CN102430031B - Traditional Chinese medicine composition for strengthening vitality and invigorating kidneys and preparation method thereof - Google Patents
Traditional Chinese medicine composition for strengthening vitality and invigorating kidneys and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for strengthening vitality and invigorating kidneys and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials: 400-600 parts of acanthopanax, 240-360 parts of epimedium, 64-96 parts of astragalus mongholicus, 32-48 parts of poria, 32-48 parts of alisma, 32-48 parts of scurfpea fruit, 32-48 parts of prepared rehmannia root, 32-48 parts of yam, 32-48 parts of semen euryales, 32-48 parts of cornel and 24-36 parts of licorice. The preparation method comprises the steps of: respectively crushing the raw materials into fine powder and coarse powder, heating for extracting under continuous reflux, filtering, concentrating to obtain extract, uniformly mixing the fine powder with the extract, granulating, and then encapsulating to obtain capsules. The traditional Chinese medicine composition provided by the invention has the functions of strengthening and restoring effects as well as invigorating the spleen and kidneys, has a significant curative effect, can significantly improve soreness and weakness of waist and knees, cold limbs and coldness fear, fatigue and inability, dizziness and tinnitus, insomnia and dreamful sleep, frequent nocturia, loose stool and other clinical symptoms caused by insufficiency of both the spleen and the kidneys, and can strengthen the body resistance, strengthen vitality and improve organism immunity.
Description
Technical field
The present invention relates to consolidate the Chinese medicine composition of holding up unit, invigorating spleen and kidney yang deficiency aspect, is a kind of Chinese medicine composition for the strong kidney of primordial qi strengthening specifically.
Background technology
Deficiency of spleen-YANG and kidneyYANG patient Chang Yin deficiency of spleen-YANG and kidneyYANG can not moisten foster, warm body and cause soreness of the waist and knees, and limb is cold is afraid of cold fatigue and weak, dizziness and tinnitus, insomnia and dreamful sleep, nocturia frequency, the symptoms such as loose stool.Use clinically at present the medicine treatments such as " JINGUI SHENQI WAN ", " Yougui Wan, the kidney-Yang-Reinforcing Bolus ", though certain curative effect is arranged, aspects such as holding up unit, invigorating spleen and kidney yang deficiency is slightly inferior consolidating.
Summary of the invention
Technical problem to be solved by this invention provides a kind of tonifying the kidney for tranquilization that has, QI invigorating tonifying YANG, strengthening the body resistance, bone and muscle strengthening, the functions such as tonifying speen and tonifying kidney, a kind of Chinese medicine composition for the strong kidney of primordial qi strengthening that mainly is applicable to spleen deficiency syndrome.
Technical problem of the present invention adopts following technical proposals to solve:
A kind of Chinese medicine composition for the strong kidney of primordial qi strengthening, its raw material and weight proportion are: 400 ~ 600 parts of Radix Et Caulis Acanthopanacis Senticosis, 240 ~ 360 parts of Herba Epimedii, 64 ~ 96 parts of the Radixs Astragali, 32 ~ 48 parts in Poria, 32 ~ 48 parts of Rhizoma Alismatis, 32 ~ 48 parts of Fructus Psoraleaes, 32 ~ 48 parts of Radix Rehmanniae Preparata, 32 ~ 48 parts of Rhizoma Dioscoreaes, 32 ~ 48 parts of Semen Euryaless, 32 ~ 48 parts of Fructus Corni, 24 ~ 36 parts in Radix Glycyrrhizae
Preparation method comprises the following steps:
A) get the Radix Astragali, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Poria, Semen Euryales, Fructus Psoraleae, Fructus Corni, Rhizoma Alismatis, Radix Glycyrrhizae powder and be broken into fine powder, fine powder is crossed 120 eye mesh screens;
B) get Radix Et Caulis Acanthopanacis Senticosi, Herba Epimedii and be ground into coarse powder by 50 mesh sieves, 7 ~ 10 times of amounts that add 75% total ethanol coarse powder amount, be heated to 82 ~ 88 ℃, continuous circumfluence extraction 12 hours, filter, filtrate recycling ethanol is concentrated into the measured value of relative density under 45 ~ 55 ℃ of temperature conditions and is 1.28 ~ 1.32 extractum;
C) with above-mentioned fine powder and extractum mixing, add an amount of dextrin, mixing, granulation, drying, capsule charge is namely made Chinese medicine composition of the present invention.
