CN102461715A - Sugar-free chewing gum capable of preventing motion sickness and preparation method thereof - Google Patents

Abstract

The invention discloses sugar-free chewing gum capable of preventing motion sickness and a preparation method thereof. The sugar-free chewing gum is prepared from the following components by weight: 10 to 20 parts of medicinal powder, 25 to 35 parts of a gum base, 5 to 15 parts of xylitol, 35 to 45 parts of sorbitol, 5 to 15 parts of mannitol, 5 to 15 parts of maltitol slurry and 3 to 5 parts of a scenting agent, wherein, the medicinal powder is prepared from 15 to 30 parts of dried orange peel, 10 to 20 parts of mint, 15 to 30 parts of ginger, 5 to 10 parts of chrysanthemum, 5 to 10 parts of cluster cardamom, 5 to 10 parts of villous amomum fruit, 5 to 10 parts of banksia rose, 5 to 10 parts of wrinkled giant hyssop and 5 to 10 parts of taurine. Compared to conventional chewing gum, the chewing gum provided in the invention has the following characteristics: intake of sugar is reduced; a pure Chinese herbal preparation capable of preventing motion sickness is introduced; side effects on human bodies are lowered down to a minimum; administration by using chewing gum brings convenience to patients suffering from motion sickness, enables a peak-valley phenomenon occurred in oral administration of medicines to be effectively avoided and mitigates side effects caused by medicines, thereby widening the scope of recipients of the chewing gum and overcoming shortcomings in the prior art.

Description

A kind of sugar-free chewing gum and preparation method thereof with anti-motion sickness function

Technical field

The present invention relates to a kind of sugar-free chewing gum and preparation method thereof, belong to food processing field with anti-motion sickness function.

Background technology

Motion sickness is claimed motion sickness again, is carsick, seasick, airsick etc. general name.When it was meant riding public transportation means, human body vestibulum auris internae statoreceptor receives overexercise to stimulate, and vestibular organ produces excessive biological electricity, affect the nerves maincenter and being in a cold sweat of occurring, feel sick, syndromes such as vomiting, dizziness.The pathogenesis of motion sickness main with influence vestibular function relevant: the utricle of the inner ear labyrinthus membranaceus of vestibular apparatus and the capsule spot of sacculus be experience about and about rectilinear motion; Three semicircular canal hair cell impressions rotatablely move; When receiving a certain amount of undesired motion, capsule spot or hair cell stimulate caused nerve impulse; Reach nucleus (nervi) vestibularis by vestibular nerve successively, reach cerebellum and hypothalamus again, thereby cause that a series of is the clinical manifestation of cardinal symptom with dizzy.Overtired, hungry, satiety, health are weak, this disease can brought out or increase the weight of to stress and the wet vexed dirt of surrounding environment all.The treatment motion sickness adopts the sedation-analgesia medicine to suppress central excitation more at present; Alleviate the alimentary canal spasm; But these medicine performance curative effect times are longer; Need take in one hour in advance more, but also with dry, drowsiness, tired, eye-blurred even cause side effect such as glaucoma, seriously influenced normal work and life.Chewing gum is to be the basis of colloid with natural gum or glycerol resin, adds a kind of people of confession that mediation compactings such as syrup, peppermint, sweetener form and puts into the sugar that mouth is chewed food, not only can eat but also can play, so liked by the people of the world.Because the matrix stickiness of chewing gum is very strong, can remove the swill of dental surface, masticatory movement in addition; Mechanical stimulus can increase the secretion of saliva again; The flushing oral surfaces has the effect of certain oral cavity cleaning, chew gum; Promoted the exercise of facial blood circulation and muscle, the growth of tooth jaw face has been had facilitation.During chew gum, salivary secretion increases, and can promote digestion.Consider the processing chewing gum but at present commercially available chewing gum is many with the single function that cleans the teeth; The chewing gum product of prevention and treatment motion sickness does not also appear in the market at present; If additional effect of preventing and treating motion sickness in traditional chewing gum; Not only make things convenient for patient's use, but also can effectively avoid the existence of the peak valley phenomenon of oral drugs, alleviated the side effect that medicine brings.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of sugar-free chewing gum with anti-motion sickness function and preparation method thereof; This chewing gum is compared with traditional chewing gum and has not only been reduced sugared absorption, has also introduced the pure Chinese medicinal preparation with anti-motion sickness function, has not only made things convenient for motion sickness patient's use; But also can effectively avoid the existence of the peak valley phenomenon of oral drugs; Alleviate the side effect that medicine brings, thereby widened audient's face of product, overcome the deficiency of prior art.

