc. and causes the sieve classification of crossing that surpasses 200 order fineness medicated powder to be difficult to carry out.The existence of above-mentioned factor has had a strong impact on standardization, the large-scale production of herbal medicine superfine powder, and the popularization on veterinary clinic and use.
Summary of the invention
The object of the invention is to provide a kind of superfine powder strong loose normal temperature preparation method, efficiently solve that the energy consumption that exists in present production is large, the medicine maximum particle diameter is difficult to accurate control, can't produce continuously, difficult problems such as dust is many in production process, make the finished medicines of preparation have rapid-action, good effect, bioavailability is high, the clinical application amount is few effect.
The strong loose normal temperature preparation method of superfine powder of the present invention comprises the steps:
The first step, choose crude drug decoction pieces Radix Codonopsis, Massa Medicata Fermentata, Fructus Hordei Germinatus, Fructus Crataegi (parched), the Radix Astragali, Poria, the Rhizoma Atractylodis Macrocephalae, Semen Alpiniae Katsumadai respectively; Clean, dry or dry to moisture≤10%;
Second step, respectively that above-mentioned raw materials medicated powder is broken at 20 ℃~25 ℃ temperature, obtaining granularity is 60~120 purpose coarse powder;
The 3rd the step, second step gained coarse powder is pressed Radix Codonopsis: the weight ratio mix homogeneously of Massa Medicata Fermentata: Fructus Hordei Germinatus: Fructus Crataegi (parched): the Radix Astragali: Poria: the Rhizoma Atractylodis Macrocephalae: Semen Alpiniae Katsumadai=10:3.5:3.5:3.5:10:7.5:5:7;
The 4th step, with the 3rd step gained coarse powder be placed in pulverize in rod mill after, be fed into special bilateral airflow sieving machine by wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine is transported to collect in tornado feeder set and namely gets the strong loose finished product of superfine powder; Do not cross the powder of 500 mesh sieves and collect and be transported to by pipeline circulation pulverizing again in described rod mill through funnel;
The described bidirectional airflow sieving machine process of sieving is:
Powder body to be fractionated is arranged in the downward screen drum of bidirectional airflow sieving machine chassis cavity intermediate openings entering into through wind stopping device, feed pipe under the power of the blowing effect of powder conveying fan in rod mill, and by the low impulsive force of powder body to be fractionated in screen drum of buffering parachuting, powder body to be fractionated is disperseed in screen drum; The powder body to be fractionated that disperses in screen drum carries out classification by screen drum under the air-introduced machine effect, the fine powder that passes screen drum namely gets the strong loose finished product of superfine powder collecting under the negative-pressure air-flow effect that air-introduced machine produces in the negative pressure chamber on bidirectional airflow sieving machine casing top is transported to tornado feeder set; The door font rotation spray trachea that is made of transverse tube and standpipe is arranged at the region division between screen drum and casing, door font rotation spray trachea forms even blowback air-flow in screen drum at screen drum end face and side, powder body in screen drum is further atomized, stop simultaneously the powder body blocking screen mesh that lumps on screen drum, do not make to collect in funnel along with the air-flow whirlpool that forms sinks to entering by the powder body of screen drum and be transported in rod mill circulation again by pipeline and pulverize.
Special bilateral airflow sieving machine of the present invention comprises casing and the downward screen drum of chamber intermediate openings that sets within it, the order number of described screen drum 〉=500 orders; The nozzle of screen drum is connected mutually with the funnel upper shed that is arranged on the casing bottom; Chassis cavity is connected with air-introduced machine by the negative pressure chamber on top; The door font rotation spray trachea that is made of transverse tube and standpipe is arranged at the region division between screen drum and casing, the puff prot of described door font rotation spray trachea is for axially being opened in groove on its tube wall along described transverse tube and standpipe respectively, described groove is offered towards the screen drum direction respectively, the groove width 0.5-2 millimeter of groove, the middle part of transverse tube and drive motors driving coupling; Be provided with blast pipe in the screen drum centre position, the transverse tube middle part that the air outlet of described blast pipe passes screen drum and door font rotation spray trachea is connected and rolls by rolling bearing and is connected; The air inlet of blast pipe extends outside described hopper side walls and is connected with the blast orifice of aerator; Be provided with feed pipe in screen drum, be provided with the buffering umbrella above the discharging opening of described feed pipe, the charging aperture of feed pipe extends outside hopper side walls and is communicated with powder conveying fan air outlet through wind stopping device.
