CN102451525B - A kind of ultrasonic therapy equipment - Google Patents
A kind of ultrasonic therapy equipment Download PDFInfo
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- CN102451525B CN102451525B CN201010526994.2A CN201010526994A CN102451525B CN 102451525 B CN102451525 B CN 102451525B CN 201010526994 A CN201010526994 A CN 201010526994A CN 102451525 B CN102451525 B CN 102451525B
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Abstract
The invention provides a kind of ultrasonic therapy equipment, this ultrasonic therapy equipment comprises: ultrasonic wave transducer transmitter, for generation of and to zone of action transmitting ultrasonic wave; Ultrasonic wave transducer receiver, for gathering acoustical signal from the described zone of action, and is converted into the signal of telecommunication by the acoustical signal collecting; Judgment means, for judging that according to the described signal of telecommunication whether the described zone of action acoustic cavitation of predetermined strength scope occurs, and obtains a judged result; Feed back control system, when the acoustic cavitation of indicating the described zone of action in described judged result is not within the scope of predetermined strength, control the ultrasound emission dosage of described ultrasonic wave transducer transmitter, make the acoustic cavitation of the described zone of action within the scope of described predetermined strength. The present invention has improved the accuracy of ultrasonic cavitation control device, has ensured result for the treatment of.
Description
Technical field
The present invention relates to medical apparatus technical field, particularly a kind of ultrasonic therapy equipment.
Background technology
High-strength ultrasonic signal can produce some biological tissues effect in tissue, for example, because tissue causes to the absorption of ultrasonic energy cell rupture, the apoptosis etc. that cell heat is downright bad, cause due to hyperacoustic mechanical effect.
Ultrasonic cavitation is a kind of hyperacoustic mechanical effect, is because high-strength ultrasonic acts on the physical phenomenon producing after the cavitation nucleus (micro-bubble) in liquid or class I liquid I. Micro-bubble is repeatedly driven by the positive and negative pressure of sound wave and produces alternately increase and compression rapidly of volume, and the bubble harmomegathus being produced by the effect of alternation acoustic pressure motion is called stable cavitation. When rapidly violent harmomegathus and while causing mechanical tension in the walls of gas-liquid two-phase medium boundary to exceed its critical value, bubble collapse produces instantaneous cavitation of bubble. When stable cavitation, air bladder resonance produces radiant force effect and micro-acoustic streaming, and these vibration source transmittings are corresponding to some arrowbands acoustical signal of sound wave driving frequency or bubble natural reonant frequency and harmonic frequency thereof. When instantaneous cavitation, follow bubble volume to dwindle or collapse moment, due to energy accumulation or discharge can produce in Local Instantaneous high temperature, Discharge illuminating, water vapour H and OH free radical discharges and with other composition generation chemical reactions, generation sound is to phenomenons such as luminous, shock wave and jets thus.
In application medical research field, recent two decades comes, and biological tissue's effect of ultrasonic cavitation is subject to broad research and application day by day: utilize its stable cavitation effect, acoustic contrast agent can significantly improve the contrast of ultrasonic image; Utilize its instantaneous cavitation effect, pulsed high-strength ultrasonic at treatment tumour, drug delivery, cause the application of the aspects such as clasmatosis or withered, block nerves conduction to have new progress.
Utilizing hyperacoustic mechanical effect to change in the process of biological properties, this change should be safe and controlled, to improve result for the treatment of, too low sound emission dosage cannot produce acoustic cavitation, too high sound dosage can cause even boiling and production fire damage causes over-treatment or other unnecessary tissue injury of tissue heat absorption.
But the control device of ultrasonic cavitation is all that the signal of telecommunication sending according to transmitting transducer transmitting terminal is controlled in existing tissue, at least there is following shortcoming in above-mentioned control mode:
Due to the distance existing between transmitting terminal and area for treatment, therefore the energy of not all transmitting can both be had an effect in area for treatment; Or due to the individual difference of biological tissue, the energy shortage of transmitting to be to cause the ultrasonic cavitation of expection, or far beyond the required energy of cavitation. Therefore these class methods can only be from rule of thumb biological tissue's effect of the actual generation of reasoning of variation of the transmitting signal of telecommunication, and it is only a kind of reasoning, is not the situation of actual generation, therefore has the possibility of erroneous judgement, also has the shortcoming that precision is not high. These shortcomings all can endanger security and the validity for the treatment of.
Summary of the invention
The object of this invention is to provide a kind of ultrasonic therapy equipment, improve the accuracy of ultrasonic cavitation control device, ensure result for the treatment of.
To achieve these goals, the embodiment of the present invention provides a kind of ultrasonic therapy equipment, comprising:
Ultrasonic wave transducer transmitter, for generation of and to zone of action transmitting ultrasonic wave;
Ultrasonic wave transducer receiver, for gathering acoustical signal from the described zone of action, and is converted into the signal of telecommunication by the acoustical signal collecting;
Judgment means, for judging that according to the described signal of telecommunication whether the described zone of action acoustic cavitation of predetermined strength scope occurs, and obtains a judged result;
Feed back control system, when the acoustic cavitation of indicating the described zone of action in described judged result is not within the scope of predetermined strength, control the ultrasound emission dosage of described ultrasonic wave transducer transmitter, make the acoustic cavitation of the described zone of action within the scope of described predetermined strength.