For solving the problems of the technologies described above; The present invention adopts following technical scheme: a kind of sugar-free chewing gum with anti-motion sickness function; Calculate by weight, it is to be prepared from 10～20 parts of medicinal powder, 25～35 parts of matrixs, 5～15 parts of xylitols, 35～45 parts of sorbierites, 5～15 portions of sweet mellow wine, 5～15 parts of maltitol pulps and 3～5 parts of flavouring agents.

Aforesaid sugar-free chewing gum with anti-motion sickness function is preferably: calculate by weight, it is to be prepared from 15 parts of medicinal powder, 30 parts of matrixs, 10 parts of xylitols, 40 parts of sorbierites, 10 portions of sweet mellow wine, 10 parts of maltitol pulps and 4 parts of flavouring agents.

Aforesaid medicinal powder; Calculate by weight, it is prepared from 15～30 parts of dried orange peels, 10～20 portions of peppermints, 15～30 portions of gingers, 5～10 parts of chrysanthemums, 5～10 portions of Amomum cardamomums, 5～10 parts of fructus amomis, 5～10 parts of banksia rose, 5～10 portions of wrinkled giant hyssops and 5～10 parts of taurines.

Aforesaid medicinal powder calculates by weight, and it is prepared from 25 parts of dried orange peels, 15 portions of peppermints, 25 portions of gingers, 7 parts of chrysanthemums, 7 portions of Amomum cardamomums, 7 parts of fructus amomis, 7 parts of banksia rose, 7 portions of wrinkled giant hyssops and 7 parts of taurines.

Aforesaid matrix calculates by weight, comprises 20～30 parts of elastomers, 20～30 parts of fillers, 5～15 parts of natural gums, 5～15 parts of plasticizer, 5～7 parts of waxes and 5～7 parts of vegetation water colloids.

Aforesaid elastomer is one or both in polybutene and the polyisobutene; Aforesaid filler is one or both in Dicalcium Phosphate and the magnesium carbonate; Aforesaid natural gum is one or both in Arabic gum and the gutta-percha; Aforesaid plasticizer is in resin and the frankincense one or both of resting in peace; Aforesaid wax is one or both in Brazil wax and the beeswax; Aforesaid vegetation water colloid is one or both in agar and the alginic acid.

Aforesaid flavouring agent is fruit flavors or mint flavored dose.

Aforesaid fruit flavors is one or both in isopropyl isobutyrate and the ethyl butyrate; Aforesaid mint flavored dose is in Fructus Piperis peppermint oil and the spearmint leaf roll peppermint oil one or both.

Aforesaid preparation method with sugar-free chewing gum of anti-motion sickness function comprises following steps:

The preparation of a medicinal powder: take by weighing dried orange peel, peppermint, ginger, chrysanthemum, Amomum cardamomum, fructus amomi, the banksia rose, wrinkled giant hyssop and taurine in proportion, boiling 3 times filters merging filtrate; Filtrating is condensed into medicinal extract, in medicinal extract, adds ethanol, leaves standstill, and draws supernatant, filter, and filtrate recycling ethanol, decompression concentrates, and gets dry extract, and dried cream powder is broken to sieve, and promptly gets;

B gets the matrix mixture by above-mentioned weight portion, evenly stirs and be heated to fusion;

C adds xylitol, sorbierite, sweet mellow wine, maltitol pulp, mint flavored dose and medicinal powder by aforementioned weight in the matrix mixture of fusion, stir, and cooling promptly gets.

Aforesaid preparation method with sugar-free chewing gum of anti-motion sickness function is specially:

The preparation of a medicinal powder: take by weighing dried orange peel, peppermint, ginger, chrysanthemum, Amomum cardamomum, fructus amomi, the banksia rose, wrinkled giant hyssop and taurine in proportion, boiling 3 times adds 8 times of water gagings for the first time, and second and third time respectively adds 6 times of water gagings, decocts 1 hour at every turn, filters merging filtrate; It is 1.1 medicinal extract that filtrating is concentrated into 50 ℃ of relative densities, adds ethanol in the medicinal extract and makes that to contain the alcohol amount be 70%, leaves standstill the absorption supernatant 24 hours; Filter, filtrate recycling ethanol, decompression concentrates, drying under reduced pressure below 80 ℃; Get dry extract, broken mistake 350～450 mesh sieves of dried cream powder promptly get;

B gets the matrix mixture by above-mentioned weight portion, evenly stirs, and under 40～50 ℃, smokes to be molten to the matrix mixture in 4～6 hours;

C keeps 45 ℃, by aforementioned weight, in the matrix mixture of fusion, adds xylitol, sorbierite, sweet mellow wine, maltitol pulp, mint flavored dose and medicinal powder, stirs 2～3 minutes, pours compressing tablet in the pattern into, and cooling promptly gets.

