CN102442633A - Numerically controlled processing instrument for microfluidic chip - Google Patents
Numerically controlled processing instrument for microfluidic chip Download PDFInfo
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- CN102442633A CN102442633A CN2010105065061A CN201010506506A CN102442633A CN 102442633 A CN102442633 A CN 102442633A CN 2010105065061 A CN2010105065061 A CN 2010105065061A CN 201010506506 A CN201010506506 A CN 201010506506A CN 102442633 A CN102442633 A CN 102442633A
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Abstract
A numerically controlled processing instrument for microfluidic chip comprises a numerically controlled milling and carving unit, a microfluidic chip base fixing table unit, a chip milling and carving control program and a computer. The numerically controlled milling and carving unit comprises a milling and carving function unit and numerically controlled positioning and moving elements in an X, a Y and a Z directions which are perpendicular to one another, so that the function of performing positioning, and milling and carving on the surface of a chip by a milling and carving component can be realized. The microfluidic chip base fixing table unit is positioned below the numerically controlled milling and carving unit, is in a plane parallel to an X-axis/Y-axis direction, and is composed of an upper layer and a lower layer, namely a main platform and an auxiliary platform, wherein the auxiliary platform is a lining board mounted on the main platform and can be dismounted and repositioned; and the chip base of a microfluidic chip is fixed on the auxiliary platform first and then fixed on the main platform, so that the purpose of accurately positioning and repositioning the chip base of the microfluidic chip can be achieved. A computer is connected and communicates with the numerically controlled milling and carving unit through a digital interface, and the chip milling and carving control program can run to realize positioning and mobile control of the milling and carving unit, so that the effect that microprocessing is performed on the surface of a chip by the milling and carving component can be achieved, and then a required micro-channel structure can be formed on the surface of the chip.
Description
Technical field
The present invention relates to a kind of micro-fluidic chip micro-machining system.
Background technology
In recent years; The micro-fluidic chip technology has microminiaturization, automation, advantage such as integrated, convenient and quick as a kind of novel analysis platform; Broad research and application have been obtained, for example cell biology, analytical chemistry, environmental monitoring and protection, judicial expertise, fields such as medicine synthetic screening, materialogy and organizational engineering in a lot of fields.
Micro-fluidic chip is the main platform that microflow control technique is realized, its characteristic mainly is to hold the construction unit of microfluid, like fluid passage, reative cell and other functional unit etc.In micro-fluidic chip research, how on different chip materials, to process multiple various structure unit, be the basis of micro-fluidic chip research and application.On the micro-fluidic chip processing technology, mainly contain laser engraving at present, chemical etching; Methods such as photoetching, these methods cut both ways, and major defect is a complicated operation; Process-cycle is long, and it is poor to polish, and material is had selection; The passage roughness is big, and poor repeatability, is difficult to as a kind of general and efficient chip processing method.Development along with modern numerical control micro-processing technology; It can satisfy the specification requirement of micro-fluidic chip on machining accuracy and yardstick; But the little process equipment of existing numerical control is not design and the processing that is exclusively used in micro-fluidic chip in design; Caused to use and gone up unnecessary troublesome operation and the waste and the destruction of material, big limitations the application of numerical control micro-processing technology in the preparation of micro-fluidic chip.
Summary of the invention
The present invention be directed to that routine is used for the deficiency of the micro-machined numerical control micro-processing technology of micro-fluidic chip and a kind of micro-fluidic chip digital control processing appearance of providing is characterized in that it based on CNC processing technology, be exclusively used in the processing of micro-fluidic chip.System is milled by micro-fluidic chip sheet base fixed station unit, numerical control and carves unit, chip and mill and carve control program and computer is formed.Micro-fluidic chip sheet base fixed station unit is positioned at digital control processing unit below, is being parallel on the axial plane of X/Y, is made up of two-layer (main platform and secondary station) up and down.Assistance platform is the liner plate that is installed on main platform, can dismantle and reorientate, and micro-fluidic chip sheet base is fixed in earlier on the assistance platform, assistance platform is fixed on the main platform again, realizes the accurate location and the resetting of micro-fluidic chip sheet base.Numerical control is milled and is carved the unit and constitute by milling numerical control location and the moving component carved on functional part and three mutual vertical direction of X/Y/Z.Computer mills through digital interface and numerical control to be carved the unit and carries out communication; The operation chip mills carves the control program realization to milling the location of carving the unit and moving control; Processing component carries out little processing at chip surface thereby quarter is milled in realization, obtains the MCA that the CAD program is designed.