Above-mentioned ultrasonic therapy equipment, wherein, described ultrasonic wave transducer transmitter and ultrasonic wave transducer receiver are focusing equipment, and the two common focal point settings.
Above-mentioned ultrasonic therapy equipment, wherein, described ultrasonic wave transducer transmitter is crossing at a certain angle with the focal spot of ultrasonic wave transducer receiver, partially overlaps.
Above-mentioned ultrasonic therapy equipment, wherein, the top, spherical crown center of described focusing ultrasonic wave transducer transmitter has a spatial accommodation, described focusing ultrasonic wave transducer receiver is arranged in described spatial accommodation, described ultrasonic wave transducer transmitter is crossing with the zero degree angle of cut with the focal spot of ultrasonic wave transducer receiver, partly or entirely overlaps.
Above-mentioned ultrasonic therapy equipment, wherein, the focusing ultrasonic wave transducer receiver of ring-type is attached to outside focusing ultrasonic wave transducer transmitter external diameter or front end coupling tapered sleeve outlet outside, the confocal point of acoustic axis altogether.
Above-mentioned ultrasonic therapy equipment, wherein, the focusing ultrasonic wave transducer receiver of described ring-type is placed and is formed along focusing ultrasonic wave transducer transmitter outer ring-like space by multiple independently ultrasonic wave transducer receivers.
Above-mentioned ultrasonic therapy equipment, wherein, described judgment means specifically comprises:
Conversion module, for utilizing Fourier analysis method, carries out time domain to spectral domain conversion to the described signal of telecommunication;
Extraction module, distributes between the predetermined high order of the work fundamental frequency of ultrasonic wave transducer transmitter or lower than the noise amplitude spectrum in the fractional harmoni frequency range of fundamental frequency for the signal extraction from spectral domain conversion;
Whether the first judge module, exist at least one discrete peak value to be greater than the peak value of the first default thresholding for judging that noise amplitude spectrum distributes, or multiple continuous peak value is greater than the peak value of the second default thresholding, obtains described judged result.
Above-mentioned ultrasonic therapy equipment, wherein, described judgment means specifically comprises:
Conversion module, for utilizing Fourier analysis method, carries out the conversion of time domain to spectral domain to the described signal of telecommunication;
Determination module, the resonance quality factor for the signal after definite spectral domain conversion at the harmonic frequency place of ultrasonic wave transducer transmitter;
The second judge module, for judging that resonance quality factor, whether in a preset range, obtain described judged result.
Above-mentioned ultrasonic therapy equipment, wherein, described judgment means specifically comprises:
Waveform envelope extraction module, for carrying out waveform envelope extraction to the described signal of telecommunication;
Time-domain integration module, extracts for waveform envelope the signal obtaining and carries out time-domain integration, obtains receiving the gross energy of signal;
The 3rd judge module, between the energy range while there is the acoustic cavitation of predetermined strength scope for more described gross energy and the zone of action that measures in advance, obtains described judged result.
Above-mentioned ultrasonic therapy equipment, wherein, judgment means specifically comprises:
Preserve module, the 3rd reference signal when the acoustic cavitation higher than predetermined strength scope occurs for the second reference signal and the zone of action when preserving the zone of action the first reference signal, the zone of action occur lower than the acoustic cavitation of predetermined strength scope while there is the acoustic cavitation of predetermined strength scope;
Cross-correlation degree computing module, for calculating the cross-correlation degree of the described signal of telecommunication and first, second, and third reference signal;
The 4th judge module, for according to described cross-correlation degree, obtains described judged result.
Above-mentioned ultrasonic therapy equipment, wherein, also comprises:
One sensor;
Second control device, for the ultrasound emission dosage of ultrasonic wave transducer transmitter described in the Data Control collecting according to described sensor.
Above-mentioned ultrasonic therapy equipment, wherein, also comprises:
Present module, for visual treatment information is provided according to described judged result.
Above-mentioned ultrasonic therapy equipment, also comprise that one can continue mobile mechanical arm and for obtaining the mechanical arm positioner of positional information, described ultrasonic wave transducer transmitter is arranged on described mechanical arm, described in present module specifically for providing visual treatment information according to described positional information and described judged result.
Above-mentioned ultrasonic therapy equipment, wherein, described ultrasonic wave transducer transmitter be one can hand-held movement ultrasound emission transducer, on described ultrasound emission transducer, be provided with one for obtaining 3 dimension space positioners of positional information, described in present module specifically for providing visual treatment information according to described positional information and described judged result.