The present invention is from spleen invigorating gas, the legislation of kidney-replenishing aspect, reusing Radix Et Caulis Acanthopanacis Senticosi, Radix Astragali tonifying the kidney for tranquilization, benefiting qi and raising yang is monarch drug, Herba Epimedii, Fructus Psoraleae kidney-replenishing, bone and muscle strengthening, tonifying kidney-yin, the spleen invigorating lung benefiting arresting seminal emission such as Radix Rehmanniae Preparata, Fructus Corni, Rhizoma Dioscoreae, Semen Euryales are ministerial drug, help again with Rhizoma Alismatis, Poria promoting diuresis to eliminate damp pathogen and help benefit to rush down, the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription is for making, and gathers altogether the function of primordial QI reinforcing original, invigorating spleen and kidney.After the patient takes, generally reflect this medication effect significantly, can obviously improve a series of cold symptom that resembles that causes owing to the spleen kidney yang deficiency of vital energy is weak.Long-term taking better effects if simultaneously, and without any side effects has the characteristics such as the low and taking convenience for the treatment of cost.
The present invention has carried out microscopical identification with medical material Radix Glycyrrhizae, Rhizoma Dioscoreae, the Radix Astragali, Fructus Corni, Radix Rehmanniae Preparata, Rhizoma Alismatis, Fructus Psoraleae etc. in target level of product quality; Medical material Radix Et Caulis Acanthopanacis Senticosi, Fructus Psoraleae, the Radix Astragali etc. are carried out thin layer chromatography differentiate that specificity, reliability are all good; And increased the assay of medical material Radix Et Caulis Acanthopanacis Senticosi, adopt the HPLC method to measure the content of effective ingredient syringoside in the Radix Et Caulis Acanthopanacis Senticosi.
The clinical 275 routine objects of observation are the patient that tcm diagnosis belongs to the deficiency of spleen-YANG and kidneyYANG disease, are divided at random two groups, " primordial qi strengthening Jianshen Capsule " treatment group 185 examples, " JINGUI SHENQI WAN " matched group 90 examples.By, Diarrhoea rare clearly to observed and recorded fear of cold 7,14,21,28 days time the before treating and after the treatment, back cold type of pain, cold and pain in the lower abdomen, soreness of the waist and knees, stool, abdominal distention, edema, nocturia, dizzy forgetful, weak asthenia and poor dreaminess totally ten binomial deficiency of spleen-YANG and kidneyYANG main symptom degree and the variations of sleeping, the result shows: " primordial qi strengthening Jianshen Capsule " can obviously improve deficiency of spleen-YANG and kidneyYANG patient's clinical symptoms, obvious effective rate and total effective rate are respectively 80.83% and 95.00%, and wherein obvious effective rate is apparently higher than " JINGUI SHENQI WAN " (P<0.01).
Product of the present invention has strengthening the body resistance, the invigorating spleen and kidney function, can obviously improve deficiency of spleen-YANG and kidneyYANG patient's the cold symptom that resembles, improve immunologic function, its effect that improves cellular immunization is excellent than " JINGUI SHENQI WAN ", cellular immunization had better adjustment effect, human peripheral blood T total lymphocyte count (T), helper T cell (T
H) and inhibition lymphocyte (T
S) adjustment of quantity is more obvious.Each 4 ~ 6 of " primordial qi strengthening Jianshen Capsule " consumption (every dress 0.4g drug particles), 2 times on the one, be advisable with 1 month the course for the treatment of, can take 1 ~ 2 course for the treatment of according to the state of an illness.This medicine is safe, nontoxic, does not find untoward reaction in the process clinical taking, and is a series of cold Chinese medicine preparation that resembles symptom that a kind of desirable treatment deficiency of spleen-YANG and kidneyYANG causes.
