CN102451525A - Ultrasonic treatment equipment - Google Patents
Ultrasonic treatment equipment Download PDFInfo
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- CN102451525A CN102451525A CN2010105269942A CN201010526994A CN102451525A CN 102451525 A CN102451525 A CN 102451525A CN 2010105269942 A CN2010105269942 A CN 2010105269942A CN 201010526994 A CN201010526994 A CN 201010526994A CN 102451525 A CN102451525 A CN 102451525A
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Abstract
The invention provides ultrasonic treatment equipment. The ultrasonic treatment equipment comprises an ultrasonic transduction transmitter, an ultrasonic transduction receiver, a judgment device and a feedback control device, wherein an ultrasonic transduction transmitter is used for generating and transmitting ultrasonic wave to an active area, an ultrasonic transduction receiver is used for collecting sound signals from the active area and converting the collected sound signals into electric signals, a judgment device is used for judging whether the active area has an acoustic cavitation in a preset strength range to acquire a judgment result, and a feedback control device is used for controlling the ultrasonic transmission dosage of the ultrasonic transduction transmitter when the judgment result indicates that the acoustic cavitation of the active area is not in the preset strength range, so that the acoustic cavitation of the active area is in the preset strength range. According to the ultrasonic treatment equipment, the accuracy of ultrasonic acoustic cavitation control means is improved, and the treatment effect is ensured.
Description
Technical field
The present invention relates to the medical apparatus technical field, particularly a kind of ultrasonic therapy equipment.
Background technology
The high-strength ultrasonic signal can produce some biological tissues effect in tissue, for example since tissue to the absorption of ultrasonic energy cause cell heat downright bad, because the cell rupture that hyperacoustic mechanical effect causes, apoptosis etc.
Ultrasonic cavitation is a kind of hyperacoustic mechanical effect, is because high-strength ultrasonic acts on the physical phenomenon that cavitation nucleus (micro-bubble) back in liquid or the class I liquid I produces.Micro-bubble is driven repeatedly by the positive negative pressure of sound wave and produces alternately increase and compression rapidly of volume, and the bubble harmomegathus motion that is produced by the effect of alternation acoustic pressure is called stable cavitation.When causing mechanical tension on the walls of gas-liquid two-phase medium boundary to exceed its marginal value when the rapidly violent harmomegathus of bubble, the bubble collapse produces instantaneous cavitation.Air bladder resonance produces radiant force effect and little acoustic streaming during stable cavitation, and these vibration source emissions are corresponding to some arrowbands acoustical signal of sound wave driving frequency or bubble natural reonant frequency and harmonic frequency thereof.During instantaneous cavitation; Follow bubble volume to dwindle or collapse moment; Since energy accumulation or discharge can produce in local TRANSIENT HIGH TEMPERATURE, Discharge illuminating, the water vapour H and the OH free radical discharges and with other composition generation chemical reactions, phenomenons such as generation sound to luminous, shock wave and jet thus.
Using medical research field, recent two decades comes, and biological tissue's effect of ultrasonic cavitation receives broad research and application day by day: utilize its stable cavitation effect, acoustic contrast agent can significantly improve the contrast of ultrasonic image; Utilize its instantaneous cavitation effect, the pulsed high-strength ultrasonic in treatment tumor, drug conveying, cause the application of aspects such as cell breakage or withered, block nerves conduction that new progress is all arranged.
Utilizing hyperacoustic mechanical effect to change in the process of biological properties; This change should be safe and controlled; To improve therapeutic effect; Cross low acoustic emission dosage and can't produce acoustic cavitation, too high sound dosage then can cause the tissue heat absorption even seethe with excitement and the production hot injury, causes over-treatment or other unnecessary tissue injury.
Yet the control device of ultrasonic cavitation all is to control according to the signal of telecommunication that the transmitting transducer transmitting terminal is sent in the existing tissue, and there is following shortcoming at least in above-mentioned control mode:
Because the distance that exists between transmitting terminal and the area for treatment, therefore the energy of not all emission can both be had an effect in area for treatment; Or because the individual variation of biological tissue, the ultrasonic cavitation of the energy shortage of emission to cause expecting, or the required energy of cavitation head and shoulders above.Therefore these class methods can only be from the variation of emission signal of telecommunication biological tissue's effect of actual generations of reasoning rule of thumb, and it only is a kind of reasoning, is not the situation of actual generation, so the possibility judged by accident of existence, also has the not high shortcoming of precision.These shortcomings all can endanger the safety and the effectiveness of treatment.
Summary of the invention
The purpose of this invention is to provide a kind of ultrasonic therapy equipment, improve the accuracy of ultrasonic cavitation control device, guarantee therapeutic effect.
To achieve these goals, the embodiment of the invention provides a kind of ultrasonic therapy equipment, comprising:
The ultrasonic wave transducer emitter is used for producing and launching ultrasound wave to the zone of action;
The ultrasonic wave transducer receptor is used for gathering acoustical signal from the said zone of action, and the acoustical signal that collects is converted into the signal of telecommunication;
Judgment means is used for judging that according to the said signal of telecommunication whether the said zone of action acoustic cavitation of predetermined strength scope takes place, and obtains a judged result;
Feed back control system; The acoustic cavitation that is used for indicating the said zone of action in said judged result is not in the predetermined strength scope time; Control the ultrasound emission dosage of said ultrasonic wave transducer emitter, the acoustic cavitation of the said zone of action is in the said predetermined strength scope.