For realizing above-mentioned purpose, the present invention adopts following operating procedure:
(1) with the surperficial MCA figure of CAD software design chips;
(2) the MCA figure that CAD software is designed converts chip to and mills the control program at quarter;
(3) micro-fluidic chip sheet base is fixed on the assistance platform, again assistance platform is fixed on the main platform;
(4) select suitable cutter, be installed on numerical control and mill to carve and mill in the tool-holder of carving functional part in the unit;
(5) control program at quarter is milled in startup, carries out little processing at chip surface, obtains required MCA.
Among the present invention, mill carve parts three mutual vertical direction of X/Y/Z the numerical control location and move, can realize by stepper motor or the rotation of driven by servomotor leading screw.
Among the present invention, stepper motor is driven by stepper motor driver, and a pulse signal can be controlled motor and rotate π/1600 radians, and leading screw pitch is 1mm weekly, and therefore, 1/1600 (0.000625) mm is moved in each pulse.
Among the present invention, the micro-fluidic chip micro-machining system can carry out moving on a large scale in three directions of X/Y/Z, and its work top can reach 20x30x6cm, can carry out the processing of large chip, also can process a plurality of chips simultaneously.
Among the present invention, described digital control processing unit mill the functional part at quarter, can be that high-speed electric expreess locomotive drives the milling cutter rotation and mills quarter, also can be electric spark burn carve, laser burn carve, ultrasonic vibrations milling mode realizes the processing of micro-fluidic chip microchannel.
Among the present invention, sheet base fixed station unit is to be made up of main platform and assistance platform, and assistance platform is the liner plate of main platform, can dismantle and reorientate.Micro-fluidic chip sheet base is fixed in earlier on the assistance platform, assistance platform is fixed on the main platform again, realizes the location and the resetting of micro-fluidic chip sheet base.
Among the present invention; Be fixed with the right angle screens on the assistance platform, be used for fixing and positioning chip sheet base, according to size, size, shape and the quantity of chip slapper base; Assistance platform can be designed to single deck tape-recorder position or many screens, and the screens spacing can customize according to the needs of chip slapper base.In addition, adopt thin double faced adhesive tape that the chip slapper base is glued on the assistance platform, the pressure fixing that can avoid adopting side direction and vertical direction causes the deformation of sheet base and little mismachining tolerance of causing.
Among the present invention; For avoiding little zero-point positioning measure error that is processed in Z-direction; Adopt microscopic examination to measure (eyepiece micrometer is auxiliary); Also can adopt CCD (charge coupled cell) imageing sensor, and contactless location, the little mismachining tolerance on the Z-direction that cutter extruding chip slapper base is caused when having avoided Z axle zero-point positioning.
Among the present invention, the chip slapper sill can be one or more in quartz, glass, monocrystalline silicon, polymethyl methacrylate, Merlon, polyamide, polyethylene, polypropylene, polystyrene, dimethyl silicone polymer, copper, aluminium, stainless steel and the nickel etc.
Among the present invention, the micro-fluidic chip micro-machining system can be adaptable across the processing of various micro-fluidic chip sheet bases; Operating aspect, the process-cycle is short, and technology is simple; Consume few; Precision is high, and good reproducibility is to facture of microchip and significant based on the basic and applied research of micro-fluidic chip.
Description of drawings
Fig. 1 is the sketch map of micro-fluidic chip micro-machining system provided by the invention.
1.X/Y/Z direction drive motor among the figure (stepping or servomotor), 2. optical axis or guide rail, 3. leading screw; 4. main platform, 5. secondary station, the 6.Z direction is located micro-positioning shooting head or microscope; 7. fixedly screens, 8. electric drill (or other mill electrical equipment at quarter), 9. hold-down nut; 10. set bolt, 11. locating holes, 12. micro-fluidic chip sheet bases.