The specific embodiment
Below in conjunction with embodiment the present invention is explained in further detail:
Embodiment 1:
Get Radix Et Caulis Acanthopanacis Senticosi 500g, Herba Epimedii 300g, Radix Astragali 80g, Poria 40g, Rhizoma Alismatis 40g, Fructus Psoraleae 40g, Radix Rehmanniae Preparata 40g, Rhizoma Dioscoreae 40g, Semen Euryales 40g, Fructus Corni 40g, Radix Glycyrrhizae 30g, the materials for later use such as dextrin 55g;
(1) get the Radix Astragali, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Poria, Semen Euryales, Fructus Psoraleae, Fructus Corni, Rhizoma Alismatis, Radix Glycyrrhizae powder and be broken into fine powder, fine powder is by 120 eye mesh screens;
(2) get Radix Et Caulis Acanthopanacis Senticosi, Herba Epimedii and be ground into coarse powder by 50 mesh sieves, add 75% ethanol 7360ML, be heated to 82 ℃, continuous circumfluence extraction 12 hours, filter, collect filtrate, being concentrated into relative density behind the filtrate recycling ethanol is measured value under ℃ temperature conditions of 1.30(45 ~ 55) extractum;
(3) with above-mentioned fine powder and extractum mixing, add the dextrin mixing, granulation, drying, capsule charge behind the dried granule granulate gets capsule, namely makes the capsule of Chinese medicine composition of the present invention.
Embodiment 2
Get Radix Et Caulis Acanthopanacis Senticosi 600g, Herba Epimedii 360g, Radix Astragali 96g, Poria 48g, Rhizoma Alismatis 48g, Fructus Psoraleae 48g, Radix Rehmanniae Preparata 48g, Rhizoma Dioscoreae 48g, Semen Euryales 48g, Fructus Corni 48g, Radix Glycyrrhizae 36g, the materials such as dextrin 65g prepare according to following steps:
(1) get the Radix Astragali, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Poria, Semen Euryales, Fructus Psoraleae, Fructus Corni, Rhizoma Alismatis, Radix Glycyrrhizae powder and be broken into fine powder, fine powder is by 120 eye mesh screens;
(2) get Radix Et Caulis Acanthopanacis Senticosi, Herba Epimedii and be ground into coarse powder by 50 mesh sieves, add 75% ethanol 9200ML, be heated to about 88 ℃, continuous circumfluence extraction 12 hours, filter, collect filtrate, being concentrated into relative density behind the filtrate recycling ethanol is measured value under ℃ temperature conditions of 1.30(45 ~ 55) extractum;
(3) with above-mentioned fine powder and extractum mixing, add the dextrin mixing, granulation, drying, capsule charge behind the dried granule granulate gets capsule, namely makes the capsule of Chinese medicine composition of the present invention.
Embodiment 3
Get Radix Et Caulis Acanthopanacis Senticosi 400g, Herba Epimedii 240g, Radix Astragali 64g, Poria 32g, Rhizoma Alismatis 32g, Fructus Psoraleae 32g, Radix Rehmanniae Preparata 32g, Rhizoma Dioscoreae 32g, Semen Euryales 32g, Fructus Corni 32g, Radix Glycyrrhizae 24g, dextrin 45g.
(1) weight ratio is got the Radix Astragali, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Poria, Semen Euryales, Fructus Psoraleae, Fructus Corni, Rhizoma Alismatis, Radix Glycyrrhizae powder and is broken into fine powder, and fine powder is by 120 eye mesh screens;
(2) get Radix Et Caulis Acanthopanacis Senticosi, Herba Epimedii and be ground into coarse powder by 50 mesh sieves, add 75% ethanol 6440ML, be heated to 85 ℃, continuous circumfluence extraction 12 hours, filter, collect filtrate, being concentrated into relative density behind the filtrate recycling ethanol is measured value under ℃ temperature conditions of 1.30(45 ~ 55) extractum;
(3) with above-mentioned fine powder and extractum mixing, add the dextrin mixing, granulation, drying, capsule charge behind the dried granule granulate gets capsule, namely makes the capsule of Chinese medicine composition of the present invention.