Above-mentioned ultrasonic therapy equipment, wherein, said ultrasonic wave transducer emitter and ultrasonic wave transducer receptor are focusing equipment, and the two confocal some setting.
Above-mentioned ultrasonic therapy equipment, wherein, the focal spot of said ultrasonic wave transducer emitter and ultrasonic wave transducer receptor intersects at a certain angle, partially overlaps.
Above-mentioned ultrasonic therapy equipment; Wherein, The top, spherical crown center of said focusing ultrasonic wave transducer emitter has a spatial accommodation; Said focusing ultrasonic wave transducer receptor is arranged in the said spatial accommodation, and the focal spot of said ultrasonic wave transducer emitter and ultrasonic wave transducer receptor intersects with the zero degree angle of cut, partly or entirely overlaps.
Above-mentioned ultrasonic therapy equipment, wherein, cyclic focusing ultrasonic wave transducer receptor is attached to outside the focusing ultrasonic wave transducer emitter external diameter or the front end coupling tapered sleeve outlet outside, the confocal point of acoustic axis altogether.
Above-mentioned ultrasonic therapy equipment, wherein, said cyclic focusing ultrasonic wave transducer receptor is placed along focusing ultrasonic wave transducer emitter outer ring-like space by a plurality of independently ultrasonic wave transducer receptors and is formed.
Above-mentioned ultrasonic therapy equipment, wherein, said judgment means specifically comprises:
Conversion module is used to utilize the Fourier analysis method, and the said signal of telecommunication is carried out time domain to the spectral domain conversion;
Extraction module is used for signal after the spectral domain conversion and extracts between the predetermined high order of the work fundamental frequency of ultrasonic wave transducer transmitter or the noise amplitude spectrum that is lower than in the mark subfrequency scope of fundamental frequency and distribute;
First judge module is used to judge whether the distribution of noise amplitude spectrum exists the peak value of at least one discrete peak value greater than the first preset thresholding, and perhaps a plurality of successive peak values obtain said judged result greater than the peak value of the second preset thresholding.
Above-mentioned ultrasonic therapy equipment, wherein, said judgment means specifically comprises:
Conversion module is used to utilize the Fourier analysis method, the said signal of telecommunication is carried out the conversion of time domain to spectral domain;
Determination module is used for confirming that signal after the spectral domain conversion is in the resonance quality factor at the harmonic frequency place of ultrasonic wave transducer transmitter;
Second judge module is used to judge whether the resonance quality factor are in a preset range, obtain said judged result.
Above-mentioned ultrasonic therapy equipment, wherein, said judgment means specifically comprises:
The waveform envelope extraction module is used for that the said signal of telecommunication is carried out waveform envelope and extracts;
The time-domain integration module is used for waveform envelope and extracts the signal obtain and carry out time-domain integration, obtains receiving the gross energy of signal;
The 3rd judge module, be used for more said gross energy and the energy range the when acoustic cavitation of predetermined strength scope takes place of the zone of action that measures in advance between, obtain said judged result.
Above-mentioned ultrasonic therapy equipment, wherein, judgment means specifically comprises:
Preserve module, the 3rd reference signal when second reference signal and the zone of action were higher than the acoustic cavitation of predetermined strength scope when first reference signal, the zone of action were lower than the acoustic cavitation of predetermined strength scope when being used to preserve the zone of action acoustic cavitation of predetermined strength scope taking place;
Cross-correlation degree computing module is used to calculate the cross-correlation degree of the said signal of telecommunication and first, second and the 3rd reference signal;
The 4th judge module is used for obtaining said judged result according to said cross-correlation degree.
Above-mentioned ultrasonic therapy equipment wherein, also comprises:
One pick off;
Second control device, the ultrasound emission dosage of the said ultrasonic wave transducer emitter of Data Control that is used for arriving according to said sensor acquisition.
Above-mentioned ultrasonic therapy equipment wherein, also comprises:
Present module, be used for visual treatment information being provided according to said judged result.
Above-mentioned ultrasonic therapy equipment; Comprise that also the mechanical arm and that can continue to move is used to obtain the mechanical arm positioner of positional information; Said ultrasonic wave transducer emitter is arranged on the said mechanical arm, and the said module that appears specifically is used for according to said positional information and said judged result visual treatment information being provided.
Above-mentioned ultrasonic therapy equipment; Wherein, Said ultrasonic wave transducer emitter is one can hand mobile ultrasound emission transducer; Said ultrasound emission transducer be provided with one be used to obtain positional information 3 dimension space positioners, the said module that appears specifically is used for according to said positional information and said judged result visual treatment information being provided.