The air inducing of described air-introduced machine is pressed and is 1000pa, and the air inducing amount is 3000m 3/ h; The rotating speed of described drive motors is 155 rev/mins; The blast pressure of described aerator is 33kpa, and the blow rate required is 320m 3/ h; The wind pressure that goes out of described powder conveying fan is 24kpa, and air output is 150m 3/ h; The sidewall of described screen drum and roof respectively with corresponding standpipe and transverse tube between distance be 25 millimeters.
The invention has the advantages that whole preparation process all carries out at normal temperatures, do not need low temperature or special additional conditions; The final drug particle diameter of preparation≤25 microns, cell wall breaking rate and bioavailability have greatly been improved, strengthened pharmacological action, thereby reduced treatment disease dosage, saved medical material, also improve simultaneously abnormal smells from the patient and the mouthfeel of medicine, make the administration of direct employing water way be achieved, changed the deficiency that Chinese powder medicine can only spice can not be drunk water and take; The bidirectional airflow sieving machine that uses in the inventive method has been simplified the strong loose preparation technology of superfine powder greatly, has realized the purpose that the Chinese powder medicine quality standard is controlled, be suitable for large-scale industrial production.
The clinical therapeutic efficacy of preparation of the present invention is verified by following test:
Trial drug and grouping:
Table 1 test grouping and medicining condition
Group Number of animals (only) Medicining condition Usage and dosage
1 10 The blank group Not medication
2 10 Strong loose fine powder high dose group 50g/ pcs/day/spice
3 10 The strong loose high dose group of superfine powder 25g/ pcs/day/spice
4 10 The strong loose middle dosage group of superfine powder 20g/ pcs/day/spice
5 10 The strong loose low dose group of superfine powder 15g/ pcs/day/spice
Trial drug:
1): superfine powder is strong loose, adopts the present invention's preparation.
2): strong loose: according to two ones of " Chinese veterinary pharmacopoeia " versions in 2010, manufacture experimently at laboratory.
Test method: select about body weight 20kg, 50 of " DLY " tri-crossbreedings, consistent according to parity, kind is identical, body weight is close, the principle of male and female half and half, being divided at random 5 groups is respectively: blank group, strong loose fine powder high dose, the strong loose high dose group of superfine powder, the strong loose middle dosage group of superfine powder, the strong loose low dose group of superfine powder, each group provides identical basal diet to test, and experimental period is 30 days.(the results are shown in Table 2).
Table 2 is respectively organized medicine to the impact of pig growth performance
Group Starting weight/kg End weight/kg Average daily gain/g Average day feed consumption/kg The material anharmonic ratio
1 21.00±0.12 37.21±0.51 540.33±0.11 1.54 2.85:1
2 20.33±0.42 39.81±0.21 649.33±0.21 1.48 2.28:1
3 20.56±0.42 41.76±0.17 706.66±0.54 1.50 2.12:1
4 20.03±0.42 39.01±0.21 632.67±0.44 1.49 2.39:1
5 20.62±0.42 38.45±0.19 594.33±0.17 1.52 2.56:1
Can find out from the result of the test that table 2 shows, in average daily gain, each organizes that all there were significant differences (p<0.05) the strong loose high dose group of superfine powder and other, illustrates that the strong loose high dose group of superfine powder can obviously improve the growth performance of pig.On average daily feed consumption rate, strong loose group of each group of superfine powder and blank group do not have significant difference, and the strong loose normal feed intake that does not affect pig of superfine powder is described.On the material anharmonic ratio, the strong loose high dose group of superfine powder can obviously reduce the material anharmonic ratio, and there were significant differences (p<0.05) with the blank group, piglet had good growth promoting function, and can obtain economic benefit preferably.Can think the strong raising piglet growth performance that is dispersed in of superfine powder, reduce feedstuff-meat ratio, reduce the diarrhea rate aspect and reach good effect.On pharmaceutical quantities, the strong loose high dose group of superfine powder is only half of strong loose fine powder group consumption, has greatly saved medical material, has reduced the medical material consumption.