Embodiment 4:
Get Radix Et Caulis Acanthopanacis Senticosi 500g, Herba Epimedii 300g, Radix Astragali 80g, Poria 40g, Rhizoma Alismatis 40g, Fructus Psoraleae 40g, Radix Rehmanniae Preparata 40g, Rhizoma Dioscoreae 40g, Semen Euryales 40g, Fructus Corni 40g, Radix Glycyrrhizae 30g;
(1) weight ratio is got the Radix Astragali, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Poria, Semen Euryales, Fructus Psoraleae, Fructus Corni, Rhizoma Alismatis, Radix Glycyrrhizae powder and is broken into fine powder, and fine powder is by 120 eye mesh screens;
(2) get Radix Et Caulis Acanthopanacis Senticosi, Herba Epimedii and be ground into coarse powder by 50 mesh sieves, add 75% ethanol 8280ML, be heated to 86 ℃, continuous circumfluence extraction 12 hours, filter, collect filtrate, being concentrated into relative density behind the filtrate recycling ethanol is measured value under ℃ temperature conditions of 1.32(45 ~ 55) extractum;
(3) with above-mentioned fine powder and extractum mixing, granulation, dry rear granulate adds magnesium stearate 12g mixing again, and tabletting namely gets tablet;
Embodiment 5
Get Radix Et Caulis Acanthopanacis Senticosi 400g, Herba Epimedii 240g, Radix Astragali 64g, Poria 32g, Rhizoma Alismatis 32g, Fructus Psoraleae 32g, Radix Rehmanniae Preparata 32g, Rhizoma Dioscoreae 32g, Semen Euryales 32g, Fructus Corni 32g, Radix Glycyrrhizae 24g;
(1) weight ratio is got the Radix Astragali, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Poria, Semen Euryales, Fructus Psoraleae, Fructus Corni, Rhizoma Alismatis, Radix Glycyrrhizae powder and is broken into fine powder, and fine powder is by 120 eye mesh screens;
(2) get Radix Et Caulis Acanthopanacis Senticosi, Herba Epimedii and be ground into coarse powder by 50 mesh sieves, add 75% ethanol 7360ML, be heated to 84 ℃, continuous circumfluence extraction 12 hours, filter, collect filtrate, being concentrated into relative density behind the filtrate recycling ethanol is measured value under ℃ temperature conditions of 1.32(45 ~ 55) extractum;
(3) with above-mentioned fine powder and extractum mixing, granulation, dry rear granulate adds magnesium stearate 9g mixing again, and tabletting namely gets tablet;
Embodiment 6
Get Radix Et Caulis Acanthopanacis Senticosi 500g, Herba Epimedii 300g, Radix Astragali 80g, Poria 40g, Rhizoma Alismatis 40g, Fructus Psoraleae 40g, Radix Rehmanniae Preparata 40g, Rhizoma Dioscoreae 40g, Semen Euryales 40g, Fructus Corni 40g, Radix Glycyrrhizae 30g, starch 75g(or make gelatinized corn starch).
(1) weight ratio is got the Radix Astragali, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Poria, Semen Euryales, Fructus Psoraleae, Fructus Corni, Rhizoma Alismatis, Radix Glycyrrhizae powder and is broken into fine powder, and fine powder is by 120 eye mesh screens;
(2) get Radix Et Caulis Acanthopanacis Senticosi, Herba Epimedii and be ground into coarse powder by 50 mesh sieves, add 75% ethanol 8280ML, be heated to about 85 ℃, continuous circumfluence extraction 12 hours, filter, collect filtrate, being concentrated into relative density behind the filtrate recycling ethanol is measured value under ℃ temperature conditions of 1.28(45 ~ 55) extractum;
(3) with above-mentioned fine powder and extractum mixing, add starch starch 75g soft material processed, pill, drying gets pill.
