CN102423396A - Composition used for treating rheumatoid arthritis - Google Patents
Composition used for treating rheumatoid arthritis Download PDFInfo
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- CN102423396A CN102423396A CN2011104456503A CN201110445650A CN102423396A CN 102423396 A CN102423396 A CN 102423396A CN 2011104456503 A CN2011104456503 A CN 2011104456503A CN 201110445650 A CN201110445650 A CN 201110445650A CN 102423396 A CN102423396 A CN 102423396A
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Abstract
The invention relates to a composition used for treating rheumatoid arthritis. The composition is formed by mixing cornus officinalis, Chinese yam, gentiana macrophylla, Ligusticum wallichii, Japanese honeysuckle stems, and cortex moutan in a weight ratio of (15-35): (10-40):(5-20):(3-18):(6-20):(5-15). With the advantages of scientific and reasonable formula, definite therapeutic effect in rheumatoid arthritis treatment, and convenient administration, the composition of the invention can effectively treat rheumatoid arthritis and alleviate the symptoms of rheumatoid arthritis. Components of the composition are all pure traditional Chinese medicines, and have no obvious adverse reaction, high security as well as good patient compliance. Compared with other medicaments for treating rheumatoid arthritis, the composition provided in the invention has low price and convenience for wide application in communities and grass-roots hospitals, and can mitigate the economic burdens of patient families and the society, thus being more practical from the aspect of pharmacoeconomics.
Description
Technical field
The present invention relates to a kind of compositions that is used to treat rheumatic arthritis.
Background technology
Rheumatic arthritis is common clinical, frequently-occurring disease, and its cause of disease is complicated, and pathological manifestations is various, and the touching difficulty of the course of disease more even makes that the people is disabled, disability, is seriously endangering people health.Existing antirheumatic mainly contains NSAID, adrenocortical steroid and immunosuppressant etc., and they mostly can only relief of symptoms, and can not stop the development of the state of an illness.
Chinese medicine belongs to the arthromyodynia category with this type of disease.Arthromyodynia is owing to exopathogen such as the human righteousness is not enough, wind and cold is damp and hot invasion and attack; Or interior living phlegm-damp, pyretic toxicity, blood stasis cause the retardance of passages through which vital energy circulates group, occur with limbs joint, myalgia weighing, numb swelling, joint stuffiness, even joint deformity, or involve the general name that internal organs are one type of disease of characteristic.
Summary of the invention
Technical problem to be solved by this invention provides a kind of compositions that is used to treat rheumatic arthritis, uses said composition treatment rheumatic arthritis, can obtain obvious curative effects.
For solving the problems of the technologies described above; The invention provides a kind of compositions that is used to treat rheumatic arthritis, press (15-35) by Fructus Corni, Rhizoma Dioscoreae, Radix Gentianae Macrophyllae, Rhizoma Chuanxiong, Caulis Lonicerae, Cortex Moutan: (10-40): (5-20): (3-18): (6-20): the weight ratio of (5-15) is mixed and is formed.
For can concise description for the purpose of the problem, below the compositions that is used to treat rheumatic arthritis according to the invention be all abbreviated as this compositions.
The Therapeutic Principle of this combination treatment rheumatic arthritis is: replenishing YIN and removing heat, blood-activating and qi-promoting collateral dredging.
Urosolic acid, puckery, tepor, the nourishing kidney the liver benefiting.The Fructus Corni total glycosides part can suppress to drench changes, lymphokine activity killer cell (LAK cell) is induced and the generation of interleukin II.But Fructus Corni total glycosides part vitro inhibition mice and people's lymphocyte reaction, the inducing and rise in value of inhibition cytotoxic T cell.
Rhizoma Dioscoreae is in the research of experimental arthritis rat, and Rhizoma Dioscoreae water extract can significantly suppress Cu
2+To the Denaturation of gamma Globulin, show to have antarthritic effect.
The Radix Gentianae Macrophyllae nature and flavor are hot, bitter, are slightly cold.Return stomach warp, Liver Channel, gallbladder meridian.Function: eradicates rheumatism, Shujin network, Qingxudong heat.Cure mainly: be used for rheumatic arthralgia, the contracture of muscle arteries and veins, joint is ached.
The Rhizoma Chuanxiong acrid in the mouth, warm in nature.Return liver, gallbladder, pericardium channel.Function with cure mainly: blood-activating and qi-promoting, wind-expelling pain-stopping.Be used to pacify nerve, positive wind syndrome of head headache, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
The Caulis Lonicerae nature and flavor are sweet, cold.Attach to the lung and stomach meridians.Function cures mainly: heat-clearing and toxic substances removing, dispelling wind collateral dredging.Be used for epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle skin infection, rheumatism pyretic arthralgia, redness and swelling of joints burning pain.
