CN102485216A - Taste-modifying medicine tablets - Google Patents
Taste-modifying medicine tablets Download PDFInfo
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- CN102485216A CN102485216A CN2010105749846A CN201010574984A CN102485216A CN 102485216 A CN102485216 A CN 102485216A CN 2010105749846 A CN2010105749846 A CN 2010105749846A CN 201010574984 A CN201010574984 A CN 201010574984A CN 102485216 A CN102485216 A CN 102485216A
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- medicine
- tablets
- taste
- modifying
- oral cavity
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Abstract
The invention relates to taste-modifying tablets, and more specifically taste-modifying medicine tablets which can be rapidly dissolved in an oral cavity and assist in transferring substances into the oral cavity. The tablets are composed of a medicine additive substance, cellulose hydroxypropyl methyl, pullulan polysaccharide, glycerin, and a taste modifying agent. Without the aid of water, the tablets can be rapidly dissolved in the oral cavity, and effective substances can be transferred into the oral cavity. The tablets are convenient to take. According to the invention, the taste modifying agent is added to the taste-modifying tablets, such that the bitter taste and odor of the medicine can be effectively inhibited and screened. Therefore, the tablets can easily be accepted by patients.
Description
Technical field
The present invention relates to a kind of refreshing tablets, more particularly, the present invention relates to a kind of can in the oral cavity, dissolve fast and to the medicine refreshing tablets of oral cavity transmitter substance.
Background technology
Present most of solid orally ingestible, like tablet, medicated powder, soft gelatin capsule, the most of need such as chewable tablet used water delivery service, if do not having to tend to delay the time of taking medicine under the situation of water.Some old peoples, infant and critically ill patient are because dysphagia; Be difficult to oral solid formulation is swallowed down; Even possibly cause respiratory tract infraction and produce and suffocate, also have some can produce the patient of the sense of feeling sick to the solid preparation of swallowing, be difficult to various oral solid formulations are swallowed down.So press for and a kind ofly can solve dysphagia, can reach a kind of new technique of taking oral solid formulation again.The thin-film carrier technology has solved this difficult problem, and it is and can in the oral cavity, combine by rapidly-soluble membrane some drug additives, health care medicine, medicine, at present, does not also have the more sophisticated product of correlation ratio on the domestic market.
Summary of the invention
The objective of the invention is provides a kind of component simple in order to overcome weak point of the prior art, does not need the water clothes just can in the oral cavity, dissolve the non-clothes type medicine refreshing tablets of telling of taking convenience fast.
In order to achieve the above object, the present invention adopts following scheme:
In sum, advantage of the present invention is following:
1, medicine refreshing tablets of the present invention is processed by medicine substance, hydroxypropyl emthylcellulose, pulullan polysaccharide, glycerol and correctives, and its composition is simple, and production cost is relatively low.
2, medicine refreshing tablets of the present invention does not need water delivery service just can in the oral cavity, dissolve fast and transmits effective substance, taking convenience to the oral cavity.
3, medicine refreshing tablets of the present invention makes the dissolution velocity of this film composition in the oral cavity can reach 8-10 second through improving the ratio of filmogen in the prescription, has improved the dissolution velocity of film, helps property of medicine material snap action in human body.
4, the present invention adds correctives in the medicine refreshing tablets, effectively suppresses and shielded the bitterness of medicine, and abnormal flavour etc. help taking of patient.
The specific embodiment
Below in conjunction with embodiment the present invention is further described:
Medicine refreshing tablets of the present invention, form by following components in weight percentage:
Medicine substance 1-40%
Hydroxypropyl emthylcellulose 20-65%
Pulullan polysaccharide 5-25%
Glycerol 5-15%
Correctives is an amount of
Embodiment 1
The medicine refreshing tablets comprises following substances in parts by weight in the present embodiment:
Borneolum Syntheticum 10
Hydroxypropyl methylcellulose 200
Pulullan polysaccharide 50
Glycerol 50
Sucrose 100
The said components material is processed the medicine refreshing tablets by following method for preparing:
1, colloidal sol: the hydroxypropyl emthylcellulose of the place's of taking by weighing 200 weight portions is put into container, adds an amount of water, swelling 4-6 hour; Process glue A; The pulullan polysaccharide of the place's of taking by weighing 50 weight portions is processed glue liquid B after the same method, and A and B are mixed the back evenly, processes rubber cement; Add 50 weight portions glycerol, 10 parts Borneolum Syntheticum and the sucrose of 100 weight portions, mix the back evenly;
2, coating: on even coating of rubber cement and centrifugal paper;
3, oven dry: the glue that will coat on the centrifugal paper is put into 105 ℃ baking oven 10min;
4, conjunctiva: forge the thin film after the oven dry gently;
5, cutting: cut into 2*2cm, about 30mg/ sheet.
Embodiment 2
The medicine refreshing tablets comprises following substances in parts by weight in the present embodiment:
Indigo Naturalis 40
Hydroxypropyl methylcellulose 65
Pulullan polysaccharide 25
Glycerol 15
Glucose 50
The said components material is processed the medicine refreshing tablets by following method for preparing:
1, colloidal sol: the hydroxypropyl emthylcellulose of the place's of taking by weighing 65 weight portions is put into container, adds an amount of water, swelling 4-6 hour; Process glue A; The pulullan polysaccharide of the place's of taking by weighing 25 weight portions is processed glue liquid B after the same method, and A and B are mixed the back evenly, processes rubber cement; Add 15 weight portions the glucose of glycerol, 40 weight portion Indigo Naturaliss and 50 weight portions, mix the back evenly;
2, coating: on even coating of rubber cement and centrifugal paper;
3, oven dry: the glue that will coat on the centrifugal paper is put into 105 ℃ baking oven 10min;
4, conjunctiva: forge the thin film after the oven dry gently;
5, cutting: cut into 2*2cm, about 30mg/ sheet.