In the medicinal powder prescription of the present invention, dried orange peel and peppermint are monarch drug in a prescription: dried orange peel, and bitter and warm in nature, strengthening the spleen and stomach, the eliminating dampness of regulating the flow of vital energy is usually used in that the spleen lung qi stagnates, the disease of smooth, vomiting and diarrhoea uncomfortable in chest; Peppermint, awakening consciousness has the effect of refresh oneself's inducing resuscitation; The two all return lung channel with and be monarch drug in a prescription, one rise and one drop helps lung qi should send out, the lung is concerned with QI of the whole body, disease being able to of waste gas general rule dizziness, vomiting subdued; Ginger and chrysanthemum are ministerial drug: the effect that ginger has good preventing or arresting vomiting town to tell, can help dried orange peel to increase preventing or arresting vomiting and render a service; The sharp vim and vigour of chrysanthemum can be controlled dizziness, alliteration, headache and disease such as dizzy; The banksia rose and wrinkled giant hyssop are assistant: banksia rose fragrance is dry, can rise and can fall, logical reason three warmers, the effect of the outstanding benefaction taste stagnation of the circulation of vital energy and stomach and alleviating pain; The wrinkled giant hyssop regulating QI to expel dampness, preventing or arresting vomiting with in, for taste are told contrary key medicine; Amomum cardamomum, fructus amomi and taurine are for making: Amomum cardamomum, and dampness elimination, promoting the circulation of qi, warm stomach cure mainly diseases such as vomiting gastric disorder causing nausea; Fructus amomi, during promoting the circulation of qi is wide,, stomach strengthening and digestion promoting has that preventing or arresting vomiting is told, the effect of smooth taste; Taurine can the neuroprotective tissue, delays nervous centralis fatigue.More than a few flavor natural traditional Chinese medicine extracts through Scientific Measurement, reasonably combined, synergy can be prevented or alleviate symptoms such as the patient is dizzy, nauseating, vomiting, dry rapidly; Simultaneously can also alleviate nervous centralis fatigue; Can not produce side effects such as drowsiness, sleepy, tired, motion sickness is had positive prevention and result of treatment.

Because chewing gum contacts with the oral cavity when edible for a long time; And need to guarantee that chewing gum base can make active component discharge smoothly; Therefore chewing gum need provide the good transmission system of active component; Therefore need carry out the combination that a large amount of screening experiments is optimized to the base-material of chewing gum, concrete The selection result is following:

I the present invention is to provide the chewing gum that can prevent motion sickness; Therefore need screen elastomer; Usually elastomer comprises natural and synthetic two types of elastomers, and we adopt BS, isobutene-iso-amylene copolymer, polyethylene and the polyisobutene in carbohydrate gum resin in the natural elastomer, gutta percha, guayule and tree crown glue and the synthetic rubber to experimentize respectively, and with the release time of active ingredient be reference index; Draw: calculate by weight; 20～30 parts of polyethylene or polyisobutene, or the mixture of the two are as the elastomer best results.

II is in carrying out elastomeric screening process; We find to add Wax can obviously increase elasticity; Wax is divided into vegetable wax and animal wax, so we adopt and use the same method, respectively to the Brazil wax of source with plant; The beeswax and the lanocerin that derive from animal screen, and The selection result shows 5～7 parts of Brazil waxs of employing or beeswax and composition thereof best results.

We also obtain different quality and denseness character through different types of plasticizer in the adjustment chewing gum formulations III; Screen to the traditional resin of resting in peace, frankincense, gum dammar and the rosin releasing effect to active ingredient among the present invention, the result shows rest in peace resin and frankincense best results.

IV is in order further to adjust the consistence of matrix; We have introduced the vegetation water colloid in prescription; In agar, alginic acid, algin, guar bean flour and carob flour, filter out, chew performance the best with the product that 5～7 parts of agar or alginic acid and the two mixture thereof obtain as the vegetation water colloid.