Cortex Moutan is cold in nature, bitter in the mouth, cold, is slightly cold.GUIXIN, liver, kidney, lung meridian.Effect cures mainly: clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis.The epidemic febrile disease pathogenic heat attacking blood system in febrile diseases; Send out speckle; Tell nosebleed; The calentura later stage, hot Fu Yin divided heating; Deficiency of YIN osteopyrexia and fever; Amenorrhea due to stagnation of blood; Dysmenorrhea; Carbuncle sore tumefacting virus; Fall and pounce on the pain of injury; The rheumatism pyretic arthralgia.When low concentration (10-15ng/kg), can significantly improve the release of acid α-naphthyl acetate esterase (ANAE) activity in the peripheral blood, lymphocyte percentage and the easy row of leukocyte inhibitive factor, thus the enhancing body cellular immune function; And can significantly improve the phagocytosis of peripheral blood neutrophil to staphylococcus aureus, and the enhancing body non-specific immunity.Cortex Moutan can make the diameter of capillary in the microcirculation on the Mus mesentery, and erythrocytic flow velocity speeds in the pipe, shows that Cortex Moutan has the improvement effect to partial microcirculation.Cortex Moutan has potentiation to immune function of mice, and mouse spleen exponential sum thymus index and lymhocyte transformation rate are obviously improved.Cortex Moutan polysaccharide effective site PSM2h can directly promote the mouse boosting cell increment external; And can work in coordination with the inductive splenocyte proliferation function of conA; Turnover of Mouse Peritoneal Macrophages also there is activation; Can strengthen the Turnover of Mouse Peritoneal Macrophages phagocytosis, and induce the synthetic nitric oxide prompting of macrophage PSM2h can strengthen the T lymphocyte function, and macrophage is had activation.
The Therapeutic Principle of this compositions is: replenishing YIN and removing heat, invigorate blood circulation, promoting of the circulation of QI and removing the obstruction in the collaterals, urosolic acid, puckery, tepor, nourishing kidney the liver benefiting; Rhizoma Dioscoreae is sweet, flat, nourishing kidney strengthening the spleen and tonifying the lung, supplementing QI and nourishing YIN; Radix Gentianae Macrophyllae is bitter, hot, be slightly cold wind-damp dispelling, reducing the asthenic fever; Rhizoma Chuanxiong is hot, warm, blood-activating and qi-promoting, wind-expelling pain-stopping; Caulis Lonicerae is sweet, cold, heat clearing away, dispelling toxins and dredging collaterals; Cortex Moutan is bitter, hot, is slightly cold clearing away heat and cooling blood, stasis-dispelling and pain-killing.Mainly gather the merit of replenishing YIN and removing heat blood-activating and qi-promoting collateral dredging altogether.
This compositions has prescription science, rationally, determined curative effect, and taking convenience, the advantage of treatment rheumatic arthritis determined curative effect can effectively treat rheumatic arthritis, alleviate the symptom of rheumatic arthritis.This compositions component all is pure Chinese medicine, no obvious adverse reaction, and safe, patient's compliance is better.With respect to the medicine of other treatment treatment rheumatic arthritis, this compositions is cheap, is convenient to community and basic hospital and is widely used, and can alleviate the financial burden of patient family and society, has more practicality from the pharmacoeconomics aspect.
Each component of this compositions all can be buied on market.
This compositions water taken after fried promptly can be used for treating rheumatic arthritis.
For further specifying the effect of this compositions, existing case with treatment is explained.
The diagnostic criteria of rheumatic arthritis:
1, medical history: before sick the hemolytic streptococcal infection history is arranged more.
2, symptom: the big joint of extremity (wrist, elbow, shoulder, ankle, knee joint, hip) migration is scurried pain or is swollen and ache.
3, sign: the joint of getting involved is red, swollen, hot, pain or swell and ache, and movable function is limited, and some cases can have low grade fever, erythema nodosum, erythema iris or heart change etc. concurrently.
4, lab testing: active stage ESR generally speeds more, and how normal nonmobile phase is.Active stage ASO many positive (more than the 1:600u), like ASO negative patient (below the 1:400u), must see has erythema iris or erythema nodosa, otherwise can not be diagnosed as rheumatic arthritis.
5, X ray examination: the rarely seen soft tissue swelling in the joint of getting involved, no sclerotin change.
The rheumatic arthritis criterion of cure: joint symptom, sign disappear, and related experiment chamber inspection ESR and ASO are normal.
