CN102421754A - 丙烯酰胺类衍生物及其制备药物的用途 - Google Patents

丙烯酰胺类衍生物及其制备药物的用途 Download PDF

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CN102421754A
CN102421754A CN2010800209820A CN201080020982A CN102421754A CN 102421754 A CN102421754 A CN 102421754A CN 2010800209820 A CN2010800209820 A CN 2010800209820A CN 201080020982 A CN201080020982 A CN 201080020982A CN 102421754 A CN102421754 A CN 102421754A
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acrylamide
phenyl
methyl
pyridin
amide
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CN102421754B (zh
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孙树萍
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Beijing Shiqiao Biopham Co ltd
YinGu Pharmaceutical Co Ltd
Beijing Shiqiao Biopharm Co Ltd
Beijing Jiashilianbo Pharm Sci and Tech Co Ltd
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Beijing Shiqiao Biopham Co ltd
YinGu Pharmaceutical Co Ltd
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

式(I)所示的丙烯酰胺类衍生物、其药学上可接受的盐和溶剂化物，以及含有所述丙烯酰胺类衍生物或其药学上可接受的盐作为活性成分的药物，所述药物可用于治疗与酪氨酸激酶特别是Bcr-Abl相关的疾病，包括增生性疾病如癌症及炎症疾病等。

Description

PCT国内申请，说明书已公开。

Claims (11)

  1. PCT国内申请，权利要求书已公开。
CN2010800209820A 2009-05-12 2010-04-27 丙烯酰胺类衍生物及其制备药物的用途 Expired - Fee Related CN102421754B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2010800209820A CN102421754B (zh) 2009-05-12 2010-04-27 丙烯酰胺类衍生物及其制备药物的用途

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CN200910136362 2009-05-12
CN200910136362.2 2009-05-12
CN200910170110.1 2009-09-03
CN200910170110 2009-09-03
PCT/CN2010/072245 WO2010130178A1 (zh) 2009-05-12 2010-04-27 丙烯酰胺类衍生物及其制备药物的用途
CN2010800209820A CN102421754B (zh) 2009-05-12 2010-04-27 丙烯酰胺类衍生物及其制备药物的用途

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CN102421754A true CN102421754A (zh) 2012-04-18
CN102421754B CN102421754B (zh) 2013-11-27

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Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2276737A1 (en) * 2008-04-17 2011-01-26 Pfizer Inc. 4- [3- (aryloxy) benzylidene]-3-methyl piperidine aryl carboxamide compounds useful as faah inhibitors
WO2012150952A1 (en) * 2011-05-04 2012-11-08 Forma Tm, Llc Novel compounds and compositions for the inhibition of nampt
CN103086982A (zh) * 2011-10-31 2013-05-08 上海壹志医药科技有限公司 嘧啶衍生物的盐
WO2021041861A1 (en) * 2019-08-30 2021-03-04 National University Of Singapore N-(2-aminophenyl)-prop-2-enamide derivatives, and uses thereof in the treatment of cancer
CN115417789B (zh) * 2022-09-03 2023-08-04 郑州大学 一种治疗帕金森氏病的化合物、其制备方法以及复方药物组合物和应用

Citations (5)

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Publication number Priority date Publication date Assignee Title
EP0330026A1 (en) * 1988-02-15 1989-08-30 Takeda Chemical Industries, Ltd. Piperidinoalkyl derivatives of carboxylic acid amides
CN1228777A (zh) * 1996-06-20 1999-09-15 克林格制药股份有限公司 吡啶基链烷烃－和吡啶基链炔径－酸酰胺作为细胞抑制剂和免疫抑制剂
EP1264820A1 (en) * 2000-03-14 2002-12-11 Fujisawa Pharmaceutical Co., Ltd. Novel amide compounds
TW200524869A (en) * 2003-07-04 2005-08-01 Shenzhen Microchip Biolog Sci Benzamide kind histon deacetylase inhibiting agent having dissociation and antibred activity and its medicinal preparation
WO2008025857A2 (en) * 2006-09-01 2008-03-06 Topotarget Switzerland Sa New method for the treatment of inflammatory diseases

Family Cites Families (1)

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Publication number Priority date Publication date Assignee Title
US7244751B2 (en) * 2003-02-14 2007-07-17 Shenzhen Chipscreen Biosciences Ltd. Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0330026A1 (en) * 1988-02-15 1989-08-30 Takeda Chemical Industries, Ltd. Piperidinoalkyl derivatives of carboxylic acid amides
CN1228777A (zh) * 1996-06-20 1999-09-15 克林格制药股份有限公司 吡啶基链烷烃－和吡啶基链炔径－酸酰胺作为细胞抑制剂和免疫抑制剂
EP1264820A1 (en) * 2000-03-14 2002-12-11 Fujisawa Pharmaceutical Co., Ltd. Novel amide compounds
TW200524869A (en) * 2003-07-04 2005-08-01 Shenzhen Microchip Biolog Sci Benzamide kind histon deacetylase inhibiting agent having dissociation and antibred activity and its medicinal preparation
WO2008025857A2 (en) * 2006-09-01 2008-03-06 Topotarget Switzerland Sa New method for the treatment of inflammatory diseases

Non-Patent Citations (3)

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Title
MARIELLE PARIS,等: "Histone Deacetylase Inhibitors: From Bench to Clinic", 《JOURNAL OF MEDICINAL CHEMISTRY》, vol. 51, no. 6, 5 February 2008 (2008-02-05), pages 1505 - 1529, XP002495888, DOI: doi:10.1021/jm7011408 *
YUBIN ZHANG,等: "HISTONE DEACETYLASE INHIBITORS FK228,N-(2-AMINOPHENYL)-4-[N-(PYRIDIN-3-YL-METHOXYCARBONYL)AMINOMETHYL]BENZAMIDE AND m-CARBOXYCINNAMIC ACID BIS-HYDROXAMIDE AUGMENT RADIATION-INDUCED CELL DEATH IN GASTROINTESTINAL ADENOCARCINOMA CELLS", 《INTERNATIONAL JOURNAL OF CANCER》, vol. 110, no. 2, 19 February 2004 (2004-02-19), pages 301 - 308 *
王立升等: "抗Gleevec(STI-571)耐受的Bcr-Abl蛋白酪氨酸激酶抑制剂研究进展", 《广西大学学报(自然科学版)》, vol. 31, no. 01, 30 March 2006 (2006-03-30), pages 10 - 13 *

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HK1166781A1 (en) 2012-11-09
CN102421754B (zh) 2013-11-27
US8426446B2 (en) 2013-04-23
US20120116075A1 (en) 2012-05-10
WO2010130178A1 (zh) 2010-11-18

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