Specific embodiments
Micro-fluidic chip is little to add man-hour carrying out, and at first the required MCA in design chips surface can be worked out the employing G code on computers, perhaps uses and derives G code again after the assisted mapping software CAD is drawn, and promptly chip mills the control program at quarter.Polymethyl methacrylate (PMMA) sheet base is cut into 5x5cm; Thin double faced adhesive tape is sticked on to be processed offside four limits; An end is stuck in the right angle screens of assistance platform then, behind the pressing paster jail secondary station is relied on main platform screens again, makes it to be fixed on the main platform through tightening nuts.According to little processing request of the microchannel processing dimension of chip, adopt and mill carving method, the milling cutter that is fit to is installed, like 0.2mm diameter straight angle milling cutter.Start chip and mill the control program at quarter, carry out the zero-point positioning of X/Y/Z direction.About the location of Z-direction, because the working depth yardstick is little, be generally less than 0.5mm, adopt microscopic examination and measurement process tool whether to touch the material piece primary surface.Microscope was calibrated through the object lens chi, can accurately measure the degree of depth that cutter gos deep into material through the scale in the eyepiece, and it is zero that the adjustment cutter rigidly connects when touching chip surface the Z axle.The operation G code is resolved software, is connected concurrent load instruction with stepper motor driver through PORT COMs such as computer parallel port or serial ports, controls milling cutter and moves and process in the X/Y/Z direction, processes required MCA in that the chip slapper primary surface is little.
After accomplishing the microchannel preparation of a chip, in the time of the preparation of another chip being carried out, can take off assistance platform from main platform; Taking off finished base from assistance platform; It is residual to adopt the alcohol wipe method to remove double faced adhesive tape, and then is installed to assistance platform to new chip slapper base with same method, is fixed on the main platform through assistance platform again; The X/Y/Z coordinate of twice base all is constant, and error can be less than 0.01mm (not considering sheet base thickness error).The operation G code is resolved software, repeats milling quarter of chip slapper primary surface MCA, can obtain an other chip with same MCA.
Claims (10)
1. a micro-fluidic chip digital control processing appearance is characterized in that this system is based on the numerical control micro-processing technology, is exclusively used in the preparation of micro-fluidic chip.System is milled by micro-fluidic chip sheet base fixed station unit, numerical control and carves unit, chip and mill and carve control program and computer is formed.Micro-fluidic chip sheet base fixed station unit is positioned at digital control processing unit below, is being parallel on the axial plane of X/Y, is made up of two-layer (main platform and secondary station) up and down.Assistance platform is the liner plate that is installed on main platform, can dismantle and reorientate, and micro-fluidic chip sheet base is fixed in earlier on the assistance platform, assistance platform is fixed on the main platform again, realizes the accurate location and the resetting of micro-fluidic chip sheet base.Numerical control is milled and is carved the unit and constitute by milling numerical control location and the moving component carved on functional part and three mutual vertical direction of X/Y/Z.Computer mills through digital interface and numerical control to be carved the unit and carries out communication; The operation chip mills carves the control program realization to milling the location of carving the unit and moving control; Processing component carries out little processing at chip surface thereby quarter is milled in realization, obtains required MCA at chip surface.
2. micro-fluidic chip micro-machining system according to claim 1, its characterization step is following successively:
(1) with the surperficial MCA figure of CAD software design chips;
(2) the MCA figure that CAD software is designed converts chip to and mills the control program at quarter;
(3) micro-fluidic chip sheet base is fixed on the assistance platform, again assistance platform is fixed on the main platform;
(4) select suitable cutter, be installed on numerical control and mill to carve and mill in the tool-holder of carving functional part in the unit;
(5) control program at quarter is milled in startup, carries out little processing at chip surface, obtains required MCA.
3. micro-fluidic chip micro-machining system according to claim 1 and 2; The numerical control location and the moving component that it is characterized in that three mutual vertical direction of X/Y/Z; Be by stepper motor or the rotation of driven by servomotor leading screw, realize milling the location of functional part at quarter and moving.
4. micro-fluidic chip micro-machining system according to claim 1 and 2; It is characterized in that stepper motor is driven by stepper motor driver, a pulse signal can be controlled motor and rotate π/1600 radians, and leading screw pitch is 1mm weekly; Therefore, 1/1600 (0.000625) mm is moved in each pulse.
5. micro-fluidic chip micro-machining system according to claim 1 and 2 is characterized in that the moving range of three directions of X/Y/Z, and promptly the work top of system can reach 20x30x6cm.