The embodiment of the present invention has following beneficial effect:
The embodiment of the present invention has proposed a kind of ultrasonic therapy equipment for high-power ultrasonic treatment, it can judge that ultrasonic cavitation effect is whether in preset range by the voice signal in detection effect region, and according to the hyperacoustic transmitting of judged result control, the accuracy that has improved ultrasonic cavitation control device, has ensured result for the treatment of. And the feature that receives signal by extraction provides treatment information to therapeutic equipment operator, and then in ultrasonic therapy process, realize the real-time feedback control treatment ultrasound emission parameter based on area for treatment sound field detection signal. Criterion using these acoustic field signal data as treatment security and validity, provides a feasible method in high intensity pulses ultrasonic therapy real-time intraoperative monitoring and postoperative curative effect assessment.
Brief description of the drawings
Fig. 1 is the structural representation of the ultrasonic therapy equipment of the embodiment of the present invention.
Detailed description of the invention
In the embodiment of the present invention, judge that by the voice signal in detection effect region ultrasonic cavitation effect is whether in preset range, and according to the hyperacoustic transmitting of judged result control, to reach predetermined result for the treatment of.
As shown in Figure 1, the ultrasonic therapy equipment of the embodiment of the present invention comprises:
Ultrasonic wave transducer transmitter, for generation of and to zone of action transmitting ultrasonic wave;
Ultrasonic wave transducer receiver, for gathering acoustical signal from the described zone of action, and is converted into the signal of telecommunication by the acoustical signal collecting;
Judgment means, for judging that according to the described signal of telecommunication whether the described zone of action acoustic cavitation of predetermined strength scope occurs, and obtains a judged result;
Feed back control system, when the acoustic cavitation of indicating the described zone of action in described judged result is not within the scope of predetermined strength, control the ultrasound emission dosage of described ultrasonic wave transducer transmitter, make the acoustic cavitation of the described zone of action within the scope of described predetermined strength.
Ultrasonic wave transducer transmitter inside has one group of crystal with piezo-electric effect, this piezo-electric crystal has special character, on crystal specific direction, add voltage exactly, can there is deformation in crystal, produce ultrasonic wave, and ultrasonic wave transducer receiver inside equally also has such one group of crystal with piezo-electric effect, when ultrasonic wave is to crystal effect, while making crystal generation deformation, on correspondence direction, voltage be will produce, the signal of telecommunication and hyperacoustic conversion realized.
In specific embodiments of the invention, ultrasonic wave transducer transmitter and ultrasonic wave transducer receiver are focusing equipment, in the time that the two is all focusing equipment, and the two common focal point settings.
Typically, the focal spot place sound intensity of focusing ultrasonic wave transducer transmitter is the strongest, is the treatment position (generation area of acoustic cavitation) of wishing. Ultrasonic wave transducer receiver adopts while focusing on receive mode, its focal spot (the sensitiveest receiving area) need to be aimed at the focal spot of focusing ultrasonic wave transducer transmitter, to improve the receiving sensitivity of acoustic cavitation signal and to reduce the noise jamming of coming outside self-focusing type ultrasonic wave transducer transmitter focal spot.
Below various possible confocal implementations are elaborated.
Implementation one
The confocal point of focusing ultrasonic wave transducer transmitter and the inclined to one side acoustic axis of focusing ultrasonic wave transducer receiver receives, and the acoustic axis of two transducers does not overlap mutually, but the intersection coincidence at a certain angle of its focal spot. Common implementation method can be according to the confocal fixed-focus formula ultrasonic wave transducer receiver that is related in focusing ultrasonic wave transducer transmitter outside.
Implementation two
Focusing ultrasonic wave transducer transmitter and focusing ultrasonic wave transducer the receiver altogether confocal point of acoustic axis receive, and the acoustic axis of two transducers overlaps mutually, and its focal spot is crossing with the zero degree angle of cut, partly or entirely overlaps.
In implementation two, the top, spherical crown center of described focusing ultrasonic wave transducer transmitter has a spatial accommodation (as hole), and then described focusing ultrasonic wave transducer receiver is arranged in described spatial accommodation.
In implementation two, although the energy emission area of focusing ultrasonic wave transducer transmitter has certain sacrifice, focusing ultrasonic wave transducer transmitter and focusing ultrasonic wave transducer receiver are wholely set, and make confocal adjustment simpler, easy to use.
Implementation three
Adopt the focusing ultrasonic wave transducer receiver of ring-type to be attached to outside focusing ultrasonic wave transducer transmitter external diameter or front end coupling tapered sleeve outlet outside, be adjacent to the zone of action and realize with the confocal point of common acoustic axis of focusing ultrasonic wave transducer transmitter and receiving.
Implementation four
In some cases, multiple focusing or non-focusing independent ultrasonic wave transducer receiver can also be placed along focusing ultrasonic wave transducer transmitter outer ring-like space, synthetic one with the coaxial confocal sound field receiving equipment of focusing ultrasonic wave transducer transmitter. This mode can solve ultrasonic wave transducer receiver and focus on the problem that sensitivity that the number ratio of transducer diameter (focal length with) excessive (receiving area is too small) causes declines, and reduces and be reflected the risk that acoustic energy damages; And focusing ultrasonic wave transducer transmitter is without its emission area of loss, and the integrated of focusing ultrasonic wave transducer receiver also easily realized.
