CN102471767B - 利用稳定辅酶的酶的稳定化 - Google Patents
利用稳定辅酶的酶的稳定化 Download PDFInfo
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- CN102471767B CN102471767B CN201080036800.9A CN201080036800A CN102471767B CN 102471767 B CN102471767 B CN 102471767B CN 201080036800 A CN201080036800 A CN 201080036800A CN 102471767 B CN102471767 B CN 102471767B
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Classifications
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
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- C12Y—ENZYMES
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- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01001—Alcohol dehydrogenase (1.1.1.1)
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- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01002—Alcohol dehydrogenase (NADP+) (1.1.1.2), i.e. aldehyde reductase
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01047—Glucose 1-dehydrogenase (1.1.1.47)
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- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01049—Glucose-6-phosphate dehydrogenase (1.1.1.49)
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- C12Y—ENZYMES
- C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)
- C12Y106/05—Oxidoreductases acting on NADH or NADPH (1.6) with a quinone or similar compound as acceptor (1.6.5)
- C12Y106/05002—NAD(P)H dehydrogenase (quinone) (1.6.5.2)
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- C12Y—ENZYMES
- C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)
- C12Y106/99—Oxidoreductases acting on NADH or NADPH (1.6) with other acceptors (1.6.99)
Landscapes
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- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
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| EP09168327.6 | 2009-08-20 | ||
| EP09168327A EP2292751A1 (de) | 2009-08-20 | 2009-08-20 | Stabilisierung von Enzymen mit stabilen Coenzymen |
| PCT/EP2010/062045 WO2011020856A1 (de) | 2009-08-20 | 2010-08-18 | Stabilisierung von enzymen mit stabilen coenzymen |
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| CN102471767A CN102471767A (zh) | 2012-05-23 |
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| WO2011012270A1 (en) * | 2009-07-27 | 2011-02-03 | Roche Diagnostics Gmbh | Enzymatic synthesis of carba-nad |
| EP2292751A1 (de) * | 2009-08-20 | 2011-03-09 | Roche Diagnostics GmbH | Stabilisierung von Enzymen mit stabilen Coenzymen |
| US8787944B2 (en) | 2011-08-18 | 2014-07-22 | Rivada Research, Llc | Method and system for providing enhanced location based information for wireless handsets |
| EP2636750A1 (en) | 2012-03-06 | 2013-09-11 | Roche Diagniostics GmbH | Compatible solute ectoine as well as derivatives thereof for enzyme stabilization |
| CN104704367A (zh) * | 2012-08-09 | 2015-06-10 | 基础服务农业研究院 | 膜组件和包含这种膜组件的侧流免疫测定装置 |
| US8921061B2 (en) | 2012-11-02 | 2014-12-30 | Roche Diagnostics Operations, Inc. | Reagent materials and associated test elements |
| EP2770064A1 (de) * | 2013-02-22 | 2014-08-27 | F. Hoffmann-La Roche AG | Hocheffiziente Herstellung von Blutglucose-Teststreifen |
| KR101847758B1 (ko) | 2014-01-24 | 2018-04-10 | 에프. 호프만-라 로슈 아게 | 유니- 및 노-코드 테스트 스트라이프 제조 방법 |
| PL3523639T3 (pl) | 2016-10-05 | 2025-03-17 | F. Hoffmann-La Roche Ag | Odczynniki wykrywające i układy elektrod do elementów diagnostycznych testów wieloanalitowych oraz sposoby ich zastosowania |
| EP3339431A1 (en) * | 2016-12-22 | 2018-06-27 | Roche Diabetes Care GmbH | Glucose dehydrogenase variants with improved properties |
| US12215359B2 (en) | 2019-05-01 | 2025-02-04 | Codexis, Inc. | Engineered glucose dehydrogenases and methods for the reductive amination of ketone and amine compounds |
| WO2020242967A1 (en) * | 2019-05-28 | 2020-12-03 | W. L. Gore & Associates, Inc. | Stabilized medical device and method for making it |
| US11918355B2 (en) * | 2019-08-30 | 2024-03-05 | Abbott Diabetes Care Inc. | Analyte sensors and sensing methods for the detection of alcohol |
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| CN101233144A (zh) * | 2005-07-28 | 2008-07-30 | 霍夫曼-拉罗奇有限公司 | 稳定的nad/nadh衍生物 |
| EP2093284A1 (de) * | 2008-02-19 | 2009-08-26 | F.Hoffmann-La Roche Ag | Stabilisierung von Dehydrogenasen mit stabilen Coenzymen |