Embodiment 7
Get Radix Et Caulis Acanthopanacis Senticosi 400g, Herba Epimedii 240g, Radix Astragali 64g, Poria 32g, Rhizoma Alismatis 32g, Fructus Psoraleae 32g, Radix Rehmanniae Preparata 32g, Rhizoma Dioscoreae 32g, Semen Euryales 32g, Fructus Corni 32g, Radix Glycyrrhizae 24g;
(1) weight ratio is got the Radix Astragali, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Poria, Semen Euryales, Fructus Psoraleae, Fructus Corni, Rhizoma Alismatis, Radix Glycyrrhizae powder and is broken into fine powder, and fine powder is by 120 eye mesh screens;
(2) get Radix Et Caulis Acanthopanacis Senticosi, Herba Epimedii and be ground into coarse powder by 50 mesh sieves, add 75% ethanol 6440ML, be heated to 85 ℃, continuous circumfluence extraction 12 hours, filter, collect filtrate, being concentrated into relative density behind the filtrate recycling ethanol is measured value under ℃ temperature conditions of 1.28(45 ~ 55) extractum;
(3) with above-mentioned fine powder and extractum mixing, add gelatinized corn starch 60g soft material processed, pill, drying gets pill.
Pharmaceutical composition of the present invention adopts the pharmaceutical preparation technology on the pharmaceutics can make capsule, tablet or three kinds of dosage forms of pill.
Claims (5)
1. a Chinese medicine composition that is used for the strong kidney of primordial qi strengthening is characterized in that its raw material and weight proportion are: 400 ~ 600 parts of Radix Et Caulis Acanthopanacis Senticosis, 240 ~ 360 parts of Herba Epimedii, 64 ~ 96 parts of the Radixs Astragali, 32 ~ 48 parts in Poria, 32 ~ 48 parts of Rhizoma Alismatis, 32 ~ 48 parts of Fructus Psoraleaes, 32 ~ 48 parts of Radix Rehmanniae Preparata, 32 ~ 48 parts of Rhizoma Dioscoreaes, 32 ~ 48 parts of Semen Euryaless, 32 ~ 48 parts of Fructus Corni, 24 ~ 36 parts in Radix Glycyrrhizae;
The preparation method of above-mentioned Chinese medicine composition for the strong kidney of primordial qi strengthening is:
A gets the Radix Astragali, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Poria, Semen Euryales, Fructus Psoraleae, Fructus Corni, Rhizoma Alismatis, Radix Glycyrrhizae powder and is broken into fine powder, and fine powder is by 120 eye mesh screens;
B gets Radix Et Caulis Acanthopanacis Senticosi, Herba Epimedii is ground into coarse powder by 50 mesh sieves, adds 7 ~ 10 times of amounts of 75% total ethanol coarse powder amount, is heated to 82 ~ 88 ℃, continuous circumfluence extraction 12 hours, filter, filtrate recycling ethanol is concentrated into the measured value of relative density under 45 ~ 55 ℃ of temperature conditions and is 1.28 ~ 1.32 extractum;
C is above-mentioned fine powder and extractum mixing, granulation, and drying, capsule charge behind the dried granule granulate namely makes capsule.
2. a kind of Chinese medicine composition for the strong kidney of primordial qi strengthening according to claim 1 is characterized in that the weight proportion of described raw material is:
40 parts in 80 parts of Poria of 300 parts of Radixs Astragali of 500 parts of Herba Epimedii of Radix Et Caulis Acanthopanacis Senticosi
40 parts of 40 portions of Rhizoma Dioscoreaes of 40 parts of Radix Rehmanniae Preparata of 40 parts of Fructus Psoraleaes of Rhizoma Alismatis
30 parts in 40 portions of Radix Glycyrrhizaes of 40 parts of Fructus Corni of Semen Euryales.
3. a kind of Chinese medicine composition for the strong kidney of primordial qi strengthening according to claim 1 and 2 is characterized in that wherein adding adjuvant: 45 ~ 65 parts in dextrin.
4. a kind of Chinese medicine composition for the strong kidney of primordial qi strengthening according to claim 3 is characterized in that adjuvant dextrin wherein is 55 parts.
5. a kind of Chinese medicine composition for the strong kidney of primordial qi strengthening according to claim 1 is characterized in that described step c with fine powder, extractum mixing, and granulation adopts the pharmaceutical preparation technology on the pharmaceutics to make tablet or pill.
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