Even more advantageously, can finely tune it and receive by adjusting the width of focusing ultrasonic wave transducer receiver or subsequent corrosion the focal spot size of sound field, utilize its distinctive laterally extending sound field characteristic, can obtain broader horizontal receiving area, make this sound field receiving equipment can receive the acoustical signal in self-focusing type ultrasonic wave transducer transmitter focus and near biological tissue thereof. Carry out along transverse movement, under the situation of scanning treatment, detecting more reliable at focusing ultrasonic wave transducer transmitter.
In specific embodiments of the invention, this ultrasonic wave transducer receiver can adopt single transducer architecture of ring-type spherical crown surface self-focusing mode or single transducer architecture of ring plain piezoelectric ceramic piece cooperation acoustic lens, it can optimize focusing acoustic field focal spot by the approach that changes spheric curvature, utilizes the focal spot sensitivity of focusing acoustic field optionally to receive the sound emission/scattered signal from appointed area.
Certainly, this ultrasonic wave transducer receiver also can adopt phase array transducer array to realize, utilize phase controlling to form focus beam, and this focus beam can be adjusted wave beam receiving area by the method that changes receiving phase, so even can realize in two-dimentional depth plane or three dimensions scanning and receive sound emission/scattered signal, show acoustic cavitation treatment testing result in the mode of image. The focal spot region of ultrasonic wave transducer receiver should have more than 20% overlapping with the focal spot of ultrasonic wave transducer transmitter, with the sensitivity that ensures that signal receives.
In specific embodiments of the invention, need to judge that according to the signal collecting whether the zone of action acoustic cavitation of predetermined strength scope occurs, and is described as follows various implementations below.
<implementation one>
In implementation one, this judgment means specifically comprises:
Conversion module, for utilizing Fourier analysis method, or Fourier analysis method in short-term, whole section of the described signal of telecommunication or segmentation are carried out to the conversion of time domain to spectral domain;
Extraction module, wide spectrum characteristic based on acoustic cavitation signal, the acoustical signal amplitude spectrum of for example extracting, in predetermined higher hamonic wave frequency range between the work fundamental frequency of ultrasonic wave transducer transmitter (2 times to 10 subfrequencies) for the signal from spectral domain conversion distributes, or for example extracts, lower than the acoustical signal amplitude spectrum distribution in the predetermined score subfrequency scope (1/4 to 3/4 subfrequency) of the work fundamental frequency of ultrasound transmitting transducer. Suggestion is avoided work fundamental frequency and the periphery frequency range thereof of ultrasonic wave transducer transmitter and is avoided the interference being transmitted by force;
Whether the first judge module, exist single or multiple discrete peak values to be greater than the peak value of the first default thresholding for judging that noise amplitude spectrum distributes, or multiple continuous peak value is greater than the peak value of the second default thresholding, obtains one first judged result;
Now judged result has 3 kinds of situations:
Situation one, exist at least one discrete peak value to be greater than the peak value of default thresholding;
Situation two, exist multiple continuous peak values to be greater than the peak value of default thresholding;
Situation three, neither exist at least one discrete peak value to be greater than the peak value of default thresholding, also do not exist multiple continuous peak values to be greater than the peak value of default thresholding.
Once ultrasonic wave transducer transmitter is launched ultrasonic wave to presumptive area, if while causing presumptive area generation acoustic cavitation, ultrasonic wave transducer transmitter focal spot place can vibrate by gassing, may occur that discrete at least one by one peak value is greater than the local peaking of default thresholding, if and ultrasound emission dosage is when excessive, there will be a lot of closely adjacent resonant frequency peaks, cause spectrum to distribute and show that continuous and local strengthens, its amplitude even surmounts the harmonic signal peak value of ultrasonic wave transducer transmitter.
Whether the acoustic cavitation that therefore can judge the zone of action based on above spectrum signature is within the scope of predetermined strength.
When occurring that result for the moment, show that the acoustic cavitation in predetermined strength scope occurs in the zone of action, and in the time there is result two, show that the zone of action exceedes the acoustic cavitation of predetermined strength scope, and in the time there is result three, show that the acoustic cavitation of the zone of action is lower than predetermined strength scope.
In the time there is result two, ultrasonic wave transducer transmitter reduces ultrasound emission dosage described in feed back control system control, and while there is result three, and ultrasonic wave transducer transmitter improves ultrasound emission dosage described in feed back control system control.
Certainly, two above-mentioned thresholdings can arrange according to demand, as require the stronger treatment occasion of acoustic cavitation, thresholding can be arranged higher, otherwise thresholding can be arranged lowlyer, this thresholding can arrange as a reference with the percentage of the harmonic signal peak value of ultrasonic wave transducer transmitter.