Rheumatic arthritis is alleviated standard: joint symptom, sign take a turn for the better, and related experiment chamber inspection ESR and ASO are normal.
Case 125 examples through above-mentioned diagnostic criteria is made a definite diagnosis adopt this combination treatment, and 15 days is a course of treatment, treat 3 courses of treatment after, cure 97 examples altogether, alleviate 26 examples, invalid 2 examples, total effective rate is 98.4%.
In sum, use this combination treatment rheumatic arthritis, determined curative effect.
The specific embodiment
Further specify the present invention through embodiment below.
Embodiment 1: be used to treat the compositions of rheumatic arthritis, be made up of mountain Zhu 25g, Rhizoma Dioscoreae 30g, Radix Gentianae Macrophyllae 12g, Rhizoma Chuanxiong 10g, Caulis Lonicerae 15g, Cortex Moutan 10g.After above-mentioned parts by weight of Chinese traditional medicine carried out dedusting, drying, pulverizing, be distributed into pouch, take every day 2-3 times, each 8-10g, warm boiled water gets final product.
Embodiment 2: be used to treat the compositions of rheumatic arthritis, be made up of mountain Zhu 15g, Rhizoma Dioscoreae 10g, Radix Gentianae Macrophyllae 5g, Rhizoma Chuanxiong 3g, Caulis Lonicerae 6g, Cortex Moutan 5g.After above-mentioned parts by weight of Chinese traditional medicine carried out dedusting, drying, pulverizing, be distributed into pouch, take every day 2-3 times, each 8-10g, warm boiled water gets final product.
Embodiment 3: be used to treat the compositions of rheumatic arthritis, be made up of mountain Zhu 35g, Rhizoma Dioscoreae 40g, Radix Gentianae Macrophyllae 20g, Rhizoma Chuanxiong 18g, Caulis Lonicerae 20g, Cortex Moutan 15g.After above-mentioned parts by weight of Chinese traditional medicine carried out dedusting, drying, pulverizing, be distributed into pouch, take every day 2-3 times, each 8-10g, warm boiled water gets final product.
This compositions can be carried out the increase and decrease of each component and weight portion according to the state of an illness in practical application.
Above-described only is one embodiment of the present invention.Should be pointed out that for the person of ordinary skill of the art under the prerequisite that does not break away from the principle of the invention, can also make conspicuous some conversion or alternative and remodeling, these also should be regarded as belonging to protection scope of the present invention.
Claims (1)
1. be used to treat the compositions of rheumatic arthritis, press (15-35) by Fructus Corni, Rhizoma Dioscoreae, Radix Gentianae Macrophyllae, Rhizoma Chuanxiong, Caulis Lonicerae, Cortex Moutan: (10-40): (5-20): (3-18): (6-20): the weight ratio of (5-15) is mixed and is formed.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110445650 CN102423396B (en) | 2011-12-28 | 2011-12-28 | Composition used for treating rheumatoid arthritis |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110445650 CN102423396B (en) | 2011-12-28 | 2011-12-28 | Composition used for treating rheumatoid arthritis |
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| CN102423396A true CN102423396A (en) | 2012-04-25 |
| CN102423396B CN102423396B (en) | 2013-12-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201110445650 Expired - Fee Related CN102423396B (en) | 2011-12-28 | 2011-12-28 | Composition used for treating rheumatoid arthritis |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1485063A (en) * | 2002-09-26 | 2004-03-31 | 纪文华 | Chinese traditional medicine formulation for rheumatism and its orthopaedic disease |
| CN1687369A (en) * | 2005-04-19 | 2005-10-26 | 石泽生 | Longevity medicinal wine and preparation method thereof |
-
2011
- 2011-12-28 CN CN 201110445650 patent/CN102423396B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1485063A (en) * | 2002-09-26 | 2004-03-31 | 纪文华 | Chinese traditional medicine formulation for rheumatism and its orthopaedic disease |
| CN1687369A (en) * | 2005-04-19 | 2005-10-26 | 石泽生 | Longevity medicinal wine and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 叶国安: "中医药治疗风湿性关节炎研究进展", 《甘肃中医》, vol. 18, no. 10, 31 October 2005 (2005-10-31), pages 9 - 11 * |
| 王福林: "中医辨证分型治疗对风湿性关节炎疼痛及关节功能的影响", 《中国临床康复》, vol. 6, no. 15, 15 August 2002 (2002-08-15) * |
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| CN102423396B (en) | 2013-12-18 |
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Granted publication date: 20131218 Termination date: 20211228 |
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