Through clinical 300 routine motion sickness patients (wherein women 160 people, male 140 people) result of use is followed the tracks of, respectively at riding in an automobile, chewing chewing gum of the present invention when train, aircraft and steamer, result of treatment is following

Clinical data shows that the total effective rate of product of the present invention reaches 99.7%, because the drug ingedient of release that can continuous and effective treatment motion sickness, so the efficient medicine that is higher than commercially available treatment treatment motion sickness of product of the present invention.

Compared with prior art; The invention provides a kind of sugar-free chewing gum with anti-motion sickness function and preparation method thereof, this chewing gum is compared with traditional chewing gum and has not only been reduced sugared absorption, has also introduced the pure Chinese medicinal preparation with anti-motion sickness function; To drop to minimum to the side effect of human body; The mode administration of employing chewing gum has not only made things convenient for motion sickness patient's use, also effectively avoids the existence of the peak valley phenomenon of oral drugs, alleviates the side effect that medicine brings; Thereby widened audient's face of product, overcome the deficiency of prior art.

The specific embodiment

Embodiment 1: the sugar-free chewing gum preparation method with anti-motion sickness function comprises following steps:

The preparation of a medicinal powder: calculate by weight; Accurately take by weighing 25 parts of dried orange peels, 15 portions of peppermints, 25 portions of gingers, 7 parts of chrysanthemums, 7 portions of Amomum cardamomums, 7 parts of fructus amomis, 7 parts of banksia rose, 7 portions of wrinkled giant hyssops and 7 parts of taurines, boiling 3 times adds 8 times of water gagings for the first time; Second and third time respectively adds 6 times of water gagings; The each decoction 1 hour filters merging filtrate; It is 1.1 medicinal extract that filtrating is concentrated into 50 ℃ of relative densities, adds ethanol in the medicinal extract and makes that to contain the alcohol amount be 70%, leaves standstill the absorption supernatant 24 hours; Filter, filtrate recycling ethanol, decompression concentrates, drying under reduced pressure below 80 ℃; Get dry extract, broken mistake 350 mesh sieves of dried cream powder promptly get;

B calculates by weight, takes by weighing 25 parts of polyisobutene, 25 parts of Dicalcium Phosphates, 5 parts of Arabic gums, rest in peace resin and frankincense each 2.5 parts, 5 parts Brazil waxs and 5 parts of agar, evenly stirs, and under 40～50 ℃, smokes to be molten to the matrix mixture in 4 hours;

Under c keeps 45 ℃, calculate by weight, in 30 parts of matrix mixtures of fusion, add 15 parts of medicinal powder, 10 parts of xylitols, 40 parts of sorbierites, 10 portions of sweet mellow wine, 10 parts of maltitol pulps and 4 portions of spearmint leaf roll peppermint oils; Stirred 2～3 minutes; Pour compressing tablet in the pattern into, cooling promptly gets.

Embodiment 2: the sugar-free chewing gum preparation method with anti-motion sickness function comprises following steps:

The preparation of a medicinal powder: calculate by weight; Accurately take by weighing 15 parts of dried orange peels, 10 portions of peppermints, 15 portions of gingers, 5 parts of chrysanthemums, 5 portions of Amomum cardamomums, 5 parts of fructus amomis, 5 parts of banksia rose, 5 portions of wrinkled giant hyssops and 5 parts of taurines, boiling 3 times adds 8 times of water gagings for the first time; Second and third time respectively adds 6 times of water gagings; The each decoction 1 hour filters merging filtrate; It is 1.1 medicinal extract that filtrating is concentrated into 50 ℃ of relative densities, adds ethanol in the medicinal extract and makes that to contain the alcohol amount be 70%, leaves standstill the absorption supernatant 24 hours; Filter, filtrate recycling ethanol, decompression concentrates, drying under reduced pressure below 80 ℃; Get dry extract, broken mistake 450 mesh sieves of dried cream powder promptly get;

B calculates by weight, takes by weighing polybutene and polyisobutene each 10 parts, Dicalcium Phosphate and each 10 parts, 15 parts gutta-percha of magnesium carbonate, 15 parts of frankincenses, 7 parts of beeswaxs and 7 parts of alginic acids, evenly stirs, and under 40～50 ℃, smokes to be molten to the matrix mixture in 6 hours;

Under c keeps 45 ℃, calculate by weight, in 25 parts of matrix mixtures of fusion, add 10 parts of medicinal powder, 5 parts of xylitols, 35 parts of sorbierites, 5 portions of sweet mellow wine, 5 parts of maltitol pulps and 3 parts of ethyl butyrates; Stirred 2～3 minutes; Pour compressing tablet in the pattern into, cooling promptly gets.