The specific implementation method of judge module can adopt simulation, numeral or modulus hybrid circuit method to realize. Employing A/D digital to analog converter after digital sample, is realized the operations such as above-mentioned conversion, extraction and judgement by the signal of telecommunication of ultrasonic wave transducer receiver to this data signal in Digital Signal Processing mode.
In implementation two, this judgment means specifically comprises:
Conversion module, for utilizing Fourier analysis method, or Fourier analysis method in short-term, whole section of the described signal of telecommunication or segmentation are carried out to the conversion of time domain to spectral domain;
Determination module, the resonance quality factor for the signal after definite spectral domain conversion at the harmonic frequency place of ultrasonic wave transducer transmitter;
The second judge module, for judging that resonance quality factor, whether in a preset range, obtain one second judged result;
Because the harmonics signal indication of arrowband does not extremely have other resonance signal sources, the resonance peak shape of expansion represents that the ultrasonic energy of this resonant frequency drives cavitation bubble to be forced to stable vibration (the bubble stabilizes vibration frequency that different bubble diameters are corresponding different, the slightly deviation of harmonic frequency of these bubble resonance frequencies and ultrasonic wave transducer transmitter, causes the resonance peak shape of expanding). Therefore, in implementation two, resonance quality factor are during higher than preset range, represent that the acoustic cavitation of the described zone of action is lower than within the scope of predetermined strength, feed back control system should increase the ultrasound emission dosage of described ultrasonic wave transducer transmitter, and resonance quality factor are during lower than preset range, represent that the acoustic cavitation of the described zone of action is higher than within the scope of predetermined strength, feed back control system should reduce the ultrasound emission dosage of described ultrasonic wave transducer transmitter.
The specific implementation method of other modules and above-mentioned implementation method one are similar.
In implementation three, this judgment means specifically comprises:
Waveform envelope extraction module, for carrying out waveform envelope extraction to the described signal of telecommunication;
Time-domain integration module, extracts for waveform envelope the signal obtaining and carries out time-domain integration, obtains receiving the gross energy of signal;
The 3rd judge module, between the energy range while there is the acoustic cavitation of predetermined strength scope for more described gross energy and the zone of action that measures in advance, obtains one the 3rd judged result;
In implementation three, between the energy range when gross energy that time-domain integration module obtains is positioned at the zone of action that measures in advance the acoustic cavitation of predetermined strength scope occurs time, show that the acoustic cavitation of predetermined strength scope occurs in the zone of action, when minimum of a value between the energy range in the time that the gross energy that time domain integration module obtains is less than the zone of action that measures in advance the acoustic cavitation of predetermined strength scope occurs, represent that the acoustic cavitation of the described zone of action is lower than within the scope of predetermined strength, feed back control system should increase the ultrasound emission dosage of described ultrasonic wave transducer transmitter, when maximum between the energy range in the time that the gross energy that time domain integration module obtains is greater than the zone of action that measures in advance the acoustic cavitation of predetermined strength scope occurs, represent that the acoustic cavitation of the described zone of action is higher than within the scope of predetermined strength, feed back control system should reduce the ultrasound emission dosage of described ultrasonic wave transducer transmitter.
Waveform envelope extraction module, time-domain integration module and the 3rd judge module of this implementation specifically can adopt the circuit such as envelope detector, integrator and subtracter to realize, thereby scheme is simple, and cost is low, easily realizes.
In implementation four, this judgment means specifically comprises:
Preserve module, the 3rd reference signal when the acoustic cavitation higher than predetermined strength scope occurs for the second reference signal and the zone of action when preserving the zone of action the first reference signal, the zone of action occur lower than the acoustic cavitation of predetermined strength scope while there is the acoustic cavitation of predetermined strength scope;
Cross-correlation degree computing module, for calculating the cross-correlation degree of the described signal of telecommunication and first, second, and third reference signal;
The 4th judge module, for according to described cross-correlation degree, obtains one the 4th judged result;
In implementation four, judge the signal of telecommunication to the first reference signal when the most relevant according to cross-correlation degree, show that the acoustic cavitation of predetermined strength scope occurs in the zone of action, when the signal of telecommunication is to the second reference signal when the most relevant, represent that the acoustic cavitation of the described zone of action is lower than within the scope of predetermined strength, feed back control system should increase the ultrasound emission dosage of described ultrasonic wave transducer transmitter, when the signal of telecommunication is to the 3rd reference signal when the most relevant, represent that the acoustic cavitation of the described zone of action is higher than within the scope of predetermined strength, feed back control system should reduce the ultrasound emission dosage of described ultrasonic wave transducer transmitter.
At this, this cross-correlation degree can realize by matched filter, utilizes matched filter principle. In the time that ultrasonic wave transducer transmitter is launched in a low voice irradiation dose, ultrasonic wave transducer receiver is launched certain certain pulses to area for treatment simultaneously, picks up corresponding signal as with reference to Design of Signal matched filter; In high power therapeutic process, ultrasonic wave transducer receiver is in impulse ejection/accepting state, the signal receiving can pass through this matched filter, its filter system output valve when very big, represent received signal and this reference signal correlation best, otherwise represent to produce marked change because the variation of area for treatment causes the signal that receives.