The embodiment of the invention has following beneficial effect:
The embodiment of the invention has proposed a kind of ultrasonic therapy equipment that is used for the high-power ultrasonic treatment; It can judge whether the ultrasonic cavitation effect is in the preset range through the acoustical signal in detection effect zone; And control hyperacoustic emission according to judged result; Improve the accuracy of ultrasonic cavitation control device, guaranteed therapeutic effect.And to the therapeutic equipment operator treatment information is provided, and then in the ultrasonic therapeutic process, realize real-time feedback control treatment ultrasound emission parameter based on area for treatment sound field detection signal through the characteristic that extract to receive signal.With the criterion of these acoustic field signal data, a feasible method that monitoring in real time and postoperative curative effect are assessed in high intensity pulses ultrasonic therapeutic art is provided as treatment safety and effectiveness.
Description of drawings
Fig. 1 is the structural representation of the ultrasonic therapy equipment of the embodiment of the invention.
The specific embodiment
In the embodiment of the invention, judge through the acoustical signal in detection effect zone whether the ultrasonic cavitation effect is in the preset range, and control hyperacoustic emission, to reach predetermined therapeutic effect according to judged result.
As shown in Figure 1, the ultrasonic therapy equipment of the embodiment of the invention comprises:
The ultrasonic wave transducer emitter is used for producing and launching ultrasound wave to the zone of action;
The ultrasonic wave transducer receptor is used for gathering acoustical signal from the said zone of action, and the acoustical signal that collects is converted into the signal of telecommunication;
Judgment means is used for judging that according to the said signal of telecommunication whether the said zone of action acoustic cavitation of predetermined strength scope takes place, and obtains a judged result;
Feed back control system; The acoustic cavitation that is used for indicating the said zone of action in said judged result is not in the predetermined strength scope time; Control the ultrasound emission dosage of said ultrasonic wave transducer emitter, the acoustic cavitation of the said zone of action is in the said predetermined strength scope.
Ultrasonic wave transducer emitter inside has one group of special crystal with piezoelectric effect, and this piezoquartz has special nature, on the crystal specific direction, adds voltage exactly; Deformation can take place in crystal, produce ultrasound wave, and ultrasonic wave transducer receptor inside equally also has such one group of special crystal with piezoelectric effect; When ultrasound wave to the crystal effect; When making crystal generation deformation, the counterparty upwards will produce voltage, has realized the signal of telecommunication and hyperacoustic conversion.
In specific embodiment of the present invention, ultrasonic wave transducer emitter and ultrasonic wave transducer receptor are focusing equipment, when the two all is focusing equipment, and the two confocal some setting.
Usually, the focal spot place sound intensity of focusing ultrasonic wave transducer emitter is the strongest, is the treatment position (generation area of acoustic cavitation) of hoping.The ultrasonic wave transducer receptor adopts when focusing on receive mode; Its focal spot (the most sensitive receiving area) needs to aim at the focal spot of focusing ultrasonic wave transducer emitter, to improve the receiving sensitivity of acoustic cavitation signal is come the outer noise of self-focusing type ultrasonic wave transducer emitter focal spot with reduction.
Be elaborated in the face of various possible confocal implementations down.
Implementation one
The confocal point of focusing ultrasonic wave transducer emitter and the inclined to one side acoustic axis of focusing ultrasonic wave transducer receptor receives, and the acoustic axis of two transducers does not overlap mutually, but the intersection coincidence at a certain angle of its focal spot.Common implementation method can be according to the confocal fixed-focus formula ultrasonic wave transducer receptor that concerns in the focusing ultrasonic wave transducer emitter outside.
Implementation two
Focusing ultrasonic wave transducer emitter and focusing ultrasonic wave transducer the receptor confocal point of acoustic axis altogether receive, and the acoustic axis of two transducers overlaps mutually, and its focal spot intersects partly or entirely coincidence with the zero degree angle of cut.
In implementation two, the top, spherical crown center of said focusing ultrasonic wave transducer emitter has a spatial accommodation (like the hole), and said then focusing ultrasonic wave transducer receptor is arranged in the said spatial accommodation.
In the implementation two, though the energy emission area of focusing ultrasonic wave transducer emitter has certain sacrifice, focusing ultrasonic wave transducer emitter and focusing ultrasonic wave transducer receptor are wholely set, and make that confocal adjustment is simpler, the convenient use.
Implementation three
Adopt cyclic focusing ultrasonic wave transducer receptor to be attached to outside the focusing ultrasonic wave transducer emitter external diameter or the front end coupling tapered sleeve outlet outside, be adjacent to the zone of action and realize receiving with the confocal point of the common acoustic axis of focusing ultrasonic wave transducer emitter.
Implementation four
Under some situation, can also a plurality of focusing or non-focusing independent ultrasonic wave transducer receptor be placed along focusing ultrasonic wave transducer emitter outer ring-like space, synthetic one with the coaxial confocal sound field receiving equipment of focusing ultrasonic wave transducer emitter.This mode can solve the ultrasonic wave transducer receptor and focus on the problem that sensitivity that the number ratio of transducer diameter (focal length with) excessive (receiving area is too small) causes descends, and reduces the risk that the acoustic energy that is reflected damages; And focusing ultrasonic wave transducer emitter need not to lose the integrated of its emission area and focusing ultrasonic wave transducer receptor and also realizes easily.