Embodiment 3: the sugar-free chewing gum preparation method with anti-motion sickness function comprises following steps:

The preparation of a medicinal powder: calculate by weight; Accurately take by weighing 30 parts of dried orange peels, 20 portions of peppermints, 30 portions of gingers, 10 parts of chrysanthemums, 10 portions of Amomum cardamomums, 10 parts of fructus amomis, 10 parts of banksia rose, 10 portions of wrinkled giant hyssops and 10 parts of taurines, boiling 3 times adds 8 times of water gagings for the first time; Second and third time respectively adds 6 times of water gagings; The each decoction 1 hour filters merging filtrate; It is 1.1 medicinal extract that filtrating is concentrated into 50 ℃ of relative densities, adds ethanol in the medicinal extract and makes that to contain the alcohol amount be 70%, leaves standstill the absorption supernatant 24 hours; Filter, filtrate recycling ethanol, decompression concentrates, drying under reduced pressure below 80 ℃; Get dry extract, broken mistake 400 mesh sieves of dried cream powder promptly get;

B calculates by weight; Take by weighing 30 parts of polyisobutene, 30 parts of magnesium carbonate, 5 parts of Arabic gums and 5 parts of gutta-percha, 10 parts of frankincense, Brazil wax and beeswax each 3 parts and 6 parts of agar; Evenly stir, under 40～50 ℃, smoke and be molten to the matrix mixture in 6 hours;

Under c keeps 45 ℃; Calculate by weight; In 35 parts of matrix mixtures of fusion, add 20 parts of medicinal powder, 15 parts of xylitols, 45 parts of sorbierites, 15 portions of sweet mellow wine, 15 parts of maltitol pulps, 2.5 parts of Fructus Piperis peppermint oils and 2.5 portions of spearmint leaf roll peppermint oils, stirred 2～3 minutes, pour compressing tablet in the pattern into; Cooling promptly gets.

Embodiment 4: the sugar-free chewing gum preparation method with anti-motion sickness function comprises following steps:

The preparation of a medicinal powder: calculate by weight, accurately take by weighing 22 parts of dried orange peels, 16 portions of peppermints, 28 portions of gingers, 6 parts of chrysanthemums, 7 portions of Amomum cardamomums, 8 parts of fructus amomis, 9 parts of banksia rose, 8 portions of wrinkled giant hyssops and 7 parts of taurines, boiling 3 times filters merging filtrate; Filtrating is condensed into medicinal extract, in medicinal extract, adds ethanol, leaves standstill, and draws supernatant, filter, and filtrate recycling ethanol, decompression concentrates, and gets dry extract, and dried cream powder is broken to sieve, and promptly gets;

Even if b is by weight, accurately take by weighing 28 parts of polybutene, 28 parts of Dicalcium Phosphates, 9 parts of Arabic gums, 11 parts of resins of resting in peace, each 3 parts preparations of 5.5 parts of beeswaxs, agar and alginic acids matrix, evenly stir and be heated to fusion;

C adds 18 parts of medicinal powder, 12 parts of xylitols, 42 parts of sorbierites, 11 portions of sweet mellow wine, 13 parts of maltitol pulps, 2 portions of isopropyl isobutyrates and 2 parts of ethyl butyrates by aforementioned weight in 28 parts of matrix mixtures of fusion, stir, and cooling promptly gets.

Claims (10)

1. sugar-free chewing gum with anti-motion sickness function; It is characterized in that: calculate by weight, it is to be prepared from 10～20 parts of medicinal powder, 25～35 parts of matrixs, 5～15 parts of xylitols, 35～45 parts of sorbierites, 5～15 portions of sweet mellow wine, 5～15 parts of maltitol pulps and 3～5 parts of flavouring agents.

2. the sugar-free chewing gum with anti-motion sickness function according to claim 1; It is characterized in that: calculate by weight, it is to be prepared from 15 parts of medicinal powder, 30 parts of matrixs, 10 parts of xylitols, 40 parts of sorbierites, 10 portions of sweet mellow wine, 10 parts of maltitol pulps and 4 parts of flavouring agents.