Certainly, in specific embodiments of the invention, this judge module can also adopt other mode to realize, as the method for random noise modeling that adopts noise signal to detect, the acoustical signal receiving is carried out to noise model parameter extraction, the methods such as such as autoregression rolling average (ARMA) model, and operation parameter threshold value is carried out the judgement of binary acoustic cavitation, at this, describe in detail no longer one by one for the mode of other realizations.
In implementation four, adopt A/D analog-digital converter can gather first, second, and third reference signal, cross-correlation degree computing module can calculate the cross-correlation coefficient (being digital matched filter) between real-time acoustic cavitation signal and certain reference signal with digital convolution. For the parameter extraction of noise model, also existing abundant practical algorithm can be for using for reference.
While composition by multiple regions in the described zone of action, in specific embodiments of the invention, can be in conjunction with the whether suitable judged result of acoustic cavitation generation and the space coordinates of the zone of action, judged result is mapped on a space curved surface, shows the acoustic cavitation effect spatial distribution of the whole area for treatment at place, the zone of action.
The space coordinates of each zone of action can be read by Mechanical Moving axle position coder separately, maybe can adopt the location tracking method that is fixed on the dimension of 3 on ultrasonic wave transducer transmitter witness marker to obtain. If this space curved surface is the plane that is parallel to body skin surface, acoustic cavitation distribution design sketch is shown as two-dimensional image. And this distribution map can further be added on the striograph of tissue, as the demonstration directly perceived of result for the treatment of.
Utilize the method for the embodiment of the present invention, in the high intensity ultrasound treatment process being formed by multiposition repeated ultrasonic irradiation at, for ongoing single ultrasound wave irradiation, adopt above-mentioned detection method, can judge whether this irradiation has produced ultrasonic cavitation effect. If this time irradiation does not produce ultrasonic cavitation, can append ultrasound wave irradiation one time in current location, tell on ensureing; If produced ultrasonic cavitation, treatment probe can move to next position and treats.
Again for example, in single ultrasound wave irradiation process, if the Fourier analysis in short-term of the signal collecting does not show real-time acoustic cavitation result, can induce acoustic cavitation to occur by the method that increases impulse amplitude and/or change pulse duty factor; Otherwise, if acoustic cavitation is too violent, can suitably reduce the intensity that impulse amplitude suppresses acoustic cavitation.
Or, in the time that ultrasonic wave transducer receiver and ultrasonic wave transducer transmitter all adopt phase array transducer structure, can electronic zoom, around the treatment position of current generation ultrasonic cavitation, the bubble cloud that utilizes current cavitation to produce, immediately the focus electron focusing of ultrasonic wave transducer transmitter is carried out to next infrasonic sound irradiation to bubble cloud edge, can adopt lower acoustical power easily to continue to excite acoustic cavitation effect; The focus of ultrasonic wave transducer receiver is also monitored with the focus respective electronic focus tracking of ultrasonic wave transducer transmitter simultaneously. Be beneficial to and expand acoustic cavitation area for treatment, shorten treatment time.
Again for example, according to the acoustic cavitation effect of some treatment position ultrasound wave irradiations above, can obtain a ultrasonic cavitation parameter area; Thereby predict the needed transmitting sound of next ultrasound wave irradiation parameter, obtain acoustic cavitation. Also can, to given patient, set up treatment parameter database in conjunction with its result for the treatment of, according to treatment history parameters, the sound irradiation parameters scope of the required employing of selected treatment next time.
Again for example, after each area for treatment completes, for whole area for treatment, in the region that does not produce ultrasonic cavitation effect, adjust impulse amplitude, pulse recurrence frequency or duty cycle parameters, again treat, to obtain more uniform curative effect.
The above-mentioned FEEDBACK CONTROL based on acoustic cavitation detection signal can realize for the tissue characteristics of the concrete therapentic part of concrete patient and adjust in real time transmitting sound parameter, is a kind of adaptive therapeutic process carrying out according to acoustic field signal feedback principle. The voice signal that utilization collects need to have a suitable feedback control algorithm as the therapy system of feedback control parameters. For concrete needs, can design a suitable systematic cost function, the indexs such as such as, cross-correlation coefficient between the size of broadband noise amplitude or signal and the reference signal collecting. The target of this feedback control algorithm is exactly in certain given transmitting sound parameter region, to find in real time the minimum of this cost function. The sound parameter that meets this condition is transmitting sound parameter optimum under current restrictive condition.
The ultrasonic therapy equipment of the embodiment of the present invention, also comprises:
One sensor;
Second control device, for the ultrasound emission dosage of ultrasonic wave transducer transmitter described in the Data Control collecting according to described sensor.
Be described as follows.