Even more advantageously; Can finely tune the focal spot size that it receives sound field through width or the subsequent corrosion of adjusting focusing ultrasonic wave transducer receptor; Utilize the sound field characteristic of its distinctive horizontal expansion; Can obtain broad more horizontal receiving area, make this sound field receiving equipment can receive the acoustical signal in self-focusing type ultrasonic wave transducer emitter focus and near the biological tissue thereof.Carry out along transverse movement detecting more reliable under the situation of scanning treatment at focusing ultrasonic wave transducer emitter.
In specific embodiment of the present invention; This ultrasonic wave transducer receptor can adopt single transducer architecture of ring-type spherical crown surface self-focusing mode or single transducer architecture that the ring plain piezoelectric ceramic piece cooperates acoustic lens; It can optimize the focusing acoustic field focal spot through the approach that changes spheric curvature, utilizes the focal spot sensitivity of focusing acoustic field to come optionally to receive the acoustic emission/scattered signal from the appointed area.
Certainly; This ultrasonic wave transducer receptor also can adopt the phase array transducer array to realize; Utilize phase controlling to form focus beam; And this focus beam can be adjusted the wave beam receiving area by the method that changes receiving phase, like this even can be implemented in two-dimentional depth plane or three dimensions scanning receives acoustic emission/scattered signal, shows acoustic cavitation with the mode of image and treats testing result.The focal spot region of ultrasonic wave transducer receptor should have overlapping more than 20% with the focal spot of ultrasonic wave transducer emitter, with the sensitivity that guarantees that signal receives.
In specific embodiment of the present invention, need to judge according to the signal that collects whether the zone of action acoustic cavitation of predetermined strength scope takes place, explain as follows in the face of various implementations down.
< implementation one >
In implementation one, this judgment means specifically comprises:
Conversion module is used to utilize the Fourier analysis method, or Fourier analysis method in short-term, and whole section of the said signal of telecommunication or segmentation are carried out the conversion of time domain to spectral domain;
Extraction module; Wide spectrum characteristic based on the acoustic cavitation signal; Be used for distributing, or extract the acoustical signal amplitude spectrum distribution in the predetermined score subfrequency scope (for example 1/4 to 3/4 subfrequency) of the work fundamental frequency that is lower than ultrasound transmitting transducer from the acoustical signal amplitude spectrum that the signal after the spectral domain conversion extracts in the predetermined higher hamonic wave frequency range between the work fundamental frequency of ultrasonic wave transducer emitter (for example 2 times to 10 subfrequencies).Suggestion is avoided the work fundamental frequency and the peripheral frequency range thereof of ultrasonic wave transducer emitter and is avoided receiving the interference that transmits by force;
First judge module is used to judge whether the distribution of noise amplitude spectrum exists the peak value of the peak value of single or a plurality of separations greater than the first preset thresholding, and perhaps a plurality of successive peak values obtain one first judged result greater than the peak value of the second preset thresholding;
This moment, judged result had 3 kinds of situation:
Situation one, there be the peak value of at least one discrete peak value greater than preset thresholding;
Situation two, there be the peak value of a plurality of successive peak values greater than preset thresholding;
Situation three, neither there be the peak value of at least one discrete peak value, also do not have the peak value of a plurality of successive peak values greater than preset thresholding greater than preset thresholding.
In case the ultrasonic wave transducer emitter is launched ultrasound wave to presumptive area; If when causing presumptive area generation acoustic cavitation, then ultrasonic wave transducer emitter focal spot place can vibrate by gassing, the local peaking of discrete at least one by one peak value greater than preset thresholding then possibly occur; And if ultrasound emission dosage is when excessive; A lot of closely adjacent resonant frequency peaks then can occur, cause spectrum to distribute and show that continuous and local strengthens, its amplitude even surmount the harmonic signal peak value of ultrasonic wave transducer emitter.
Whether the acoustic cavitation that therefore can judge the zone of action based on above spectrum signature is in the predetermined strength scope.
When the result occurring for the moment; Show that the zone of action is in the acoustic cavitation of predetermined strength scope, and when result two occurring, show that the acoustic cavitation of predetermined strength scope takes place to surpass in the zone of action; And when result three occurring, show that the acoustic cavitation of the zone of action is lower than the predetermined strength scope.
When result two occurring, feed back control system is controlled said ultrasonic wave transducer emitter and is reduced ultrasound emission dosage, and when result three occurring, feed back control system is controlled said ultrasonic wave transducer emitter and improved ultrasound emission dosage.
Certainly; Two above-mentioned thresholdings can be according to the demand setting; As require the stronger treatment occasion of acoustic cavitation; Can thresholding be provided with higherly, otherwise can thresholding be provided with lowly, this thresholding can be provided with the percentage ratio of the harmonic signal peak value of ultrasonic wave transducer emitter as a reference.
