CN102421781A - 吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用 - Google Patents
吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用 Download PDFInfo
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- CN102421781A CN102421781A CN2011800020688A CN201180002068A CN102421781A CN 102421781 A CN102421781 A CN 102421781A CN 2011800020688 A CN2011800020688 A CN 2011800020688A CN 201180002068 A CN201180002068 A CN 201180002068A CN 102421781 A CN102421781 A CN 102421781A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
本发明涉及吡咯并N杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用。具体而言,本发明涉及式(I)所示的(R,Z)-2-(5-氟-2-氧代-1,2-二氢-吲哚-3-次甲基)-5-(2-羟基-3-吗啡啉-4-基-丙基)-3-甲基-5,6,7,8-四氢-1H-吡咯并[3,2-c]吖庚因-4-酮的可药用的盐,其制备方法以及作为治疗剂特别是作为蛋白激酶抑制剂的用途。
Description
PCT国内申请,说明书已公开。
Claims (1)
- PCT国内申请,权利要求书已公开。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011800020688A CN102421781A (zh) | 2010-02-04 | 2011-01-07 | 吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201010109068.5 | 2010-02-04 | ||
CN2010101090685A CN102146082A (zh) | 2010-02-04 | 2010-02-04 | 吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用 |
PCT/CN2011/070076 WO2011095068A1 (zh) | 2010-02-04 | 2011-01-07 | 吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用 |
CN2011800020688A CN102421781A (zh) | 2010-02-04 | 2011-01-07 | 吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN102421781A true CN102421781A (zh) | 2012-04-18 |
Family
ID=44354948
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2010101090685A Pending CN102146082A (zh) | 2010-02-04 | 2010-02-04 | 吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用 |
CN2011800020688A Pending CN102421781A (zh) | 2010-02-04 | 2011-01-07 | 吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2010101090685A Pending CN102146082A (zh) | 2010-02-04 | 2010-02-04 | 吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用 |
Country Status (11)
Country | Link |
---|---|
US (1) | US20120295887A1 (zh) |
EP (1) | EP2532666A1 (zh) |
JP (1) | JP2013518828A (zh) |
KR (1) | KR20120130089A (zh) |
CN (2) | CN102146082A (zh) |
AU (1) | AU2011213440A1 (zh) |
BR (1) | BR112012018658A2 (zh) |
CA (1) | CA2786927A1 (zh) |
MX (1) | MX2012008611A (zh) |
RU (1) | RU2012136378A (zh) |
WO (1) | WO2011095068A1 (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201402071D0 (en) * | 2014-02-07 | 2014-03-26 | Galapagos Nv | Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
CN112778187B (zh) * | 2021-01-06 | 2022-10-28 | 烟台舜康生物科技有限公司 | 一种海那替尼中间体的合成方法及所得的海纳替尼中间体 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001064681A2 (en) * | 2000-02-28 | 2001-09-07 | Sugen, Inc. | 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors |
WO2007085188A1 (en) * | 2006-01-27 | 2007-08-02 | Shanghai Hengrui Pharmaceutical Co. Ltd. | Pyrrolo [3,2-c] pyridine-4-one 2-indolinone protein kinase inhibitors |
WO2008138232A1 (fr) * | 2007-05-14 | 2008-11-20 | Shanghai Hengrui Pharmaceutical Co., Ltd. | Dérivés pyrrolo-azotés hétérocycliques, leur préparation et leur utilisation pharmaceutique |
WO2008138184A1 (fr) * | 2007-05-14 | 2008-11-20 | Shanghai Hengrui Pharmaceutical Co.Ltd. | Dérivés de pyrrolo-azacycles, leur procédé de fabrication et leur utilisation en tant qu'inhibiteurs de protéine kinases |
-
2010
- 2010-02-04 CN CN2010101090685A patent/CN102146082A/zh active Pending
-
2011
- 2011-01-07 MX MX2012008611A patent/MX2012008611A/es not_active Application Discontinuation
- 2011-01-07 BR BR112012018658A patent/BR112012018658A2/pt not_active Application Discontinuation
- 2011-01-07 AU AU2011213440A patent/AU2011213440A1/en not_active Abandoned
- 2011-01-07 KR KR1020127019373A patent/KR20120130089A/ko not_active Application Discontinuation
- 2011-01-07 CA CA2786927A patent/CA2786927A1/en not_active Abandoned
- 2011-01-07 CN CN2011800020688A patent/CN102421781A/zh active Pending
- 2011-01-07 US US13/574,272 patent/US20120295887A1/en not_active Abandoned
- 2011-01-07 WO PCT/CN2011/070076 patent/WO2011095068A1/zh active Application Filing
- 2011-01-07 RU RU2012136378/04A patent/RU2012136378A/ru not_active Application Discontinuation
- 2011-01-07 JP JP2012551483A patent/JP2013518828A/ja active Pending
- 2011-01-07 EP EP11739347A patent/EP2532666A1/en not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001064681A2 (en) * | 2000-02-28 | 2001-09-07 | Sugen, Inc. | 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors |
WO2007085188A1 (en) * | 2006-01-27 | 2007-08-02 | Shanghai Hengrui Pharmaceutical Co. Ltd. | Pyrrolo [3,2-c] pyridine-4-one 2-indolinone protein kinase inhibitors |
WO2008138232A1 (fr) * | 2007-05-14 | 2008-11-20 | Shanghai Hengrui Pharmaceutical Co., Ltd. | Dérivés pyrrolo-azotés hétérocycliques, leur préparation et leur utilisation pharmaceutique |
WO2008138184A1 (fr) * | 2007-05-14 | 2008-11-20 | Shanghai Hengrui Pharmaceutical Co.Ltd. | Dérivés de pyrrolo-azacycles, leur procédé de fabrication et leur utilisation en tant qu'inhibiteurs de protéine kinases |
Also Published As
Publication number | Publication date |
---|---|
JP2013518828A (ja) | 2013-05-23 |
BR112012018658A2 (pt) | 2016-05-03 |
WO2011095068A1 (zh) | 2011-08-11 |
EP2532666A1 (en) | 2012-12-12 |
US20120295887A1 (en) | 2012-11-22 |
KR20120130089A (ko) | 2012-11-28 |
CA2786927A1 (en) | 2011-08-11 |
MX2012008611A (es) | 2012-08-15 |
AU2011213440A1 (en) | 2012-08-09 |
RU2012136378A (ru) | 2014-03-10 |
CN102146082A (zh) | 2011-08-10 |
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Application publication date: 20120418 |