Should can also be used in combination with other sensor technologies by the FEEDBACK CONTROL self adaptation therapeutic process based on receiving signal, especially for the fat treatment that disappears of the ultrasonic shaping of subcutaneous fat, can adopt temperature under near infrared ray sensor detection of skin surface and shallow epidermis skin, the FEEDBACK CONTROL treatment transmitting sound dosage of measured skin temperature can prevent skin injury. Or the optical signal of the near infrared band producing when (being approximately less than 1 cm distance), strong instantaneous ultrasonic cavitation bubble broke in the near infrared ray sensor reception skin superficial tissue of employing suitable wavelength, detects the second reference data outside extent of cavitation as removing ultrasonic wave transducer transmitter. In addition, instantaneous ultrasonic cavitation meeting causes H and the release of OH free radical in water, and near infrared ray Spectrum Analysis technology, also to base OH ion concentration sensitivity, can also be used as another means real-time or the rear acoustic cavitation curative effect evaluation for the treatment of.
Certainly,, in the embodiment of the present invention, ultrasonic therapy equipment can also comprise and presents module, for providing visual treatment results according to described judged result.
Visual treatment results need to be controlled according to positional information, in the specific embodiment of the invention, this ultrasound transmitting transducer can be arranged at and can continue on mobile mechanical arm, by the mobile area for treatment needing that covers of mechanical arm, described ultrasonic wave transducer transmitter can be also one can hand-held movement ultrasound emission transducer.
In the time that ultrasound transmitting transducer can be arranged on the mechanical arm that can continue to move, the positional information of described ultrasound transmitting transducer can obtain according to the mechanical arm positioner for obtaining positional information. Describedly present the ultrasonic cavitation testing result that module obtains according to the positional information of ultrasound transmitting transducer described in therapeutic process with in each position, can reconstruct area for treatment acoustic cavitation effect, and can additive fusion carry out image in human body therapy region and show treatment information.
And when described ultrasonic wave transducer transmitter be one can hand-held movement ultrasound emission transducer, on described ultrasound emission transducer, be provided with one for obtaining 3 dimension space positioners of positional information, along with the movement of described ultrasonic wave transducer transmitter, can obtain the acoustic cavitation result of each point, build curative effect according to the acoustic cavitation signal judged result of ultrasound wave irradiation positional information and this position and distribute for showing treatment information. The described module that presents is specifically for providing visual treatment information according to described positional information and described judged result. Namely, present the ultrasonic cavitation testing result that module obtains according to the positional information of ultrasound transmitting transducer described in therapeutic process with in each position, can reconstruct area for treatment acoustic cavitation effect, and can additive fusion carry out image in human body therapy region and show treatment information.
To sum up, the embodiment of the present invention has proposed a kind of ultrasonic therapy equipment for high-power ultrasonic treatment, it can judge that ultrasonic cavitation effect is whether in preset range by the voice signal in detection effect region, and according to the hyperacoustic transmitting of judged result control, the accuracy that has improved ultrasonic cavitation control device, has ensured result for the treatment of. And the feature that receives signal by extraction provides treatment information to therapeutic equipment operator, and then in ultrasonic therapy process, realize the real-time feedback control treatment ultrasound emission parameter based on area for treatment sound field detection signal. Criterion using these acoustic field signal data as treatment security and validity, provides a feasible method in high intensity pulses ultrasonic therapy real-time intraoperative monitoring and postoperative curative effect assessment.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (14)
1. a ultrasonic therapy equipment, is characterized in that, comprising:
Ultrasonic wave transducer transmitter, for generation of and to zone of action transmitting ultrasonic wave;
Ultrasonic wave transducer receiver, for gathering acoustical signal from the described zone of action, and by the sound letter collectingNumber be converted into the signal of telecommunication;
Judgment means, described judgment means comprises: conversion module, arrives for the described signal of telecommunication is carried out to time domainSpectral domain conversion; The first judge module, for judging whether the signal from spectral domain conversion exists at least oneDiscrete peak value is greater than the peak value of the first default thresholding, or multiple continuous peak value is greater than the second default thresholdingPeak value, obtain described judged result;
Feed back control system, for indicating the acoustic cavitation of the described zone of action not predetermined in described judged resultIn strength range time, control the ultrasound emission dosage of described ultrasonic wave transducer transmitter, make the described zone of actionAcoustic cavitation within the scope of described predetermined strength; Wherein, when existing at least in the signal after spectral domain conversionA discrete peak value is greater than the peak value of the first default thresholding, does not exist again multiple continuous peak values to be greater than secondThe peak value of default thresholding, described judged result indicates the acoustic cavitation of the described zone of action not at predetermined strength modelIn enclosing.
2. ultrasonic therapy equipment according to claim 1, is characterized in that, described ultrasonic wavesEnergy transmitter and ultrasonic wave transducer receiver are focusing equipment, and the two common focal point settings.
3. ultrasonic therapy equipment according to claim 2, is characterized in that, described ultrasonic wavesEnergy transmitter is crossing at a certain angle with the focal spot of ultrasonic wave transducer receiver, partially overlaps.