The practical implementation method of judge module can adopt simulation, numeral or modulus hybrid circuit method to realize.Adopt the A/D digital to analog converter with the signal of telecommunication of ultrasonic wave transducer receptor behind digital sample, this digital signal is realized operations such as above-mentioned conversion, extraction and judgement with the Digital Signal Processing mode.
In implementation two, this judgment means specifically comprises:
Conversion module is used to utilize the Fourier analysis method, or Fourier analysis method in short-term, and whole section of the said signal of telecommunication or segmentation are carried out the conversion of time domain to spectral domain;
Determination module is used for confirming that signal after the spectral domain conversion is in the resonance quality factor at the harmonic frequency place of ultrasonic wave transducer transmitter;
Second judge module is used to judge whether the resonance quality factor are in a preset range, obtains one second judged result;
Because extremely the harmonics signal indication of arrowband does not have other resonance signal sources; The resonance peak shape of expansion representes that then the ultrasonic energy of this resonant frequency drives cavitation bubble and receives to compel stable vibration (the bubble stabilizes frequency of vibration that different bubble diameters are corresponding different; The harmonic frequency of these bubble resonance frequencies and ultrasonic wave transducer emitter is deviation slightly, causes the resonance peak shape of expanding).Therefore; In implementation two, when the resonance quality factor are higher than preset range, represent that the acoustic cavitation of the said zone of action is lower than in the predetermined strength scope; Feed back control system should increase the ultrasound emission dosage of said ultrasonic wave transducer emitter; And the resonance quality factor represent that the acoustic cavitation of the said zone of action is higher than in the predetermined strength scope when being lower than preset range, and feed back control system should reduce the ultrasound emission dosage of said ultrasonic wave transducer emitter.
The practical implementation method and the above-mentioned implementation method one of other modules are similar.
In implementation three, this judgment means specifically comprises:
The waveform envelope extraction module is used for that the said signal of telecommunication is carried out waveform envelope and extracts;
The time-domain integration module is used for waveform envelope and extracts the signal obtain and carry out time-domain integration, obtains receiving the gross energy of signal;
The 3rd judge module, be used for more said gross energy and the energy range the when acoustic cavitation of predetermined strength scope takes place of the zone of action that measures in advance between, obtain one the 3rd judged result;
In implementation three; In the time of between the energy range that the gross energy that the time-domain integration module obtains is positioned at the zone of action that measures in advance when the acoustic cavitation of predetermined strength scope takes place; Show that then the acoustic cavitation of predetermined strength scope takes place in the zone of action; During minima between the energy range when the acoustic cavitation of predetermined strength scope takes place less than the zone of action that measures in advance for gross energy that the time domain integration module obtains; The acoustic cavitation of representing the said zone of action is lower than in the predetermined strength scope; Feed back control system should increase the ultrasound emission dosage of said ultrasonic wave transducer emitter; During maximum between the energy range when the acoustic cavitation of predetermined strength scope takes place greater than the zone of action that measures in advance for gross energy that the time domain integration module obtains, represent that the acoustic cavitation of the said zone of action is higher than in the predetermined strength scope, feed back control system should reduce the ultrasound emission dosage of said ultrasonic wave transducer emitter.
The waveform envelope extraction module of this implementation, time-domain integration module and the 3rd judge module specifically can adopt circuit such as envelope detector, integrator and subtractor to realize, thereby scheme is simple, and cost is low, are prone to realize.
In implementation four, this judgment means specifically comprises:
Preserve module, the 3rd reference signal when second reference signal and the zone of action were higher than the acoustic cavitation of predetermined strength scope when first reference signal, the zone of action were lower than the acoustic cavitation of predetermined strength scope when being used to preserve the zone of action acoustic cavitation of predetermined strength scope taking place;
Cross-correlation degree computing module is used to calculate the cross-correlation degree of the said signal of telecommunication and first, second and the 3rd reference signal;
The 4th judge module is used for obtaining one the 4th judged result according to said cross-correlation degree;
In implementation four; Judge the signal of telecommunication when the most relevant according to the cross-correlation degree with first reference signal; Show that then the acoustic cavitation of predetermined strength scope takes place in the zone of action, when the signal of telecommunication is the most relevant with second reference signal, representes that the acoustic cavitation of the said zone of action is lower than in the predetermined strength scope; Feed back control system should increase the ultrasound emission dosage of said ultrasonic wave transducer emitter; When the signal of telecommunication is the most relevant with the 3rd reference signal, represent that the acoustic cavitation of the said zone of action is higher than in the predetermined strength scope, feed back control system should reduce the ultrasound emission dosage of said ultrasonic wave transducer emitter.
At this, this cross-correlation degree can realize through matched filter, utilizes the matched filter principle.When the ultrasonic wave transducer emitter was launched in a low voice irradiation dose, the ultrasonic wave transducer receptor to certain certain pulses of area for treatment emission, picked up corresponding signal Design of Signal matched filter as a reference simultaneously; In the high power therapeutic process; The ultrasonic wave transducer receptor is in pulse emission/accepting state; The signal that receives can pass through this matched filter; Represent when its filter system output valve is very big that the signal and this reference signal dependency that are received are best, otherwise then represent because the signal that the variation of area for treatment causes receiving produces significant change.
