CN102458407B - 用作单酰甘油脂肪酶抑制剂的杂芳族和芳族哌嗪基氮杂环丁基酰胺 - Google Patents
用作单酰甘油脂肪酶抑制剂的杂芳族和芳族哌嗪基氮杂环丁基酰胺 Download PDFInfo
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- CN102458407B CN102458407B CN201080028761.8A CN201080028761A CN102458407B CN 102458407 B CN102458407 B CN 102458407B CN 201080028761 A CN201080028761 A CN 201080028761A CN 102458407 B CN102458407 B CN 102458407B
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- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17166109P | 2009-04-22 | 2009-04-22 | |
| US61/171661 | 2009-04-22 | ||
| US61/171,661 | 2009-04-22 | ||
| PCT/US2010/032100 WO2010124122A1 (en) | 2009-04-22 | 2010-04-22 | Heteroaromatic and aromatic piperazinyl azetidinyl amides as monoacylglycerol lipase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102458407A CN102458407A (zh) | 2012-05-16 |
| CN102458407B true CN102458407B (zh) | 2014-03-05 |
Family
ID=42226535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080028761.8A Expired - Fee Related CN102458407B (zh) | 2009-04-22 | 2010-04-22 | 用作单酰甘油脂肪酶抑制剂的杂芳族和芳族哌嗪基氮杂环丁基酰胺 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP2421535A1 (de) |
| JP (1) | JP2012524810A (de) |
| KR (1) | KR20120005517A (de) |
| CN (1) | CN102458407B (de) |
| AU (1) | AU2010238746B2 (de) |
| BR (1) | BRPI1014874A2 (de) |
| CA (1) | CA2759706A1 (de) |
| IL (1) | IL215797A0 (de) |
| RU (1) | RU2011147201A (de) |
| TW (1) | TW201103914A (de) |
| WO (1) | WO2010124122A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2849782A1 (en) * | 2011-09-30 | 2013-04-04 | Janssen Pharmaceutica Nv | Monoacylglycerol lipase inhibitors for the treatment of metabolic diseases and related disorders |
| WO2014100834A1 (en) * | 2012-12-21 | 2014-06-26 | The Regents Of The University Of California | Methods and compositions for treatment of cyanide and hydrogen sulfide toxicity |
| EP3087067B1 (de) | 2013-12-26 | 2018-10-24 | Takeda Pharmaceutical Company Limited | 4-(piperrazin-1-yl)-pyrrolidin-2-on-verbindungen als monoacylglycerinlipase(magl)inhibitoren |
| EP3279191B1 (de) | 2015-03-30 | 2020-09-02 | Takeda Pharmaceutical Company Limited | Heterocyclische verbindung |
| US10463753B2 (en) | 2016-02-19 | 2019-11-05 | Lundbeck La Jolla Research Center, Inc. | Radiolabeled monoacylglycerol lipase occupancy probe |
| US10610520B2 (en) | 2016-03-31 | 2020-04-07 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US10323026B2 (en) | 2016-03-31 | 2019-06-18 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| MX2020007318A (es) | 2017-09-29 | 2020-08-24 | Takeda Pharmaceuticals Co | Compuesto heterociclico. |
| TW201936602A (zh) | 2017-11-28 | 2019-09-16 | 瑞士商赫孚孟拉羅股份公司 | 新雜環化合物 |
| TW201930300A (zh) * | 2017-12-15 | 2019-08-01 | 瑞士商赫孚孟拉羅股份公司 | 新雜環化合物 |
| EA202190886A1 (ru) * | 2018-09-28 | 2021-09-07 | Янссен Фармацевтика Нв | Модуляторы моноацилглицерин-липазы |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2915199B1 (fr) * | 2007-04-18 | 2010-01-22 | Sanofi Aventis | Derives de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur preparation et leur application en therapeutique. |
| EP2180048B1 (de) * | 2008-10-09 | 2014-12-17 | Janssen Pharmaceutica N.V. | Alternative Kristallform von Monoacylglycerinlipase (MGLL) |
-
2010
- 2010-04-22 EP EP10714829A patent/EP2421535A1/de not_active Withdrawn
- 2010-04-22 JP JP2012507395A patent/JP2012524810A/ja active Pending
- 2010-04-22 KR KR1020117027431A patent/KR20120005517A/ko not_active Application Discontinuation
- 2010-04-22 WO PCT/US2010/032100 patent/WO2010124122A1/en active Application Filing
- 2010-04-22 BR BRPI1014874A patent/BRPI1014874A2/pt active Search and Examination
- 2010-04-22 CA CA2759706A patent/CA2759706A1/en not_active Abandoned
- 2010-04-22 CN CN201080028761.8A patent/CN102458407B/zh not_active Expired - Fee Related
- 2010-04-22 RU RU2011147201/15A patent/RU2011147201A/ru not_active Application Discontinuation
- 2010-04-22 TW TW099112745A patent/TW201103914A/zh unknown
- 2010-04-22 AU AU2010238746A patent/AU2010238746B2/en not_active Ceased
-
2011
- 2011-10-23 IL IL215797A patent/IL215797A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2011147201A (ru) | 2013-05-27 |
| AU2010238746B2 (en) | 2015-02-19 |
| CN102458407A (zh) | 2012-05-16 |
| TW201103914A (en) | 2011-02-01 |
| AU2010238746A1 (en) | 2011-11-10 |
| EP2421535A1 (de) | 2012-02-29 |
| CA2759706A1 (en) | 2010-10-28 |
| KR20120005517A (ko) | 2012-01-16 |
| IL215797A0 (en) | 2012-01-31 |
| WO2010124122A1 (en) | 2010-10-28 |
| JP2012524810A (ja) | 2012-10-18 |
| BRPI1014874A2 (pt) | 2016-04-12 |
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