CN102462861A - 一种医用金属植入材料多孔钽的制备方法 - Google Patents
一种医用金属植入材料多孔钽的制备方法 Download PDFInfo
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- CN102462861A CN102462861A CN2010105470804A CN201010547080A CN102462861A CN 102462861 A CN102462861 A CN 102462861A CN 2010105470804 A CN2010105470804 A CN 2010105470804A CN 201010547080 A CN201010547080 A CN 201010547080A CN 102462861 A CN102462861 A CN 102462861A
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- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 title claims abstract description 143
- 229910052715 tantalum Inorganic materials 0.000 title claims abstract description 86
- 239000000463 material Substances 0.000 title claims abstract description 38
- 229910052751 metal Inorganic materials 0.000 title abstract description 23
- 239000002184 metal Substances 0.000 title abstract description 23
- 238000002360 preparation method Methods 0.000 title abstract description 13
- 239000007943 implant Substances 0.000 title abstract description 8
- 238000005245 sintering Methods 0.000 claims abstract description 79
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 36
- 239000006260 foam Substances 0.000 claims abstract description 36
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 35
- 239000002002 slurry Substances 0.000 claims abstract description 34
- 229920002472 Starch Polymers 0.000 claims abstract description 27
- 239000008107 starch Substances 0.000 claims abstract description 27
- 235000019698 starch Nutrition 0.000 claims abstract description 27
- 239000000843 powder Substances 0.000 claims abstract description 23
- 239000002245 particle Substances 0.000 claims abstract description 22
- 239000011812 mixed powder Substances 0.000 claims abstract description 17
- 238000000137 annealing Methods 0.000 claims abstract description 16
- 238000001035 drying Methods 0.000 claims abstract description 12
- 239000011230 binding agent Substances 0.000 claims abstract description 11
- 239000002270 dispersing agent Substances 0.000 claims abstract description 11
- 239000012153 distilled water Substances 0.000 claims abstract description 10
- 238000012805 post-processing Methods 0.000 claims abstract description 10
- 230000001681 protective effect Effects 0.000 claims abstract description 9
- 239000011261 inert gas Substances 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 claims description 51
- 238000009413 insulation Methods 0.000 claims description 39
- 229920005830 Polyurethane Foam Polymers 0.000 claims description 24
- 239000011496 polyurethane foam Substances 0.000 claims description 24
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 22
- 230000014759 maintenance of location Effects 0.000 claims description 15
- 238000001291 vacuum drying Methods 0.000 claims description 13
- 238000001816 cooling Methods 0.000 claims description 12
- 229910052786 argon Inorganic materials 0.000 claims description 11
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 9
- 239000001301 oxygen Substances 0.000 claims description 9
- 229910052760 oxygen Inorganic materials 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 8
- 238000007598 dipping method Methods 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- 230000011218 segmentation Effects 0.000 claims description 4
- 238000010792 warming Methods 0.000 claims description 4
- 239000011148 porous material Substances 0.000 abstract description 33
- 238000005470 impregnation Methods 0.000 abstract description 2
- 238000005238 degreasing Methods 0.000 abstract 1
- 238000004891 communication Methods 0.000 description 15
- 238000005452 bending Methods 0.000 description 11
- 239000008187 granular material Substances 0.000 description 9
- 229920003023 plastic Polymers 0.000 description 8
- 239000004033 plastic Substances 0.000 description 8
- 238000005303 weighing Methods 0.000 description 8
- 210000000988 bone and bone Anatomy 0.000 description 7
- 238000009826 distribution Methods 0.000 description 7
- 239000007789 gas Substances 0.000 description 7
- 239000012535 impurity Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 238000005187 foaming Methods 0.000 description 6
- 150000002739 metals Chemical class 0.000 description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 4
- 239000000428 dust Substances 0.000 description 4
- 229910052573 porcelain Inorganic materials 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 239000000470 constituent Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000007769 metal material Substances 0.000 description 3
- 229920002635 polyurethane Polymers 0.000 description 3
- 239000004814 polyurethane Substances 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 238000009827 uniform distribution Methods 0.000 description 3