3. the sugar-free chewing gum with anti-motion sickness function according to claim 1 and 2; It is characterized in that: calculate by weight, described medicinal powder is prepared from 15～30 parts of dried orange peels, 10～20 portions of peppermints, 15～30 portions of gingers, 5～10 parts of chrysanthemums, 5～10 portions of Amomum cardamomums, 5～10 parts of fructus amomis, 5～10 parts of banksia rose, 5～10 portions of wrinkled giant hyssops and 5～10 parts of taurines.

4. the sugar-free chewing gum with anti-motion sickness function according to claim 3; It is characterized in that: calculate by weight, described medicinal powder is prepared from 25 parts of dried orange peels, 15 portions of peppermints, 25 portions of gingers, 7 parts of chrysanthemums, 7 portions of Amomum cardamomums, 7 parts of fructus amomis, 7 parts of banksia rose, 7 portions of wrinkled giant hyssops and 7 parts of taurines.

5. the sugar-free chewing gum with anti-motion sickness function according to claim 1 and 2; It is characterized in that: calculate by weight, described matrix comprises 20～30 parts of elastomers, 20～30 parts of fillers, 5～15 parts of natural gums, 5～15 parts of plasticizer, 5～7 parts of waxes and 5～7 parts of vegetation water colloids.

6. the sugar-free chewing gum with anti-motion sickness function according to claim 5 is characterized in that: described elastomer is one or both in polybutene and the polyisobutene; Described filler is one or both in Dicalcium Phosphate and the magnesium carbonate; Described natural gum is one or both in Arabic gum and the gutta-percha; Described plasticizer is in resin and the frankincense one or both of resting in peace; Described wax is one or both in Brazil wax and the beeswax; Described vegetation water colloid is one or both in agar and the alginic acid.

7. the sugar-free chewing gum with anti-motion sickness function according to claim 1 and 2 is characterized in that: described flavouring agent is fruit flavors or mint flavored dose.

8. the sugar-free chewing gum with anti-motion sickness function according to claim 7 is characterized in that: described fruit flavors is one or both in isopropyl isobutyrate and the ethyl butyrate; Described mint flavored dose is in Fructus Piperis peppermint oil and the spearmint leaf roll peppermint oil one or both.

9. by the arbitrary described preparation method with sugar-free chewing gum of anti-motion sickness function of claim 1～8, it is characterized in that: described preparation method comprises following steps:

The preparation of a medicinal powder: take by weighing dried orange peel, peppermint, ginger, chrysanthemum, Amomum cardamomum, fructus amomi, the banksia rose, wrinkled giant hyssop and taurine in proportion, boiling 3 times filters merging filtrate; Filtrating is condensed into medicinal extract, in medicinal extract, adds ethanol, leaves standstill, and draws supernatant, filter, and filtrate recycling ethanol, decompression concentrates, and gets dry extract, and dried cream powder is broken to sieve, and promptly gets;

B gets the matrix mixture by above-mentioned weight portion, evenly stirs and be heated to fusion;

C adds xylitol, sorbierite, sweet mellow wine, maltitol pulp, mint flavored dose and medicinal powder by aforementioned weight in the matrix mixture of fusion, stir, and cooling promptly gets.

10. the preparation method with sugar-free chewing gum of anti-motion sickness function according to claim 9 is characterized in that: described preparation method comprises following steps:

The preparation of a medicinal powder: take by weighing dried orange peel, peppermint, ginger, chrysanthemum, Amomum cardamomum, fructus amomi, the banksia rose, wrinkled giant hyssop and taurine in proportion, boiling 3 times adds 8 times of water gagings for the first time, and second and third time respectively adds 6 times of water gagings, decocts 1 hour at every turn, filters merging filtrate; It is 1.1 medicinal extract that filtrating is concentrated into 50 ℃ of relative densities, adds ethanol in the medicinal extract and makes that to contain the alcohol amount be 70%, leaves standstill the absorption supernatant 24 hours; Filter, filtrate recycling ethanol, decompression concentrates, drying under reduced pressure below 80 ℃; Get dry extract, broken mistake 350～450 mesh sieves of dried cream powder promptly get;

B gets the matrix mixture by above-mentioned weight portion, evenly stirs, and under 40～50 ℃, smokes to be molten to the matrix mixture in 4～6 hours;

C keeps 45 ℃, by aforementioned weight, in the matrix mixture of fusion, adds xylitol, sorbierite, sweet mellow wine, maltitol pulp, mint flavored dose and medicinal powder, stirs 2～3 minutes, pours compressing tablet in the pattern into, and cooling promptly gets.