Description of drawings
Fig. 1 is the production equipment system figure of the method for the invention.
Fig. 2 is the structural representation of special bilateral airflow sieving machine of the present invention.
The specific embodiment
As shown in Figure 1, 2, the strong loose normal temperature preparation method of superfine powder of the present invention comprises the steps:
The first step, choose crude drug decoction pieces Radix Codonopsis, Massa Medicata Fermentata, Fructus Hordei Germinatus, Fructus Crataegi (parched), the Radix Astragali, Poria, the Rhizoma Atractylodis Macrocephalae, Semen Alpiniae Katsumadai respectively; Clean, dry or dry to moisture≤10%;
Second step, respectively that above-mentioned raw materials medicated powder is broken at 20 ℃~25 ℃ temperature, obtaining granularity is 60~120 purpose coarse powder;
The 3rd the step, second step gained coarse powder is pressed Radix Codonopsis: the weight ratio mix homogeneously of Massa Medicata Fermentata: Fructus Hordei Germinatus: Fructus Crataegi (parched): the Radix Astragali: Poria: the Rhizoma Atractylodis Macrocephalae: Semen Alpiniae Katsumadai=10:3.5:3.5:3.5:10:7.5:5:7;
The 4th goes on foot, at first opens powder conveying fan 15, air-introduced machine 5, aerator 11, drive motors 8.The blow pressure of powder conveying fan 15 is 24kpa, and the blowing amount is 150m 3/ h; The air inducing of air-introduced machine 5 is pressed and is 1000pa, and the air inducing amount is 3000m 3/ h; The blast pressure of aerator 11 is 33kpa, blow rate required 320m 3/ h; The rotating speed of drive motors 8 is 155 rev/mins;
1, with after the 3rd step, the gained coarse powder was placed in the interior pulverizing of rod mill 16, the interior powder body to be fractionated of rod mill 16 is arranged in the downward screen drum 2 of casing 1 inner chamber intermediate openings being brought into by high velocity air through wind stopping device 14, feed pipe 12 under the power of the blowing effect of powder conveying fan 15, and reduce the impulsive force of powder body to be fractionated in screen drum 2 by buffering umbrella 13, make powder body to be fractionated in the interior dispersion of screen drum 2; The order number of screen drum 2 is 500 orders;
2, the powder body to be fractionated of screen drum 2 interior dispersions carries out classification by screen drum 2 under air-introduced machine 5 effect, and the fine powder that passes screen drum 2 namely gets the strong loose finished product of superfine powder collecting under the negative-pressure air-flow effect that air-introduced machine 5 produces in the negative pressure chamber 4 on casing 1 top is transported to tornado feeder set 17.The powder body by screen drum 2 does not sink through collecting with the funnel 3 that screen drum 2 under sheds are connected mutually and being transported to circulation pulverizing again in described rod mill 16 by pipeline 18;
3, door font rotation spray trachea rotates by rolling bearing 10 under drive motors 8 drives, the wind that aerator 11 is sent is in blast pipe 9 enters described transverse tube 6 and standpipe 7, and through be opened in vertically respectively the puff prot ejection that has the groove structure on transverse tube 6 and standpipe 7 tube walls towards screen drum 2 directions, form even blowback air-flow in screen drum 2 at screen drum 2 end faces and side, powder body in screen drum 2 is further atomized, stop simultaneously the powder body blocking screen mesh that lumps on screen drum 2, make not powder body by screen drum 2 along with the air-flow whirlpool that forms sinks to entering in funnel 3.The groove width that is opened in vertically respectively groove on transverse tube 6 and standpipe 7 tube walls is selected between 0.5 millimeter-2 millimeters as required, between the roof of transverse tube 6 and standpipe 7 and corresponding screen drum 2 and sidewall apart from being respectively 25 millimeters.