Certainly, in specific embodiment of the present invention, this judge module can also adopt other mode to realize; As adopt the method for the random noise modeling that noise signal detects; Acoustical signal to receiving is carried out the noise model parameter extraction, methods such as for example autoregression rolling average (ARMA) model, and the operation parameter threshold value is carried out the judgement of binary acoustic cavitation; At this, specify no longer one by one for the mode of other realizations.
In implementation four; Adopt the A/D analog-digital converter can gather first, second and the 3rd reference signal, cross-correlation degree computing module can be used the cross-correlation coefficient (being digital matched filter) between digital convolution calculating real-time acoustic cavitation signal and certain reference signal.For the parameter extraction of noise model, also existing abundant practical algorithm can supply to use for reference.
When forming by a plurality of zones in the said zone of action; In specific embodiment of the present invention; Can combine acoustic cavitation that whether suitable the judged result and the space coordinates of the zone of action take place; Be mapped to judged result on the space curved surface, show the acoustic cavitation effect spatial distribution of the whole area for treatment at place, the zone of action.
The space coordinates of each zone of action can be read by mechanical shifting axle position coder separately, maybe can adopt the location tracking method that is fixed in the dimension of 3 on ultrasonic wave transducer emitter witness marker to obtain.If this space curved surface is the plane that is parallel to the body skin surface, then acoustic cavitation distribution design sketch is shown as two-dimensional image.And this scattergram can further be added on the striograph of tissue, as the demonstration directly perceived of therapeutic effect.
Utilize the method for the embodiment of the invention; In the high intensity ultrasound treatment process of forming by multiposition repeated ultrasonic irradiation at; For ongoing single ultrasonic irradiation, adopt above-mentioned detection method, can judge whether this irradiation has produced the ultrasonic cavitation effect.If this irradiation does not produce ultrasonic cavitation, then can append ultrasonic irradiation one time in current location, tell on assurance; If produced ultrasonic cavitation, then the treatment probe can move to next position and treats.
Again for example, in single ultrasonic irradiation process,, then can induce acoustic cavitation to take place through the method that increases pulse amplitude and/or change pulse duty factor if the analysis of fourier spectrum in short-term of the signal that collects does not show real-time acoustic cavitation result; Otherwise,, then can suitably reduce the intensity that pulse amplitude suppresses acoustic cavitation if acoustic cavitation is too violent.
Perhaps; When ultrasonic wave transducer receptor and ultrasonic wave transducer emitter all adopt the phase array transducer structure; Can electronic zoom, around the treatment position of current generation ultrasonic cavitation, the bubble cloud that utilizes current cavitation to produce; Focus electron focusing with the ultrasonic wave transducer emitter carries out next infrasonic sound irradiation to bubble cloud edge immediately, can adopt lower acoustical power easily to continue to excite the acoustic cavitation effect; The focus of ultrasonic wave transducer receptor is also monitored with the focus respective electronic focus tracking of ultrasonic wave transducer emitter simultaneously.Be beneficial to expansion acoustic cavitation area for treatment, shorten treatment time.
Again for example, according to the acoustic cavitation effect of the some treatment position ultrasonic irradiation in front, can obtain a ultrasonic cavitation parameter area; Thereby predict the needed emission sound of next ultrasonic irradiation parameter, obtain acoustic cavitation.Also can set up the treatment parameter database in conjunction with its therapeutic effect to given patient, according to the treatment history parameters, the sound irradiation parameters scope of the required employing of selected treatment next time.
Again for example, after each area for treatment was accomplished, for whole area for treatment, in the zone that does not produce the ultrasonic cavitation effect, adjustment pulse amplitude, pulse recurrence frequency or duty cycle parameters were treated once more, so that obtain curative effect more uniformly.
Above-mentioned feedback control based on the acoustic cavitation detection signal can realize adjusting emission sound parameter in real time to the tissue characteristics of the concrete therapentic part of concrete patient, is a kind of adaptive therapeutic process that carries out according to the acoustic field signal feedback principle.The acoustical signal that utilization collects needs a suitable feedback control algorithm as the therapy system of feedback control parameters.To concrete needs, can design a suitable systematic cost function, for example the size of wide spectrum noise amplitude or signal that collects and the indexs such as cross-correlation coefficient between the reference signal.The target of this feedback control algorithm is exactly to seek the minimum of this cost function in real time between certain given emission sound parameter region.The sound parameter that meets this condition is emission sound parameter optimum under the current restrictive condition.
The ultrasonic therapy equipment of the embodiment of the invention also comprises:
One pick off;
Second control device, the ultrasound emission dosage of the said ultrasonic wave transducer emitter of Data Control that is used for arriving according to said sensor acquisition.
Explain as follows.