- 206010028851 Necrosis Diseases 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 210000003054 facial bone Anatomy 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 210000002454 frontal bone Anatomy 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 239000006262 metallic foam Substances 0.000 description 2
- 230000017074 necrotic cell death Effects 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 230000011164 ossification Effects 0.000 description 2
- 206010031264 Osteonecrosis Diseases 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000007767 bonding agent Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000005234 chemical deposition Methods 0.000 description 1
- 238000005229 chemical vapour deposition Methods 0.000 description 1
- 230000001149 cognitive effect Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 210000000963 osteoblast Anatomy 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000003870 refractory metal Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
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Abstract
Description
实施例 | 钽粉粒径(μm)/氧含量(%) | 聚乙烯醇(g)/水(ml) | 钽粉加淀粉/聚乙烯醇水溶液(以重量份计) | 聚氨酯泡沫孔径(mm) | 聚氨酯泡沫密度(g/cm3) | 聚氨酯泡沫硬度(°) |
6 | 小于10/0.1% | 2/100 | 3.8/1 | 0.50 | 0.015 | 55 |
7 | 小于10/0.1% | 3/100 | 4.2/1 | 0.89 | 0.020 | 65 |
8 | 小于9.0/0.1% | 4/100 | 3.7/1 | 0.75 | 0.027 | 75 |
9 | 小于10/0.1% | 5/100 | 5.5/1 | 0.85 | 0.032 | 52 |
10 | 小于9.5/0.1% | 5/100 | 6.0/1 | 0.65 | 0.017 | 63 |
11 | 小于10/0.1% | 6/100 | 3.0/1 | 0.65 | 0.025 | 78 |
实施例 | 6 | 7 | 8 | 9 | 10 | 11 |
密度(g/cm3) | 8.2 | 7.8 | 6.4 | 5.3 | 4.8 | 5.5 |
孔隙率(%) | 51 | 53 | 61 | 68 | 71 | 65 |
孔径(μm) | 180 | 210 | 220 | 240 | 265 | 250 |
弹性模量(GPa) | 4.5 | 3.9 | 3.6 | 3.2 | 3.0 | 4.2 |
屈服强度(MPa) | 80 | 80 | 78 | 75 | 65 | 80 |
抗压强度(MPa) | 85 | 80 | 80 | 76 | 70 | 90 |
硬度(MPa) | 260 | 230 | 210 | 200 | 200 | 185 |
塑性变形量(%) | 11.30 | 11.20 | 10.25 | 10.22 | 9.28 | 9.29 |
抗拉强度(MPa) | 68 | 66 | 67 | 68 | 69 | 70 |
断后延展率(%) | 11.70 | 10.60 | 9.50 | 9.65 | 9.55 | 9.75 |
烧结颈断裂率(%) | 51 | 50 | 55 | 60 | 43 | 52 |
颗粒内部断裂率(%) | 49 | 50 | 45 | 40 | 57 | 41 |
Claims (9)
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN114855024A (zh) * | 2022-05-10 | 2022-08-05 | 南方科技大学 | 多孔钽医用植入材料及其制备方法和应用 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0560279A1 (en) * | 1992-03-11 | 1993-09-15 | Ultramet | Open cell tantalum structures for cancellous bone implants and cell and tissue receptors |
WO1997031738A1 (en) * | 1996-02-27 | 1997-09-04 | Astro Met, Inc. | Porous materials and method for producing |
WO2002066693A1 (en) * | 2001-02-19 | 2002-08-29 | Isotis N.V. | Porous metals and metal coatings for implants |
CN101250638A (zh) * | 2007-02-21 | 2008-08-27 | 德普伊产品公司 | 多孔金属泡沫结构及其制造方法 |
CN101549175A (zh) * | 2009-05-15 | 2009-10-07 | 中南大学 | 一种孔隙非均匀分布仿生骨质材料制造方法 |
EP2149414A1 (en) * | 2008-07-30 | 2010-02-03 | Nederlandse Centrale Organisatie Voor Toegepast Natuurwetenschappelijk Onderzoek TNO | Method of manufacturing a porous magnesium, or magnesium alloy, biomedical implant or medical appliance. |
-
2010
- 2010-11-17 CN CN201010547080.4A patent/CN102462861B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0560279A1 (en) * | 1992-03-11 | 1993-09-15 | Ultramet | Open cell tantalum structures for cancellous bone implants and cell and tissue receptors |
WO1997031738A1 (en) * | 1996-02-27 | 1997-09-04 | Astro Met, Inc. | Porous materials and method for producing |
WO2002066693A1 (en) * | 2001-02-19 | 2002-08-29 | Isotis N.V. | Porous metals and metal coatings for implants |
CN101250638A (zh) * | 2007-02-21 | 2008-08-27 | 德普伊产品公司 | 多孔金属泡沫结构及其制造方法 |
EP2149414A1 (en) * | 2008-07-30 | 2010-02-03 | Nederlandse Centrale Organisatie Voor Toegepast Natuurwetenschappelijk Onderzoek TNO | Method of manufacturing a porous magnesium, or magnesium alloy, biomedical implant or medical appliance. |
CN101549175A (zh) * | 2009-05-15 | 2009-10-07 | 中南大学 | 一种孔隙非均匀分布仿生骨质材料制造方法 |
Non-Patent Citations (2)
Title |
---|
《中国有色金属学报》 20101031 节云峰等 "烧结温度对泡沫铌力学性能及微观组织的影响" 第2014-2018页 1-9 第20卷, 第10期 * |
节云峰等: ""烧结温度对泡沫铌力学性能及微观组织的影响"", 《中国有色金属学报》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114855024A (zh) * | 2022-05-10 | 2022-08-05 | 南方科技大学 | 多孔钽医用植入材料及其制备方法和应用 |
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Inventor after: Ye Lei Inventor before: Ruan Jianming Inventor before: Ye Lei Inventor before: Xie Jianquan Inventor before: Jie Yunfeng Inventor before: Wang Zhiqiang Inventor before: Feng Hua Inventor before: Zhou Jian |
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Effective date of registration: 20151214 Address after: 400042 Chongqing city Yubei District Qinye Road No. 9 Patentee after: Chongqing Runze Pharmaceutical Co., Ltd. Address before: 325000 Zhejiang city of Wenzhou province Longwan high tech Industrial Park, Aojiang Road No. 81 building two floor B Patentee before: WENZHOU ZHICHUANG TECHNOLOGY CO., LTD. |