The strong loose finished product of the superfine powder of gained is sub-packed in aluminium foil bag, every bag of 100g, 200g, 500g, 1000g or 2000g storage.

Claims (1)

1. the strong loose normal temperature preparation method of superfine powder, is characterized in that: comprise the steps:
The first step, choose crude drug decoction pieces Radix Codonopsis, Massa Medicata Fermentata, Fructus Hordei Germinatus, Fructus Crataegi (parched), the Radix Astragali, Poria, the Rhizoma Atractylodis Macrocephalae, Semen Alpiniae Katsumadai respectively; Clean, dry or dry to moisture≤10%;
Second step, respectively that above-mentioned raw materials medicated powder is broken at 20 ℃~25 ℃ temperature, obtaining granularity is 60~120 purpose coarse powder;
The 3rd the step, second step gained coarse powder is pressed Radix Codonopsis: the weight ratio mix homogeneously of Massa Medicata Fermentata: Fructus Hordei Germinatus: Fructus Crataegi (parched): the Radix Astragali: Poria: the Rhizoma Atractylodis Macrocephalae: Semen Alpiniae Katsumadai=10:3.5:3.5:3.5:10:7.5:5:7;
The 4th step, with the 3rd step gained coarse powder be placed in pulverize in rod mill (16) after, be fed into special bilateral airflow sieving machine by wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine (5) is transported to that in tornado feeder set (17), collection namely gets the strong loose finished product of superfine powder; The powder of not crossing 500 mesh sieves is collected and is passed through pipeline (18) through funnel (3) and is transported in described rod mill (16) circulation again and pulverizes; The described bidirectional airflow sieving machine process of sieving is:
Powder body to be fractionated is arranged in the downward screen drum (2) of bidirectional airflow sieving machine casing (1) inner chamber intermediate openings entering into through wind stopping device (14), feed pipe (12) under the power of the blowing effect of powder conveying fan (15) in rod mill (16), and reduce the impulsive force of powder body to be fractionated in screen drum (2) by buffering umbrella (13), powder body to be fractionated is disperseed in screen drum (2); The powder body to be fractionated that disperses in screen drum (2) carries out classification by screen drum (2) air-introduced machine (5) effect is lower, the fine powder that passes screen drum (2) under the negative-pressure air-flow effect of air-introduced machine (5) generation in the negative pressure chamber (4) on bidirectional airflow sieving machine casing (1) top is transported to tornado feeder set (17) collection namely get the strong loose finished product of superfine powder; At the region division that is positioned between screen drum (2) and casing (1), the door font rotation spray trachea that is made of transverse tube (6) and standpipe (7) is arranged, door font rotation spray trachea forms evenly the blowback air-flow in the screen drum (2) in screen drum (2) end face and side, powder body in screen drum (2) is further atomized, stop simultaneously powder body at the upper blocking screen mesh that lumps of screen drum (2), make not collect in funnel (3) along with the air-flow whirlpool that forms sinks to entering and pass through pipeline (18) by the powder body of screen drum (2) to be transported to circulation pulverizing again in rod mill (16).
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CN102406688B (en) * 2011-11-28 2013-12-04 河南省康星药业股份有限公司 Normal-temperature preparation method of codonopsis pilosula submicron powder
CN103211093A (en) * 2013-03-27 2013-07-24 广州绿州生物技术有限公司 Chinese herbal medicine growth promotion feed additive for livestock and preparation method of feed additive
CN107348363A (en) * 2017-08-01 2017-11-17 重庆保卫食品有限公司 Method for crushing fermented soya bean caking
CN107223875A (en) * 2017-08-01 2017-10-03 重庆保卫食品有限公司 A kind of device of broken fermented soya bean caking

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