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| DE2061984C3 (de) | 1970-12-16 | 1974-04-11 | Boehringer Mannheim Gmbh, 6800 Mannheim | Reagens zur Bestimmung der Lactat-Dehydrogenase im Farbtest |
| US5032506A (en) | 1986-12-16 | 1991-07-16 | Enzymatics, Inc. | Color control system |
| US5609718A (en) | 1995-09-29 | 1997-03-11 | Micron Technology, Inc. | Method and apparatus for measuring a change in the thickness of polishing pads used in chemical-mechanical planarization of semiconductor wafers |
| DE19543493A1 (de) * | 1995-11-22 | 1997-05-28 | Boehringer Mannheim Gmbh | Stabilisierte Coenzym-Lösungen und deren Verwendung zur Bestimmung von Dehydrogenasen bzw. deren Substrate im alkalischen Milieu |
| US5801006A (en) | 1997-02-04 | 1998-09-01 | Specialty Assays, Inc. | Use of NADPH and NADH analogs in the measurement of enzyme activities and metabolites |
| US6380380B1 (en) | 1999-01-04 | 2002-04-30 | Specialty Assays, Inc. | Use of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucliotide phosphate (NADP) analogs to measure enzyme activities metabolites and substrates |
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| WO2001094370A1 (en) | 2000-06-07 | 2001-12-13 | Wako Pure Chemical Industries, Ltd. | Coenzyme derivatives and enzymes appropriate therefor |
| BR0309947B1 (pt) | 2002-05-16 | 2013-11-26 | Processo e dispositivo para produção de camadas de polímero sobre um suporte transparente, sua utilização e processo para produção de um sensor | |
| MXPA06001719A (es) | 2003-08-11 | 2006-05-19 | Codexis Inc | Polipeptidos de glucosa deshidrogenasa mejorados, y polinucleotidos relacionados. |
| DE102006035020B4 (de) * | 2005-07-28 | 2018-08-23 | Roche Diabetes Care Gmbh | Stabilisierung von NAD/NADH |
| US7553615B2 (en) | 2005-07-28 | 2009-06-30 | Roche Diagnostics Operations, Inc. | Compounds, methods, complexes, apparatuses and uses relating to stabile forms of NAD/NADH |
| US20070196899A1 (en) | 2005-11-29 | 2007-08-23 | Sony Corporation | Mutant protein having diaphorase activity |
| GB0625671D0 (en) | 2006-12-21 | 2007-01-31 | Oxford Biosensors Ltd | Protein formulation |
| EP1964927A1 (de) * | 2007-02-27 | 2008-09-03 | F. Hoffmann-La Roche AG | Chinone als Mediatoren für photometrische Teste |
| EP2287605A1 (de) * | 2009-08-20 | 2011-02-23 | Roche Diagnostics GmbH | Vereinfachte Magazinierung integrierter Systeme |
| EP2292751A1 (de) * | 2009-08-20 | 2011-03-09 | Roche Diagnostics GmbH | Stabilisierung von Enzymen mit stabilen Coenzymen |
| EP2333544A1 (de) * | 2009-12-11 | 2011-06-15 | F. Hoffmann-La Roche AG | Sterilisierbare Chemie für Testelemente |
| WO2011073258A1 (de) * | 2009-12-16 | 2011-06-23 | F. Hoffmann-La Roche Ag | Detektion der zersetzung von enzymen in einem testelement durch kontrollierte freisetzung von geschütztem analyt |
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2009
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- 2010-08-18 WO PCT/EP2010/062045 patent/WO2011020856A1/de not_active Ceased
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| CN101233144A (zh) * | 2005-07-28 | 2008-07-30 | 霍夫曼-拉罗奇有限公司 | 稳定的nad/nadh衍生物 |
| EP2093284A1 (de) * | 2008-02-19 | 2009-08-26 | F.Hoffmann-La Roche Ag | Stabilisierung von Dehydrogenasen mit stabilen Coenzymen |
| CN101945999A (zh) * | 2008-02-19 | 2011-01-12 | 霍夫曼-拉罗奇有限公司 | 使用稳定辅酶的脱氢酶稳定作用 |
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| Separation and Properties of Two Novel NADP+-dependent Alcohol Dehydrogenases from Euglena gracilis Z;Iqbal Munir et al;《Pakistan Journal of Biological Sciences》;20061231;第9卷(第15期);2743-2747 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102471767A (zh) | 2012-05-23 |
| CA2770249C (en) | 2015-04-28 |
| KR20120064076A (ko) | 2012-06-18 |
| US20170073661A1 (en) | 2017-03-16 |
| US20120276565A1 (en) | 2012-11-01 |
| JP5851401B2 (ja) | 2016-02-03 |
| JP2013502212A (ja) | 2013-01-24 |
| EP2292751A1 (de) | 2011-03-09 |
| WO2011020856A1 (de) | 2011-02-24 |
| KR20150070443A (ko) | 2015-06-24 |
| EP2467478A1 (de) | 2012-06-27 |
| MX2012001946A (es) | 2012-04-02 |
| KR101554457B1 (ko) | 2015-09-30 |
| CA2770249A1 (en) | 2011-02-24 |
| EP2467478B1 (de) | 2015-09-16 |
| US9540702B2 (en) | 2017-01-10 |
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