4. ultrasonic therapy equipment according to claim 2, is characterized in that, described focusing superThe top, spherical crown center of sound wave transducing transmitter has a spatial accommodation, and described focusing ultrasonic wave transducer receivesDevice is arranged in described spatial accommodation, the focal spot of described ultrasonic wave transducer transmitter and ultrasonic wave transducer receiverIntersect with the zero degree angle of cut, partly or entirely overlap.
5. ultrasonic therapy equipment according to claim 2, is characterized in that, ring-type focusingUltrasonic wave transducer receiver is attached to outside focusing ultrasonic wave transducer transmitter external diameter or front end coupling tapered sleeveOutlet outside, the altogether confocal point of acoustic axis.
6. ultrasonic therapy equipment according to claim 5, is characterized in that, described ring-type poly-Burnt formula ultrasonic wave transducer receiver by multiple independently ultrasonic wave transducer receivers along focusing ultrasonic wave transducerComposition is placed in transmitter outer ring-like space.
7. ultrasonic therapy equipment according to claim 1, is characterized in that, described judgment meansSpecifically also comprise:
Extraction module, extracts the work between ultrasonic wave transducer transmitter for the signal from spectral domain conversionThe predetermined high order of fundamental frequency or distribute lower than the noise amplitude spectrum in the fractional harmoni frequency range of fundamental frequency;
Whether described the first judge module exists at least one discrete specifically for judging that noise amplitude spectrum distributesPeak value be greater than the peak value of the first default thresholding, or multiple continuous peak value is greater than the peak of the second default thresholdingValue, obtains described judged result.
8. ultrasonic therapy equipment according to claim 1, is characterized in that,
Described conversion module utilizes Fourier analysis method, and the described signal of telecommunication is carried out to time domain to spectral domain conversion.
9. ultrasonic therapy equipment according to claim 1, is characterized in that, described judgment meansSpecifically comprise:
Waveform envelope extraction module, for carrying out waveform envelope extraction to the described signal of telecommunication;
Time-domain integration module, extracts for waveform envelope the signal obtaining and carries out time-domain integration, obtains receiving letterNumber gross energy;
The 3rd judge module, occurs predetermined for more described gross energy and the zone of action measuring in advanceBetween the energy range when acoustic cavitation of strength range, obtain described judged result.
10. ultrasonic therapy equipment according to claim 1, is characterized in that, judgment means is concreteComprise:
Preserve module, for preserve the zone of action while there is the acoustic cavitation of predetermined strength scope first with reference to letterNumber, the zone of action the second reference signal and zone of action while occurring lower than the acoustic cavitation of predetermined strength scopeThe 3rd reference signal while occurring higher than the acoustic cavitation of predetermined strength scope;
Cross-correlation degree computing module, for calculating the described signal of telecommunication and first, second, and third reference signalCross-correlation degree;
The 4th judge module, for according to described cross-correlation degree, obtains described judged result.
11. according to the ultrasonic therapy equipment described in any one in claim 1-10, it is characterized in that,Also comprise:
One sensor;
Second control device, sends out for ultrasonic wave transducer described in the Data Control collecting according to described sensorThe ultrasound emission dosage of emitter.
12. ultrasonic therapy equipments according to claim 1, is characterized in that, also comprise:
Present module, for visual treatment information is provided according to described judged result.
13. ultrasonic therapy equipments according to claim 12, is characterized in that, described ultrasonic waveTherapeutic equipment also comprises that one can continue mobile mechanical arm and for obtaining the mechanical arm of positional informationPositioner, described ultrasonic wave transducer transmitter is arranged on described mechanical arm, described in present module and specifically useIn providing visual treatment information according to described positional information and described judged result.
14. ultrasonic therapy equipments according to claim 12, is characterized in that, described ultrasonic waveTransducing transmitter be one can hand-held movement ultrasound emission transducer, on described ultrasound emission transducer, arrangeHave one for obtaining 3 dimension space positioners of positional information, described in present module specifically for described in basisPositional information and described judged result provide visual treatment information.
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| CN113117257B (en) * | 2019-12-30 | 2023-07-11 | 重庆融海超声医学工程研究中心有限公司 | Method and device for detecting cavitation effect and ultrasonic treatment equipment |
| CN113117268B (en) * | 2019-12-30 | 2023-12-15 | 重庆融海超声医学工程研究中心有限公司 | Device for detecting cavitation effect and ultrasonic treatment equipment |
| CN113893468B (en) * | 2020-06-22 | 2023-03-21 | 飞依诺科技(苏州)有限公司 | Method and device for adjusting therapeutic ultrasonic waves, computer equipment and storage medium |
| CN111840040B (en) * | 2020-07-06 | 2022-10-28 | 聊城市蓓智信息科技有限公司 | Leg physical therapy system and method using mobile platform |
| CN113426651A (en) * | 2021-05-21 | 2021-09-24 | 四川步歌科技有限公司 | Ultrasonic circuit and pain therapeutic apparatus comprising same |
| CN116439981B (en) * | 2023-06-16 | 2023-11-24 | 北京航空航天大学 | Shock wave treatment feedback device |
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