Should can also use with other sensor technology combinations based on the feedback control self adaptation therapeutic process that receives signal; Especially for the fat treatment that disappears of the ultrasonic shaping of subcutaneous fat; Can adopt temperature under near infrared ray sensor skin surface and the shallow epidermis skin, the feedback control treatment emission sound dosage of measured skin temperature can prevent skin injury.Perhaps adopt the near infrared ray pick off of suitable wavelength to receive the optical signal of the near infrared band that produces when (approximately less than 1 cm distance) strong instantaneous ultrasonic cavitation bubble breaks in the skin superficial tissue, as second reference data of removing outside the ultrasonic wave transducer emitter detection extent of cavitation.In addition, instantaneous ultrasonic cavitation meeting causes that H and OH free radical discharge in the water, and near infrared ray Spectrum Analysis technology is also responsive to base OH ion concentration, can also be as in real time or another means utilization of treatment back acoustic cavitation curative effect assessment.
Certainly, in the embodiment of the invention, ultrasonic therapy equipment can also comprise and presents module, is used for according to said judged result visual therapeutic outcome being provided.
Visual therapeutic outcome need be controlled according to positional information; In the specific embodiment of the invention; This ultrasound transmitting transducer can be arranged on the mechanical arm that can continue to move; The area for treatment that mobile covering through mechanical arm needs, said ultrasonic wave transducer emitter also can be one can hand mobile ultrasound emission transducer.
When ultrasound transmitting transducer can be arranged on the mechanical arm that can continue to move, the positional information of said ultrasound transmitting transducer can obtain according to the mechanical arm positioner that is used to obtain positional information.The said module that appears is according to the positional information of ultrasound transmitting transducer described in the therapeutic process and the ultrasonic cavitation testing result that obtains in each position; Can reconstruct area for treatment acoustic cavitation effect, and can superpose to merge and carry out pictorial display treatment information in the human body therapy zone.
And when said ultrasonic wave transducer emitter be one can hand mobile ultrasound emission transducer; Said ultrasound emission transducer be provided with one be used to obtain positional information 3 dimension space positioners; Along with moving of said ultrasonic wave transducer emitter, can access the acoustic cavitation result of each point, make up curative effect according to the acoustic cavitation signal judged result of ultrasonic irradiation positional information and this position and distribute and supply to show that treatment information uses.The said module that appears specifically is used for according to said positional information and said judged result visual treatment information being provided.The just said module that appears is according to the positional information of ultrasound transmitting transducer described in the therapeutic process and the ultrasonic cavitation testing result that obtains in each position; Can reconstruct area for treatment acoustic cavitation effect, and can superpose to merge and carry out pictorial display treatment information in the human body therapy zone.
To sum up; The embodiment of the invention has proposed a kind of ultrasonic therapy equipment that is used for the high-power ultrasonic treatment; It can judge whether the ultrasonic cavitation effect is in the preset range through the acoustical signal in detection effect zone; And control hyperacoustic emission according to judged result, and improved the accuracy of ultrasonic cavitation control device, guaranteed therapeutic effect.And to the therapeutic equipment operator treatment information is provided, and then in the ultrasonic therapeutic process, realize real-time feedback control treatment ultrasound emission parameter based on area for treatment sound field detection signal through the characteristic that extract to receive signal.With the criterion of these acoustic field signal data, a feasible method that monitoring in real time and postoperative curative effect are assessed in high intensity pulses ultrasonic therapeutic art is provided as treatment safety and effectiveness.
The above only is a preferred implementation of the present invention; Should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the principle of the invention; Can also make some improvement and retouching, these improvement and retouching also should be regarded as protection scope of the present invention.
Claims (14)
1. a ultrasonic therapy equipment is characterized in that, comprising:
The ultrasonic wave transducer emitter is used for producing and launching ultrasound wave to the zone of action;
The ultrasonic wave transducer receptor is used for gathering acoustical signal from the said zone of action, and the acoustical signal that collects is converted into the signal of telecommunication;
Judgment means is used for judging that according to the said signal of telecommunication whether the said zone of action acoustic cavitation of predetermined strength scope takes place, and obtains a judged result;
Feed back control system; The acoustic cavitation that is used for indicating the said zone of action in said judged result is not in the predetermined strength scope time; Control the ultrasound emission dosage of said ultrasonic wave transducer emitter, the acoustic cavitation of the said zone of action is in the said predetermined strength scope.
2. ultrasonic therapy equipment according to claim 1 is characterized in that, said ultrasonic wave transducer emitter and ultrasonic wave transducer receptor are focusing equipment, and the two confocal some setting.
3. ultrasonic therapy equipment according to claim 2 is characterized in that, the focal spot of said ultrasonic wave transducer emitter and ultrasonic wave transducer receptor intersects at a certain angle, partially overlaps.
4. ultrasonic therapy equipment according to claim 2; It is characterized in that; The top, spherical crown center of said focusing ultrasonic wave transducer emitter has a spatial accommodation; Said focusing ultrasonic wave transducer receptor is arranged in the said spatial accommodation, and the focal spot of said ultrasonic wave transducer emitter and ultrasonic wave transducer receptor intersects with the zero degree angle of cut, partly or entirely overlaps.