Embodiment 3
The medicine refreshing tablets comprises following substances in parts by weight in the present embodiment:
The mixture 30 of Realgar, dried Alumen, Borneolum Syntheticum
Hydroxypropyl methylcellulose 45
Pulullan polysaccharide 20
Glycerol 8
Sweetener 20
The said components material is processed the medicine refreshing tablets by following method for preparing:
1, colloidal sol: the hydroxypropyl emthylcellulose of the place's of taking by weighing 45 weight portions is put into container, adds an amount of water, swelling 4-6 hour; Process glue A; The pulullan polysaccharide of the place's of taking by weighing 20 weight portions is processed glue liquid B after the same method, and A and B are mixed the back evenly, processes rubber cement; Add 8 weight portions glycerol, Realgar, dried Alumen, the mixture of Borneolum Syntheticum and the sweetener of 20 weight portions of 30 weight portions, mix the back evenly;
2, coating: on even coating of rubber cement and centrifugal paper;
3, oven dry: the glue that will coat on the centrifugal paper is put into 105 ℃ baking oven 10min;
4, conjunctiva: forge the thin film after the oven dry gently;
5, cutting: cut into 2*2cm, about 30mg/ sheet.
Claims (6)
1. medicine refreshing tablets, form by following components in weight percentage:
Medicine substance 1-40%
Hydroxypropyl emthylcellulose 20-65%
Pulullan polysaccharide 5-25%
Glycerol 5-15%
Correctives is an amount of
2. medicine refreshing tablets according to claim 1, form by following components in weight percentage:
Medicine substance 20-30%
Hydroxypropyl emthylcellulose 20-45%
Pulullan polysaccharide 15-20%
Glycerol 8-10%
Correctives is an amount of
3. medicine refreshing tablets according to claim 1, wherein the medicine substance can be the medicine of treatment oral ulcer.
4. medicine refreshing tablets according to claim 1, wherein hydroxyl alkane methylcellulose is a hydroxypropyl methylcellulose.
5. medicine refreshing tablets according to claim 1, wherein correctives is sucrose, glucose or sweetener.
6. medicine refreshing tablets according to claim 3, the medicine of wherein treating oral ulcer are Realgar, dried Alumen, Borneolum Syntheticum mixture, Indigo Naturalis or Borneolum Syntheticum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105749846A CN102485216A (en) | 2010-12-03 | 2010-12-03 | Taste-modifying medicine tablets |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105749846A CN102485216A (en) | 2010-12-03 | 2010-12-03 | Taste-modifying medicine tablets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102485216A true CN102485216A (en) | 2012-06-06 |
Family
ID=46150811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010105749846A Pending CN102485216A (en) | 2010-12-03 | 2010-12-03 | Taste-modifying medicine tablets |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102485216A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102987202A (en) * | 2012-11-01 | 2013-03-27 | 汕头市金平区嘉士隆食品实业有限公司 | Film-like lozenge and manufacturing method thereof |
| CN114949232A (en) * | 2018-06-13 | 2022-08-30 | 南京紫鸿生物科技有限公司 | Sugar fine particles and preparation method, equipment and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1500521A (en) * | 2002-06-18 | 2004-06-02 | 山东绿叶制药股份有限公司 | Keep-in-mouth tablet for oral ulcer and preparation method |
| CN1686163A (en) * | 2005-03-28 | 2005-10-26 | 彭招源 | Medicine for treating oral cavity ulcer |
| CN1706269A (en) * | 2005-05-17 | 2005-12-14 | 汕头市富味制果厂有限公司 | Instant tasty and refreshing tablet and its making process |
| CN1706366A (en) * | 2005-04-28 | 2005-12-14 | 美晨集团股份有限公司 | Breath freshening tablet |
-
2010
- 2010-12-03 CN CN2010105749846A patent/CN102485216A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1500521A (en) * | 2002-06-18 | 2004-06-02 | 山东绿叶制药股份有限公司 | Keep-in-mouth tablet for oral ulcer and preparation method |
| CN1686163A (en) * | 2005-03-28 | 2005-10-26 | 彭招源 | Medicine for treating oral cavity ulcer |
| CN1706366A (en) * | 2005-04-28 | 2005-12-14 | 美晨集团股份有限公司 | Breath freshening tablet |
| CN1706269A (en) * | 2005-05-17 | 2005-12-14 | 汕头市富味制果厂有限公司 | Instant tasty and refreshing tablet and its making process |
Non-Patent Citations (3)
| Title |
|---|
| 傅超美等: "《药用辅料学》", 31 October 2008, 中国中医药出版社 * |
| 刘谋泉，孔美兰: "以普鲁兰多糖为粘合剂的维生素C泡腾片的工艺研究", 《食品工业科技》 * |
| 金征宇等: "《碳水化合物化学-原理与应用》", 31 January 2008, 化学工业出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102987202A (en) * | 2012-11-01 | 2013-03-27 | 汕头市金平区嘉士隆食品实业有限公司 | Film-like lozenge and manufacturing method thereof |
| CN102987202B (en) * | 2012-11-01 | 2014-07-23 | 汕头市金平区嘉士隆食品实业有限公司 | Film-like lozenge and manufacturing method thereof |
| CN114949232A (en) * | 2018-06-13 | 2022-08-30 | 南京紫鸿生物科技有限公司 | Sugar fine particles and preparation method, equipment and application thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120606 |