6. micro-fluidic chip micro-machining system according to claim 1 and 2; What it is characterized in that the digital control processing unit mills the functional part at quarter; Can be that high-speed electric expreess locomotive drives milling cutter rotation milling, also can be electric spark burn carve, laser burn carve, ultrasonic vibrations milling mode realizes the processing of micro-fluidic chip microchannel.
7. micro-fluidic chip micro-machining system according to claim 1 and 2 is characterized in that micro-fluidic chip sheet base fixed station unit, is to be made up of main platform and assistance platform, and assistance platform is the liner plate of main platform, can dismantle and reorientate.Micro-fluidic chip sheet base is fixed in earlier on the assistance platform, assistance platform is fixed on the main platform again, realizes the location and the resetting of micro-fluidic chip sheet base.
8. micro-fluidic chip micro-machining system according to claim 1 and 2; It is characterized in that being fixed with on the assistance platform right angle screens; Be used for fixing and positioning chip sheet base; According to size, size, shape and the quantity of chip slapper base, assistance platform can be designed to single deck tape-recorder position or many screens, and the screens spacing can customize according to the size of chip slapper base.
9. micro-fluidic chip micro-machining system according to claim 1 and 2; It is characterized in that the location on the Z-direction; Adopt microscopic (eyepiece micrometer is auxiliary to be accomplished); And contactless location, the little mismachining tolerance on the Z-direction that cutter extruding chip slapper base is caused when having avoided Z axle zero-point positioning.
10. micro-fluidic chip micro-machining system according to claim 1 and 2; It is characterized in that the fixing of micro-fluidic chip sheet base; Adopt thin double faced adhesive tape to be glued on the secondary station, the pressure fixing of avoiding adopting side direction and vertical direction causes the deformation of sheet base and little mismachining tolerance of causing.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010105065061A CN102442633A (en) | 2010-10-14 | 2010-10-14 | Numerically controlled processing instrument for microfluidic chip |
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| CN2010105065061A CN102442633A (en) | 2010-10-14 | 2010-10-14 | Numerically controlled processing instrument for microfluidic chip |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103170382A (en) * | 2013-02-01 | 2013-06-26 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | Machining process of biochip microfluidic module |
| CN106423318A (en) * | 2016-10-26 | 2017-02-22 | 重庆大学 | Method for producing glass micro-fluidic control chip by means of numerical control engraving technology |
| WO2021043013A1 (en) * | 2019-09-05 | 2021-03-11 | The Chinese University Of Hong Kong | Automatic micromilling platform for microfluidic devices |
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| US20060153741A1 (en) * | 2002-11-15 | 2006-07-13 | Tamata-Tlo Corporation | Micro fluidic control device and process for producing the same |
| US20090166562A1 (en) * | 2006-06-07 | 2009-07-02 | Micah James Atkin | Production of microfluidic devices using laser-induced shockwaves |
| CN201399678Y (en) * | 2009-04-24 | 2010-02-10 | 上海电机学院 | Numerically controlled milling and grinding machining tool |
| CN201430723Y (en) * | 2009-07-02 | 2010-03-24 | 黄介军 | Digital control engraving machine |
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Patent Citations (4)
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| US20060153741A1 (en) * | 2002-11-15 | 2006-07-13 | Tamata-Tlo Corporation | Micro fluidic control device and process for producing the same |
| US20090166562A1 (en) * | 2006-06-07 | 2009-07-02 | Micah James Atkin | Production of microfluidic devices using laser-induced shockwaves |
| CN201399678Y (en) * | 2009-04-24 | 2010-02-10 | 上海电机学院 | Numerically controlled milling and grinding machining tool |
| CN201430723Y (en) * | 2009-07-02 | 2010-03-24 | 黄介军 | Digital control engraving machine |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103170382A (en) * | 2013-02-01 | 2013-06-26 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | Machining process of biochip microfluidic module |
| CN106423318A (en) * | 2016-10-26 | 2017-02-22 | 重庆大学 | Method for producing glass micro-fluidic control chip by means of numerical control engraving technology |
| WO2021043013A1 (en) * | 2019-09-05 | 2021-03-11 | The Chinese University Of Hong Kong | Automatic micromilling platform for microfluidic devices |
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Application publication date: 20120509 |