5. ultrasonic therapy equipment according to claim 2 is characterized in that, cyclic focusing ultrasonic wave transducer receptor is attached to outside the focusing ultrasonic wave transducer emitter external diameter or the front end coupling tapered sleeve outlet outside, the confocal point of acoustic axis altogether.
6. ultrasonic therapy equipment according to claim 5 is characterized in that, said cyclic focusing ultrasonic wave transducer receptor is placed along focusing ultrasonic wave transducer emitter outer ring-like space by a plurality of independently ultrasonic wave transducer receptors and formed.
7. ultrasonic therapy equipment according to claim 1 is characterized in that, said judgment means specifically comprises:
Conversion module is used to utilize the Fourier analysis method, and the said signal of telecommunication is carried out time domain to the spectral domain conversion;
Extraction module is used for signal after the spectral domain conversion and extracts between the predetermined high order of the work fundamental frequency of ultrasonic wave transducer transmitter or the noise amplitude spectrum that is lower than in the mark subfrequency scope of fundamental frequency and distribute;
First judge module is used to judge whether the distribution of noise amplitude spectrum exists the peak value of at least one discrete peak value greater than the first preset thresholding, and perhaps a plurality of successive peak values obtain said judged result greater than the peak value of the second preset thresholding.
8. ultrasonic therapy equipment according to claim 1 is characterized in that, said judgment means specifically comprises:
Conversion module is used to utilize the Fourier analysis method, the said signal of telecommunication is carried out the conversion of time domain to spectral domain;
Determination module is used for confirming that signal after the spectral domain conversion is in the resonance quality factor at the harmonic frequency place of ultrasonic wave transducer transmitter;
Second judge module is used to judge whether the resonance quality factor are in a preset range, obtain said judged result.
9. ultrasonic therapy equipment according to claim 1 is characterized in that, said judgment means specifically comprises:
The waveform envelope extraction module is used for that the said signal of telecommunication is carried out waveform envelope and extracts;
The time-domain integration module is used for waveform envelope and extracts the signal obtain and carry out time-domain integration, obtains receiving the gross energy of signal;
The 3rd judge module, be used for more said gross energy and the energy range the when acoustic cavitation of predetermined strength scope takes place of the zone of action that measures in advance between, obtain said judged result.
10. ultrasonic therapy equipment according to claim 1 is characterized in that judgment means specifically comprises:
Preserve module, the 3rd reference signal when second reference signal and the zone of action were higher than the acoustic cavitation of predetermined strength scope when first reference signal, the zone of action were lower than the acoustic cavitation of predetermined strength scope when being used to preserve the zone of action acoustic cavitation of predetermined strength scope taking place;
Cross-correlation degree computing module is used to calculate the cross-correlation degree of the said signal of telecommunication and first, second and the 3rd reference signal;
The 4th judge module is used for obtaining said judged result according to said cross-correlation degree.
11. according to any described ultrasonic therapy equipment among the claim 1-10, it is characterized in that, also comprise:
One pick off;
Second control device, the ultrasound emission dosage of the said ultrasonic wave transducer emitter of Data Control that is used for arriving according to said sensor acquisition.
12. ultrasonic therapy equipment according to claim 1 is characterized in that, also comprises:
Present module, be used for visual treatment information being provided according to said judged result.
13. ultrasonic therapy equipment according to claim 12; It is characterized in that; Said ultrasonic therapy equipment comprises that also the mechanical arm and that can continue to move is used to obtain the mechanical arm positioner of positional information; Said ultrasonic wave transducer emitter is arranged on the said mechanical arm, and the said module that appears specifically is used for according to said positional information and said judged result visual treatment information being provided.
14. ultrasonic therapy equipment according to claim 12; It is characterized in that; Said ultrasonic wave transducer emitter is one can hand mobile ultrasound emission transducer; Said ultrasound emission transducer be provided with one be used to obtain positional information 3 dimension space positioners, the said module that appears specifically is used for according to said positional information and said judged result visual treatment information being provided.
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| CN113117268A (en) * | 2019-12-30 | 2021-07-16 | 重庆融海超声医学工程研究中心有限公司 | Method and device for detecting cavitation effect and ultrasonic treatment equipment |
| CN113117257A (en) * | 2019-12-30 | 2021-07-16 | 重庆融海超声医学工程研究中心有限公司 | Method and device for detecting cavitation effect and ultrasonic treatment equipment |
| CN113426651A (en) * | 2021-05-21 | 2021-09-24 | 四川步歌科技有限公司 | Ultrasonic circuit and pain therapeutic apparatus comprising same |
| CN113893468A (en) * | 2020-06-22 | 2022-01-07 | 飞依诺科技(苏州)有限公司 | Method and device for adjusting therapeutic ultrasonic waves, computer equipment and storage medium |
| CN116439981A (en) * | 2023-06-16 | 2023-07-18 | 北京航空航天大学 | Shock wave treatment feedback device |
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| CN116439981A (en) * | 2023-06-16 | 2023-07-18 | 北京航空航天大学 | Shock wave treatment feedback device |
| CN116439981B (en) * | 2023-06-16 | 2023-11-24 | 北京航空航天大学 | Shock wave treatment feedback device |
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